Dnmt3l (DNA methyltransferase 3-like) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Dnmt3l (DNA methyltransferase 3-like) Mus musculus
Analyze
Symbol: Dnmt3l
Name: DNA methyltransferase 3-like
RGD ID: 1615141
MGI Page MGI
Description: Enables enzyme activator activity. Involved in several processes, including epigenetic regulation of gene expression; male meiosis I; and negative regulation of DNA methylation-dependent heterochromatin formation. Acts upstream of or within several processes, including chorionic trophoblast cell differentiation; epigenetic regulation of gene expression; and placenta development. Located in condensed nuclear chromosome; cytoplasm; and heterochromatin. Part of ESC/E(Z) complex. Is expressed in several structures, including alimentary system; brain; early conceptus; gonad; and sensory organ. Orthologous to human DNMT3L (DNA methyltransferase 3 like).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: D6Ertd14; D6Ertd14e; DNA (cytosine-5)-methyltransferase 3-like; DNA (cytosine-5-)-methyltransferase 3-like; ecat; ecat7; MGC102308
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Dnmt3l-ps1  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391077,878,121 - 77,899,456 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1077,877,781 - 77,899,456 (+)EnsemblGRCm39 Ensembl
GRCm381078,042,287 - 78,063,622 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,041,947 - 78,063,622 (+)EnsemblGRCm38mm10GRCm38
MGSCv371077,505,032 - 77,526,360 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361077,452,971 - 77,466,744 (+)NCBIMGSCv36mm8
Celera1079,081,287 - 79,102,649 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
alpha-Zearalanol  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (EXP)
carbon nanotube  (EXP)
chlorpyrifos  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cypermethrin  (ISO)
diarsenic trioxide  (ISO)
dimethylselenide  (ISO)
ethylparaben  (ISO)
folic acid  (EXP)
fulvestrant  (EXP)
genistein  (EXP)
hydrogen peroxide  (ISO)
hydroxyl  (ISO)
hypochlorous acid  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
menadione  (EXP)
methylmercury chloride  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (EXP,ISO)
stigmasterol  (EXP)
succimer  (EXP)
tebuconazole  (ISO)
testosterone  (ISO)
titanium dioxide  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. Kovacheva VP, etal., J Biol Chem. 2007 Oct 26;282(43):31777-88. Epub 2007 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10022980   PMID:10349636   PMID:10716651   PMID:10725249   PMID:10857753   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11306809   PMID:11719692   PMID:11934864  
PMID:12202768   PMID:12466851   PMID:12466854   PMID:12466855   PMID:12477932   PMID:12787504   PMID:12904583   PMID:12930754   PMID:14610273   PMID:14681479   PMID:14998934   PMID:15015937  
PMID:15063176   PMID:15317747   PMID:15318244   PMID:15489334   PMID:15567719   PMID:15671018   PMID:15739230   PMID:15753313   PMID:16141072   PMID:16141073   PMID:16211598   PMID:16283622  
PMID:16403808   PMID:16543361   PMID:16627687   PMID:16920095   PMID:16999741   PMID:17048991   PMID:17060371   PMID:17445268   PMID:17616512   PMID:17687327   PMID:17713477   PMID:17875220  
PMID:17938196   PMID:17942418   PMID:17967881   PMID:17982445   PMID:18381894   PMID:18480470   PMID:18544626   PMID:18663141   PMID:18784354   PMID:18799693   PMID:18836209   PMID:18922463  
PMID:18945701   PMID:18953337   PMID:19515852   PMID:19727073   PMID:19921333   PMID:20011505   PMID:20018712   PMID:20059948   PMID:20211142   PMID:20300987   PMID:20362542   PMID:20587527  
PMID:20833365   PMID:21056461   PMID:21124827   PMID:21233130   PMID:21483837   PMID:21553025   PMID:21589869   PMID:21645502   PMID:21674058   PMID:21677750   PMID:21706000   PMID:21731673  
PMID:21873635   PMID:21949694   PMID:21991325   PMID:22448252   PMID:22449967   PMID:22671959   PMID:22705479   PMID:22723905   PMID:22761581   PMID:23034635   PMID:23154982   PMID:23159436  
PMID:23293288   PMID:23473982   PMID:23637617   PMID:23866265   PMID:24036309   PMID:24074865   PMID:24183668   PMID:24183939   PMID:24357321   PMID:24457600   PMID:24576537   PMID:24589776  
PMID:24599402   PMID:24850856   PMID:24941955   PMID:24952961   PMID:24991018   PMID:24995522   PMID:25142465   PMID:25344072   PMID:25416063   PMID:25503965   PMID:25683717   PMID:25725066  
PMID:25772451   PMID:26109049   PMID:26159833   PMID:26417043   PMID:26589352   PMID:26751286   PMID:27072294   PMID:27606421   PMID:27856912   PMID:28118982   PMID:28228259   PMID:28749988  
PMID:28938467   PMID:29941866   PMID:30185906   PMID:30321403   PMID:30834655   PMID:30995416   PMID:31040401   PMID:31067460   PMID:31558711   PMID:32173286   PMID:32367046   PMID:32452519  
PMID:32514790   PMID:32674113   PMID:32892421   PMID:32929285   PMID:33199444   PMID:33718357   PMID:34174172   PMID:34401671   PMID:34912016   PMID:35410378   PMID:35721752   PMID:38237590  
PMID:38355793   PMID:38359823   PMID:38625792   PMID:38627502  


Genomics

Comparative Map Data
Dnmt3l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391077,878,121 - 77,899,456 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1077,877,781 - 77,899,456 (+)EnsemblGRCm39 Ensembl
GRCm381078,042,287 - 78,063,622 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,041,947 - 78,063,622 (+)EnsemblGRCm38mm10GRCm38
MGSCv371077,505,032 - 77,526,360 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361077,452,971 - 77,466,744 (+)NCBIMGSCv36mm8
Celera1079,081,287 - 79,102,649 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
DNMT3L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382144,246,339 - 44,261,897 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2144,246,339 - 44,262,216 (-)EnsemblGRCh38hg38GRCh38
GRCh372145,666,222 - 45,681,780 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,490,651 - 44,506,527 (-)NCBINCBI36Build 36hg18NCBI36
Build 342144,490,650 - 44,506,527NCBI
Celera2130,771,480 - 30,787,356 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2131,036,675 - 31,052,591 (-)NCBIHuRef
CHM1_12145,226,863 - 45,242,733 (-)NCBICHM1_1
T2T-CHM13v2.02142,600,400 - 42,615,957 (-)NCBIT2T-CHM13v2.0
Dnmt3l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,614,591 - 10,628,989 (-)NCBIGRCr8
mRatBN7.22010,614,933 - 10,629,337 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,614,934 - 10,629,516 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2011,314,285 - 11,328,650 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,675,187 - 10,689,553 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,147,204 - 11,161,604 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,344,513 - 11,359,090 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,344,514 - 11,359,090 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02013,514,653 - 13,529,169 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42010,958,957 - 10,973,422 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12010,959,183 - 10,973,649 (-)NCBI
Celera2012,120,702 - 12,135,281 (-)NCBICelera
Cytogenetic Map20p12NCBI
Dnmt3l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540741,177,582 - 41,186,965 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540741,177,582 - 41,186,965 (+)NCBIChiLan1.0ChiLan1.0
DNMT3L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22240,255,079 - 40,269,622 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12135,105,200 - 35,119,723 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02130,503,194 - 30,520,237 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12143,798,778 - 43,814,283 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2143,798,778 - 43,814,283 (-)Ensemblpanpan1.1panPan2
DNMT3L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13138,099,100 - 38,111,432 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3137,256,521 - 37,272,413 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03137,646,747 - 37,659,063 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3137,645,326 - 37,659,391 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13137,513,901 - 37,526,213 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03137,497,879 - 37,510,191 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03137,992,522 - 38,008,421 (-)NCBIUU_Cfam_GSD_1.0
Dnmt3l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497137,307,350 - 37,324,745 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936500143,078 - 160,212 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936500143,078 - 160,318 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNMT3L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13207,119,051 - 207,132,538 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113207,119,025 - 207,141,990 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213216,998,088 - 217,011,839 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNMT3L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1287,991,868 - 88,006,399 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl287,991,936 - 88,005,459 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605416,105,634 - 16,119,773 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnmt3l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474529,869,196 - 29,878,169 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474529,869,174 - 29,878,189 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnmt3l
655 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1191
Count of miRNA genes:380
Interacting mature miRNAs:420
Transcripts:ENSMUST00000000746, ENSMUST00000123940, ENSMUST00000131825, ENSMUST00000135316, ENSMUST00000138785, ENSMUST00000139539, ENSMUST00000144446, ENSMUST00000151242
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7398721682491121Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse

Markers in Region
Dnmt3l  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371077,514,576 - 77,515,628UniSTSGRCm37
MGSCv371077,515,547 - 77,516,743UniSTSGRCm37
MGSCv371077,514,583 - 77,515,524UniSTSGRCm37
MGSCv371077,514,737 - 77,515,599UniSTSGRCm37
Celera1079,090,865 - 79,091,917UniSTS
Celera1079,091,836 - 79,093,032UniSTS
Celera1079,091,026 - 79,091,888UniSTS
Celera1079,090,872 - 79,091,813UniSTS
Cytogenetic Map10C1UniSTS
cM Map1041.6UniSTS
D10Jhu43  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381078,045,148 - 78,045,345UniSTSGRCm38
MGSCv371077,507,893 - 77,508,090UniSTSGRCm37
Celera1079,084,148 - 79,084,345UniSTS
Cytogenetic Map10C1UniSTS
cM Map1041.7UniSTS
RH125967  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381078,063,362 - 78,063,608UniSTSGRCm38
MGSCv371077,526,107 - 77,526,353UniSTSGRCm37
Celera1079,102,396 - 79,102,642UniSTS
Cytogenetic Map10C1UniSTS
cM Map67.2UniSTS
cM Map1041.6UniSTS
cM Map10 UniSTS
cM Map6 UniSTS
Whitehead/MRC_RH10877.41UniSTS
Aire  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381078,045,389 - 78,045,530UniSTSGRCm38
MGSCv371077,508,134 - 77,508,275UniSTSGRCm37
Celera1079,084,389 - 79,084,526UniSTS
Cytogenetic Map10C1UniSTS
cM Map1041.6UniSTS
Aire  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381078,041,575 - 78,042,133UniSTSGRCm38
MGSCv371077,504,320 - 77,504,878UniSTSGRCm37
Celera1079,080,575 - 79,081,133UniSTS
Cytogenetic Map10C1UniSTS
cM Map1041.6UniSTS
Dnmt3l  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381078,052,802 - 78,053,998UniSTSGRCm38
MGSCv371077,515,547 - 77,516,743UniSTSGRCm37
Celera1079,091,836 - 79,093,032UniSTS
Cytogenetic Map10C1UniSTS
Dnmt3l  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381078,051,838 - 78,052,779UniSTSGRCm38
MGSCv371077,514,583 - 77,515,524UniSTSGRCm37
Celera1079,090,872 - 79,091,813UniSTS
Cytogenetic Map10C1UniSTS
Dnmt3l  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10C1UniSTS
Dnmt3l  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381078,051,831 - 78,052,883UniSTSGRCm38
MGSCv371077,514,576 - 77,515,628UniSTSGRCm37
Celera1079,090,865 - 79,091,917UniSTS
Cytogenetic Map10C1UniSTS
Dnmt3l  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381078,051,992 - 78,052,854UniSTSGRCm38
MGSCv371077,514,737 - 77,515,599UniSTSGRCm37
Celera1079,091,026 - 79,091,888UniSTS
