Gene: Tmie (transmembrane inner ear) Mus musculus
Analyze
Symbol:
Tmie
Name:
transmembrane inner ear
Description:
INVOLVED IN inner ear morphogenesis; sensory perception of sound; ASSOCIATED WITH abnormal behavior; abnormal nursing; abnormal reflex; ASSOCIATED WITH autosomal recessive nonsyndromic deafness 6 (ortholog); Hearing Loss (ortholog); nonsyndromic deafness (ortholog); FOUND IN integral component of membrane (inferred); membrane (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; carbon nanotube
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
5131400L21Rik; Mm.87012; spinner; sr; transmembrane inner ear expressed protein
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TMIE (transmembrane inner ear) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Tmie (transmembrane inner ear) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Tmie (transmembrane inner ear) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TMIE (transmembrane inner ear) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Tmie (transmembrane inner ear) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TMIE (transmembrane inner ear) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
TMIE (transmembrane inner ear)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Rattus norvegicus (Norway rat):
Tmie (transmembrane inner ear)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
tmie (transmembrane inner ear)
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, PhylomeDB, TreeFam, ZFIN)
Drosophila melanogaster (fruit fly):
CG15130
Alliance
DIOPT (OrthoFinder, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
Y39A1C.1
Alliance
DIOPT (OrthoFinder, PANTHER, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 110,865,687 - 110,880,073 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 110,768,550 - 110,782,587 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 110,710,862 - 110,724,899 (-) NCBI mm8 Celera 9 110,587,099 - 110,606,043 (-) NCBI Celera Cytogenetic Map 9 F2 NCBI cM Map 9 60.79 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - OMIM
autosomal recessive nonsyndromic deafness 6 ISO RGD:1343102 7240710 OMIM
Gene-Chemical Interaction Annotations
(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE decreases expression ISO RGD:1562523 6480464 Topotecan results in decreased expression of TMIE mRNA CTD PMID:25729387 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions ISO RGD:1562523 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of TMIE mRNA CTD PMID:25729387 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of TMIE mRNA CTD PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of TMIE mRNA CTD PMID:26290441 , PMID:28922406 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of TMIE mRNA CTD PMID:18648102 6-propyl-2-thiouracil increases expression ISO RGD:1562523 6480464 Propylthiouracil results in increased expression of TMIE mRNA CTD PMID:24780913 aflatoxin B1 decreases methylation ISO RGD:1343102 6480464 Aflatoxin B1 results in decreased methylation of TMIE intron CTD PMID:30157460 benzo[e]pyrene decreases methylation ISO RGD:1343102 6480464 benzo(e)pyrene results in decreased methylation of TMIE intron CTD PMID:30157460 bisphenol A affects expression ISO RGD:1562523 6480464 bisphenol A affects the expression of TMIE mRNA CTD PMID:25181051 bisphenol A increases methylation ISO RGD:1562523 6480464 bisphenol A results in increased methylation of TMIE gene CTD PMID:28505145 butanal increases expression ISO RGD:1343102 6480464 butyraldehyde results in increased expression of TMIE mRNA CTD PMID:26079696 carbon nanotube affects expression EXP 6480464 Nanotubes, Carbon affects the expression of TMIE mRNA CTD PMID:25620056 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of TMIE mRNA CTD PMID:25554681 , PMID:25620056 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TMIE gene CTD PMID:20938992 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of TMIE mRNA CTD PMID:19770486 cyclosporin A increases expression ISO RGD:1343102 6480464 Cyclosporine results in increased expression of TMIE mRNA CTD PMID:27989131 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of TMIE mRNA CTD PMID:21266533 entinostat increases expression ISO RGD:1343102 6480464 entinostat results in increased expression of TMIE mRNA CTD PMID:27188386 ethanol increases expression EXP 6480464 Ethanol results in increased expression of TMIE mRNA CTD PMID:30319688 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TMIE gene CTD PMID:20938992 glycidol increases expression ISO RGD:1562523 6480464 glycidol results in increased expression of TMIE mRNA CTD PMID:24915197 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TMIE gene CTD PMID:20938992 methapyrilene decreases methylation ISO RGD:1343102 6480464 Methapyrilene results in decreased methylation of TMIE intron CTD PMID:30157460 methotrexate affects expression EXP 6480464 Methotrexate affects the expression of TMIE mRNA CTD PMID:18502557 oxaliplatin multiple interactions ISO RGD:1562523 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of TMIE mRNA CTD PMID:25729387 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of TMIE mRNA CTD PMID:17562736 phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of TMIE mRNA CTD PMID:23091169 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of TMIE mRNA CTD PMID:20813756 rotenone decreases expression ISO RGD:1343102 6480464 Rotenone results in decreased expression of TMIE mRNA CTD PMID:29955902 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of TMIE mRNA CTD PMID:23221170 topotecan decreases expression ISO RGD:1562523 6480464 Topotecan results in decreased expression of TMIE mRNA CTD PMID:25729387 topotecan multiple interactions ISO RGD:1562523 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of TMIE mRNA CTD PMID:25729387 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of TMIE mRNA CTD PMID:17292431 valproic acid increases expression ISO RGD:1343102 6480464 Valproic Acid results in increased expression of TMIE mRNA CTD PMID:29154799
Gene Ontology Annotations
Biological Process inner ear morphogenesis IMP MGI:MGI:1857053 2290270 (MGI:MGI:2183496, PMID:12140191) MGI MGI:MGI:2183496 , PMID:12140191 inner ear morphogenesis IBA MGI:MGI:2159400 , PANTHER:PTN002008581 2290270 (PMID:21873635) GO_Central PMID:21873635 sensory perception of sound IMP MGI:MGI:1857053 2290270 (MGI:MGI:2183496, PMID:12140191) MGI MGI:MGI:2183496 , PMID:12140191 sensory perception of sound IBA MGI:MGI:2159400 , PANTHER:PTN002008581 2290270 (PMID:21873635) GO_Central PMID:21873635 Cellular Component integral component of membrane IEA UniProtKB-KW:KW-0812 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 Molecular Function protein binding IPI UniProtKB:A1Y9I9 2290270 (MGI:MGI:6100205, PMID:28504928) UniProtKB MGI:MGI:6100205 , PMID:28504928
Phenotype Annotations
4141833 W10q13_m weight 10 weeks QTL 13 (mouse) Not determined 63332429 120362868 Mouse 12904947 Tammq7_m tibialis anterior muscle mass QTL 7 (mouse) 9 91683173 124595110 Mouse 13463478 Mchq18_m mean corpuscular hemoglobin QTL 18 (mouse) 9 91641084 124595110 Mouse 1302001 Bdln5_m body length 5 (mouse) Not determined 9 93762590 124595110 Mouse 13463474 Hbbcq5_m hemoglobin concentration QTL 5 (mouse) 9 91641084 124595110 Mouse 10054492 El7_m epilepsy 7 (mouse) Not determined 9 75775364 114474379 Mouse 12910772 Lvic6_m liver iron content 6 (mouse) 9 91413879 124595110 Mouse 1357461 Idd2_m insulin dependent diabetes susceptibility 2 (mouse) Not determined 9 82910333 116910428 Mouse 11081166 Psl5_m promotion susceptibility QTL 5 (mouse) 9 94981301 112872929 Mouse 1357627 Tgq2_m triglyceride QTL 2 (mouse) Not determined 9 102000187 124595110 Mouse 1302103 Dob2_m dietary obesity 2 (mouse) Not determined 9 86239845 120289624 Mouse 1301192 Skts6_m skin tumor susceptibility 6 (mouse) Not determined 9 78640645 112640755 Mouse 13463477 Rbc9_m red blood cell count 9 (mouse) 9 91641084 124595110 Mouse 10412290 Pvacm1l_m plasma vascular cell adhesion molecule 1 levels (mouse) Not determined 9 103289445 124595110 Mouse 10766454 Char10_m P. chabaudi malaria resistance QTL 10 (mouse) 9 82910333 116910428 Mouse 1357635 Splq4_m spleen weight QTL 4 (mouse) Not determined 9 63332429 120362868 Mouse 1357657 Pymr_m Plasmodium yoelli malaria resistance (mouse) Not determined 9 89977005 118938021 Mouse 10412242 Alpq8_m alcohol preference QTL 8 (mouse) Not determined 9 89284925 123284925 Mouse 1300549 Bbaa17_m B. burgdorferi-associated arthritis 17 (mouse) Not determined 9 86230401 120230530 Mouse 12904961 Gmmq7_m gastrocnemius muscle mass QTL 7 (mouse) 9 91683173 124595110 Mouse 1558767 Skmw11_m skeletal muscle weight 11 (mouse) Not determined 9 91641084 124595110 Mouse 13463480 Mchcq2_m mean corpuscular hemoglobin concentration QTL 2 (mouse) 9 91641084 124595110 Mouse 12910773 Splic3_m spleen iron content 3 (mouse) 9 91413879 124595110 Mouse 12879896 Berr3_m berghei resistance locus 3 (mouse) 9 103289445 124595110 Mouse 11537364 Cnes5_m C. neoformans susceptibility locus 5 (mouse) 9 96917590 124595110 Mouse 14746992 Manh67_m mandible shape 67 (mouse) 9 94036768 124595110 Mouse 10401247 Bglu14_m blood glucose level 14 (mouse) Not determined 9 79397810 113397888 Mouse 4141545 Tailaq2_m tail length adjusted QTL 2 (mouse) Not determined 63332429 120362868 Mouse 1300884 Sluc11_m susceptibility to lung cancer 11 (mouse) Not determined 9 82910333 116910428 Mouse 1302065 El1_m epilepsy 1 (mouse) Not determined 9 75775364 114474379 Mouse 1301732 Char1_m P. chabaudi malaria resistance QTL 1 (mouse) Not determined 9 81798268 115798392 Mouse 1301789 Pbwg4_m postnatal body weight growth 4 (mouse) Not determined 9 103289445 124595110 Mouse 11251716 Siim2_m stress induced immobility 2 (mouse) 9 86748483 120748483 Mouse 12880422 V25Dq6_m vitamin D inactive form serum level QTL 6 (mouse) 9 87800000 121800000 Mouse 1357648 Obq18_m obesity QTL 18 (mouse) Not determined 9 102000187 124595110 Mouse 1301487 Nociq1_m nociceptive sensitivity inflammatory QTL 1 (mouse) Not determined 9 84528818 118528921 Mouse 1301297 Lcho1_m liver cholesterol 1 (mouse) Not determined 9 101060861 124595110 Mouse 1301649 Psl1_m promotion susceptibility QTL 1 (mouse) Not determined 9 89412277 123412396 Mouse 12910770 Splic1_m spleen iron content 1 (mouse) 9 91413879 124595110 Mouse 1301484 Bwq6_m body weight (mouse) Not determined 9 93762590 124595110 Mouse 13463475 Hctq7_m hematocrit QTL 7 (mouse) 9 91641084 124595110 Mouse 13515058 Adip20d_m adiposity 20d (mouse) 9 108915010 118915010 Mouse 12904937 Edlmmq9_m extensor digitorum longus muscle mass QTL 9 (mouse) 9 91683173 124595110 Mouse
Predicted Target Of
Count of predictions: 399 Count of miRNA genes: 286 Interacting mature miRNAs: 330 Transcripts: ENSMUST00000050958 Prediction methods: Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
