Ppp4r3c1 (protein phosphatase 4 regulatory subunit 3C1) - Rat Genome Database

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Gene: Ppp4r3c1 (protein phosphatase 4 regulatory subunit 3C1) Mus musculus
Analyze
Symbol: Ppp4r3c1
Name: protein phosphatase 4 regulatory subunit 3C1
RGD ID: 1614879
MGI Page MGI
Description: Predicted to enable protein phosphatase activator activity. Predicted to be involved in DNA damage response. Predicted to be part of protein phosphatase 4 complex. Predicted to be active in nucleoplasm. Orthologous to human PPP4R3C (protein phosphatase 4 regulatory subunit 3C).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4930415L06Rik; MGC183898; MGC183900; Ppp4r3c; Ppp4r3cp; putative SMEK homolog 3; RP23-45G5.1; SMEK homolog 2, suppressor of mek1; Smek homolog 3; Smek3p
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm4746  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X88,973,703 - 88,976,458 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX88,973,704 - 88,976,458 (-)EnsemblGRCm39 Ensembl
GRCm38X89,930,097 - 89,932,852 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX89,930,098 - 89,932,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X87,175,436 - 87,178,191 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X86,182,817 - 86,185,571 (-)NCBIMGSCv36mm8
CeleraX57,573,136 - 57,575,900 (-)NCBICelera
Cytogenetic MapXC1NCBI
cM MapX39.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21873635  


Genomics

Comparative Map Data
Ppp4r3c1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X88,973,703 - 88,976,458 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX88,973,704 - 88,976,458 (-)EnsemblGRCm39 Ensembl
GRCm38X89,930,097 - 89,932,852 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX89,930,098 - 89,932,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X87,175,436 - 87,178,191 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X86,182,817 - 86,185,571 (-)NCBIMGSCv36mm8
CeleraX57,573,136 - 57,575,900 (-)NCBICelera
Cytogenetic MapXC1NCBI
cM MapX39.95NCBI
PPP4R3C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X27,460,207 - 27,463,341 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX27,460,207 - 27,463,341 (-)EnsemblGRCh38hg38GRCh38
GRCh37X27,478,324 - 27,481,458 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X27,388,247 - 27,391,379 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX31,606,919 - 31,610,049 (-)NCBICelera
Cytogenetic MapXp21.3NCBI
HuRefX25,217,742 - 25,220,867 (-)NCBIHuRef
CHM1_1X27,509,142 - 27,512,272 (-)NCBICHM1_1
T2T-CHM13v2.0X27,050,535 - 27,053,669 (-)NCBIT2T-CHM13v2.0
Ppp4r3c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X57,585,557 - 57,694,044 (+)NCBIGRCr8
mRatBN7.2X53,630,250 - 53,722,658 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.0X57,866,391 - 57,872,247 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X58,652,562 - 58,659,331 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X76,213,379 - 76,215,790 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX54,235,119 - 54,237,475 (+)NCBICelera
Cytogenetic MapXq21NCBI
PPP4R3C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X29,254,061 - 29,260,078 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X29,257,441 - 29,263,458 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X20,054,934 - 20,058,418 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X27,411,140 - 27,414,264 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX27,411,142 - 27,414,318 (-)Ensemblpanpan1.1panPan2
LOC491791
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X22,666,395 - 22,670,128 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX27,624,163 - 27,626,986 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X22,680,135 - 22,682,958 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X22,722,580 - 22,725,403 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X22,736,440 - 22,739,263 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X22,805,720 - 22,808,543 (-)NCBIUU_Cfam_GSD_1.0
LOC100515114
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X23,301,323 - 23,303,743 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X25,019,135 - 25,022,454 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP4R3C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X25,913,708 - 25,917,148 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605627,868,035 - 27,870,563 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ppp4r3c1
89 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:66
Interacting mature miRNAs:67
Transcripts:ENSMUST00000088146
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
25314311Syncl3_msynaptonemal complex length 3 (mouse)X5198887789743606Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
13464140Hdlq108_mHDL QTL 108 (mouse)X5777196091771960Mouse
25314316Mlh1fc3_mMLH1 foci count 3 (mouse)X6134360689843606Mouse
25314318Sccor2_msynaptonemal complex length to mean MLH1 count ratio 2 (mouse)X7054360696543606Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse
12879918Shm4_msperm head morphology 4 (mouse)X72072050102062720Mouse
1357500Mdmsc6_mmodifier of muscularity 6 (mouse)Not determinedX75306671109306758Mouse
1302054Gct4_mgranulosa cell tumorigenesis 4 (mouse)Not determinedX76124336102062720Mouse
11075102Modc2_mmodifier of Odc2 (mouse)X80189914114190059Mouse
4141803Lmr30_mleishmaniasis resistance 30 (mouse)Not determined85062606119062720Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000088146   ⟹   ENSMUSP00000085471
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX88,973,704 - 88,976,458 (-)Ensembl
GRCm38.p6 EnsemblX89,930,098 - 89,932,852 (-)Ensembl
RefSeq Acc Id: NM_001033880   ⟹   NP_001029052
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X88,973,703 - 88,976,458 (-)NCBI
GRCm38X89,930,097 - 89,932,852 (-)ENTREZGENE
MGSCv37X87,175,436 - 87,178,191 (-)RGD
CeleraX57,573,136 - 57,575,900 (-)RGD
cM MapX ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001029052 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI50986 (Get FASTA)   NCBI Sequence Viewer  
  AAI50988 (Get FASTA)   NCBI Sequence Viewer  
  BAE21372 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000085471
  ENSMUSP00000085471.3
GenBank Protein Q3V0Y1 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001029052   ⟸   NM_001033880
- UniProtKB: A2AG62 (UniProtKB/Swiss-Prot),   Q3V0Y1 (UniProtKB/Swiss-Prot),   B2RX57 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000085471   ⟸   ENSMUST00000088146
Protein Domains
Serine/threonine-protein phosphatase 4 regulatory

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3V0Y1-F1-model_v2 AlphaFold Q3V0Y1 1-813 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3588286 AgrOrtholog
Ensembl Genes ENSMUSG00000035387 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000088146 ENTREZGENE
  ENSMUST00000088146.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF625 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:245511 UniProtKB/Swiss-Prot
MGD MGI:3588286 ENTREZGENE
NCBI Gene 245511 ENTREZGENE
PANTHER ATP SYNTHASE GAMMA-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN PPP4R3C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SMK-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp4r3c1 PhenoGen
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AG62 ENTREZGENE
  B2RX57 ENTREZGENE, UniProtKB/TrEMBL
  P4R3C_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2AG62 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-04-24 Ppp4r3c1  protein phosphatase 4 regulatory subunit 3C1  4930415L06Rik  RIKEN cDNA 4930415L06 gene  Symbol and/or name updated 27372883 PROVISIONAL