Defa39 (defensin, alpha, 39) - Rat Genome Database

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Gene: Defa39 (defensin, alpha, 39) Mus musculus
Analyze
No known orthologs.
Symbol: Defa39
Name: defensin, alpha, 39
RGD ID: 1614785
MGI Page MGI
Description: Predicted to enable protein homodimerization activity. Acts upstream of or within response to bacterium. Predicted to be located in azurophil granule. Predicted to be active in extracellular space. Orthologous to human DEFA4 (defensin alpha 4) and DEFA6 (defensin alpha 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Alpha-defensin-related sequence 1-like; AY76118; AY761184; cDNA sequence AY761184; CRS1C; CRS1C-3; CRS1C-6; hypothetical protein LOC382000; novel defensin-related cryptidin; uncharacterized protein LOC382000
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39822,192,540 - 22,193,663 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl822,192,535 - 22,193,661 (-)EnsemblGRCm39 Ensembl
GRCm38821,702,524 - 21,703,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl821,702,519 - 21,703,645 (-)EnsemblGRCm38mm10GRCm38
MGSCv37822,812,996 - 22,814,119 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36823,168,069 - 23,169,192 (-)NCBIMGSCv36mm8
Cytogenetic Map8A2NCBI
cM Map810.35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:15494476   PMID:16141072   PMID:16141073   PMID:20003482   PMID:21677750   PMID:21873635   PMID:23012479  


Genomics

Variants

.
Variants in Defa39
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:152
Interacting mature miRNAs:159
Transcripts:ENSMUST00000071886
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8721249923753815Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1708262628849467Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000071886   ⟹   ENSMUSP00000071783
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl822,192,535 - 22,193,661 (-)Ensembl
GRCm38.p6 Ensembl821,702,519 - 21,703,645 (-)Ensembl
RefSeq Acc Id: NM_001007582   ⟹   NP_001007583
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39822,192,540 - 22,193,663 (-)NCBI
GRCm38821,702,524 - 21,703,647 (-)ENTREZGENE
MGSCv37822,812,996 - 22,814,119 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001007583 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA20976 (Get FASTA)   NCBI Sequence Viewer  
  AAW83123 (Get FASTA)   NCBI Sequence Viewer  
  ACF04796 (Get FASTA)   NCBI Sequence Viewer  
  BAB25701 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000071783
  ENSMUSP00000071783.7
Reference Protein Sequences
RefSeq Acc Id: NP_001007583   ⟸   NM_001007582
- Peptide Label: precursor
- UniProtKB: Q9QVW7 (UniProtKB/Swiss-Prot),   P17533 (UniProtKB/Swiss-Prot),   Q9D848 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000071783   ⟸   ENSMUST00000071886
Protein Domains
Alpha-defensin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D848-F1-model_v2 AlphaFold Q9D848 1-116 view protein structure

Promoters
RGD ID:8666629
Promoter ID:EPDNEW_M11345
Type:multiple initiation site
Name:AY761184_1
Description:Mus musculus cDNA sequence AY761184 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38821,703,647 - 21,703,707EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3611585 AgrOrtholog
Ensembl Genes ENSMUSG00000058618 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000071886 ENTREZGENE
  ENSMUST00000071886.7 UniProtKB/TrEMBL
InterPro Alpha-defensin UniProtKB/TrEMBL
  Defensin_propep UniProtKB/TrEMBL
KEGG Report mmu:382000 UniProtKB/TrEMBL
MGD MGI:3611585 ENTREZGENE
NCBI Gene 382000 ENTREZGENE
PANTHER ALPHA-DEFENSIN 1-RELATED UniProtKB/TrEMBL
  PTHR11876 UniProtKB/TrEMBL
Pfam Defensin_propep UniProtKB/TrEMBL
PhenoGen Defa39 PhenoGen
PIRSF Alpha-defensin UniProtKB/TrEMBL
SMART Defensin_propep UniProtKB/TrEMBL
UniProt B3VKY5_MOUSE UniProtKB/TrEMBL
  P17533 ENTREZGENE
  Q9D848 ENTREZGENE, UniProtKB/TrEMBL
  Q9QVW7 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-20 Defa39  defensin, alpha, 39  AY761184  cDNA sequence AY761184  Symbol and/or name change 5135510 APPROVED