Ano8 (anoctamin 8) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Ano8 (anoctamin 8) Mus musculus
Analyze
Symbol: Ano8
Name: anoctamin 8
RGD ID: 1614781
MGI Page MGI
Description: Predicted to be involved in chloride transport and transmembrane transport. Localizes to intracellular. Is expressed in several structures, including alimentary system; central nervous system; head mesenchyme; sensory organ; and viscerocranium. Orthologous to human ANO8 (anoctamin 8); INTERACTS WITH folic acid; hydrogen peroxide; miconazole.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: anoctamin-8; BC053460; Tmem16h; transmembrane protein 16H
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,928,660 - 71,938,735 (-)NCBIGRCm39mm39
GRCm38871,476,016 - 71,486,092 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,476,019 - 71,485,963 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,999,918 - 74,009,966 (-)NCBIGRCm37mm9NCBIm37
MGSCv36874,400,583 - 74,415,056 (-)NCBImm8
Celera873,995,236 - 74,022,527 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:15368895   PMID:15489334   PMID:15647853   PMID:18729231   PMID:19059364   PMID:20056604   PMID:21873635   PMID:23532839  


Genomics

Comparative Map Data
Ano8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,928,660 - 71,938,735 (-)NCBIGRCm39mm39
GRCm38871,476,016 - 71,486,092 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,476,019 - 71,485,963 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,999,918 - 74,009,966 (-)NCBIGRCm37mm9NCBIm37
MGSCv36874,400,583 - 74,415,056 (-)NCBImm8
Celera873,995,236 - 74,022,527 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
ANO8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1917,323,223 - 17,334,855 (-)EnsemblGRCh38hg38GRCh38
GRCh381917,323,223 - 17,334,855 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371917,434,032 - 17,445,638 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,295,034 - 17,306,638 (-)NCBINCBI36hg18NCBI36
Celera1917,335,762 - 17,347,370 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,000,467 - 17,012,064 (-)NCBIHuRef
CHM1_11917,433,463 - 17,445,074 (-)NCBICHM1_1
Ano8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01619,884,661 - 19,894,608 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,886,051 - 19,894,591 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,746,782 - 19,756,332 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,646,561 - 18,656,780 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1618,369,579 - 18,378,174 (-)NCBICelera
Cytogenetic Map16p14NCBI
Ano8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955524904,119 - 911,673 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955524903,750 - 912,827 (+)NCBIChiLan1.0ChiLan1.0
ANO8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11917,785,205 - 17,797,051 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1917,785,485 - 17,796,856 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01916,811,353 - 16,822,786 (-)NCBIMhudiblu_PPA_v0panPan3
ANO8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2045,428,054 - 45,438,372 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12045,428,532 - 45,437,897 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ano8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365963,533,359 - 3,542,890 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANO8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl260,357,255 - 60,369,956 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1260,357,194 - 60,367,248 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ANO8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,829,808 - 15,841,393 (-)NCBI
ChlSab1.1 Ensembl615,830,087 - 15,841,298 (-)Ensembl
Ano8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624908619,887 - 630,244 (+)NCBI

Position Markers
AI607903  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38871,499,342 - 71,499,488UniSTSGRCm38
MGSCv37874,023,241 - 74,023,387UniSTSGRCm37
Celera874,009,627 - 74,009,773UniSTS
Cytogenetic Map8B3.3UniSTS
Whitehead/MRC_RH8766.18UniSTS
RH125129  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38871,475,730 - 71,475,906UniSTSGRCm38
MGSCv37873,999,629 - 73,999,805UniSTSGRCm37
Celera873,994,947 - 73,995,123UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map8C1UniSTS
UniSTS:235922  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38871,510,802 - 71,511,104UniSTSGRCm38
MGSCv37874,034,701 - 74,035,003UniSTSGRCm37
Celera874,021,169 - 74,021,471UniSTS
Cytogenetic Map8B3.3UniSTS
Plvap  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38871,508,414 - 71,509,066UniSTSGRCm38
MGSCv37874,032,313 - 74,032,965UniSTSGRCm37
Celera874,018,781 - 74,019,433UniSTS
Cytogenetic Map8B3.3UniSTS
cM Map833.5UniSTS
Plvap  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38871,508,413 - 71,508,888UniSTSGRCm38
MGSCv37874,032,312 - 74,032,787UniSTSGRCm37
Celera874,018,780 - 74,019,255UniSTS
Cytogenetic Map8B3.3UniSTS
cM Map833.5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:237
Count of miRNA genes:188
Interacting mature miRNAs:208
Transcripts:ENSMUST00000093450
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001164679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030243644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030243645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC127416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK173222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE853122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG092477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU708306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD355145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK624319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX201380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000093450   ⟹   ENSMUSP00000091157
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,476,019 - 71,485,963 (-)Ensembl
RefSeq Acc Id: ENSMUST00000212768
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,476,843 - 71,483,738 (-)Ensembl
RefSeq Acc Id: ENSMUST00000213016
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,476,843 - 71,484,049 (-)Ensembl
RefSeq Acc Id: ENSMUST00000213382   ⟹   ENSMUSP00000149365
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,476,019 - 71,485,963 (-)Ensembl
RefSeq Acc Id: NM_001164679   ⟹   NP_001158151
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,928,663 - 71,938,711 (-)NCBI
GRCm38871,476,019 - 71,486,067 (-)NCBI
MGSCv37873,999,918 - 74,009,966 (-)RGD
Celera873,995,236 - 74,022,527 (-)ENTREZGENE
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509686   ⟹   XP_006509749
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,928,665 - 71,938,735 (-)NCBI
GRCm38871,476,016 - 71,486,091 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509688   ⟹   XP_006509751
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,928,665 - 71,938,735 (-)NCBI
GRCm38871,476,016 - 71,486,091 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509690   ⟹   XP_006509753
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,928,665 - 71,938,716 (-)NCBI
GRCm38871,476,016 - 71,486,091 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312871   ⟹   XP_017168360
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,928,660 - 71,938,735 (-)NCBI
GRCm38871,476,016 - 71,486,091 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312872   ⟹   XP_017168361
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,928,665 - 71,938,735 (-)NCBI
GRCm38871,476,016 - 71,486,091 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312873   ⟹   XP_017168362
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,928,665 - 71,938,734 (-)NCBI
GRCm38871,476,016 - 71,486,092 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030243644   ⟹   XP_030099504
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,928,665 - 71,938,735 (-)NCBI
GRCm38871,476,016 - 71,486,091 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030243645   ⟹   XP_030099505
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,928,660 - 71,938,735 (-)NCBI
GRCm38871,476,019 - 71,486,091 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001158151   ⟸   NM_001164679
- UniProtKB: Q6PB70 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509753   ⟸   XM_006509690
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006509751   ⟸   XM_006509688
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006509749   ⟸   XM_006509686
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017168361   ⟸   XM_017312872
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017168360   ⟸   XM_017312871
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017168362   ⟸   XM_017312873
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_030099504   ⟸   XM_030243644
- Peptide Label: isoform X7
RefSeq Acc Id: XP_030099505   ⟸   XM_030243645
- Peptide Label: isoform X8
RefSeq Acc Id: ENSMUSP00000091157   ⟸   ENSMUST00000093450
RefSeq Acc Id: ENSMUSP00000149365   ⟸   ENSMUST00000213382

Promoters
RGD ID:8667423
Promoter ID:EPDNEW_M11731
Type:initiation region
Name:Ano8_1
Description:Mus musculus anoctamin 8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38871,486,048 - 71,486,108EPDNEW
RGD ID:6848379
Promoter ID:MM_ACW:47895
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell
Transcripts:TMEM16H.CSEP07,   TMEM16H.DSEP07,   TMEM16H.ESEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36874,008,126 - 74,008,626 (-)MPROMDB
RGD ID:6842789
Promoter ID:MM_KWN:54787
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   Spleen
Transcripts:ENSMUST00000093450,   UC009MDL.1,   UC009MDM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36874,009,711 - 74,010,452 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2687327 AgrOrtholog
Ensembl Genes ENSMUSG00000034863 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000091157 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000149365 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000093450 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000213382 UniProtKB/TrEMBL
InterPro Anoctamin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anoctamin-8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:382014 UniProtKB/Swiss-Prot
MGD MGI:2687327 ENTREZGENE
NCBI Gene 382014 ENTREZGENE
PANTHER PTHR12308 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12308:SF33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Anoctamin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ano8 PhenoGen
UniGene Mm.260360 ENTREZGENE
  Mm.475713 ENTREZGENE
UniProt A0A1L1SR96_MOUSE UniProtKB/TrEMBL
  ANO8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q05CB5 UniProtKB/Swiss-Prot
  Q69ZE4 UniProtKB/Swiss-Prot