Med11 (mediator complex subunit 11) - Rat Genome Database

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Gene: Med11 (mediator complex subunit 11) Mus musculus
Analyze
Symbol: Med11
Name: mediator complex subunit 11
RGD ID: 1615123
MGI Page MGI
Description: Predicted to enable transcription coregulator activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in nucleus. Predicted to be part of core mediator complex; mediator complex; and ubiquitin ligase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human MED11 (mediator complex subunit 11).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110030J09Rik; AI465144; AW545069; mediator of RNA polymerase II transcription subunit 11; mediator of RNA polymerase II transcription, subunit 11 homolog; RP23-42P20.8
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,342,744 - 70,344,558 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,342,745 - 70,344,553 (+)EnsemblGRCm39 Ensembl
GRCm381170,451,918 - 70,453,732 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,451,919 - 70,453,727 (+)EnsemblGRCm38mm10GRCm38
MGSCv371170,265,433 - 70,267,229 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,268,126 - 70,269,922 (+)NCBIMGSCv36mm8
Celera1177,997,896 - 77,999,692 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Mediator complex and transcription regulation. Poss ZC, etal., Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):575-608. doi: 10.3109/10409238.2013.840259. Epub 2013 Oct 3.
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11559591   PMID:12466851   PMID:12477932   PMID:14610273   PMID:14638676  
PMID:16141072   PMID:16141073   PMID:21677750   PMID:21873635   PMID:24194600   PMID:24882805   PMID:27626380  


Genomics

Comparative Map Data
Med11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,342,744 - 70,344,558 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,342,745 - 70,344,553 (+)EnsemblGRCm39 Ensembl
GRCm381170,451,918 - 70,453,732 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,451,919 - 70,453,727 (+)EnsemblGRCm38mm10GRCm38
MGSCv371170,265,433 - 70,267,229 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,268,126 - 70,269,922 (+)NCBIMGSCv36mm8
Celera1177,997,896 - 77,999,692 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
MED11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,731,428 - 4,733,607 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,731,428 - 4,733,608 (+)EnsemblGRCh38hg38GRCh38
GRCh37174,634,723 - 4,636,902 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,581,472 - 4,583,645 (+)NCBINCBI36Build 36hg18NCBI36
Celera174,649,916 - 4,652,104 (+)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef174,523,800 - 4,525,991 (+)NCBIHuRef
CHM1_1174,643,443 - 4,645,633 (+)NCBICHM1_1
T2T-CHM13v2.0174,621,086 - 4,623,276 (+)NCBIT2T-CHM13v2.0
Med11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,662,956 - 55,664,574 (+)NCBIGRCr8
mRatBN7.21055,164,322 - 55,165,940 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,164,326 - 55,166,533 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,843,238 - 59,844,857 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,331,747 - 59,333,366 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,830,947 - 54,832,566 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,057,272 - 57,059,415 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,057,608 - 57,059,403 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,814,268 - 56,816,652 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,293,731 - 57,295,536 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1054,310,621 - 54,312,426 (+)NCBICelera
Cytogenetic Map10q24NCBI
Med11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546710,129,005 - 10,130,612 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546710,129,005 - 10,130,612 (+)NCBIChiLan1.0ChiLan1.0
MED11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21912,348,948 - 12,351,154 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11714,317,159 - 14,319,417 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0174,787,139 - 4,789,339 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1174,777,157 - 4,779,403 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl174,777,157 - 4,779,403 (+)Ensemblpanpan1.1panPan2
MED11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,821,263 - 31,822,946 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,821,610 - 31,822,890 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha531,959,820 - 31,962,235 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0531,925,597 - 31,928,012 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1531,892,640 - 31,894,325 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,852,322 - 31,854,007 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,027,834 - 32,030,249 (-)NCBIUU_Cfam_GSD_1.0
Med11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560252,735,207 - 52,736,697 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366773,164,070 - 3,166,102 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366773,164,290 - 3,166,734 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,150,448 - 52,152,204 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,150,535 - 52,152,366 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,269,860 - 54,273,347 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MED11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,211,592 - 4,213,639 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,211,692 - 4,213,232 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605917,427,369 - 17,429,393 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Med11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247868,586,321 - 8,588,273 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247868,586,222 - 8,590,121 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Med11
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:433
Count of miRNA genes:291
Interacting mature miRNAs:315
Transcripts:ENSMUST00000019067, ENSMUST00000151013, ENSMUST00000152348
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116899082672490826Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116899082672490826Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116899082672490826Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116899082672490826Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116899082672490826Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116899082672490826Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116899082672490826Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116899082672490826Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116899082672490826Mouse

Markers in Region
AW545069  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381170,453,184 - 70,453,313UniSTSGRCm38
MGSCv371170,266,686 - 70,266,815UniSTSGRCm37
Celera1177,999,149 - 77,999,278UniSTS
Cytogenetic Map11B3UniSTS
Whitehead/MRC_RH11906.67UniSTS
AI465144  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381170,453,491 - 70,453,591UniSTSGRCm38
MGSCv371170,266,993 - 70,267,093UniSTSGRCm37
Celera1177,999,456 - 77,999,556UniSTS
Cytogenetic Map11B3UniSTS
Whitehead/MRC_RH11906.67UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000019067   ⟹   ENSMUSP00000019067
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,342,745 - 70,344,553 (+)Ensembl
GRCm38.p6 Ensembl1170,451,919 - 70,453,727 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151013   ⟹   ENSMUSP00000134323
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,342,745 - 70,344,066 (+)Ensembl
GRCm38.p6 Ensembl1170,451,919 - 70,453,240 (+)Ensembl
RefSeq Acc Id: ENSMUST00000152348
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,342,758 - 70,344,390 (+)Ensembl
GRCm38.p6 Ensembl1170,451,932 - 70,453,564 (+)Ensembl
RefSeq Acc Id: NM_025397   ⟹   NP_079673
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,342,744 - 70,344,558 (+)NCBI
GRCm381170,451,918 - 70,453,732 (+)NCBI
MGSCv371170,265,433 - 70,267,229 (+)RGD
Celera1177,997,896 - 77,999,692 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_079673   ⟸   NM_025397
- UniProtKB: Q3V4D0 (UniProtKB/Swiss-Prot),   Q9D8C6 (UniProtKB/Swiss-Prot),   G3UZ31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000134323   ⟸   ENSMUST00000151013
RefSeq Acc Id: ENSMUSP00000019067   ⟸   ENSMUST00000019067

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D8C6-F1-model_v2 AlphaFold Q9D8C6 1-117 view protein structure

Promoters
RGD ID:6821243
Promoter ID:MM_KWN:8211
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000013628,   OTTMUST00000013629,   OTTMUST00000013630
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361170,264,686 - 70,265,637 (+)MPROMDB
RGD ID:8675344
Promoter ID:EPDNEW_M15689
Type:initiation region
Name:Med11_1
Description:Mus musculus mediator complex subunit 11 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381170,451,918 - 70,451,978EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913422 AgrOrtholog
Ensembl Genes ENSMUSG00000018923 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000019067 ENTREZGENE
  ENSMUST00000019067.8 UniProtKB/Swiss-Prot
  ENSMUST00000151013.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.3490 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Mediator_Med11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:66172 UniProtKB/Swiss-Prot
MGD MGI:1913422 ENTREZGENE
NCBI Gene 66172 ENTREZGENE
PANTHER MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22890 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Med11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Med11 PhenoGen
UniProt G3UZ31 ENTREZGENE, UniProtKB/TrEMBL
  MED11_MOUSE UniProtKB/Swiss-Prot
  Q3V4D0 ENTREZGENE
  Q9D8C6 ENTREZGENE
UniProt Secondary Q3V4D0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-26 Med11  mediator complex subunit 11    mediator of RNA polymerase II transcription, subunit 11 homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED