Cdc73 (cell division cycle 73, Paf1/RNA polymerase II complex component) - Rat Genome Database

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Gene: Cdc73 (cell division cycle 73, Paf1/RNA polymerase II complex component) Mus musculus
Analyze
Symbol: Cdc73
Name: cell division cycle 73, Paf1/RNA polymerase II complex component
RGD ID: 1614198
MGI Page MGI
Description: Predicted to enable RNA polymerase II complex binding activity. Involved in several processes, including cellular response to lipopolysaccharide; endodermal cell fate commitment; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of apoptotic process; regulation of cell growth; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cdc73/Paf1 complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Used to study hyperparathyroidism. Human ortholog(s) of this gene implicated in hyperparathyroidism and parathyroid carcinoma. Orthologous to human CDC73 (cell division cycle 73).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 8430414L16Rik; BC027756; C130030P16Rik; C81219; cell division cycle 73, Paf1/RNA polymerase II complex component, homolog; cell division cycle protein 73 homolog; Hrp; Hrpt2; hyperparathyroidism 2 homolog; hyperparathyroidism 2 protein homolog; MGC29274; MGC36559; parafibromin; Vcell division cycle 73, Paf1/RNA polymerase II complex component, homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,479,014 - 143,578,631 (-)NCBIGRCm39mm39
GRCm39 Ensembl1143,474,538 - 143,578,631 (-)Ensembl
GRCm381143,603,276 - 143,702,893 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,598,800 - 143,702,893 (-)EnsemblGRCm38mm10GRCm38
MGSCv371145,454,629 - 145,549,814 (-)NCBIGRCm37mm9NCBIm37
MGSCv361145,369,717 - 145,464,902 (-)NCBImm8
Celera1146,186,403 - 146,281,769 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map162.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Cdc73/Paf1 complex  (IBA,ISO)
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal digestive system morphology  (IAGP)
abnormal gland physiology  (IAGP)
abnormal jaw morphology  (IAGP)
abnormal myometrium morphology  (IAGP)
abnormal nervous system development  (IAGP)
abnormal reflex  (IAGP)
absent inner cell mass proliferation  (IAGP)
absent trophectoderm cell proliferation  (IAGP)
ascites  (IAGP)
decreased abdominal adipose tissue amount  (IAGP)
decreased cell proliferation  (IAGP)
decreased embryo size  (IAGP)
decreased locomotor activity  (IAGP)
decreased pulmonary respiratory rate  (IAGP)
decreased skeletal muscle mass  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
embryonic lethality before implantation, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
endometrium hyperplasia  (IAGP)
failure of embryo implantation  (IAGP)
hepatic necrosis  (IAGP)
increased activity of parathyroid  (IAGP)
increased apoptosis  (IAGP)
increased circulating calcium level  (IAGP)
increased circulating parathyroid hormone level  (IAGP)
increased fibroblast apoptosis  (IAGP)
increased parathyroid adenoma incidence  (IAGP)
increased parathyroid gland tumor incidence  (IAGP)
increased uterus tumor incidence  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
renal necrosis  (IAGP)
small heart  (IAGP)
small kidney  (IAGP)
small liver  (IAGP)
small lung  (IAGP)
small salivary gland  (IAGP)
small seminal vesicle  (IAGP)
small spleen  (IAGP)
small stomach  (IAGP)
small testis  (IAGP)
uterus cyst  (IAGP)
weight loss  (IAGP)
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273  
PMID:15489334   PMID:15489855   PMID:15580289   PMID:15741177   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17296600   PMID:17911113   PMID:18212049   PMID:18799693   PMID:19345177  
PMID:21589869   PMID:21677750   PMID:21873635   PMID:22083510   PMID:22252316   PMID:23166327   PMID:23791194   PMID:23900238   PMID:27749823   PMID:27864380   PMID:28288139   PMID:28384511  
PMID:28671696   PMID:31031188   PMID:31138677  


Genomics

Comparative Map Data
Cdc73
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,479,014 - 143,578,631 (-)NCBIGRCm39mm39
GRCm39 Ensembl1143,474,538 - 143,578,631 (-)Ensembl
GRCm381143,603,276 - 143,702,893 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,598,800 - 143,702,893 (-)EnsemblGRCm38mm10GRCm38
MGSCv371145,454,629 - 145,549,814 (-)NCBIGRCm37mm9NCBIm37
MGSCv361145,369,717 - 145,464,902 (-)NCBImm8
Celera1146,186,403 - 146,281,769 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map162.52NCBI
CDC73
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381193,122,031 - 193,254,815 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1193,121,983 - 193,254,815 (+)EnsemblGRCh38hg38GRCh38
GRCh371193,091,161 - 193,223,945 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361191,357,784 - 191,487,679 (+)NCBINCBI36hg18NCBI36
Build 341189,822,817 - 189,952,713NCBI
Celera1166,200,694 - 166,333,560 (+)NCBI
Cytogenetic Map1q31.2NCBI
HuRef1164,326,911 - 164,459,852 (+)NCBIHuRef
CHM1_11194,512,977 - 194,645,669 (+)NCBICHM1_1
Cdc73
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21355,357,226 - 55,449,690 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1355,357,226 - 55,449,656 (-)Ensembl
Rnor_6.01360,403,771 - 60,496,511 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1360,403,771 - 60,496,511 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01365,392,579 - 65,485,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41357,441,674 - 57,534,385 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11357,455,753 - 57,548,465 (-)NCBI
Celera1355,444,707 - 55,537,113 (-)NCBICelera
Cytogenetic Map13q21NCBI
Cdc73
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540630,533,060 - 30,665,812 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540630,533,919 - 30,665,812 (+)NCBIChiLan1.0ChiLan1.0
CDC73
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11172,875,365 - 173,004,942 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,875,365 - 173,004,934 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01168,581,730 - 168,710,915 (+)NCBIMhudiblu_PPA_v0panPan3
CDC73
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1385,826,209 - 5,937,930 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl385,805,916 - 5,938,111 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha385,923,156 - 6,034,975 (-)NCBI
ROS_Cfam_1.0385,842,156 - 5,954,484 (-)NCBI
ROS_Cfam_1.0 Ensembl385,841,856 - 5,954,492 (-)Ensembl
UMICH_Zoey_3.1385,841,710 - 5,953,973 (-)NCBI
UNSW_CanFamBas_1.0386,206,980 - 6,319,388 (-)NCBI
UU_Cfam_GSD_1.0386,435,831 - 6,547,946 (-)NCBI
Cdc73
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934480,662,470 - 80,779,375 (-)NCBI
SpeTri2.0NW_0049366381,365,457 - 1,482,497 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC73
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl10575,074 - 667,434 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.110575,075 - 667,618 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2102,279,054 - 2,305,137 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDC73
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12536,167,482 - 36,302,918 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2536,170,134 - 36,302,812 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605537,127,006 - 37,251,142 (-)NCBIVero_WHO_p1.0
Cdc73
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624814298,015 - 460,314 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH142331  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381143,608,151 - 143,608,349UniSTSGRCm38
MGSCv371145,455,281 - 145,455,479UniSTSGRCm37
Celera1146,187,055 - 146,187,253UniSTS
Cytogenetic Map1FUniSTS
cM Map177.8UniSTS
RH142465  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381143,647,903 - 143,648,061UniSTSGRCm38
MGSCv371145,495,033 - 145,495,191UniSTSGRCm37
Celera1146,226,818 - 146,226,976UniSTS
Cytogenetic Map1FUniSTS
cM Map177.8UniSTS
HRPT2__6588  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381143,607,504 - 143,608,390UniSTSGRCm38
MGSCv371145,454,634 - 145,455,520UniSTSGRCm37
Celera1146,186,408 - 146,187,294UniSTS
Cytogenetic Map1FUniSTS
cM Map177.8UniSTS
RH127034  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381143,603,737 - 143,603,972UniSTSGRCm38
MGSCv371145,450,867 - 145,451,102UniSTSGRCm37
Celera1146,182,642 - 146,182,877UniSTS
Cytogenetic Map1FUniSTS
cM Map177.8UniSTS
Whitehead/MRC_RH11951.98UniSTS
B3galt2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381143,646,623 - 143,647,236UniSTSGRCm38
MGSCv371145,493,753 - 145,494,366UniSTSGRCm37
Celera1146,225,538 - 146,226,151UniSTS
Cytogenetic Map1FUniSTS
cM Map1 UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301710Bmd5_mbone mineral density 5 (mouse)Not determined1139602037173602216Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1301458Skts8_mskin tumor susceptibility 8 (mouse)Not determined1135794822169795012Mouse
1301467Pcir1_mperiosteal circumference 1 (mouse)Not determined1141233173175233272Mouse
1301191Stia1_mserum transfer induced arthritis 1 (mouse)Not determined1141233173175233272Mouse
1301523Ccrs1_mcorpus callosum hemisphere surface size 1 (mouse)Not determined1139602037173602216Mouse
1558720Bpq8_mblood pressure QTL 8 (mouse)Not determined1143284665177284803Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129130858163130993Mouse
1301979Melm1_mmelanoma modifier 1 (mouse)Not determined1109638262143638479Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118099720152099816Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1302193Cpfd1_mcerebellum pattern fissures (mouse)Not determined1139602037173602216Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1357434Obsty1_mobesity 1 (mouse)Not determined1136209950170210094Mouse
1301894Skull2_mskull morphology 2 (mouse)Not determined1139602037173602216Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110553179144553298Mouse
1357602Vtbt2_mvertebral trabecular bone trait 2 (mouse)Not determined1139602037173602216Mouse
4141233Femwf12_mfemur work to failure 12 (mouse)Not determined141233173175233272Mouse
1302128Ity3_mimmunity to S. typhimurium 3 (mouse)Not determined11131156308165139464Mouse
1300696Bpq2_mblood pressure QTL 2 (mouse)Not determined1139602037173602216Mouse
1300740Tne1_mtotal number errors (mouse)Not determined1139602037173602216Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1301408Lore8_mloss of righting induced by ethanol 8 (mouse)Not determined1135877901169878015Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112131005146131085Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
1301151Hdlq14_mHDL QTL 14 (mouse)Not determined1142489543176489734Mouse
4141160Cq1_mcholesterol QTL 1 (mouse)Not determined1139452188173452308Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110553179144553298Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116290836150290937Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
4142014Wbcq5_mwhite blood cell quantitative locus 5 (mouse)Not determined1141095010175095156Mouse
27226740Metcl13_mmetatarsal-calcaneal length 13, 16 week (mouse)1121727729153775746Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
12880408V125Dq3_mvitamin D active form serum level QTL 3 (mouse)1122927738156927738Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
27226743Metcl7_mmetatarsal-calcaneal length 7, 10 week (mouse)1121727729153875746Mouse
11533913Rd6m1_mretinal degeneration 6 modifier 1 (mouse)1141233173175233272Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
14746980Manh50_mmandible shape 50 (mouse)1134131564168131564Mouse
13504831Bacszq1_mbaculum size QTL 1 (mouse)1134331161148128608Mouse
11049576Lmr8a_mleishmaniasis resistance 8a (mouse)1139602037173602216Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
12790994Aaaq1_maortic arch angle QTL 1 (mouse)1109495943143495943Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194127725148775742Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir155mmu-miR-155-5pOncomiRDBexternal_infoNANA23166327

Predicted Target Of
Summary Value
Count of predictions:2747
Count of miRNA genes:860
Interacting mature miRNAs:1162
Transcripts:ENSMUST00000018337, ENSMUST00000105081, ENSMUST00000159794, ENSMUST00000162638
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_145991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006529365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006529366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC175246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK029710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL592403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL592433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB645172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000018337   ⟹   ENSMUSP00000018337
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1143,474,538 - 143,578,631 (-)Ensembl
GRCm38.p6 Ensembl1143,598,800 - 143,702,893 (-)Ensembl
RefSeq Acc Id: ENSMUST00000159794   ⟹   ENSMUSP00000139872
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1143,567,053 - 143,577,938 (-)Ensembl
GRCm38.p6 Ensembl1143,691,315 - 143,702,200 (-)Ensembl
RefSeq Acc Id: ENSMUST00000162638
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1143,481,899 - 143,516,319 (-)Ensembl
GRCm38.p6 Ensembl1143,606,161 - 143,640,581 (-)Ensembl
RefSeq Acc Id: ENSMUST00000188838
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1143,509,589 - 143,512,315 (-)Ensembl
GRCm38.p6 Ensembl1143,633,851 - 143,636,577 (-)Ensembl
RefSeq Acc Id: ENSMUST00000189597
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1143,515,208 - 143,518,263 (-)Ensembl
GRCm38.p6 Ensembl1143,639,470 - 143,642,525 (-)Ensembl
RefSeq Acc Id: ENSMUST00000212510
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1143,532,130 - 143,578,362 (-)Ensembl
GRCm38.p6 Ensembl1143,656,392 - 143,702,624 (-)Ensembl
RefSeq Acc Id: NM_145991   ⟹   NP_666103
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391143,479,014 - 143,578,631 (-)NCBI
GRCm381143,603,276 - 143,702,893 (-)NCBI
MGSCv371145,454,629 - 145,549,814 (-)RGD
Celera1146,186,403 - 146,281,769 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006529365   ⟹   XP_006529428
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391143,524,477 - 143,578,626 (-)NCBI
GRCm381143,648,739 - 143,702,888 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006529366   ⟹   XP_006529429
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391143,510,848 - 143,578,626 (-)NCBI
GRCm381143,636,851 - 143,702,888 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_666103   ⟸   NM_145991
- UniProtKB: Q8JZM7 (UniProtKB/Swiss-Prot),   Q3U5E6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006529429   ⟸   XM_006529366
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006529428   ⟸   XM_006529365
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000139872   ⟸   ENSMUST00000159794
RefSeq Acc Id: ENSMUSP00000018337   ⟸   ENSMUST00000018337

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8JZM7-F1-model_v2 AlphaFold Q8JZM7 1-531 view protein structure

Promoters
RGD ID:6875166
Promoter ID:EPDNEW_M1033
Type:initiation region
Name:Cdc73_1
Description:Mus musculus cell division cycle 73, Paf1/RNA polymerase II complexcomponent , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381143,702,812 - 143,702,872EPDNEW
RGD ID:6817494
Promoter ID:MM_KWN:2332
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000076604,   OTTMUST00000076703
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361145,487,631 - 145,488,131 (-)MPROMDB
RGD ID:6817493
Promoter ID:MM_KWN:2334
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B4
Transcripts:OTTMUST00000076702,   OTTMUST00000076704
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361145,549,421 - 145,550,222 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2384876 AgrOrtholog
Ensembl Genes ENSMUSG00000026361 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000018337 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000139872 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000018337 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000159794 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.11990 UniProtKB/Swiss-Prot
InterPro Cdc73/Parafibromin UniProtKB/Swiss-Prot
  CDC73_C UniProtKB/Swiss-Prot
  CDC73_C_sf UniProtKB/Swiss-Prot
  Cdc73_N UniProtKB/Swiss-Prot
KEGG Report mmu:214498 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2384876 ENTREZGENE
NCBI Gene 214498 ENTREZGENE
PANTHER PTHR12466 UniProtKB/Swiss-Prot
Pfam CDC73_C UniProtKB/Swiss-Prot
  CDC73_N UniProtKB/Swiss-Prot
PhenoGen Cdc73 PhenoGen
UniProt A0A087WPQ2_MOUSE UniProtKB/TrEMBL
  CDC73_MOUSE UniProtKB/Swiss-Prot
  Q3U5E6 ENTREZGENE, UniProtKB/TrEMBL
  Q8JZM7 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-10 Cdc73  cell division cycle 73, Paf1/RNA polymerase II complex component  Cdc73  cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED