Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of MTFR1 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MTFR1 mRNA | CTD | PMID:22206623 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of MTFR1 mRNA | CTD | PMID:20106945 and PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of MTFR1 mRNA | CTD | PMID:21570461 | 2,6-dinitrotoluene | affects expression | ISO | Mtfr1 (Rattus norvegicus) | 6480464 | 2 and 6-dinitrotoluene affects the expression of MTFR1 mRNA | CTD | PMID:21346803 | 2-palmitoylglycerol | increases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of MTFR1 mRNA | CTD | PMID:37199045 | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of MTFR1 mRNA | CTD | PMID:26251327 | 3H-1,2-dithiole-3-thione | decreases expression | ISO | Mtfr1 (Rattus norvegicus) | 6480464 | 1 and 2-dithiol-3-thione results in decreased expression of MTFR1 mRNA | CTD | PMID:19162173 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | Mtfr1 (Rattus norvegicus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of MTFR1 mRNA | CTD | PMID:30723492 | 5-aza-2'-deoxycytidine | affects expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Decitabine affects the expression of MTFR1 mRNA | CTD | PMID:23300844 | 6-propyl-2-thiouracil | decreases expression | ISO | Mtfr1 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of MTFR1 mRNA | CTD | PMID:24780913 | acetamide | decreases expression | ISO | Mtfr1 (Rattus norvegicus) | 6480464 | acetamide results in decreased expression of MTFR1 mRNA | CTD | PMID:31881176 | acrolein | multiple interactions | ISO | MTFR1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of MTFR1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of MTFR1 mRNA | CTD | PMID:32699268 | aflatoxin B1 | increases methylation | ISO | MTFR1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of MTFR1 gene | CTD | PMID:27153756 | all-trans-retinoic acid | decreases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of MTFR1 mRNA | CTD | PMID:23724009 and PMID:33167477 | alpha-pinene | multiple interactions | ISO | MTFR1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of MTFR1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of MTFR1 mRNA | CTD | PMID:32699268 | antirheumatic drug | increases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of MTFR1 mRNA | CTD | PMID:24449571 | Aroclor 1254 | decreases expression | EXP | | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of MTFR1 mRNA | CTD | PMID:23650126 | arsenite(3-) | multiple interactions | ISO | MTFR1 (Homo sapiens) | 6480464 | arsenite promotes the reaction [G3BP1 protein binds to MTFR1 mRNA] | CTD | PMID:32406909 | atrazine | increases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Atrazine results in increased expression of MTFR1 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of MTFR1 mRNA | CTD | PMID:26496743 | benzo[a]pyrene | decreases methylation | ISO | MTFR1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of MTFR1 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20018196 | benzo[e]pyrene | increases methylation | ISO | MTFR1 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of MTFR1 intron | CTD | PMID:30157460 | bisphenol A | decreases expression | ISO | Mtfr1 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of MTFR1 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | Mtfr1 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of MTFR1 mRNA | CTD | PMID:30816183 and PMID:32145629 | chrysene | decreases expression | EXP | | 6480464 | chrysene results in decreased expression of MTFR1 mRNA | CTD | PMID:26377693 | cisplatin | affects expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Cisplatin affects the expression of MTFR1 mRNA | CTD | PMID:23300844 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of MTFR1 mRNA | CTD | PMID:21139344 | cyclosporin A | increases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of MTFR1 mRNA | CTD | PMID:20106945 more ... | diuron | increases expression | ISO | Mtfr1 (Rattus norvegicus) | 6480464 | Diuron results in increased expression of MTFR1 mRNA | CTD | PMID:21551480 | doxorubicin | decreases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of MTFR1 mRNA | CTD | PMID:29803840 | epoxiconazole | decreases expression | EXP | | 6480464 | epoxiconazole results in decreased expression of MTFR1 mRNA | CTD | PMID:35436446 | ethyl methanesulfonate | decreases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in decreased expression of MTFR1 mRNA | CTD | PMID:23649840 | fluoxetine | increases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Fluoxetine results in increased expression of MTFR1 mRNA | CTD | PMID:37386098 | folic acid | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MTFR1 mRNA | CTD | PMID:22206623 | formaldehyde | decreases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of MTFR1 mRNA | CTD | PMID:23649840 | FR900359 | increases phosphorylation | ISO | MTFR1 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of