Evi2b (ecotropic viral integration site 2b) - Rat Genome Database

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Gene: Evi2b (ecotropic viral integration site 2b) Mus musculus
Analyze
Symbol: Evi2b
Name: ecotropic viral integration site 2b
RGD ID: 1614950
MGI Page MGI
Description: Involved in several processes, including myeloid cell development; positive regulation of neutrophil differentiation; and regulation of stem cell division. Is expressed in several structures, including Harderian gland; alimentary system; hemolymphoid system; integumental system; and reproductive system. Orthologous to human EVI2B (ecotropic viral integration site 2B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ecotropic viral integration site 2B protein; Ev; Evi-2; EVI-2B; Evi2; MGC28913
RGD Orthologs
Human
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391179,404,211 - 79,414,588 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1179,405,882 - 79,414,588 (-)EnsemblGRCm39 Ensembl
GRCm381179,513,385 - 79,523,762 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1179,515,056 - 79,523,762 (-)EnsemblGRCm38mm10GRCm38
MGSCv371179,326,887 - 79,344,091 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361179,329,580 - 79,346,754 (-)NCBIMGSCv36mm8
Celera1189,146,067 - 89,163,271 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.8NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2167436   PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16138909   PMID:16141072   PMID:16141073  
PMID:21873635   PMID:24194600   PMID:28186500   PMID:32554809  


Genomics

Comparative Map Data
Evi2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391179,404,211 - 79,414,588 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1179,405,882 - 79,414,588 (-)EnsemblGRCm39 Ensembl
GRCm381179,513,385 - 79,523,762 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1179,515,056 - 79,523,762 (-)EnsemblGRCm38mm10GRCm38
MGSCv371179,326,887 - 79,344,091 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361179,329,580 - 79,346,754 (-)NCBIMGSCv36mm8
Celera1189,146,067 - 89,163,271 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.8NCBI
EVI2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381731,303,770 - 31,314,054 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1731,303,770 - 31,314,105 (-)EnsemblGRCh38hg38GRCh38
GRCh371729,630,788 - 29,641,072 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361726,654,914 - 26,665,256 (-)NCBINCBI36Build 36hg18NCBI36
Build 341726,654,918 - 26,665,217NCBI
Celera1726,551,516 - 26,561,851 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1725,841,391 - 25,851,732 (-)NCBIHuRef
CHM1_11729,693,971 - 29,704,313 (-)NCBICHM1_1
T2T-CHM13v2.01732,249,455 - 32,259,731 (-)NCBIT2T-CHM13v2.0
EVI2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1243,553,898 - 43,561,755 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11243,553,891 - 43,561,759 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21245,379,579 - 45,387,442 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EVI2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11624,765,211 - 24,776,208 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660755,300,061 - 5,310,475 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Evi2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248753,890,001 - 3,891,362 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248753,889,436 - 3,896,710 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Evi2b
242 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1360
Count of miRNA genes:626
Interacting mature miRNAs:793
Transcripts:ENSMUST00000093983
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301078Alcp2_malcohol preference locus 2 (mouse)Not determined117220979684731462Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
12903994Opfaq3_mopen field activity QTL 3 (mouse)117373754182069425Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
4141365Ltxs3_mlethal factor toxin susceptibility 3 (mouse)Not determined117757387380746358Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse

Markers in Region
AW491894  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381179,527,442 - 79,527,571UniSTSGRCm38
MGSCv371179,340,944 - 79,341,073UniSTSGRCm37
Celera1189,160,124 - 89,160,253UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map11B4-5UniSTS
cM Map1146.13UniSTS
Whitehead/MRC_RH111005.69UniSTS
Evi2b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B5UniSTS
cM Map11 UniSTS
D11Bhm165  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381179,525,644 - 79,525,912UniSTSGRCm38
MGSCv371179,339,146 - 79,339,414UniSTSGRCm37
Celera1189,158,326 - 89,158,594UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map11B4-5UniSTS
cM Map1146.13UniSTS
cM Map1146.06UniSTS
D11Bhm166  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381179,514,710 - 79,514,921UniSTSGRCm38
MGSCv371179,328,212 - 79,328,423UniSTSGRCm37
Celera1189,147,392 - 89,147,603UniSTS
Cytogenetic Map11B4-5UniSTS
Cytogenetic Map11B5UniSTS
cM Map1146.13UniSTS
D11Bhm167  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381179,514,572 - 79,514,731UniSTSGRCm38
MGSCv371179,328,074 - 79,328,233UniSTSGRCm37
Celera1189,147,254 - 89,147,413UniSTS
Cytogenetic Map11B4-5UniSTS
Cytogenetic Map11B5UniSTS
cM Map1146.13UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000179322   ⟹   ENSMUSP00000136153
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1179,405,882 - 79,414,588 (-)Ensembl
GRCm38.p6 Ensembl1179,515,056 - 79,523,762 (-)Ensembl
RefSeq Acc Id: NM_001077496   ⟹   NP_001070964
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391179,404,211 - 79,414,588 (-)NCBI
GRCm381179,513,385 - 79,523,762 (-)NCBI
MGSCv371179,326,887 - 79,344,091 (-)RGD
Celera1189,146,067 - 89,156,444 (-)NCBI
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001070964 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH17548 (Get FASTA)   NCBI Sequence Viewer  
  BAE20560 (Get FASTA)   NCBI Sequence Viewer  
  BAE41820 (Get FASTA)   NCBI Sequence Viewer  
  BAE42611 (Get FASTA)   NCBI Sequence Viewer  
  EDL15610 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000136153
  ENSMUSP00000136153.2
GenBank Protein Q8VD58 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001070964   ⟸   NM_001077496
- Peptide Label: precursor
- UniProtKB: Q3U1A3 (UniProtKB/Swiss-Prot),   Q8VD58 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000136153   ⟸   ENSMUST00000179322

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VD58-F1-model_v2 AlphaFold Q8VD58 1-444 view protein structure

Promoters
RGD ID:6820833
Promoter ID:MM_KWN:8758
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:NM_001077496
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361179,337,201 - 79,337,752 (-)MPROMDB
RGD ID:6820835
Promoter ID:MM_KWN:8760
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:NM_001033711,   OTTMUST00000000580,   UC007KKP.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361179,343,714 - 79,344,214 (-)MPROMDB
RGD ID:8675768
Promoter ID:EPDNEW_M15915
Type:initiation region
Name:Evi2b_1
Description:Mus musculus ecotropic viral integration site 2b , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381179,523,728 - 79,523,788EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1890682 AgrOrtholog
Ensembl Genes ENSMUSG00000093938 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000179322 ENTREZGENE
  ENSMUST00000179322.2 UniProtKB/Swiss-Prot
InterPro EVI2B UniProtKB/Swiss-Prot
KEGG Report mmu:101488212 UniProtKB/Swiss-Prot
  mmu:216984 UniProtKB/Swiss-Prot
MGD MGI:1890682 ENTREZGENE
NCBI Gene 216984 ENTREZGENE
PANTHER PROTEIN EVI2B UniProtKB/Swiss-Prot
  PTHR15384 UniProtKB/Swiss-Prot
PhenoGen Evi2b PhenoGen
UniProt EVI2B_MOUSE UniProtKB/Swiss-Prot
  Q3U1A3 ENTREZGENE
  Q8VD58 ENTREZGENE
UniProt Secondary Q3U1A3 UniProtKB/Swiss-Prot