Mex3a (mex3 RNA binding family member A) - Rat Genome Database

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Gene: Mex3a (mex3 RNA binding family member A) Mus musculus
Analyze
Symbol: Mex3a
Name: mex3 RNA binding family member A
RGD ID: 1615056
MGI Page MGI
Description: Predicted to enable RNA binding activity. Predicted to be located in P-body and cytosol. Is expressed in central nervous system and sensory organ. Orthologous to human MEX3A (mex-3 RNA binding family member A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2700083E18Rik; AA387377; Gm411; mex3 homolog A; ring finger and KH domain containing 4; Rkhd; Rkhd4; RNA-binding protein MEX3A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,439,253 - 88,448,701 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,439,702 - 88,448,703 (+)EnsemblGRCm39 Ensembl
GRCm38388,531,946 - 88,541,394 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,532,395 - 88,541,396 (+)EnsemblGRCm38mm10GRCm38
MGSCv37388,339,970 - 88,345,302 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,621,975 - 88,627,307 (+)NCBIMGSCv36mm8
Celera388,575,852 - 88,581,184 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.86NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)
P-body  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:14610273   PMID:15582152   PMID:16033648   PMID:16141072   PMID:16141073  
PMID:16602821   PMID:18799693   PMID:21267068   PMID:23408853   PMID:25043184   PMID:28285904   PMID:32052574   PMID:33072742   PMID:33159833   PMID:33638620   PMID:36276637   PMID:36690670  
PMID:37433992  


Genomics

Comparative Map Data
Mex3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,439,253 - 88,448,701 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,439,702 - 88,448,703 (+)EnsemblGRCm39 Ensembl
GRCm38388,531,946 - 88,541,394 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,532,395 - 88,541,396 (+)EnsemblGRCm38mm10GRCm38
MGSCv37388,339,970 - 88,345,302 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,621,975 - 88,627,307 (+)NCBIMGSCv36mm8
Celera388,575,852 - 88,581,184 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.86NCBI
MEX3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,072,013 - 156,082,465 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,072,013 - 156,082,465 (-)EnsemblGRCh38hg38GRCh38
GRCh371156,041,804 - 156,052,256 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,308,428 - 154,318,413 (-)NCBINCBI36Build 36hg18NCBI36
Celera1129,114,865 - 129,124,850 (-)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1127,404,324 - 127,414,055 (-)NCBIHuRef
CHM1_11157,437,912 - 157,447,901 (-)NCBICHM1_1
T2T-CHM13v2.01155,210,478 - 155,220,930 (-)NCBIT2T-CHM13v2.0
Mex3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,287,900 - 176,297,369 (+)NCBIGRCr8
mRatBN7.22173,990,098 - 173,999,567 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,989,856 - 173,997,377 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,134,244 - 181,143,710 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,156,608 - 179,166,074 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,756,693 - 173,766,160 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,893,678 - 187,902,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,893,368 - 187,898,310 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,296,269 - 207,304,946 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,645,985 - 180,652,134 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2167,935,343 - 167,943,958 (+)NCBICelera
Cytogenetic Map2q34NCBI
Mex3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,255,704 - 2,260,770 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,255,612 - 2,260,860 (-)NCBIChiLan1.0ChiLan1.0
MEX3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2193,763,754 - 93,774,219 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,495,712 - 93,506,166 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01131,414,225 - 131,424,680 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,243,223 - 135,253,325 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,247,776 - 135,254,034 (-)Ensemblpanpan1.1panPan2
MEX3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,742,777 - 41,749,730 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,742,785 - 41,747,628 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,232,076 - 41,239,280 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,609,117 - 41,616,337 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,609,117 - 41,614,198 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,389,958 - 41,397,175 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,443,321 - 41,448,536 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,727,730 - 41,734,949 (+)NCBIUU_Cfam_GSD_1.0
Mex3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,302,102 - 26,309,232 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,334,575 - 5,339,507 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,334,026 - 5,339,536 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEX3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,949,459 - 93,955,640 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,949,876 - 93,957,797 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,692,116 - 102,701,725 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MEX3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,781,766 - 7,793,373 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660387,079,472 - 7,089,416 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mex3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,416,288 - 1,421,277 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248851,412,031 - 1,422,297 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mex3a
319 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3429
Count of miRNA genes:870
Interacting mature miRNAs:1247
Transcripts:ENSMUST00000172699
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
10043981Cia5a_mcollagen induced arthritis QTL 5a (mouse)Not determined38717045489140094Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse

Markers in Region
Mex3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38388,536,089 - 88,536,628UniSTSGRCm38
MGSCv37388,340,011 - 88,340,550UniSTSGRCm37
Celera388,575,893 - 88,576,432UniSTS
Cytogenetic Map3F1UniSTS
cM Map3 UniSTS
UniSTS:234722  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38388,540,706 - 88,540,934UniSTSGRCm38
MGSCv37388,344,628 - 88,344,856UniSTSGRCm37
Celera388,580,510 - 88,580,738UniSTS
Cytogenetic Map3F1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000172699   ⟹   ENSMUSP00000134222
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl388,439,702 - 88,448,703 (+)Ensembl
GRCm38.p6 Ensembl388,532,395 - 88,541,396 (+)Ensembl
RefSeq Acc Id: NM_001029890   ⟹   NP_001025061
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39388,439,253 - 88,448,701 (+)NCBI
GRCm38388,531,946 - 88,541,394 (+)NCBI
MGSCv37388,339,970 - 88,345,302 (+)RGD
Celera388,565,814 - 88,581,198 (+)ENTREZGENE
cM Map3 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001025061 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000134222
  ENSMUSP00000134222.2
Reference Protein Sequences
RefSeq Acc Id: NP_001025061   ⟸   NM_001029890
- UniProtKB: G3UYU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000134222   ⟸   ENSMUST00000172699
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3UYU0-F1-model_v2 AlphaFold G3UYU0 1-520 view protein structure

Promoters
RGD ID:6847752
Promoter ID:MM_ACW:32276
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   MEF_B4,   MEF_B6
Transcripts:MEX3A.ASEP07,   MEX3A.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36388,335,776 - 88,336,767 (+)MPROMDB
RGD ID:6834080
Promoter ID:MM_KWN:34861
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:NM_001029890
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36388,340,491 - 88,344,222 (+)MPROMDB
RGD ID:6881154
Promoter ID:EPDNEW_M4028
Type:initiation region
Name:Mex3a_1
Description:Mus musculus mex3 RNA binding family member A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38388,532,369 - 88,532,429EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919890 AgrOrtholog
Ensembl Genes ENSMUSG00000074480 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000172699 ENTREZGENE
  ENSMUST00000172699.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1370.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro IPR004087 UniProtKB/TrEMBL
  KH-I_MEX3_rpt1 UniProtKB/TrEMBL
  KH-I_MEX3_rpt2 UniProtKB/TrEMBL
  KH_dom_type_1_sf UniProtKB/TrEMBL
  KH_type_1 UniProtKB/TrEMBL
  MEX3 UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report mmu:72640 UniProtKB/TrEMBL
MGD MGI:1919890 ENTREZGENE
NCBI Gene 72640 ENTREZGENE
PANTHER RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  RNA-BINDING PROTEIN MEX3A UniProtKB/TrEMBL
Pfam KH_1 UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/TrEMBL
PhenoGen Mex3a PhenoGen
PROSITE KH_TYPE_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART RING UniProtKB/TrEMBL
  SM00322 UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF54791 UniProtKB/TrEMBL
UniProt G3UYU0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Mex3a  mex3 RNA binding family member A    mex3 homolog A (C. elegans)  Symbol and/or name change 5135510 APPROVED