Serpina3a (serine (or cysteine) peptidase inhibitor, clade A, member 3A) - Rat Genome Database

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Gene: Serpina3a (serine (or cysteine) peptidase inhibitor, clade A, member 3A) Mus musculus
Analyze
No known orthologs.
Symbol: Serpina3a
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3A
RGD ID: 1614296
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4933406L18Rik; alpha-1 antiproteinase; ant; antitrypsin; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3A; serine (or cysteine) proteinase inhibitor, clade A, member 3A; serine protease inhibitor A3A; serpin A3A
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912104,078,983 - 104,088,155 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12104,078,983 - 104,088,155 (+)EnsemblGRCm39 Ensembl
GRCm3812104,112,724 - 104,121,896 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12104,112,724 - 104,121,896 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712105,350,934 - 105,360,106 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612104,513,774 - 104,522,946 (+)NCBIMGSCv36mm8
Celera12105,330,701 - 105,340,186 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1253.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12659817   PMID:15489334   PMID:15638460   PMID:16141072   PMID:16141073   PMID:21267068  
PMID:21677750   PMID:21873635   PMID:24172014   PMID:32274496   PMID:35678316  


Genomics

Variants

.
Variants in Serpina3a
322 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:196
Count of miRNA genes:155
Interacting mature miRNAs:157
Transcripts:ENSMUST00000021496, ENSMUST00000109965
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse
25823169Hrsq8_mhost response to SARS QTL 8, log titer (mouse)1281696245108495368Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
12910790Pwgrq7_mpre-weaning growth rate QTL 7 (mouse)1290937367108645308Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
10412192Bbaa27_mB.burgdorferi-associated arthritis 27 (mouse)Not determined1291254220107308393Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
11039526Ccc1_mcolitis susceptibility in the Collaborative Cross 1 (mouse)1293528334111028223Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
25394546Skmw76_mskeletal muscle weight 76, TA (mouse)12102593095106941888Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000021496   ⟹   ENSMUSP00000021496
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12104,082,229 - 104,087,777 (+)Ensembl
GRCm38.p6 Ensembl12104,115,970 - 104,121,518 (+)Ensembl
RefSeq Acc Id: ENSMUST00000109965   ⟹   ENSMUSP00000105591
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12104,078,983 - 104,088,155 (+)Ensembl
GRCm38.p6 Ensembl12104,112,724 - 104,121,896 (+)Ensembl
RefSeq Acc Id: ENSMUST00000185595   ⟹   ENSMUSP00000140024
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12104,079,039 - 104,088,067 (+)Ensembl
GRCm38.p6 Ensembl12104,112,780 - 104,121,808 (+)Ensembl
RefSeq Acc Id: NM_001167705   ⟹   NP_001161177
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912104,078,983 - 104,088,155 (+)NCBI
GRCm3812104,112,724 - 104,121,896 (+)NCBI
MGSCv3712105,350,934 - 105,360,106 (+)RGD
Celera12105,330,701 - 105,340,186 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_028740   ⟹   NP_083016
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912104,078,983 - 104,088,155 (+)NCBI
GRCm3812104,112,724 - 104,121,896 (+)NCBI
Celera12105,330,701 - 105,340,186 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001161177 (Get FASTA)   NCBI Sequence Viewer  
  NP_083016 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH63325 (Get FASTA)   NCBI Sequence Viewer  
  BAB30388 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000021496.8
  ENSMUSP00000105591
  ENSMUSP00000105591.2
  ENSMUSP00000140024
  ENSMUSP00000140024.3
GenBank Protein Q6P4P1 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001161177   ⟸   NM_001167705
- Peptide Label: isoform 1
- UniProtKB: Q9D490 (UniProtKB/Swiss-Prot),   Q6P4P1 (UniProtKB/Swiss-Prot),   H7BWY0 (UniProtKB/TrEMBL),   A0A087WQ35 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_083016   ⟸   NM_028740
- Peptide Label: isoform 2
- UniProtKB: Q6P4P1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000140024   ⟸   ENSMUST00000185595
RefSeq Acc Id: ENSMUSP00000105591   ⟸   ENSMUST00000109965
RefSeq Acc Id: ENSMUSP00000021496   ⟸   ENSMUST00000021496
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P4P1-F1-model_v2 AlphaFold Q6P4P1 1-422 view protein structure

Promoters
RGD ID:8679126
Promoter ID:EPDNEW_M17594
Type:single initiation site
Name:Serpina3a_1
Description:Mus musculus serine peptidase inhibitor, clade A, member 3A ,transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812104,112,724 - 104,112,784EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921319 AgrOrtholog
Ensembl Genes ENSMUSG00000041536 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021496.8 UniProtKB/TrEMBL
  ENSMUST00000109965 ENTREZGENE
  ENSMUST00000109965.8 UniProtKB/Swiss-Prot
  ENSMUST00000185595 ENTREZGENE
  ENSMUST00000185595.7 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Serpin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:74069 UniProtKB/Swiss-Prot
MGD MGI:1921319 ENTREZGENE
NCBI Gene 74069 ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE PROTEASE INHIBITOR A3A-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serpin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Serpina3a PhenoGen
SMART SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WQ35 ENTREZGENE
  H7BWY0 ENTREZGENE, UniProtKB/TrEMBL
  Q6P4P1 ENTREZGENE
  Q9D490 ENTREZGENE
  SPA3A_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A0A087WQ35 UniProtKB/TrEMBL
  Q9D490 UniProtKB/Swiss-Prot