Defb14 (defensin beta 14) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Defb14 (defensin beta 14) Mus musculus
Analyze
Symbol: Defb14
Name: defensin beta 14
RGD ID: 1614133
MGI Page MGI
Description: Enables chemoattractant activity. Acts upstream of or within cell chemotaxis and defense response to bacterium. Predicted to be active in extracellular space. Is expressed in skin. Orthologous to human DEFB103A (defensin beta 103A) and DEFB103B (defensin beta 103B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BD-14; beta-defensin 14; defensin, beta 14; mBD-14; mBD14
RGD Orthologs
Human
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39819,213,172 - 19,245,342 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl819,244,373 - 19,245,228 (+)EnsemblGRCm39 Ensembl
GRCm38819,160,244 - 19,195,309 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl819,194,357 - 19,195,212 (+)EnsemblGRCm38mm10GRCm38
MGSCv37819,194,328 - 19,195,309 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36819,194,334 - 19,195,189 (+)NCBIMGSCv36mm8
Celera819,317,849 - 19,318,830 (+)NCBICelera
Cytogenetic Map8A1.3NCBI
cM Map810.35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Vertebrate Trait

References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:18167348   PMID:18180295   PMID:20003482   PMID:20483750   PMID:21115716   PMID:21677750   PMID:21873635   PMID:22174455   PMID:22504651   PMID:24489798   PMID:28647345  
PMID:29253819   PMID:29723492   PMID:30973865   PMID:33412104   PMID:38355793  


Genomics

Comparative Map Data
Defb14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39819,213,172 - 19,245,342 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl819,244,373 - 19,245,228 (+)EnsemblGRCm39 Ensembl
GRCm38819,160,244 - 19,195,309 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl819,194,357 - 19,195,212 (+)EnsemblGRCm38mm10GRCm38
MGSCv37819,194,328 - 19,195,309 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36819,194,334 - 19,195,189 (+)NCBIMGSCv36mm8
Celera819,317,849 - 19,318,830 (+)NCBICelera
Cytogenetic Map8A1.3NCBI
cM Map810.35NCBI
DEFB103A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3887,881,392 - 7,882,663 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl87,881,392 - 7,882,663 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl87,428,888 - 7,430,348 (-)EnsemblGRCh38hg38GRCh38
GRCh3787,738,914 - 7,740,185 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3687,776,136 - 7,777,596 (+)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map8p23.1NCBI
HuRef86,934,690 - 6,936,069 (-)NCBIHuRef
CHM1_187,804,318 - 7,805,713 (+)NCBICHM1_1
T2T-CHM13v2.0812,027,390 - 12,028,661 (+)NCBIT2T-CHM13v2.0
Defb14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81677,365,892 - 77,369,668 (-)NCBIGRCr8
mRatBN7.21670,663,443 - 70,668,473 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,663,333 - 70,666,540 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1675,940,391 - 75,941,249 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01679,403,557 - 79,404,415 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,652,995 - 74,653,853 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,647,523 - 75,650,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,647,680 - 75,648,538 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01675,247,809 - 75,250,820 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41675,455,087 - 75,455,945 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1668,531,179 - 68,532,037 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
CBD103
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11658,965,216 - 58,966,773 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1658,965,216 - 58,967,712 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1654,487,571 - 54,489,128 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01657,081,626 - 57,083,181 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1657,070,481 - 57,083,181 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11659,123,440 - 59,124,995 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01655,093,003 - 55,094,561 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01655,467,668 - 55,469,226 (+)NCBIUU_Cfam_GSD_1.0
LOC404703
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1537,957,488 - 38,066,223 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11537,960,248 - 38,065,632 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Defb14
2682 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:101
Interacting mature miRNAs:105
Transcripts:ENSMUST00000052601
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8721249923753815Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1708262628849467Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse

Markers in Region
UniSTS:492990  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38819,194,357 - 19,195,212UniSTSGRCm38
MGSCv37819,194,357 - 19,195,212UniSTSGRCm37
Celera819,317,878 - 19,318,733UniSTS
Cytogenetic Map8A1.3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000052601   ⟹   ENSMUSP00000062781
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl819,244,373 - 19,245,228 (+)Ensembl
GRCm38.p6 Ensembl819,194,357 - 19,195,212 (+)Ensembl
RefSeq Acc Id: NM_183026   ⟹   NP_898847
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39819,244,344 - 19,245,342 (+)NCBI
GRCm38819,194,328 - 19,195,309 (+)NCBI
MGSCv37819,194,328 - 19,195,309 (+)RGD
Celera819,317,849 - 19,318,830 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006508792   ⟹   XP_006508855
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39819,213,172 - 19,245,325 (+)NCBI
GRCm38819,160,244 - 19,195,309 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006508794   ⟹   XP_006508857
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39819,237,353 - 19,245,325 (+)NCBI
GRCm38819,187,337 - 19,195,309 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006508795   ⟹   XP_006508858
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39819,237,353 - 19,245,325 (+)NCBI
GRCm38819,187,337 - 19,195,309 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006508797   ⟹   XP_006508860
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39819,237,353 - 19,245,325 (+)NCBI
GRCm38819,187,337 - 19,195,309 (+)NCBI
Sequence:
RefSeq Acc Id: NP_898847   ⟸   NM_183026
- Peptide Label: precursor
- UniProtKB: Q14BD1 (UniProtKB/Swiss-Prot),   Q7TNV9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006508855   ⟸   XM_006508792
- Peptide Label: isoform X1
- UniProtKB: Q14BD1 (UniProtKB/Swiss-Prot),   Q7TNV9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006508860   ⟸   XM_006508797
- Peptide Label: isoform X1
- UniProtKB: Q14BD1 (UniProtKB/Swiss-Prot),   Q7TNV9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006508858   ⟸   XM_006508795
- Peptide Label: isoform X1
- UniProtKB: Q14BD1 (UniProtKB/Swiss-Prot),   Q7TNV9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006508857   ⟸   XM_006508794
- Peptide Label: isoform X1
- UniProtKB: Q14BD1 (UniProtKB/Swiss-Prot),   Q7TNV9 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000062781   ⟸   ENSMUST00000052601

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TNV9-F1-model_v2 AlphaFold Q7TNV9 1-67 view protein structure

Promoters
RGD ID:8666575
Promoter ID:EPDNEW_M11319
Type:single initiation site
Name:Defb14_1
Description:Mus musculus defensin beta 14 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38819,194,328 - 19,194,388EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2675345 AgrOrtholog
Ensembl Genes ENSMUSG00000046354 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000052601 ENTREZGENE
  ENSMUST00000052601.4 UniProtKB/Swiss-Prot
Gene3D-CATH Antimicrobial Peptide, Beta-defensin 2, Chain A UniProtKB/Swiss-Prot
InterPro Defensin_beta-typ UniProtKB/Swiss-Prot
KEGG Report mmu:244332 UniProtKB/Swiss-Prot
MGD MGI:2675345 ENTREZGENE
NCBI Gene 244332 ENTREZGENE
PANTHER BETA-DEFENSIN UniProtKB/Swiss-Prot
  BETA-DEFENSIN 103 UniProtKB/Swiss-Prot
Pfam Defensin_beta UniProtKB/Swiss-Prot
PhenoGen Defb14 PhenoGen
Superfamily-SCOP Defensin-like UniProtKB/Swiss-Prot
UniProt DFB14_MOUSE UniProtKB/Swiss-Prot
  Q14BD1 ENTREZGENE
  Q14BD2_MOUSE UniProtKB/TrEMBL
  Q7TNV9 ENTREZGENE
UniProt Secondary Q14BD1 UniProtKB/Swiss-Prot