Cytogenetic Map10C1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001081695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001284197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001284198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001284199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001284200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC153507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF073797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF220524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ404467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV473569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV511576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF051621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF051622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF051623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF051624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000000746   ⟹   ENSMUSP00000000746
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1077,885,676 - 77,899,456 (+)Ensembl
GRCm38.p6 Ensembl1078,049,842 - 78,063,622 (+)Ensembl
Ensembl Acc Id: ENSMUST00000123940   ⟹   ENSMUSP00000123015
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1077,891,169 - 77,899,449 (+)Ensembl
GRCm38.p6 Ensembl1078,055,335 - 78,063,615 (+)Ensembl
Ensembl Acc Id: ENSMUST00000131825   ⟹   ENSMUSP00000119571
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1077,891,169 - 77,899,449 (+)Ensembl
GRCm38.p6 Ensembl1078,055,335 - 78,063,615 (+)Ensembl
Ensembl Acc Id: ENSMUST00000135316
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1077,877,781 - 77,881,737 (+)Ensembl
GRCm38.p6 Ensembl1078,041,947 - 78,045,903 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138785   ⟹   ENSMUSP00000121562
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1077,878,121 - 77,899,456 (+)Ensembl
GRCm38.p6 Ensembl1078,042,287 - 78,063,622 (+)Ensembl
Ensembl Acc Id: ENSMUST00000139539   ⟹   ENSMUSP00000117827
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1077,891,169 - 77,899,449 (+)Ensembl
GRCm38.p6 Ensembl1078,055,335 - 78,063,615 (+)Ensembl
Ensembl Acc Id: ENSMUST00000144446
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1077,890,669 - 77,893,202 (+)Ensembl
GRCm38.p6 Ensembl1078,054,835 - 78,057,368 (+)Ensembl
Ensembl Acc Id: ENSMUST00000151242   ⟹   ENSMUSP00000116970
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1077,885,793 - 77,899,450 (+)Ensembl
GRCm38.p6 Ensembl1078,049,959 - 78,063,616 (+)Ensembl
RefSeq Acc Id: NM_001081695   ⟹   NP_001075164
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391077,878,121 - 77,899,456 (+)NCBI
GRCm381078,042,287 - 78,063,622 (+)NCBI
MGSCv371077,505,032 - 77,526,360 (+)RGD
Celera1079,081,287 - 79,102,656 (+)NCBI
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001284197   ⟹   NP_001271126
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391077,885,793 - 77,899,456 (+)NCBI
GRCm381078,049,959 - 78,063,622 (+)NCBI
Celera1079,081,287 - 79,102,656 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001284198   ⟹   NP_001271127
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391077,891,169 - 77,899,456 (+)NCBI
GRCm381078,055,335 - 78,063,622 (+)NCBI
Celera1079,081,287 - 79,102,656 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001284199   ⟹   NP_001271128
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391077,891,169 - 77,899,456 (+)NCBI
GRCm381078,055,335 - 78,063,622 (+)NCBI
Celera1079,081,287 - 79,102,656 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001284200   ⟹   NP_001271129
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391077,891,169 - 77,899,456 (+)NCBI
GRCm381078,055,335 - 78,063,622 (+)NCBI
Celera1079,081,287 - 79,102,656 (+)NCBI
Sequence:
RefSeq Acc Id: NM_019448   ⟹   NP_062321
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391077,885,676 - 77,899,456 (+)NCBI
GRCm381078,049,842 - 78,063,622 (+)NCBI
MGSCv371077,505,032 - 77,526,360 (+)RGD
Celera1079,081,287 - 79,102,656 (+)NCBI
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_001075164   ⟸   NM_001081695
- Peptide Label: isoform 1
