Pes1 (pescadillo ribosomal biogenesis factor 1) - Rat Genome Database

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Gene: Pes1 (pescadillo ribosomal biogenesis factor 1) Mus musculus
Analyze
Symbol: Pes1
Name: pescadillo ribosomal biogenesis factor 1
RGD ID: 1614385
MGI Page MGI
Description: Predicted to enable RNA binding activity. Acts upstream of or within maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleolus organization; and protein localization to organelle. Located in condensed chromosome and nucleolus. Part of PeBoW complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human PES1 (pescadillo ribosomal biogenesis factor 1).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: pescadillo homolog; pescadillo homolog 1, containing BRCT domain
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm5472   Gm5910  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,913,975 - 3,930,004 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,913,975 - 3,930,004 (+)EnsemblGRCm39 Ensembl
GRCm38113,963,975 - 3,980,004 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,963,975 - 3,980,004 (+)EnsemblGRCm38mm10GRCm38
MGSCv37113,863,978 - 3,880,007 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,863,978 - 3,880,007 (+)NCBIMGSCv36mm8
Celera114,459,252 - 4,475,281 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. An overview of pre-ribosomal RNA processing in eukaryotes. Henras AK, etal., Wiley Interdiscip Rev RNA. 2015 Mar-Apr;6(2):225-42. doi: 10.1002/wrna.1269. Epub 2014 Oct 27.
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11071894   PMID:11076861   PMID:11112348   PMID:11217851   PMID:12237316   PMID:12466851   PMID:12477932   PMID:12520002  
PMID:14610273   PMID:15169904   PMID:15225545   PMID:15273728   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16738141   PMID:17308336   PMID:17967808   PMID:18799693  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:22560297   PMID:24194600   PMID:24457600   PMID:25190460   PMID:25557119   PMID:26336360   PMID:28378742   PMID:30457570   PMID:31106266  
PMID:36114006   PMID:36775058  


Genomics

Comparative Map Data
Pes1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,913,975 - 3,930,004 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,913,975 - 3,930,004 (+)EnsemblGRCm39 Ensembl
GRCm38113,963,975 - 3,980,004 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,963,975 - 3,980,004 (+)EnsemblGRCm38mm10GRCm38
MGSCv37113,863,978 - 3,880,007 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,863,978 - 3,880,007 (+)NCBIMGSCv36mm8
Celera114,459,252 - 4,475,281 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.79NCBI
PES1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382230,576,625 - 30,607,013 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2230,576,625 - 30,607,083 (-)EnsemblGRCh38hg38GRCh38
GRCh372230,972,612 - 31,003,000 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,302,612 - 29,317,894 (-)NCBINCBI36Build 36hg18NCBI36
Build 342229,297,166 - 29,312,448NCBI
Celera2214,772,326 - 14,802,877 (-)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2213,934,640 - 13,965,216 (-)NCBIHuRef
CHM1_12230,931,893 - 30,962,440 (-)NCBICHM1_1
T2T-CHM13v2.02231,040,029 - 31,070,584 (-)NCBIT2T-CHM13v2.0
Pes1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81483,074,346 - 83,090,726 (+)NCBIGRCr8
mRatBN7.21478,850,754 - 78,867,134 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,850,709 - 78,867,134 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1483,291,743 - 83,307,958 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,531,829 - 84,548,044 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01480,977,538 - 80,993,773 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,211,600 - 84,227,980 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,211,600 - 84,227,978 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,895,325 - 84,911,705 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,616,451 - 84,632,831 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1477,762,760 - 77,779,140 (+)NCBICelera
Cytogenetic Map14q21NCBI
Pes1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,792,182 - 4,808,258 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,794,189 - 4,808,235 (-)NCBIChiLan1.0ChiLan1.0
PES1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22340,536,102 - 40,566,257 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12243,234,571 - 43,250,104 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02211,604,897 - 11,620,187 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12229,405,669 - 29,420,974 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,406,095 - 29,420,868 (-)Ensemblpanpan1.1panPan2
PES1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,655,994 - 23,672,707 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2623,656,404 - 23,672,641 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,526,732 - 23,543,417 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02624,040,189 - 24,056,897 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2624,040,198 - 24,056,878 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12623,741,437 - 23,758,135 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02624,004,340 - 24,021,023 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02624,064,876 - 24,081,566 (-)NCBIUU_Cfam_GSD_1.0
Pes1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118116,593,668 - 116,608,341 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936904126,003 - 140,235 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936904125,922 - 140,559 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PES1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,476,801 - 47,495,982 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,478,378 - 47,495,983 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,580,252 - 50,597,924 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PES1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,453,184 - 13,469,115 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1913,453,160 - 13,469,012 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045112,664,119 - 112,680,080 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pes1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247476,933,081 - 6,947,423 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247476,932,691 - 6,947,599 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pes1
374 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1131
Count of miRNA genes:385
Interacting mature miRNAs:441
Transcripts:ENSMUST00000020705, ENSMUST00000109985, ENSMUST00000130973, ENSMUST00000137544
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse

Markers in Region
Pes1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38113,977,269 - 3,977,474UniSTSGRCm38
MGSCv37113,877,272 - 3,877,477UniSTSGRCm37
Celera114,472,546 - 4,472,751UniSTS
Cytogenetic Map11A1UniSTS
cM Map11 UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000020705   ⟹   ENSMUSP00000020705
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl113,913,975 - 3,930,004 (+)Ensembl
GRCm38.p6 Ensembl113,963,975 - 3,980,004 (+)Ensembl
RefSeq Acc Id: ENSMUST00000109985   ⟹   ENSMUSP00000105612
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl113,913,975 - 3,930,004 (+)Ensembl
GRCm38.p6 Ensembl113,963,975 - 3,980,004 (+)Ensembl
RefSeq Acc Id: ENSMUST00000130973
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl113,914,009 - 3,920,835 (+)Ensembl
GRCm38.p6 Ensembl113,964,009 - 3,970,835 (+)Ensembl
RefSeq Acc Id: ENSMUST00000137544
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl113,914,049 - 3,926,884 (+)Ensembl
GRCm38.p6 Ensembl113,964,049 - 3,976,884 (+)Ensembl
RefSeq Acc Id: NM_022889   ⟹   NP_075027
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,913,975 - 3,930,004 (+)NCBI
GRCm38113,963,975 - 3,980,004 (+)NCBI
MGSCv37113,863,978 - 3,880,007 (+)RGD
Celera114,459,252 - 4,475,281 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_075027   ⟸   NM_022889
- UniProtKB: Q542F0 (UniProtKB/Swiss-Prot),   Q9EQ61 (UniProtKB/Swiss-Prot),   Q5SQ20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000020705   ⟸   ENSMUST00000020705
RefSeq Acc Id: ENSMUSP00000105612   ⟸   ENSMUST00000109985
Protein Domains
BRCT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EQ61-F1-model_v2 AlphaFold Q9EQ61 1-584 view protein structure

Promoters
RGD ID:6821529
Promoter ID:MM_KWN:6200
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000109985,   NM_022889,   OTTMUST00000011217,   OTTMUST00000011218
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36113,863,599 - 3,864,099 (+)MPROMDB
RGD ID:8673762
Promoter ID:EPDNEW_M14912
Type:initiation region
Name:Pes1_1
Description:Mus musculus pescadillo ribosomal biogenesis factor 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38113,964,000 - 3,964,060EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1890613 AgrOrtholog
Ensembl Genes ENSMUSG00000020430 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020705 ENTREZGENE
  ENSMUST00000020705.5 UniProtKB/Swiss-Prot
  ENSMUST00000109985.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BRCT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BRCT_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:64934 UniProtKB/Swiss-Prot
MGD MGI:1890613 ENTREZGENE
NCBI Gene 64934 ENTREZGENE
PANTHER PESCADILLO HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12221 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BRCT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pescadillo_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pes1 PhenoGen
PROSITE BRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt PESC_MOUSE UniProtKB/Swiss-Prot
  Q542F0 ENTREZGENE
  Q5SQ20 ENTREZGENE, UniProtKB/TrEMBL
  Q9EQ61 ENTREZGENE
UniProt Secondary Q542F0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Pes1  pescadillo ribosomal biogenesis factor 1    pescadillo homolog 1, containing BRCT domain (zebrafish)  Symbol and/or name change 5135510 APPROVED