Foxl1 (forkhead box L1) - Rat Genome Database

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Gene: Foxl1 (forkhead box L1) Mus musculus
Analyze
Symbol: Foxl1
Name: forkhead box L1
RGD ID: 1614457
MGI Page MGI
Description: Exhibits DNA-binding transcription factor activity. Involved in several processes, including Peyer's patch morphogenesis; proteoglycan biosynthetic process; and visceral mesoderm-endoderm interaction involved in midgut development. Predicted to localize to nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; sensory organ; and urinary system. Orthologous to human FOXL1 (forkhead box L1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: fkh-6; Fkh6; forkhead box protein L1; forkhead homolog 6; forkhead-related protein FKHL11; FREA; FREAC7; transcription factor FKH-6
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398121,854,424 - 121,857,383 (+)NCBIGRCm39mm39
GRCm39 Ensembl8121,854,679 - 121,857,383 (+)Ensembl
GRCm388121,127,685 - 121,130,644 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8121,127,940 - 121,130,644 (+)EnsemblGRCm38mm10GRCm38
MGSCv378123,651,585 - 123,654,544 (+)NCBIGRCm37mm9NCBIm37
MGSCv368124,013,939 - 124,014,949 (+)NCBImm8
Celera8125,345,766 - 125,348,725 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map870.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7689224   PMID:7957066   PMID:8674414   PMID:9203584   PMID:10349636   PMID:10615124   PMID:10926756   PMID:11042159   PMID:11076861   PMID:11162636   PMID:11217851   PMID:11555641  
PMID:12466851   PMID:12477932   PMID:12648490   PMID:12812790   PMID:14681479   PMID:15155178   PMID:15188402   PMID:15240114   PMID:15618518   PMID:15650110   PMID:16141072   PMID:16141073  
PMID:16230531   PMID:16469829   PMID:16618389   PMID:18287559   PMID:19049965   PMID:19105206   PMID:19841618   PMID:20059953   PMID:21873635   PMID:22988430   PMID:23226461   PMID:23369715  
PMID:24952961   PMID:25286440   PMID:27736991   PMID:28797033   PMID:28867346   PMID:28994389   PMID:30916783  


Genomics

Comparative Map Data
Foxl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398121,854,424 - 121,857,383 (+)NCBIGRCm39mm39
GRCm39 Ensembl8121,854,679 - 121,857,383 (+)Ensembl
GRCm388121,127,685 - 121,130,644 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8121,127,940 - 121,130,644 (+)EnsemblGRCm38mm10GRCm38
MGSCv378123,651,585 - 123,654,544 (+)NCBIGRCm37mm9NCBIm37
MGSCv368124,013,939 - 124,014,949 (+)NCBImm8
Celera8125,345,766 - 125,348,725 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map870.34NCBI
FOXL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1686,576,368 - 86,583,478 (+)EnsemblGRCh38hg38GRCh38
GRCh381686,578,549 - 86,583,478 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371686,612,155 - 86,617,084 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361685,169,616 - 85,172,805 (+)NCBINCBI36hg18NCBI36
Build 341685,169,830 - 85,170,868NCBI
Celera1670,913,076 - 70,916,265 (+)NCBI
Cytogenetic Map16q24.1NCBI
HuRef1672,351,923 - 72,355,112 (+)NCBIHuRef
CHM1_11688,023,838 - 88,027,027 (+)NCBICHM1_1
Foxl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21949,196,255 - 49,200,682 (+)NCBI
Rnor_6.0 Ensembl1953,055,745 - 53,056,770 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01953,054,887 - 53,058,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01963,799,271 - 63,802,117 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1948,442,841 - 48,446,578 (+)NCBICelera
Cytogenetic Map19q12NCBI
FOXL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11686,580,646 - 86,583,593 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01667,249,157 - 67,252,278 (+)NCBIMhudiblu_PPA_v0panPan3
FOXL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1566,281,543 - 66,287,357 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl566,283,528 - 66,284,598 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha566,293,564 - 66,299,385 (-)NCBI
ROS_Cfam_1.0566,503,066 - 66,508,886 (-)NCBI
UMICH_Zoey_3.1566,525,951 - 66,531,764 (-)NCBI
UNSW_CanFamBas_1.0566,361,136 - 66,366,956 (-)NCBI
UU_Cfam_GSD_1.0566,774,376 - 66,780,196 (-)NCBI
Foxl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934926,471,248 - 26,476,373 (-)NCBI
SpeTri2.0NW_0049366412,226,489 - 2,227,613 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl62,542,675 - 2,543,691 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.162,540,748 - 2,544,978 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.262,748,329 - 2,750,723 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FOXL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1571,960,154 - 71,968,629 (+)NCBI
ChlSab1.1 Ensembl571,963,965 - 71,965,002 (+)Ensembl
Vero_WHO_p1.0NW_0236660473,739,091 - 3,744,440 (-)NCBI
Foxl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247462,640,486 - 2,645,326 (+)NCBI