- UniProtKB: Q9CWR8 (UniProtKB/Swiss-Prot),   A3EWM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_062321   ⟸   NM_019448
- Peptide Label: isoform 1
- UniProtKB: Q9CWR8 (UniProtKB/Swiss-Prot),   A3EWM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001271126   ⟸   NM_001284197
- Peptide Label: isoform 1
- UniProtKB: Q9CWR8 (UniProtKB/Swiss-Prot),   A3EWM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001271127   ⟸   NM_001284198
- Peptide Label: isoform 2
- UniProtKB: D3YUQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001271128   ⟸   NM_001284199
- Peptide Label: isoform 2
- UniProtKB: D3YUQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001271129   ⟸   NM_001284200
- Peptide Label: isoform 2
- UniProtKB: D3YUQ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000117827   ⟸   ENSMUST00000139539
Ensembl Acc Id: ENSMUSP00000121562   ⟸   ENSMUST00000138785
Ensembl Acc Id: ENSMUSP00000000746   ⟸   ENSMUST00000000746
Ensembl Acc Id: ENSMUSP00000116970   ⟸   ENSMUST00000151242
Ensembl Acc Id: ENSMUSP00000119571   ⟸   ENSMUST00000131825
Ensembl Acc Id: ENSMUSP00000123015   ⟸   ENSMUST00000123940
Protein Domains
ADD   PHD-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CWR8-F1-model_v2 AlphaFold Q9CWR8 1-421 view protein structure

Promoters
RGD ID:6819188
Promoter ID:MM_KWN:4711
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:OTTMUST00000086337,   OTTMUST00000086338
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361077,512,556 - 77,513,056 (+)MPROMDB
RGD ID:6848956
Promoter ID:MM_XEF:730
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:NM_013369,   NM_175867
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361077,513,796 - 77,514,296 (+)MPROMDB
RGD ID:6819187
Promoter ID:MM_KWN:4712
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   ES_Cell
Transcripts:OTTMUST00000086339,   OTTMUST00000086340,   OTTMUST00000086341,   OTTMUST00000086343
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361077,517,419 - 77,517,919 (+)MPROMDB
RGD ID:8672472
Promoter ID:EPDNEW_M14266
Type:initiation region
Name:Dnmt3l_1
Description:Mus musculus DNA (cytosine-5-)-methyltransferase 3-like , transcriptvariant 6, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14267  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381078,049,950 - 78,050,010EPDNEW
RGD ID:8672474
Promoter ID:EPDNEW_M14267
Type:multiple initiation site
Name:Dnmt3l_2
Description:Mus musculus DNA (cytosine-5-)-methyltransferase 3-like , transcriptvariant 6, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14266  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381078,055,345 - 78,055,405EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1859287 AgrOrtholog
Ensembl Genes ENSMUSG00000000730 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000000746 ENTREZGENE
  ENSMUST00000000746.12 UniProtKB/Swiss-Prot
  ENSMUST00000123940 ENTREZGENE
  ENSMUST00000123940.2 UniProtKB/TrEMBL
  ENSMUST00000131825 ENTREZGENE
  ENSMUST00000131825.8 UniProtKB/TrEMBL
  ENSMUST00000138785 ENTREZGENE
  ENSMUST00000138785.8 UniProtKB/Swiss-Prot
  ENSMUST00000139539 ENTREZGENE
  ENSMUST00000139539.8 UniProtKB/TrEMBL
  ENSMUST00000151242 ENTREZGENE
  ENSMUST00000151242.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNMT3_ADD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNMT3_ADD_PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:54427 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1859287 ENTREZGENE
NCBI Gene 54427 ENTREZGENE
PANTHER DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23068:SF13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADD_DNMT3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADDz_Dnmt3b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dnmt3l PhenoGen
PROSITE ADD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57903 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A3EWM2 ENTREZGENE, UniProtKB/TrEMBL
  D3YUQ4 ENTREZGENE, UniProtKB/TrEMBL
  DNM3L_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Dnmt3l  DNA methyltransferase 3-like  Dnmt3l  DNA (cytosine-5-)-methyltransferase 3-like  Symbol and/or name change 5135510 APPROVED