Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | ISO | Atxn7l1 (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATXN7L1 mRNA] | CTD | PMID:31150632 | (-)-epigallocatechin 3-gallate | increases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | epigallocatechin gallate results in increased expression of ATXN7L1 mRNA | CTD | PMID:22079256 | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | ATXN7L1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ATXN7L1 mRNA | CTD | PMID:22079256 | 1-naphthyl isothiocyanate | decreases expression | ISO | Atxn7l1 (Rattus norvegicus) | 6480464 | 1-Naphthylisothiocyanate results in decreased expression of ATXN7L1 mRNA | CTD | PMID:30723492 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of ATXN7L1 mRNA | CTD | PMID:22574217 | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of ATXN7L1 mRNA | CTD | PMID:26251327 | 3,4-methylenedioxymethamphetamine | increases methylation | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased methylation of ATXN7L1 promoter | CTD | PMID:26251327 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | ATXN7L1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ATXN7L1 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | increases methylation | EXP | | 6480464 | bisphenol S results in increased methylation of ATXN7L1 exon | CTD | PMID:33297965 | 4-hydroxyphenyl retinamide | decreases expression | EXP | | 6480464 | Fenretinide results in decreased expression of ATXN7L1 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | ISO | Atxn7l1 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of ATXN7L1 mRNA | CTD | PMID:24780913 | aflatoxin B1 | affects expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of ATXN7L1 protein | CTD | PMID:20106945 | aflatoxin B1 | increases methylation | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of ATXN7L1 intron | CTD | PMID:30157460 | aflatoxin B1 | decreases methylation | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of ATXN7L1 gene | CTD | PMID:27153756 | antirheumatic drug | decreases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of ATXN7L1 mRNA | CTD | PMID:24449571 | benzo[a]pyrene | decreases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of ATXN7L1 mRNA | CTD | PMID:20064835 more ... | benzo[a]pyrene | affects methylation | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of ATXN7L1 intron | CTD | PMID:30157460 | benzo[a]pyrene | increases methylation | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of ATXN7L1 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of ATXN7L1 mRNA | CTD | PMID:19770486 | bisphenol A | decreases expression | ISO | Atxn7l1 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of ATXN7L1 mRNA | CTD | PMID:25181051 | bisphenol A | decreases methylation | ISO | ATXN7L1 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of ATXN7L1 gene | CTD | PMID:31601247 | bisphenol A | affects expression | ISO | Atxn7l1 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of ATXN7L1 mRNA | CTD | PMID:30816183 | bisphenol A | increases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of ATXN7L1 mRNA | CTD | PMID:29275510 and PMID:36232920 | bisphenol A | multiple interactions | ISO | ATXN7L1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of ATXN7L1 gene and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ATXN7L1 mRNA | CTD | PMID:28628672 and PMID:31601247 | butanal | decreases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of ATXN7L1 mRNA | CTD | PMID:26079696 | cadmium atom | multiple interactions | ISO | ATXN7L1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of ATXN7L1 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | ATXN7L1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of ATXN7L1 mRNA | CTD | PMID:35301059 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | ATXN7L1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ATXN7L1 gene] | CTD | PMID:28238834 | chlordecone | affects response to substance | ISO | ATXN7L1 (Homo sapiens) | 6480464 | ATXN7L1 gene SNP affects the susceptibility to Chlordecone | CTD | PMID:25622337 | cisplatin | decreases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of ATXN7L1 mRNA | CTD | PMID:27594783 | cisplatin | multiple interactions | ISO | ATXN7L1 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of ATXN7L1 mRNA | CTD | PMID:27392435 | cyclosporin A | decreases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of ATXN7L1 mRNA | CTD | PMID:20106945 | cyclosporin A | decreases methylation | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Cyclosporine results in decreased methylation of ATXN7L1 promoter | CTD | PMID:27989131 | dexamethasone | multiple interactions | ISO | ATXN7L1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ATXN7L1 mRNA | CTD | PMID:28628672 | dibutyl phthalate | decreases expression | ISO | Atxn7l1 (Rattus norvegicus) | 6480464 | Dibutyl Phthalate results in decreased expression of ATXN7L1 mRNA | CTD | PMID:21266533 | dorsomorphin | multiple interactions | ISO | ATXN7L1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATXN7L1 mRNA | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of ATXN7L1 mRNA | CTD | PMID:29803840 | epoxiconazole | increases expression | EXP | | 6480464 | epoxiconazole results in increased expression of ATXN7L1 mRNA | CTD | PMID:35436446 | fipronil | decreases expression | ISO | Atxn7l1 (Rattus norvegicus) | 6480464 | fipronil results in decreased expression of ATXN7L1 mRNA | CTD | PMID:34044035 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of ATXN7L1 mRNA | CTD | PMID:25629700 | fulvestrant | multiple interactions | ISO | ATXN7L1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of ATXN7L1 gene | CTD | PMID:31601247 | gentamycin | increases expression | ISO | Atxn7l1 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of ATXN7L1 mRNA | CTD | PMID:33387578 | hydralazine | multiple interactions | ISO | ATXN7L1 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of ATXN7L1 mRNA | CTD | PMID:17183730 | indometacin | multiple interactions | ISO | ATXN7L1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ATXN7L1 mRNA | CTD | PMID:28628672 | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of ATXN7L1 mRNA | CTD | PMID:26307267 | methoxychlor | affects methylation | ISO | Atxn7l1 (Rattus norvegicus) | 6480464 | Methoxychlor affects the methylation of ATXN7L1 gene | CTD | PMID:35440735 | nickel sulfate | increases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of ATXN7L1 mRNA | CTD | PMID:22714537 | paracetamol | increases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of ATXN7L1 mRNA | CTD | PMID:22230336 | paracetamol | decreases expression | ISO | Atxn7l1 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of ATXN7L1 mRNA | CTD | PMID:33387578 | paracetamol | decreases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of ATXN7L1 mRNA | CTD | PMID:29067470 | perfluorohexanesulfonic acid | increases expression | EXP | | 6480464 | perfluorohexanesulfonic acid results in increased expression of ATXN7L1 mRNA | CTD | PMID:37995155 | potassium chromate | multiple interactions | ISO | ATXN7L1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ATXN7L1 mRNA | CTD | PMID:22079256 | potassium chromate | decreases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of ATXN7L1 mRNA | CTD | PMID:22079256 | pregnenolone 16alpha-carbonitrile | decreases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in decreased expression of ATXN7L1 mRNA | CTD | PMID:28903501 | propiconazole | increases expression | EXP | | 6480464 | propiconazole results in increased expression of ATXN7L1 mRNA | CTD | PMID:21278054 | SB 431542 | multiple interactions | ISO | ATXN7L1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATXN7L1 mRNA | CTD | PMID:27188386 | silicon dioxide | increases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of ATXN7L1 mRNA | CTD | PMID:25895662 | tebuconazole | decreases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | tebuconazole results in decreased expression of ATXN7L1 mRNA | CTD | PMID:30458266 | testosterone | decreases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of ATXN7L1 mRNA | CTD | PMID:33359661 | tetrachloromethane | decreases expression | ISO | Atxn7l1 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in decreased expression of ATXN7L1 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | ISO | Atxn7l1 (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATXN7L1 mRNA] | CTD | PMID:31150632 | thioacetamide | decreases expression | ISO | Atxn7l1 (Rattus norvegicus) | 6480464 | Thioacetamide results in decreased expression of ATXN7L1 mRNA | CTD | PMID:23411599 and PMID:34492290 | trichostatin A | decreases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of ATXN7L1 mRNA | CTD | PMID:24935251 | triptonide | decreases expression | EXP | | 6480464 | triptonide results in decreased expression of ATXN7L1 mRNA | CTD | PMID:33045310 | urethane | decreases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Urethane results in decreased expression of ATXN7L1 mRNA | CTD | PMID:28818685 | valproic acid | multiple interactions | ISO | ATXN7L1 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of ATXN7L1 mRNA | CTD | PMID:17183730 | valproic acid | decreases methylation | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of ATXN7L1 gene | CTD | PMID:29154799 | valproic acid | decreases expression | ISO | ATXN7L1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of ATXN7L1 mRNA | CTD | PMID:23179753 and PMID:24935251 | vinclozolin | increases expression | ISO | Atxn7l1 (Rattus norvegicus) | 6480464 | vinclozolin results in increased expression of ATXN7L1 mRNA | CTD | PMID:23034163 | vorinostat | multiple interactions | ISO | ATXN7L1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATXN7L1 mRNA | CTD | PMID:27188386 | |