Position Markers
X92498  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388121,129,125 - 121,129,324UniSTSGRCm38
MGSCv378123,653,025 - 123,653,224UniSTSGRCm37
Celera8125,347,206 - 125,347,405UniSTS
Cytogenetic Map8E1UniSTS
cM Map865.5UniSTS
Whitehead/MRC_RH81416.9UniSTS
Foxl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388121,128,371 - 121,128,968UniSTSGRCm38
MGSCv378123,652,271 - 123,652,868UniSTSGRCm37
Celera8125,346,452 - 125,347,049UniSTS
Cytogenetic Map8E1UniSTS
cM Map865.5UniSTS
Foxd4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381924,901,109 - 24,901,895UniSTSGRCm38
MGSCv371924,975,599 - 24,976,385UniSTSGRCm37
Celera1925,676,309 - 25,677,094UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map19BUniSTS
cM Map865.5UniSTS
cM Map1917.5UniSTS
UniSTS:491230  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388121,127,940 - 121,129,029UniSTSGRCm38
MGSCv378123,651,840 - 123,652,929UniSTSGRCm37
Celera8125,346,021 - 125,347,110UniSTS
Cytogenetic Map8E1UniSTS
cM Map865.5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889000000130800000Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined895518613129018580Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)896900000129401213Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)897663894129401213Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined897836895129401213Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899101792129401213Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899101792129401213Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100238570129401213Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8102716921127055036Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8104307238129401213Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8104307238129401213Mouse
14746994Manh65_mmandible shape 65 (mouse)8105762890129401213Mouse
10412273Fcd1_mfunctional capillary density 1 (mouse)Not determined8109688333129401213Mouse
10412274Leci1_mleukocyte endothelial cell interactions 1 (mouse)Not determined8109688333129401213Mouse
12904938Edlmmq7_mextensor digitorum longus muscle mass QTL 7 (mouse)8110755016129401213Mouse
12904960Gmmq6_mgastrocnemius muscle mass QTL 6 (mouse)8110755016129401213Mouse
4141546Mrdq3_mmodifier of retinal degeneration QTL 3 (mouse)Not determined113712788125329141Mouse
26884375Skwq2_mskull length QTL 2, 5 week (mouse)8120000000131200000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:734
Count of miRNA genes:466
Interacting mature miRNAs:556
Transcripts:ENSMUST00000062634, ENSMUST00000181609
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000181609   ⟹   ENSMUSP00000137732
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl8121,127,940 - 121,130,644 (+)Ensembl
RefSeq Acc Id: NM_008024   ⟹   NP_032050
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398121,854,424 - 121,857,383 (+)NCBI
GRCm388121,127,685 - 121,130,644 (+)ENTREZGENE
MGSCv378123,651,585 - 123,654,544 (+)RGD
Celera8125,345,766 - 125,348,725 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032050   ⟸   NM_008024
- UniProtKB: Q64731 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000137732   ⟸   ENSMUST00000181609

Promoters
RGD ID:8668481
Promoter ID:EPDNEW_M12271
Type:multiple initiation site
Name:Foxl1_1
Description:Mus musculus forkhead box L1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388121,127,854 - 121,127,914EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1347469 AgrOrtholog
Ensembl Genes ENSMUSG00000097084 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000137732 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000181609 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
InterPro Fork_head_dom UniProtKB/Swiss-Prot
  TF_fork_head_CS_1 UniProtKB/Swiss-Prot
  TF_fork_head_CS_2 UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report mmu:14241 UniProtKB/Swiss-Prot
MGD MGI:1347469 ENTREZGENE
NCBI Gene 14241 ENTREZGENE
Pfam Forkhead UniProtKB/Swiss-Prot
PhenoGen Foxl1 PhenoGen
PRINTS FORKHEAD UniProtKB/Swiss-Prot
PROSITE FORK_HEAD_1 UniProtKB/Swiss-Prot
  FORK_HEAD_2 UniProtKB/Swiss-Prot
  FORK_HEAD_3 UniProtKB/Swiss-Prot
SMART SM00339 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt FOXL1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8BQE0_MOUSE UniProtKB/TrEMBL
UniProt Secondary B2RQ86 UniProtKB/Swiss-Prot