Atf7ip2 (activating transcription factor 7 interacting protein 2) - Rat Genome Database

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Gene: Atf7ip2 (activating transcription factor 7 interacting protein 2) Mus musculus
Analyze
Symbol: Atf7ip2
Name: activating transcription factor 7 interacting protein 2
RGD ID: 1614288
MGI Page MGI
Description: Predicted to enable transcription coregulator activity. Predicted to be involved in positive regulation of DNA methylation-dependent heterochromatin formation and regulation of DNA-templated transcription. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; gut; heart; liver; and lung. Orthologous to human ATF7IP2 (activating transcription factor 7 interacting protein 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4930558K11Rik; activating transcription factor 7-interacting protein 2; BC018510; Get-1; MBD1-containing chromatin-associated factor 2; MGC6783; protein similar to MCAF2; PS; PSM2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391610,010,513 - 10,068,595 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1610,010,576 - 10,069,342 (+)EnsemblGRCm39 Ensembl
GRCm381610,192,649 - 10,250,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1610,192,712 - 10,251,478 (+)EnsemblGRCm38mm10GRCm38
MGSCv371610,192,999 - 10,243,144 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361610,106,290 - 10,156,629 (+)NCBIMGSCv36mm8
Celera1610,826,131 - 10,876,320 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map165.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:14681479   PMID:16141072   PMID:16141073   PMID:16850184  
PMID:17431699   PMID:18287559   PMID:18799693   PMID:21267068   PMID:21873635   PMID:34709266   PMID:37542719  


Genomics

Comparative Map Data
Atf7ip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391610,010,513 - 10,068,595 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1610,010,576 - 10,069,342 (+)EnsemblGRCm39 Ensembl
GRCm381610,192,649 - 10,250,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1610,192,712 - 10,251,478 (+)EnsemblGRCm38mm10GRCm38
MGSCv371610,192,999 - 10,243,144 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361610,106,290 - 10,156,629 (+)NCBIMGSCv36mm8
Celera1610,826,131 - 10,876,320 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map165.5NCBI
ATF7IP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381610,386,061 - 10,483,638 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1610,326,434 - 10,483,638 (+)EnsemblGRCh38hg38GRCh38
GRCh371610,479,918 - 10,577,495 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361610,430,226 - 10,484,996 (+)NCBINCBI36Build 36hg18NCBI36
Build 341610,430,225 - 10,484,995NCBI
Celera1610,690,093 - 10,744,829 (+)NCBICelera
Cytogenetic Map16p13.2-p13.13NCBI
HuRef1610,399,242 - 10,496,846 (+)NCBIHuRef
CHM1_11610,479,841 - 10,577,424 (+)NCBICHM1_1
T2T-CHM13v2.01610,421,735 - 10,519,259 (+)NCBIT2T-CHM13v2.0
Atf7ip2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8105,909,898 - 5,952,844 (-)NCBIGRCr8
mRatBN7.2105,403,099 - 5,445,989 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl105,403,105 - 5,446,142 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1010,099,399 - 10,142,039 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0109,620,576 - 9,663,387 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0105,258,752 - 5,301,500 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0105,476,205 - 5,519,893 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl105,476,966 - 5,511,955 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0104,297,228 - 4,340,498 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4105,356,438 - 5,399,673 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera104,419,013 - 4,461,981 (-)NCBICelera
Cytogenetic Map10q11NCBI
Atf7ip2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554427,894,518 - 7,941,580 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554427,896,626 - 7,975,579 (-)NCBIChiLan1.0ChiLan1.0
ATF7IP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21810,850,826 - 11,018,846 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11614,626,607 - 14,794,674 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0169,314,019 - 9,411,940 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11610,545,087 - 10,642,209 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1610,589,012 - 10,642,209 (+)Ensemblpanpan1.1panPan2
ATF7IP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1632,078,700 - 32,128,491 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl632,079,186 - 32,118,658 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha633,460,859 - 33,516,213 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0632,261,952 - 32,317,341 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl632,261,957 - 32,317,506 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1632,074,922 - 32,130,345 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0631,947,684 - 32,002,777 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0632,373,245 - 32,428,680 (-)NCBIUU_Cfam_GSD_1.0
Atf7ip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344110,949,807 - 110,990,344 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365308,796,077 - 8,830,847 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365308,795,303 - 8,832,683 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATF7IP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl332,523,463 - 32,598,855 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1332,523,462 - 32,598,946 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2333,324,469 - 33,378,479 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATF7IP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.159,880,656 - 9,972,528 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl59,924,868 - 9,973,606 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606820,193,373 - 20,286,510 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atf7ip2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248247,783,337 - 7,855,024 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248247,779,900 - 7,880,243 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atf7ip2
2069 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:674
Count of miRNA genes:477
Interacting mature miRNAs:567
Transcripts:ENSMUST00000044005, ENSMUST00000100191, ENSMUST00000117220, ENSMUST00000119023, ENSMUST00000133674
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120780888Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122500574Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122520318Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16122897739Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
1302106Rapop1_mradiation-induced apoptosis 1 (mouse)Not determined16378077915731053Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16713690629225471Mouse
1357658Dice1a_mdetermination of interleukin 4 commitment 1a (mouse)Not determined16780110010957706Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
13432183Rotse3_mrotarod training saline/ethanol 3 (mouse)16991777110617771Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000044005   ⟹   ENSMUSP00000036731
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1610,010,576 - 10,060,915 (+)Ensembl
GRCm38.p6 Ensembl1610,192,712 - 10,243,051 (+)Ensembl
RefSeq Acc Id: ENSMUST00000100191   ⟹   ENSMUSP00000097766
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1610,010,790 - 10,045,007 (+)Ensembl
GRCm38.p6 Ensembl1610,192,926 - 10,227,143 (+)Ensembl
RefSeq Acc Id: ENSMUST00000117220   ⟹   ENSMUSP00000113573
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1610,010,786 - 10,058,678 (+)Ensembl
GRCm38.p6 Ensembl1610,192,922 - 10,240,814 (+)Ensembl
RefSeq Acc Id: ENSMUST00000119023   ⟹   ENSMUSP00000113480
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1610,010,770 - 10,055,152 (+)Ensembl
GRCm38.p6 Ensembl1610,192,906 - 10,237,288 (+)Ensembl
RefSeq Acc Id: ENSMUST00000133674
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1610,010,811 - 10,032,095 (+)Ensembl
GRCm38.p6 Ensembl1610,192,947 - 10,214,231 (+)Ensembl
RefSeq Acc Id: ENSMUST00000230872   ⟹   ENSMUSP00000155077
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1610,030,670 - 10,069,342 (+)Ensembl
GRCm38.p6 Ensembl1610,212,806 - 10,251,478 (+)Ensembl
RefSeq Acc Id: NM_029253   ⟹   NP_083529
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391610,010,770 - 10,055,151 (+)NCBI
GRCm381610,192,906 - 10,237,287 (+)NCBI
MGSCv371610,192,999 - 10,243,144 (+)RGD
Celera1610,826,131 - 10,876,320 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_153123   ⟹   NP_694763
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391610,010,770 - 10,060,915 (+)NCBI
GRCm381610,192,906 - 10,243,051 (+)NCBI
MGSCv371610,192,999 - 10,243,144 (+)RGD
Celera1610,826,131 - 10,876,320 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006522682   ⟹   XP_006522745
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391610,010,518 - 10,060,336 (+)NCBI
GRCm381610,192,654 - 10,242,472 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006522684   ⟹   XP_006522747
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391610,010,515 - 10,060,336 (+)NCBI
GRCm381610,192,651 - 10,242,472 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011246039   ⟹   XP_011244341
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391610,010,513 - 10,068,595 (+)NCBI
GRCm381610,192,649 - 10,250,731 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_694763   ⟸   NM_153123
- Peptide Label: isoform 1
- UniProtKB: Q8BPC5 (UniProtKB/Swiss-Prot),   Q4VIF3 (UniProtKB/Swiss-Prot),   Q3UT16 (UniProtKB/Swiss-Prot),   Q9D4T8 (UniProtKB/Swiss-Prot),   Q3UL97 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_083529   ⟸   NM_029253
- Peptide Label: isoform 2
- UniProtKB: Q3UL97 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006522747   ⟸   XM_006522684
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006522745   ⟸   XM_006522682
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011244341   ⟸   XM_011246039
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000113480   ⟸   ENSMUST00000119023
RefSeq Acc Id: ENSMUSP00000155077   ⟸   ENSMUST00000230872
RefSeq Acc Id: ENSMUSP00000097766   ⟸   ENSMUST00000100191
RefSeq Acc Id: ENSMUSP00000113573   ⟸   ENSMUST00000117220
RefSeq Acc Id: ENSMUSP00000036731   ⟸   ENSMUST00000044005
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3UL97-F1-model_v2 AlphaFold Q3UL97 1-452 view protein structure

Promoters
RGD ID:6826819
Promoter ID:MM_KWN:20070
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:ENSMUST00000117220,   ENSMUST00000119023,   OTTMUST00000068367,   OTTMUST00000068371,   UC007YDF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361610,192,761 - 10,193,261 (+)MPROMDB
RGD ID:8685408
Promoter ID:EPDNEW_M20735
Type:single initiation site
Name:Atf7ip2_1
Description:Mus musculus activating transcription factor 7 interacting protein2 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381610,192,808 - 10,192,868EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1922579 AgrOrtholog
Ensembl Genes ENSMUSG00000039200 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000044005 ENTREZGENE
  ENSMUST00000044005.14 UniProtKB/Swiss-Prot
  ENSMUST00000100191.4 UniProtKB/Swiss-Prot
  ENSMUST00000117220.8 UniProtKB/Swiss-Prot
  ENSMUST00000119023 ENTREZGENE
  ENSMUST00000119023.8 UniProtKB/Swiss-Prot
  ENSMUST00000230872.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro ATF7-int UniProtKB/Swiss-Prot
  ATF7IP_BD UniProtKB/Swiss-Prot
  FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
KEGG Report mmu:75329 UniProtKB/Swiss-Prot
MGD MGI:1922579 ENTREZGENE
NCBI Gene 75329 ENTREZGENE
PANTHER PTHR23210 UniProtKB/Swiss-Prot
  PTHR23210:SF23 UniProtKB/Swiss-Prot
Pfam ATF7IP_BD UniProtKB/Swiss-Prot
  fn3_4 UniProtKB/Swiss-Prot
PhenoGen Atf7ip2 PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot
UniProt A0A2R8W6K8_MOUSE UniProtKB/TrEMBL
  MCAF2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UT16 ENTREZGENE
  Q4VIF3 ENTREZGENE
  Q8BPC5 ENTREZGENE
  Q8K3D7_MOUSE UniProtKB/TrEMBL
  Q9D4T8 ENTREZGENE
UniProt Secondary Q3UT16 UniProtKB/Swiss-Prot
  Q4VIF3 UniProtKB/Swiss-Prot
  Q8BPC5 UniProtKB/Swiss-Prot
  Q9D4T8 UniProtKB/Swiss-Prot