Pwwp4b (PWWP domain containing 4B) - Rat Genome Database

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Gene: Pwwp4b (PWWP domain containing 4B) Mus musculus
Analyze
No known orthologs.
Symbol: Pwwp4b
Name: PWWP domain containing 4B
RGD ID: 1614666
MGI Page MGI
Description: Is expressed in heart. Orthologous to human PWWP4 (PWWP domain containing 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DXBay18; hypothetical protein LOC574405; uncharacterized protein LOC574405
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,180,829 - 72,193,071 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX72,180,838 - 72,193,056 (-)EnsemblGRCm39 Ensembl
GRCm38X73,137,223 - 73,149,466 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,137,232 - 73,149,450 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X70,382,571 - 70,394,789 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X69,389,952 - 69,402,170 (-)NCBIMGSCv36mm8
Cytogenetic MapXA7.3NCBI
cM MapX37.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8088815   PMID:8828036   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073  


Genomics

Variants

.
Variants in Pwwp4b
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:183
Count of miRNA genes:175
Interacting mature miRNAs:179
Transcripts:ENSMUST00000080324
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3526365377043606Mouse
1301009Pbwg7_mpostnatal body weight growth 7 (mouse)Not determinedX3911371473113814Mouse
4141565Pbwg21_mpostnatal body weight growth 21 (mouse)Not determinedX3911371473113814Mouse
1300794Spha2_msperm head anomaly 2 (mouse)Not determinedX3992149886260137Mouse
4142200Rtwq1_mreduced testis weight QTL 1 (mouse)Not determined4147706075477203Mouse
1301278Bdln1_mbody length 1 (mouse)Not determinedX4170210675702218Mouse
1300702Fcsa4_mfemoral cross-sectional area 4 (mouse)Not determinedX4602744480027567Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
25314311Syncl3_msynaptonemal complex length 3 (mouse)X5198887789743606Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
10412108Desp5_mdespair 5 (mouse)Not determinedX5472235188722351Mouse
13464140Hdlq108_mHDL QTL 108 (mouse)X5777196091771960Mouse
25314316Mlh1fc3_mMLH1 foci count 3 (mouse)X6134360689843606Mouse
25314318Sccor2_msynaptonemal complex length to mean MLH1 count ratio 2 (mouse)X7054360696543606Mouse
1357730Hstx1_mhybrid sterility, X chromosome 1 (mouse)Not determinedX7145385277600812Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse
12879918Shm4_msperm head morphology 4 (mouse)X72072050102062720Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000080324   ⟹   ENSMUSP00000079200
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,180,838 - 72,193,056 (-)Ensembl
GRCm38.p6 EnsemblX73,137,232 - 73,149,450 (-)Ensembl
RefSeq Acc Id: NM_001025384   ⟹   NP_001020555
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,180,838 - 72,193,056 (-)NCBI
GRCm38X73,137,232 - 73,149,450 (-)NCBI
MGSCv37X70,382,571 - 70,394,789 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006528192   ⟹   XP_006528255
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,180,829 - 72,192,427 (-)NCBI
GRCm38X73,137,223 - 73,148,821 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006528193   ⟹   XP_006528256
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,180,829 - 72,193,071 (-)NCBI
GRCm38X73,137,223 - 73,149,466 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006528194   ⟹   XP_006528257
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,180,829 - 72,190,291 (-)NCBI
GRCm38X73,137,223 - 73,146,685 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006528195   ⟹   XP_006528258
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,180,829 - 72,190,291 (-)NCBI
GRCm38X73,137,223 - 73,146,685 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006528196   ⟹   XP_006528259
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,180,829 - 72,192,430 (-)NCBI
GRCm38X73,137,223 - 73,148,824 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006528197   ⟹   XP_006528260
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,180,829 - 72,193,066 (-)NCBI
GRCm38X73,137,223 - 73,149,461 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006528198   ⟹   XP_006528261
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,180,829 - 72,190,291 (-)NCBI
GRCm38X73,137,223 - 73,146,685 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006528199   ⟹   XP_006528262
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,180,829 - 72,192,434 (-)NCBI
GRCm38X73,137,223 - 73,148,828 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006528200   ⟹   XP_006528263
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,180,829 - 72,190,291 (-)NCBI
GRCm38X73,137,223 - 73,146,685 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001020555   ⟸   NM_001025384
- UniProtKB: Q52KH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528260   ⟸   XM_006528197
- Peptide Label: isoform X1
- UniProtKB: Q52KH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528256   ⟸   XM_006528193
- Peptide Label: isoform X1
- UniProtKB: Q52KH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528262   ⟸   XM_006528199
- Peptide Label: isoform X1
- UniProtKB: Q52KH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528259   ⟸   XM_006528196
- Peptide Label: isoform X1
- UniProtKB: Q52KH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528255   ⟸   XM_006528192
- Peptide Label: isoform X1
- UniProtKB: Q52KH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528263   ⟸   XM_006528200
- Peptide Label: isoform X1
- UniProtKB: Q52KH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528257   ⟸   XM_006528194
- Peptide Label: isoform X1
- UniProtKB: Q52KH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528258   ⟸   XM_006528195
- Peptide Label: isoform X1
- UniProtKB: Q52KH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528261   ⟸   XM_006528198
- Peptide Label: isoform X1
- UniProtKB: Q52KH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000079200   ⟸   ENSMUST00000080324
Protein Domains
MUM1-like PWWP   PWWP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q52KH6-F1-model_v2 AlphaFold Q52KH6 1-695 view protein structure

Promoters
RGD ID:13680692
Promoter ID:EPDNEW_M24495
Type:multiple initiation site
Name:DXBay18_1
Description:Mus musculus DNA segment, Chr X, Baylor 18 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X73,149,408 - 73,149,468EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99870 AgrOrtholog
Ensembl Genes ENSMUSG00000067771 UniProtKB/TrEMBL
  ENSMUSG00000071745 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000080324 ENTREZGENE
  ENSMUST00000080324.4 UniProtKB/TrEMBL
  ENSMUST00000088459.9 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.140 UniProtKB/TrEMBL
  6.10.300.20 UniProtKB/TrEMBL
InterPro MUM1-like UniProtKB/TrEMBL
  MUM1-like_PWWP UniProtKB/TrEMBL
  PWP3A_3B_4_C UniProtKB/TrEMBL
  PWP3A_3B_4_N UniProtKB/TrEMBL
KEGG Report mmu:574404 UniProtKB/TrEMBL
  mmu:574405 UniProtKB/TrEMBL
MGD MGI:99870 ENTREZGENE
NCBI Gene 574405 ENTREZGENE
PANTHER PTHR31333 UniProtKB/TrEMBL
  PWWP DOMAIN-CONTAINING 4 UniProtKB/TrEMBL
Pfam MUM1-like_PWWP UniProtKB/TrEMBL
  PWP3A-B_C UniProtKB/TrEMBL
  PWP3A-B_N UniProtKB/TrEMBL
PhenoGen Pwwp4b PhenoGen
Superfamily-SCOP Tudor/PWWP/MBT UniProtKB/TrEMBL
UniProt Q52KH6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-10-19 Pwwp4b  PWWP domain containing 4B  DXBay18  DNA segment, Chr X, Baylor 18  Symbol and/or name updated 27372883 PROVISIONAL