Tmie (transmembrane inner ear) - Rat Genome Database
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Gene: Tmie (transmembrane inner ear) Mus musculus
Analyze
Symbol: Tmie
Name: transmembrane inner ear
RGD ID: 1614414
MGI Page MGI
Description: Involved in inner ear morphogenesis and sensory perception of sound. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 6 and sensorineural hearing loss. Orthologous to human TMIE (transmembrane inner ear); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5131400L21Rik; Mm.87012; spinner; sr; transmembrane inner ear expressed protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,694,755 - 110,709,141 (-)NCBIGRCm39mm39
GRCm389110,865,687 - 110,880,073 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,865,711 - 110,880,113 (-)EnsemblGRCm38mm10GRCm38
MGSCv379110,768,550 - 110,782,587 (-)NCBIGRCm37mm9NCBIm37
MGSCv369110,710,862 - 110,724,899 (-)NCBImm8
Celera9110,587,099 - 110,606,043 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8647934   PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12140191   PMID:12466851   PMID:12477932   PMID:14027064   PMID:14610273   PMID:16141072  
PMID:16141073   PMID:16235133   PMID:16602821   PMID:17219777   PMID:18586001   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23582420   PMID:25467981   PMID:28504928   PMID:30078710  
PMID:32343945   PMID:32929005  


Genomics

Comparative Map Data
Tmie
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,694,755 - 110,709,141 (-)NCBIGRCm39mm39
GRCm389110,865,687 - 110,880,073 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,865,711 - 110,880,113 (-)EnsemblGRCm38mm10GRCm38
MGSCv379110,768,550 - 110,782,587 (-)NCBIGRCm37mm9NCBIm37
MGSCv369110,710,862 - 110,724,899 (-)NCBImm8
Celera9110,587,099 - 110,606,043 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
TMIE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl346,694,528 - 46,710,886 (+)EnsemblGRCh38hg38GRCh38
GRCh38346,693,778 - 46,710,886 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37346,742,823 - 46,752,413 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,717,827 - 46,727,205 (+)NCBINCBI36hg18NCBI36
Build 34346,717,826 - 46,727,205NCBI
Celera346,680,576 - 46,691,109 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef346,785,701 - 46,795,263 (+)NCBIHuRef
CHM1_1346,692,939 - 46,702,529 (+)NCBICHM1_1
Tmie
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08119,142,116 - 119,157,071 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,142,434 - 119,157,071 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,480,524 - 118,495,446 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,254,502 - 115,269,123 (-)NCBIRGSC3.4rn4RGSC3.4
Celera8110,132,596 - 110,147,266 (-)NCBICelera
Cytogenetic Map8q32NCBI
Tmie
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542025,428,503 - 25,435,701 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542025,428,542 - 25,435,701 (-)NCBIChiLan1.0ChiLan1.0
TMIE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v0346,590,527 - 46,608,981 (+)NCBIMhudiblu_PPA_v0panPan3
TMIE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2042,053,817 - 42,061,262 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12042,052,607 - 42,061,424 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tmie
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936596531,260 - 540,608 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMIE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,624,154 - 29,633,013 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,623,905 - 29,633,016 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21333,028,518 - 33,030,240 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMIE
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1228,114,995 - 8,133,827 (+)NCBI
Tmie
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473074,498,257 - 74,506,180 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
13515058Adip20d_madiposity 20d (mouse)9108915010118915010Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:399
Count of miRNA genes:286
Interacting mature miRNAs:330
Transcripts:ENSMUST00000050958
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000050958   ⟹   ENSMUSP00000060148
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9110,865,711 - 110,880,113 (-)Ensembl
RefSeq Acc Id: ENSMUST00000198062
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9110,875,428 - 110,879,305 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199189
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9110,875,476 - 110,876,021 (-)Ensembl
RefSeq Acc Id: NM_146260   ⟹   NP_666372
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,694,755 - 110,709,141 (-)NCBI
GRCm389110,865,687 - 110,880,073 (-)NCBI
MGSCv379110,768,550 - 110,782,587 (-)RGD
Celera9110,587,099 - 110,606,043 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006512007   ⟹   XP_006512070
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,694,775 - 110,708,681 (-)NCBI
GRCm389110,865,707 - 110,879,655 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006512008   ⟹   XP_006512071
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,694,775 - 110,709,140 (-)NCBI
GRCm389110,865,707 - 110,880,072 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006512014   ⟹   XP_006512077
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,694,775 - 110,708,421 (-)NCBI
GRCm389110,865,707 - 110,879,655 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244163   ⟹   XP_030100023
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,694,775 - 110,709,141 (-)NCBI
GRCm389110,865,707 - 110,880,073 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036154760   ⟹   XP_036010653
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,694,775 - 110,704,022 (-)NCBI
RefSeq Acc Id: XM_036154761   ⟹   XP_036010654
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,694,775 - 110,708,423 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_666372   ⟸   NM_146260
- Peptide Label: precursor
- UniProtKB: Q8K467 (UniProtKB/Swiss-Prot),   B2RSF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006512077   ⟸   XM_006512014
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006512071   ⟸   XM_006512008
- Peptide Label: isoform X2
- UniProtKB: Q8K467 (UniProtKB/Swiss-Prot),   B2RSF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006512070   ⟸   XM_006512007
- Peptide Label: isoform X2
- UniProtKB: Q8K467 (UniProtKB/Swiss-Prot),   B2RSF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030100023   ⟸   XM_030244163
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000060148   ⟸   ENSMUST00000050958
RefSeq Acc Id: XP_036010654   ⟸   XM_036154761
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036010653   ⟸   XM_036154760
- Peptide Label: isoform X1

Promoters
RGD ID:6845263
Promoter ID:MM_KWN:58944
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney
Transcripts:OTTMUST00000051525
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369110,782,324 - 110,782,824 (-)MPROMDB
RGD ID:8671034
Promoter ID:EPDNEW_M13548
Type:multiple initiation site
Name:Tmie_1
Description:Mus musculus transmembrane inner ear , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389110,880,073 - 110,880,133EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2159400 AgrOrtholog
Ensembl Genes ENSMUSG00000049555 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000060148 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000050958 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro TMIE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20776 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2159400 ENTREZGENE
NCBI Gene 20776 ENTREZGENE
PANTHER PTHR28635 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TMIE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmie PhenoGen
UniGene Mm.390229 ENTREZGENE
UniProt B2RSF0 ENTREZGENE, UniProtKB/TrEMBL
  Q8CCX1_MOUSE UniProtKB/TrEMBL
  Q8K467 ENTREZGENE, UniProtKB/Swiss-Prot