Mief2 (mitochondrial elongation factor 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Mief2 (mitochondrial elongation factor 2) Mus musculus
Analyze
Symbol: Mief2
Name: mitochondrial elongation factor 2
RGD ID: 1614899
MGI Page MGI
Description: Involved in positive regulation of mitochondrial fission. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 49. Orthologous to human MIEF2 (mitochondrial elongation factor 2); PARTICIPATES IN mitochondria fission pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI482195; Gm11; MGC113770; mitochondrial dynamic protein MID49; mitochondrial dynamic protein of 49 kDa homolog; mitochondrial dynamics protein MID49; mitochondrial dynamics protein of 49 kDa homolog; Smc; Smcr7; Smith-Magenis syndrome chromosomal region candidate gene 7 protein homolog; Smith-Magenis syndrome chromosome region, candidate 7 homolog (human0
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,619,224 - 60,623,777 (+)NCBIGRCm39mm39
GRCm39 Ensembl1160,619,224 - 60,623,777 (+)Ensembl
GRCm381160,728,398 - 60,732,951 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,728,398 - 60,732,951 (+)EnsemblGRCm38mm10GRCm38
MGSCv371160,541,900 - 60,546,453 (+)NCBIGRCm37mm9NCBIm37
MGSCv361160,544,593 - 60,549,146 (+)NCBImm8
Celera1164,989,255 - 64,993,808 (+)NCBICelera
Cytogenetic Map11B2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15782199   PMID:16141072   PMID:16141073   PMID:17273973   PMID:18799693   PMID:21124890  
PMID:21873635   PMID:23283981   PMID:23375831   PMID:23921378   PMID:24508339   PMID:24515348   PMID:25581164   PMID:26101352   PMID:27076521  


Genomics

Comparative Map Data
Mief2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,619,224 - 60,623,777 (+)NCBIGRCm39mm39
GRCm39 Ensembl1160,619,224 - 60,623,777 (+)Ensembl
GRCm381160,728,398 - 60,732,951 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,728,398 - 60,732,951 (+)EnsemblGRCm38mm10GRCm38
MGSCv371160,541,900 - 60,546,453 (+)NCBIGRCm37mm9NCBIm37
MGSCv361160,544,593 - 60,549,146 (+)NCBImm8
Celera1164,989,255 - 64,993,808 (+)NCBICelera
Cytogenetic Map11B2NCBI
MIEF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1718,260,597 - 18,266,552 (+)EnsemblGRCh38hg38GRCh38
GRCh381718,260,662 - 18,266,552 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371718,163,976 - 18,169,866 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361718,104,594 - 18,109,820 (+)NCBINCBI36hg18NCBI36
Build 341718,105,148 - 18,109,818NCBI
Celera1719,104,964 - 19,110,211 (+)NCBI
Cytogenetic Map17p11.2NCBI
HuRef1717,917,104 - 17,922,351 (+)NCBIHuRef
CHM1_11718,172,628 - 18,177,875 (+)NCBICHM1_1
Mief2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21045,408,055 - 45,414,144 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1045,408,082 - 45,414,144 (+)Ensembl
Rnor_6.01046,969,531 - 46,975,572 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,972,038 - 46,974,806 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01046,742,493 - 46,748,566 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,875,425 - 46,880,362 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1044,663,259 - 44,669,300 (+)NCBICelera
Cytogenetic Map10q22NCBI
Mief2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547811,057,462 - 11,061,852 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547811,056,489 - 11,063,142 (-)NCBIChiLan1.0ChiLan1.0
MIEF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11737,944,215 - 37,949,451 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1737,944,215 - 37,949,451 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01732,805,453 - 32,810,668 (+)NCBIMhudiblu_PPA_v0panPan3
MIEF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,293,922 - 41,303,031 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl541,295,915 - 41,300,589 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha541,433,114 - 41,442,515 (-)NCBI
Mief2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,063,879 - 61,069,509 (-)NCBI
SpeTri2.0NW_0049367411,797,717 - 1,803,367 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIEF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,466,190 - 60,475,092 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,461,373 - 60,475,695 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MIEF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11617,301,133 - 17,306,791 (+)NCBI
ChlSab1.1 Ensembl1617,301,629 - 17,308,780 (+)Ensembl
Vero_WHO_p1.0NW_0236660593,595,731 - 3,601,001 (-)NCBI
Mief2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248493,207,698 - 3,213,121 (-)NCBI

Position Markers
UniSTS:236593  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381160,732,082 - 60,732,285UniSTSGRCm38
MGSCv371160,545,584 - 60,545,787UniSTSGRCm37
Celera1164,992,939 - 64,993,142UniSTS
Cytogenetic Map11B2UniSTS
AI482195  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381160,732,382 - 60,732,478UniSTSGRCm38
MGSCv371160,545,884 - 60,545,980UniSTSGRCm37
Celera1164,993,239 - 64,993,335UniSTS
Cytogenetic Map11B2UniSTS
Whitehead/MRC_RH11800.82UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11330000060800000Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11330000063000000Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11890000061500000Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111160000068600000Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111180000066100000Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1231863768609504Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111231863768609504Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111231863768609504Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1231863768609504Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1231863768609504Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111231863768609504Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1231863768609504Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1231863768609504Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1231863768609504Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111231863768609504Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111231863768609504Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111231863769794121Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111710617567187585Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111783196668609504Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112827504662275149Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112867832062678320Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112881775462817873Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113111738265117382Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113220975066209867Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113568778969794161Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113661246070618665Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113672273870723028Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5417484463428696Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115417484467187585Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115419011565213015Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5539415972319101Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115936579169591873Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:766
Count of miRNA genes:478
Interacting mature miRNAs:548
Transcripts:ENSMUST00000018743, ENSMUST00000146159, ENSMUST00000154890
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000018743   ⟹   ENSMUSP00000018743
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1160,619,224 - 60,623,777 (+)Ensembl
GRCm38.p6 Ensembl1160,728,398 - 60,732,951 (+)Ensembl
RefSeq Acc Id: ENSMUST00000146159
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1160,619,271 - 60,621,489 (+)Ensembl
GRCm38.p6 Ensembl1160,728,445 - 60,730,663 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154890
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1160,619,269 - 60,621,822 (+)Ensembl
GRCm38.p6 Ensembl1160,728,443 - 60,730,996 (+)Ensembl
RefSeq Acc Id: NM_001009927   ⟹   NP_001009927
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391160,619,224 - 60,623,777 (+)NCBI
GRCm381160,728,398 - 60,732,951 (+)ENTREZGENE
MGSCv371160,541,900 - 60,546,453 (+)RGD
Celera1164,989,255 - 64,993,808 (+)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001009927   ⟸   NM_001009927
- UniProtKB: Q5NCS9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000018743   ⟸   ENSMUST00000018743
Protein Domains
Mab-21

Promoters
RGD ID:6822166
Promoter ID:MM_KWN:7738
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001009927,   OTTMUST00000017731,   OTTMUST00000017732
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361160,540,911 - 60,542,027 (+)MPROMDB
RGD ID:8674890
Promoter ID:EPDNEW_M15476
Type:initiation region
Name:Mief2_1
Description:Mus musculus mitochondrial elongation factor 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381160,728,492 - 60,728,552EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2144199 AgrOrtholog
Ensembl Genes ENSMUSG00000018599 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000018743 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000018743 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Mab-21_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:237781 UniProtKB/Swiss-Prot
MGD MGI:2144199 ENTREZGENE
NCBI Gene 237781 ENTREZGENE
Pfam Mab-21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mief2 PhenoGen
SMART Mab-21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MID49_MOUSE UniProtKB/Swiss-Prot
  Q3TB59_MOUSE UniProtKB/TrEMBL
  Q5NCS9 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-10-22 Mief2  mitochondrial elongation factor 2  Smcr7  Smith-Magenis syndrome chromosome region, candidate 7 homolog (human)  Symbol and/or name change 5135510 APPROVED