Insyn2b (inhibitory synaptic factor family member 2B) - Rat Genome Database

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Gene: Insyn2b (inhibitory synaptic factor family member 2B) Mus musculus
Analyze
Symbol: Insyn2b
Name: inhibitory synaptic factor family member 2B
RGD ID: 1614667
MGI Page MGI
Description: Predicted to be involved in inhibitory postsynaptic potential. Predicted to be active in postsynaptic density. Is expressed in gonad; ovary; and testis. Orthologous to human INSYN2B (inhibitory synaptic factor family member 2B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EG574403; Fam196; Fam196b; family with sequence similarity 196, member B; Gm6041; hypothetical protein LOC574403; MGC99845
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391134,264,822 - 34,372,642 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1134,264,758 - 34,372,640 (+)EnsemblGRCm39 Ensembl
GRCm381134,314,822 - 34,422,642 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,314,758 - 34,422,640 (+)EnsemblGRCm38mm10GRCm38
MGSCv371134,214,822 - 34,322,640 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361134,214,822 - 34,322,640 (+)NCBIMGSCv36mm8
Celera1136,726,207 - 36,834,375 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1119.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:19864314   PMID:21873635   PMID:22417325   PMID:22844512  


Genomics

Comparative Map Data
Insyn2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391134,264,822 - 34,372,642 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1134,264,758 - 34,372,640 (+)EnsemblGRCm39 Ensembl
GRCm381134,314,822 - 34,422,642 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,314,758 - 34,422,640 (+)EnsemblGRCm38mm10GRCm38
MGSCv371134,214,822 - 34,322,640 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361134,214,822 - 34,322,640 (+)NCBIMGSCv36mm8
Celera1136,726,207 - 36,834,375 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1119.72NCBI
INSYN2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385169,861,303 - 169,980,495 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5169,861,303 - 169,980,495 (-)EnsemblGRCh38hg38GRCh38
GRCh375169,288,307 - 169,407,499 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365169,223,297 - 169,340,322 (-)NCBINCBI36Build 36hg18NCBI36
Celera5165,322,310 - 165,439,373 (-)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5164,388,897 - 164,505,800 (-)NCBIHuRef
CHM1_15168,723,110 - 168,840,179 (-)NCBICHM1_1
T2T-CHM13v2.05170,396,711 - 170,518,930 (-)NCBIT2T-CHM13v2.0
Insyn2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81019,420,561 - 19,528,006 (+)NCBIGRCr8
mRatBN7.21018,916,721 - 19,023,859 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1019,003,131 - 19,022,139 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01019,270,956 - 19,392,214 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1019,366,793 - 19,368,532 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01019,149,321 - 19,265,167 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41019,383,104 - 19,401,226 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1018,549,000 - 18,660,453 (+)NCBICelera
Cytogenetic Map10q12NCBI
Insyn2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540822,841,584 - 22,863,256 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540822,842,645 - 22,864,156 (-)NCBIChiLan1.0ChiLan1.0
INSYN2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24165,024,830 - 165,143,499 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15163,164,374 - 163,283,055 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05165,227,463 - 165,346,288 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15171,987,796 - 172,105,936 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5171,988,980 - 172,009,754 (-)Ensemblpanpan1.1panPan2
INSYN2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1441,871,751 - 41,987,310 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl441,964,892 - 42,024,748 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha441,824,091 - 41,939,533 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0442,248,028 - 42,399,305 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl442,248,073 - 42,442,172 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1442,065,489 - 42,180,888 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0442,251,962 - 42,367,449 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0442,762,931 - 42,878,508 (+)NCBIUU_Cfam_GSD_1.0
Insyn2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721396,079,657 - 96,189,263 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366094,890,470 - 4,911,947 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366094,802,587 - 4,911,945 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INSYN2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1653,941,568 - 54,057,671 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11653,939,487 - 54,057,671 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21658,457,046 - 58,507,714 (+)NCBISscrofa10.2Sscrofa10.2susScr3
INSYN2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12372,078,442 - 72,197,715 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2372,080,294 - 72,100,012 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660346,464,019 - 6,584,554 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Insyn2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473320,076,826 - 20,100,153 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473319,982,815 - 20,099,782 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Insyn2b
3709 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1940
Count of miRNA genes:531
Interacting mature miRNAs:662
Transcripts:ENSMUST00000093192, ENSMUST00000165963
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1300990Bits3_mbitterness sensitivity 3 (mouse)Not determined11837212142372260Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
1302171Pgia28_mproteoglycan induced arthritis 28 (mouse)Not determined11890609742906218Mouse
4141047Nilac1_mnicotine induced locomotor activity 1 (mouse)Not determined11901178043011942Mouse
13524844Ppiq9_mprepulse inhibition QTL 9 (mouse)11904999735077325Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111095123244951464Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111095123244951464Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
10412216Eae44_mexperimental allergic encephalomyelitis susceptibility 44 (mouse)Not determined111226863739950840Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1300607Tnbs2_mtri-nitrobenzene sulfonic acid susceptible 2 (mouse)Not determined112489805235126680Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
1301814Bbaa7_mB.burgdorferi-associated arthritis 7 (mouse)Not determined112601178044264695Mouse
12910801Pwbwq14_mpost-weaning body weight QTL 14 (mouse)112719805750636094Mouse
12910804Pwbwq16_mpost-weaning body weight QTL 16 (mouse)112719805750636094Mouse
12910806Pwbwq15_mpost-weaning body weight QTL 15 (mouse)112719805750636094Mouse
12910817Pwgrq20_mpost-weaning growth rate QTL 20 (mouse)112719805750636094Mouse
12910818Ogrq5_moverall growth rate QTL 5 (mouse)112719805750636094Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000093192   ⟹   ENSMUSP00000090883
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1134,264,822 - 34,372,639 (+)Ensembl
GRCm38.p6 Ensembl1134,314,822 - 34,422,639 (+)Ensembl
RefSeq Acc Id: ENSMUST00000165963   ⟹   ENSMUSP00000129183
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1134,264,758 - 34,372,640 (+)Ensembl
GRCm38.p6 Ensembl1134,314,758 - 34,422,640 (+)Ensembl
RefSeq Acc Id: NM_001025382   ⟹   NP_001020553
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391134,264,822 - 34,372,640 (+)NCBI
GRCm381134,314,822 - 34,422,640 (+)NCBI
MGSCv371134,214,822 - 34,322,640 (+)RGD
Celera1136,726,207 - 36,834,375 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006514763   ⟹   XP_006514826
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391134,326,089 - 34,372,642 (+)NCBI
GRCm381134,376,085 - 34,422,642 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001020553 (Get FASTA)   NCBI Sequence Viewer  
  XP_006514826 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH72605 (Get FASTA)   NCBI Sequence Viewer  
  EDL23724 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000090883.4
  ENSMUSP00000129183
  ENSMUSP00000129183.2
GenBank Protein Q6GQV1 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001020553   ⟸   NM_001025382
- UniProtKB: Q6GQV1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006514826   ⟸   XM_006514763
- Peptide Label: isoform X1
- UniProtKB: Q6GQV1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000090883   ⟸   ENSMUST00000093192
RefSeq Acc Id: ENSMUSP00000129183   ⟸   ENSMUST00000165963

