Cyp2w1 (cytochrome P450, family 2, subfamily w, polypeptide 1) - Rat Genome Database

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Gene: Cyp2w1 (cytochrome P450, family 2, subfamily w, polypeptide 1) Mus musculus
Analyze
Symbol: Cyp2w1
Name: cytochrome P450, family 2, subfamily w, polypeptide 1
RGD ID: 1614687
MGI Page MGI
Description: Predicted to enable several functions, including heme binding activity; retinoic acid 4-hydroxylase activity; and retinoid binding activity. Predicted to be involved in several processes, including aflatoxin metabolic process; phospholipid metabolic process; and retinoic acid catabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in cell surface and endoplasmic reticulum lumen. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in colon; large intestine; and small intestine. Orthologous to human CYP2W1 (cytochrome P450 family 2 subfamily W member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytochrome P450 2W1; Gm455
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,338,371 - 139,345,362 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5139,338,372 - 139,342,788 (+)EnsemblGRCm39 Ensembl
GRCm385139,352,616 - 139,359,607 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,352,617 - 139,357,033 (+)EnsemblGRCm38mm10GRCm38
MGSCv375139,828,571 - 139,832,987 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365139,606,259 - 139,610,675 (+)NCBIMGSCv36mm8
Celera5136,406,834 - 136,411,079 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map578.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21873635   PMID:25844926  


Genomics

Comparative Map Data
Cyp2w1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,338,371 - 139,345,362 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5139,338,372 - 139,342,788 (+)EnsemblGRCm39 Ensembl
GRCm385139,352,616 - 139,359,607 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,352,617 - 139,357,033 (+)EnsemblGRCm38mm10GRCm38
MGSCv375139,828,571 - 139,832,987 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365139,606,259 - 139,610,675 (+)NCBIMGSCv36mm8
Celera5136,406,834 - 136,411,079 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map578.44NCBI
CYP2W1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387983,181 - 989,640 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7983,181 - 989,640 (+)EnsemblGRCh38hg38GRCh38
GRCh3771,022,817 - 1,029,276 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367989,361 - 995,802 (+)NCBINCBI36Build 36hg18NCBI36
Build 347796,234 - 802,517NCBI
Celera7990,578 - 996,997 (+)NCBICelera
Cytogenetic Map7p22.3NCBI
HuRef7939,494 - 945,913 (+)NCBIHuRef
CHM1_171,021,926 - 1,028,345 (+)NCBICHM1_1
T2T-CHM13v2.071,088,177 - 1,094,636 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v271,077,465 - 1,083,884 (+)NCBI
Cyp2w1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81220,405,400 - 20,410,282 (-)NCBIGRCr8
mRatBN7.21215,291,552 - 15,296,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,291,704 - 15,296,421 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01217,382,749 - 17,387,909 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,383,159 - 17,387,879 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,367,866 - 19,374,746 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,792,480 - 15,797,202 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11215,822,407 - 15,827,127 (-)NCBI
Celera1217,045,261 - 17,050,420 (-)NCBICelera
Cytogenetic Map12q11NCBI
LOC102016571
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,705,068 - 8,712,121 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,705,068 - 8,711,266 (+)NCBIChiLan1.0ChiLan1.0
CYP2W1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v265,928,225 - 5,935,241 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1754,252,914 - 54,259,930 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v071,140,855 - 1,147,788 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.171,353,510 - 1,369,487 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl71,353,510 - 1,362,781 (+)Ensemblpanpan1.1panPan2
CYP2W1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1615,883,248 - 15,889,508 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl615,881,636 - 15,889,186 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha617,354,512 - 17,362,330 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0616,012,124 - 16,019,942 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,012,367 - 16,019,917 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1615,814,985 - 15,822,771 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0615,741,518 - 15,749,310 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,029,717 - 16,037,535 (-)NCBIUU_Cfam_GSD_1.0
LOC101970215
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344143,793,867 - 143,807,376 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367541,203,017 - 1,208,131 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367541,203,004 - 1,208,131 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP2W1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3642,471 - 648,909 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13641,997 - 649,313 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23744,864 - 752,709 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP2W1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12820,580,272 - 20,592,771 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2820,582,287 - 20,591,497 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660901,103,793 - 1,111,633 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101698313
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474026,544,715 - 26,549,433 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474026,545,725 - 26,551,906 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp2w1
300 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:208
Count of miRNA genes:196
Interacting mature miRNAs:206
Transcripts:ENSMUST00000031521
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125178229141700466Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
13464143Bbaa2b_mB.burgdorferi-associated arthritis 2b (mouse)5133052969140709801Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000031521   ⟹   ENSMUSP00000031521
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5139,338,372 - 139,342,788 (+)Ensembl
GRCm38.p6 Ensembl5139,352,617 - 139,357,033 (+)Ensembl
RefSeq Acc Id: ENSMUST00000197955   ⟹   ENSMUSP00000143138
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5139,340,331 - 139,342,422 (+)Ensembl
GRCm38.p6 Ensembl5139,354,576 - 139,356,667 (+)Ensembl
RefSeq Acc Id: ENSMUST00000200478
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5139,338,372 - 139,340,377 (+)Ensembl
GRCm38.p6 Ensembl5139,352,617 - 139,354,622 (+)Ensembl
RefSeq Acc Id: NM_001160265   ⟹   NP_001153737
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395139,338,371 - 139,345,357 (+)NCBI
GRCm385139,352,616 - 139,359,602 (+)NCBI
MGSCv375139,828,571 - 139,832,987 (+)RGD
Celera5136,406,834 - 136,411,079 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006504719   ⟹   XP_006504782
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395139,338,376 - 139,345,362 (+)NCBI
GRCm385139,352,621 - 139,359,607 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006504720   ⟹   XP_006504783
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395139,338,376 - 139,345,362 (+)NCBI
GRCm385139,352,621 - 139,359,607 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006504721   ⟹   XP_006504784
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395139,339,245 - 139,345,362 (+)NCBI
GRCm385139,353,490 - 139,359,607 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006504722   ⟹   XP_006504785
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395139,338,376 - 139,342,691 (+)NCBI
GRCm385139,352,621 - 139,356,936 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001153737   ⟸   NM_001160265
- Peptide Label: precursor
- UniProtKB: E9Q816 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006504782   ⟸   XM_006504719
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006504783   ⟸   XM_006504720
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006504785   ⟸   XM_006504722
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006504784   ⟸   XM_006504721
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSMUSP00000143138   ⟸   ENSMUST00000197955
RefSeq Acc Id: ENSMUSP00000031521   ⟸   ENSMUST00000031521

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9Q816-F1-model_v2 AlphaFold E9Q816 1-493 view protein structure

Promoters
RGD ID:6888550
Promoter ID:EPDNEW_M7726
Type:single initiation site
Name:Cyp2w1_1
Description:Mus musculus cytochrome P450, family 2, subfamily w, polypeptide1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385139,352,616 - 139,352,676EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3616076 AgrOrtholog
Ensembl Genes ENSMUSG00000029541 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031521 ENTREZGENE
  ENSMUST00000031521.13 UniProtKB/Swiss-Prot
  ENSMUST00000197955.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:545817 UniProtKB/Swiss-Prot
MGD MGI:3616076 ENTREZGENE
NCBI Gene 545817 ENTREZGENE
PANTHER CYTOCHROME P450 2W1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYP2W1 RGD
PhenoGen Cyp2w1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JFE3_MOUSE UniProtKB/TrEMBL
  CP2W1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE