Pdxp (pyridoxal (pyridoxine, vitamin B6) phosphatase) - Rat Genome Database

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Gene: Pdxp (pyridoxal (pyridoxine, vitamin B6) phosphatase) Mus musculus
Analyze
Symbol: Pdxp
Name: pyridoxal (pyridoxine, vitamin B6) phosphatase
RGD ID: 1615139
MGI Page MGI
Description: Enables magnesium ion binding activity; protein homodimerization activity; and pyridoxal phosphatase activity. Involved in dephosphorylation and pyridoxal phosphate catabolic process. Located in cell-cell junction. Is expressed in alimentary system; eye; limb; nervous system; and tail. Orthologous to human PDXP (pyridoxal phosphatase); PARTICIPATES IN hypophosphatasia pathway; vitamin B6 metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1600027H05Rik; AB041662; Chr; chronophilin; chronophin; PLP phosphatase; PLP-phosophatase; PLPP; pyridoxal 5'-phosphate phosphatase; pyridoxal phosphate phosphatase
RGD Orthologs
Human
Rat
Chinchilla
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391578,796,342 - 78,803,717 (+)NCBIGRCm39mm39
GRCm39 Ensembl1578,798,119 - 78,803,717 (+)Ensembl
GRCm381578,912,160 - 78,919,517 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1578,913,919 - 78,919,517 (+)EnsemblGRCm38mm10GRCm38
MGSCv371578,744,349 - 78,749,947 (+)NCBIGRCm37mm9NCBIm37
MGSCv361578,741,174 - 78,746,772 (+)NCBImm8
MGSCv361579,638,039 - 79,643,637 (+)NCBImm8
Celera8110,672,269 - 110,684,203 (-)NCBICelera
Cytogenetic Map15E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14522954   PMID:14681479   PMID:15033168   PMID:15489334   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:19000834   PMID:21267068   PMID:21873635   PMID:23793062   PMID:24338473   PMID:24338687   PMID:25783190   PMID:27212638   PMID:30327125   PMID:31320629  
PMID:33414453  


Genomics

Comparative Map Data
Pdxp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391578,796,342 - 78,803,717 (+)NCBIGRCm39mm39
GRCm39 Ensembl1578,798,119 - 78,803,717 (+)Ensembl
GRCm381578,912,160 - 78,919,517 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1578,913,919 - 78,919,517 (+)EnsemblGRCm38mm10GRCm38
MGSCv371578,744,349 - 78,749,947 (+)NCBIGRCm37mm9NCBIm37
MGSCv361578,741,174 - 78,746,772 (+)NCBImm8
MGSCv361579,638,039 - 79,643,637 (+)NCBImm8
Celera8110,672,269 - 110,684,203 (-)NCBICelera
Cytogenetic Map15E1NCBI
PDXP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2237,658,723 - 37,666,932 (+)EnsemblGRCh38hg38GRCh38
GRCh382237,658,723 - 37,666,932 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372238,054,730 - 38,062,939 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,384,683 - 36,392,885 (+)NCBINCBI36hg18NCBI36
Build 342236,379,237 - 36,387,439NCBI
Celera2221,856,602 - 21,864,785 (+)NCBI
Cytogenetic Map22q13.1NCBI
HuRef2221,021,805 - 21,030,000 (+)NCBIHuRef
CHM1_12238,013,473 - 38,021,654 (+)NCBICHM1_1
Pdxp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27110,472,515 - 110,477,963 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl7110,472,515 - 110,477,963 (+)Ensembl
Rnor_6.07120,140,460 - 120,145,908 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,140,460 - 120,145,908 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07120,132,151 - 120,137,599 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47116,880,751 - 116,886,199 (+)NCBIRGSC3.4rn4RGSC3.4
Celera7106,806,678 - 106,812,126 (+)NCBICelera
Cytogenetic Map7q34NCBI
Pdxp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541324,055,900 - 24,063,902 (+)NCBIChiLan1.0ChiLan1.0
PDXP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11026,945,751 - 26,952,234 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1026,946,838 - 26,952,217 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1026,900,405 - 26,906,862 (-)NCBI
ROS_Cfam_1.01027,737,639 - 27,744,136 (-)NCBI
UMICH_Zoey_3.11027,459,875 - 27,466,333 (-)NCBI
UNSW_CanFamBas_1.01027,768,698 - 27,775,155 (-)NCBI
UU_Cfam_GSD_1.01027,945,988 - 27,952,450 (-)NCBI
LOC101971587
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,410,176 - 10,416,350 (-)NCBI
SpeTri2.0NW_0049364923,420,590 - 3,426,764 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDXP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl510,162,642 - 10,169,512 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1510,162,642 - 10,169,726 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.257,735,323 - 7,737,336 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pdxp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475210,244,424 - 10,251,072 (-)NCBIHetGla_female_1.0hetGla2


