Trim12a (tripartite motif-containing 12A) - Rat Genome Database

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Gene: Trim12a (tripartite motif-containing 12A) Mus musculus
Analyze
No known orthologs.
Symbol: Trim12a
Name: tripartite motif-containing 12A
RGD ID: 1614266
MGI Page MGI
Description: Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; protein K63-linked ubiquitination; and regulation of signal transduction. Located in cytoplasm. Is expressed in bladder and testis. Orthologous to human TRIM5 (tripartite motif containing 5); INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2310043C01Rik; Gm15134; Trim; Trim12; tripartite motif protein 12; tripartite motif-containing 12; tripartite motif-containing protein 12; tripartite motif-containing protein 12A
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397103,949,100 - 103,964,765 (-)NCBIGRCm39mm39
GRCm39 Ensembl7103,949,101 - 103,964,673 (-)Ensembl
GRCm387104,299,893 - 104,315,558 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7104,299,894 - 104,315,466 (-)EnsemblGRCm38mm10GRCm38
MGSCv377111,448,411 - 111,464,009 (-)NCBIGRCm37mm9NCBIm37
MGSCv367104,177,412 - 104,189,284 (-)NCBImm8
Cytogenetic Map7E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA,ISO)
cytosol  (IBA)
nucleoplasm  (IBA)
omegasome  (ISO)
P-body  (ISO)

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11331580   PMID:11544199   PMID:12466851   PMID:12477932   PMID:14744882   PMID:15618518   PMID:16141072   PMID:16141073  
PMID:17525270   PMID:18287559   PMID:19147168   PMID:19648292   PMID:19706712   PMID:21267068   PMID:21873635   PMID:32325033  


Genomics


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718994869119886157Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730500000109400000Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736580590116817642Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745512542119094307Mouse
13208555Lgth10_mbody length 10 (mouse)752000000126000000Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)755169841117223580Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)757300000134400000Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)762100000121800000Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)762100000124100000Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765600000126900000Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)768200000105800000Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)768200000119900000Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)768200000124600000Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)768200000125400000Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)770300000120900000Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770493929104494171Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772614164106614164Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773400000126100000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)774076757108076757Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)775200000122600000Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)775200000122600000Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775745007109745138Mouse
14746989Manh62_mmandible shape 62 (mouse)776093321110093321Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)779000000137300000Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80902474114902584Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780902474114902584Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)781200000127100000Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781600000124600000Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781800000126900000Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)782200000126900000Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785400000124600000Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785716387112934612Mouse
1301647Elpt_melevated leptin (mouse)Not determined786850979120851122Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787394725121394859Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787394725121394859Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787394725121394859Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787493929119886157Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787600000126900000Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787600000126900000Mouse
27095929Pglq8_mpelvic girdle length QTL 8, 10 week (mouse)788200000108500000Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791883789125883949Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791883789125883949Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793792641127792834Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798565687132565775Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798795739132795739Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined7100238481134238481Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7101151499135151620Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7101394038135394119Mouse
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7102094158136094307Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7102094158136094307Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7102094158136094307Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102885996136886157Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:684
Count of miRNA genes:383
Interacting mature miRNAs:419
Transcripts:ENSMUST00000070943, ENSMUST00000106837, ENSMUST00000106839, ENSMUST00000126145, ENSMUST00000134564, ENSMUST00000142641
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001368753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001368754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_023835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030243080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030243081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030243082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030243083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC142110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF220126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM246341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV553257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000070943   ⟹   ENSMUSP00000065008
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7104,303,591 - 104,315,463 (-)Ensembl
RefSeq Acc Id: ENSMUST00000106837   ⟹   ENSMUSP00000102450
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7104,299,897 - 104,315,455 (-)Ensembl
RefSeq Acc Id: ENSMUST00000106839   ⟹   ENSMUSP00000102452
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7104,299,897 - 104,315,456 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126145
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7104,306,934 - 104,315,343 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134564
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7104,311,079 - 104,315,466 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142641
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7104,299,894 - 104,301,034 (-)Ensembl
RefSeq Acc Id: NM_001368753   ⟹   NP_001355682
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397103,949,104 - 103,964,702 (-)NCBI
GRCm387104,299,897 - 104,315,495 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001368754   ⟹   NP_001355683
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397103,952,798 - 103,964,702 (-)NCBI
GRCm387104,303,591 - 104,315,495 (-)NCBI
Sequence:
RefSeq Acc Id: NM_023835   ⟹   NP_076324
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397103,949,104 - 103,964,702 (-)NCBI
GRCm387104,299,897 - 104,315,495 (-)NCBI
MGSCv377111,448,411 - 111,464,009 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017312372   ⟹   XP_017167861
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397103,949,104 - 103,964,765 (-)NCBI
GRCm387104,299,893 - 104,315,558 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312373   ⟹   XP_017167862
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397103,949,104 - 103,964,741 (-)NCBI
GRCm387104,299,893 - 104,315,541 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312375   ⟹   XP_017167864
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397103,949,100 - 103,964,741 (-)NCBI
GRCm387104,299,893 - 104,315,541 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030243080   ⟹   XP_030098940
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397103,949,104 - 103,964,741 (-)NCBI
GRCm387104,299,893 - 104,315,541 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030243081   ⟹   XP_030098941
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397103,949,103 - 103,964,741 (-)NCBI
GRCm387104,299,893 - 104,315,541 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030243082   ⟹   XP_030098942
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397103,949,104 - 103,964,741 (-)NCBI
GRCm387104,299,893 - 104,315,541 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030243083   ⟹   XP_030098943
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397103,949,100 - 103,960,237 (-)NCBI
GRCm387104,299,893 - 104,314,355 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_076324   ⟸   NM_023835
- Peptide Label: isoform 2
- UniProtKB: Q99PQ1 (UniProtKB/Swiss-Prot),   A0A0R4J1B5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017167864   ⟸   XM_017312375
- Peptide Label: isoform X2
- UniProtKB: D3YVI1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017167861   ⟸   XM_017312372
- Peptide Label: isoform X1
- UniProtKB: Q99PQ1 (UniProtKB/Swiss-Prot),   A0A0R4J1B5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017167862   ⟸   XM_017312373
- Peptide Label: isoform X1
- UniProtKB: Q99PQ1 (UniProtKB/Swiss-Prot),   A0A0R4J1B5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030098941   ⟸   XM_030243081
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030098940   ⟸   XM_030243080
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030098942   ⟸   XM_030243082
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030098943   ⟸   XM_030243083
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001355682   ⟸   NM_001368753
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001355683   ⟸   NM_001368754
- Peptide Label: isoform 3
RefSeq Acc Id: ENSMUSP00000065008   ⟸   ENSMUST00000070943
RefSeq Acc Id: ENSMUSP00000102450   ⟸   ENSMUST00000106837
RefSeq Acc Id: ENSMUSP00000102452   ⟸   ENSMUST00000106839
Protein Domains
B box-type   RING-type

Promoters
RGD ID:8665077
Promoter ID:EPDNEW_M10570
Type:initiation region
Name:Trim12a_1
Description:Mus musculus tripartite motif-containing 12A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387104,315,435 - 104,315,495EPDNEW
RGD ID:6842250
Promoter ID:MM_KWN:52003
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:ENSMUST00000106837,   NM_023835,   OTTMUST00000045972,   OTTMUST00000045973,   UC009IVX.1,   UC009IVY.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367111,463,791 - 111,464,291 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1923931 AgrOrtholog
Ensembl Genes ENSMUSG00000066258 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000065008 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000102450 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000102452 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000070943 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000106837 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000106839 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro TRIM5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_B-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:76681 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1923931 ENTREZGENE
NCBI Gene 76681 ENTREZGENE
PANTHER PTHR24103:SF416 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-B_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trim12a PhenoGen
PROSITE ZF_BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J1B5 ENTREZGENE, UniProtKB/TrEMBL
  D3YVI1 ENTREZGENE, UniProtKB/TrEMBL
  Q504P5_MOUSE UniProtKB/TrEMBL
  Q99PQ1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9D704 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Trim12a  tripartite motif-containing 12A  Trim12  tripartite motif-containing 12  Symbol and/or name change 5135510 APPROVED