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6GQV1-F1-model_v2 AlphaFold Q6GQV1 1-535 view protein structure

Promoters
RGD ID:8674286
Promoter ID:EPDNEW_M15173
Type:initiation region
Name:Fam196b_2
Description:Mus musculus family with sequence similarity 196, member B ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15174  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381134,314,778 - 34,314,838EPDNEW
RGD ID:8674288
Promoter ID:EPDNEW_M15174
Type:single initiation site
Name:Fam196b_1
Description:Mus musculus family with sequence similarity 196, member B ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15173  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381134,372,359 - 34,372,419EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3643491 AgrOrtholog
Ensembl Genes ENSMUSG00000069911 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000093192.4 UniProtKB/Swiss-Prot
  ENSMUST00000165963 ENTREZGENE
  ENSMUST00000165963.9 UniProtKB/Swiss-Prot
InterPro INSYN2 UniProtKB/Swiss-Prot
KEGG Report mmu:574403 UniProtKB/Swiss-Prot
MGD MGI:3643491 ENTREZGENE
NCBI Gene 574403 ENTREZGENE
PANTHER PROTEIN INSYN2B UniProtKB/Swiss-Prot
  PTHR28682 UniProtKB/Swiss-Prot
Pfam FAM196 UniProtKB/Swiss-Prot
PhenoGen Insyn2b PhenoGen
UniProt INY2B_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-23 Insyn2b  inhibitory synaptic factor family member 2B  Fam196b  family with sequence similarity 196, member B  Symbol and/or name change 5135510 APPROVED