MTFR1 protein | CTD | PMID:37730182 | gentamycin | increases expression | ISO | Mtfr1 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of MTFR1 mRNA | CTD | PMID:33387578 | lead(0) | affects expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Lead affects the expression of MTFR1 mRNA | CTD | PMID:28903495 | linsidomine | increases oxidation | ISO | Mtfr1 (Rattus norvegicus) | 6480464 | linsidomine results in increased oxidation of MTFR1 protein | CTD | PMID:28086193 | methapyrilene | increases methylation | ISO | MTFR1 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of MTFR1 intron | CTD | PMID:30157460 | oxaliplatin | multiple interactions | ISO | Mtfr1 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of MTFR1 mRNA | CTD | PMID:25729387 | oxaliplatin | decreases expression | ISO | Mtfr1 (Rattus norvegicus) | 6480464 | oxaliplatin results in decreased expression of MTFR1 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | MTFR1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of MTFR1 mRNA more ... | CTD | PMID:32699268 | paracetamol | increases expression | ISO | Mtfr1 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of MTFR1 mRNA | CTD | PMID:33387578 | picoxystrobin | increases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | picoxystrobin results in increased expression of MTFR1 mRNA | CTD | PMID:33512557 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of MTFR1 mRNA | CTD | PMID:17426115 | quercetin | decreases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of MTFR1 mRNA | CTD | PMID:21632981 | quercetin | decreases phosphorylation | ISO | MTFR1 (Homo sapiens) | 6480464 | Quercetin results in decreased phosphorylation of MTFR1 protein | CTD | PMID:35688186 | rotenone | increases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Rotenone results in increased expression of MTFR1 mRNA | CTD | PMID:33512557 | sulindac sulfide | increases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | sulindac sulfide results in increased expression of MTFR1 mRNA | CTD | PMID:16184548 | sunitinib | increases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of MTFR1 mRNA | CTD | PMID:31533062 | thapsigargin | increases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Thapsigargin results in increased expression of MTFR1 mRNA | CTD | PMID:22378314 | topotecan | decreases expression | ISO | Mtfr1 (Rattus norvegicus) | 6480464 | Topotecan results in decreased expression of MTFR1 mRNA | CTD | PMID:25729387 | topotecan | multiple interactions | ISO | Mtfr1 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of MTFR1 mRNA | CTD | PMID:25729387 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of MTFR1 mRNA | CTD | PMID:33045310 | tunicamycin | increases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of MTFR1 mRNA | CTD | PMID:22378314 | valproic acid | increases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of MTFR1 mRNA | CTD | PMID:19101580 more ... | valproic acid | affects expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of MTFR1 mRNA | CTD | PMID:25979313 | vitamin E | decreases expression | ISO | MTFR1 (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of MTFR1 mRNA | CTD | PMID:19244175 | | 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Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Molecular Function
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Gene-Chemical Interaction Annotations
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Phenotype Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 2. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:8889548 | PMID:10349636 | PMID:10512203 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:12466851 | PMID:12477932 | PMID:12520002 | PMID:12904583 | PMID:14610273 | PMID:15389597 |
| PMID:15489334 | PMID:15582152 | PMID:15782199 | PMID:15840001 | PMID:16141072 | PMID:16141073 | PMID:17709566 | PMID:17967808 | PMID:18614015 | PMID:18799693 | PMID:18973680 | PMID:20568109 |
| PMID:21677750 | PMID:21873635 | PMID:26633713 |
Genomics
Comparative Map Data
| Mtfr1 (Mus musculus - house mouse) |
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| MTFR1 (Homo sapiens - human) |
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| Mtfr1 (Rattus norvegicus - Norway rat) |
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| Mtfr1 (Chinchilla lanigera - long-tailed chinchilla) |
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| MTFR1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| MTFR1 (Canis lupus familiaris - dog) |
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| Mtfr1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| MTFR1 (Sus scrofa - pig) |
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| MTFR1 (Chlorocebus sabaeus - green monkey) |
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| Mtfr1 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Mtfr1
1143 total Variants 
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