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15610000086800000Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156100000100900000Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15690000084700000Mouse
1301433Rapop5_mradiation-induced apoptosis 5 (mouse)Not determined15927293679590561Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402117102988123Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800000102100000Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578270103517472Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800000086800000Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154230000095600000Mouse
1300644Fob3_mF-line obesity QTL 3 (mouse)11.3Not determined154414443889377036Mouse
1301568Tria2_mT-cell receptor induced activation 2 (mouse)Not determined154498729278987432Mouse
1357756Alaa4_malopecia areata 4 (mouse)Not determined154651779780517996Mouse
10755515Amzn3_manatomical modifier of Zfp423 3 (mouse)154651779780517996Mouse
1301006Hfib1_mhepatic fibrogenesis 1 (mouse)Not determined154743448581434630Mouse
1301860Gct3_mgranulosa cell tumorigenesis 3 (mouse)Not determined154753774781537842Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154850000098500000Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548500000101800000Mouse
1301429Pcir3_mperiosteal circumference 3 (mouse)Not determined154859351382593647Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155128885985288984Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155154651285546662Mouse
10412067Pain2_mpain 2 (mouse)Not determined155177349085773777Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155181398385822600Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155193466685934802Mouse
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155370000089700000Mouse
13504731Cath5_mcarotid atherosclerosis 5 (mouse)155491728088917280Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556323312103517472Mouse
27095936Ulnl4_mulna length 4, 5 week (mouse)155690000087800000Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155724515691245304Mouse
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155724515691245304Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156170000095700000Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156327970297279794Mouse
1558786Msq1_mMAV-1 susceptibility QTL 1 (mouse)Not determined156351779781202235Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564434485103517472Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156492762598927745Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156545237799456827Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156564117599641298Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567386497101386646Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570461452104043685Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570465070104043685Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570465070104043685Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572498466104043685Mouse
1302002Cocia2_mcocaine induced activation 2 (mouse)Not determined157250061080014977Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573545941104043685Mouse
15092079Igly6_mIgG glycosylation 6, GP6 (mouse)157422869182789955Mouse
13442492Mecth2_mmechanosensation threshold 2 (mouse)157479100079503000Mouse
1301472Pain1_mpain 1 (mouse)Not determined157544899790928982Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577629711104043685Mouse
15092080Igly7_mIgG glycosylation 7, GP10 (mouse)157791071982789955Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78716903102993272Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578716903102993272Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:506
Count of miRNA genes:346
Interacting mature miRNAs:395
Transcripts:ENSMUST00000089378
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_020271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003951417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB041662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI845716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI852697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL592169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY366300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU148105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY060098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX236940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000089378   ⟹   ENSMUSP00000086796
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1578,798,119 - 78,803,717 (+)Ensembl
GRCm38.p6 Ensembl1578,913,919 - 78,919,517 (+)Ensembl
RefSeq Acc Id: NM_020271   ⟹   NP_064667
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391578,798,119 - 78,803,717 (+)NCBI
GRCm381578,913,919 - 78,919,517 (+)ENTREZGENE
MGSCv371578,744,349 - 78,749,947 (+)RGD
Celera15110,672,269 - 110,684,203 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_003951417
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391578,796,342 - 78,803,717 (+)NCBI
GRCm381578,912,160 - 78,919,517 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_064667   ⟸   NM_020271
- UniProtKB: P60487 (UniProtKB/Swiss-Prot),   Q6IS27 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000086796   ⟸   ENSMUST00000089378

Promoters
RGD ID:6826333
Promoter ID:MM_KWN:19023
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_020271,   OTTMUST00000049697
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361578,743,011 - 78,744,532 (+)MPROMDB
RGD ID:8684292
Promoter ID:EPDNEW_M20177
Type:initiation region
Name:Pdxp_1
Description:Mus musculus pyridoxal (pyridoxine, vitamin B6) phosphatase ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381578,913,960 - 78,914,020EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919282 AgrOrtholog
Ensembl Genes ENSMUSG00000116165 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000086796 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000089378 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HAD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-SF_hydro_IIA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGP_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:57028 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1919282 ENTREZGENE
NCBI Gene 57028 ENTREZGENE
Pfam Hydrolase_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdxp PhenoGen
PIRSF PGP-type_phosphatase UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs HAD-SF-IIA UniProtKB/Swiss-Prot
  PGP_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P60487 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5U5Y4_MOUSE UniProtKB/TrEMBL
  Q6IS27 ENTREZGENE, UniProtKB/TrEMBL
  Q9JJ90_MOUSE UniProtKB/TrEMBL