Mageb6b1 (MAGE family member B6B1)

Gene: Mageb6b1 (MAGE family member B6B1) Mus musculus

Analyze

Symbol:

Mageb6b1

Name:

MAGE family member B6B1

RGD ID:

1614081

MGI Page

MGI

Description:

Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including MAGEB6B (MAGE family member B6B).

Type:

protein-coding

RefSeq Status:

INFERRED

Previously known as:

EG278167; Gm5072; hypothetical protein LOC278167; melanoma antigen, family B-like; uncharacterized protein LOC278167

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MAGEB6B (MAGE family member B6B)	HGNC	Ensembl, Panther
Rattus norvegicus (Norway rat):	Mageb4 (MAGE family member B4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MAGEB6B (MAGE family member B6B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC119868268 (melanoma-associated antigen B4-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	MAGEB6 (MAGE family member B6)	HGNC	Ensembl, Panther, Treefam
Homo sapiens (human):	MAGEB17 (MAGE family member B17)	HGNC	HomoloGene, OrthoDB
Chinchilla lanigera (long-tailed chinchilla):	Mageb17 (MAGE family member B17)	ENTREZGENE	gene_group.gz
Alliance orthologs ³
Homo sapiens (human):	MAGEB6 (MAGE family member B6)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Homo sapiens (human):	MAGEB6B (MAGE family member B6B)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Rattus norvegicus (Norway rat):	Mageb6b1 (MAGE family member B6B1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MAGEB17 (MAGE family member B17)	Alliance	DIOPT (HGNC)
Danio rerio (zebrafish):	ndnl2 (necdin-like 2)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	MAGE	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	NSE3	Alliance	DIOPT (Hieranoid\|PANTHER)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	90,436,106 - 90,437,140 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	90,436,106 - 90,437,140 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	91,392,500 - 91,393,534 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	91,392,500 - 91,393,534 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	88,637,839 - 88,638,873 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	87,645,219 - 87,646,253 (+)	NCBI		MGSCv36	mm8
Cytogenetic Map	X	C2	NCBI
cM Map	X	40.37	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

resveratrol (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of transcription by RNA polymerase II (IBA)

Cellular Component

nucleus (IBA)

Molecular Function

molecular_function (ND)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:21873635

Genomics

Comparative Map Data

Mageb6b1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	90,436,106 - 90,437,140 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	90,436,106 - 90,437,140 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	91,392,500 - 91,393,534 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	91,392,500 - 91,393,534 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	88,637,839 - 88,638,873 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	87,645,219 - 87,646,253 (+)	NCBI		MGSCv36	mm8
Cytogenetic Map	X	C2	NCBI
cM Map	X	40.37	NCBI

MAGEB6B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	26,160,601 - 26,162,410 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	26,160,601 - 26,162,410 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	26,178,718 - 26,180,527 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	26,088,639 - 26,089,862 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	X	30,306,156 - 30,307,965 (+)	NCBI		Celera
Cytogenetic Map	X	p21.3	NCBI
HuRef	X	23,917,642 - 23,919,438 (+)	NCBI		HuRef
CHM1_1	X	26,210,301 - 26,212,188 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	25,747,914 - 25,749,723 (+)	NCBI		T2T-CHM13v2.0

Mageb4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	60,708,194 - 60,781,862 (-)	NCBI		GRCr8
mRatBN7.2	X	56,732,666 - 56,805,927 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	56,733,000 - 56,805,937 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	58,092,789 - 58,189,749 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	61,593,147 - 61,692,045 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	59,211,269 - 59,285,567 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	61,103,031 - 61,151,601 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	61,103,011 - 61,151,601 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	61,686,435 - 61,734,447 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	79,295,352 - 79,364,435 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	57,220,008 - 57,233,511 (-)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

MAGEB6B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	27,962,650 - 27,965,590 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	27,966,031 - 27,968,971 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	18,762,234 - 18,763,457 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	26,125,511 - 26,126,734 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	26,125,511 - 26,126,734 (+)	Ensembl	panpan1.1		panPan2

LOC119868268
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ROS_Cfam_1.0	X	21,598,715 - 21,600,077 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	X	21,630,094 - 21,631,564 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	21,669,882 - 21,671,417 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	21,723,228 - 21,724,577 (+)	NCBI		UU_Cfam_GSD_1.0

Variants

Variants in Mageb6b1
24 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	79
Count of miRNA genes:	77
Interacting mature miRNAs:	78
Transcripts:	ENSMUST00000063726
Prediction methods:	Miranda, Pita, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
13464140	Hdlq108_m	HDL QTL 108 (mouse)					X	57771960	91771960	Mouse
1302054	Gct4_m	granulosa cell tumorigenesis 4 (mouse)			Not determined		X	76124336	102062720	Mouse
4141803	Lmr30_m	leishmaniasis resistance 30 (mouse)			Not determined			85062606	119062720	Mouse
4141630	Gct6_m	granulosa cell tumorigenesis 6 (mouse)			Not determined			47179121	129764756	Mouse
25314318	Sccor2_m	synaptonemal complex length to mean MLH1 count ratio 2 (mouse)					X	70543606	96543606	Mouse
4141665	Mhysq2_m	male hybrid sterility QTL 2 (mouse)			Not determined			71453852	139203212	Mouse
1357433	Dbts2_m	diabetes 2 (mouse)			Not determined		X	7226295	150107038	Mouse
13824980	Ferq1_m	genetic fertility QTL 1 (mouse)					X	54045360	148782996	Mouse
12879918	Shm4_m	sperm head morphology 4 (mouse)					X	72072050	102062720	Mouse
11075102	Modc2_m	modifier of Odc2 (mouse)					X	80189914	114190059	Mouse
1357500	Mdmsc6_m	modifier of muscularity 6 (mouse)			Not determined		X	75306671	109306758	Mouse

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001114678	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AL731781	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000063726 ⟹ ENSMUSP00000064613

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	X	90,436,106 - 90,437,140 (+)	Ensembl
GRCm38.p6 Ensembl	X	91,392,500 - 91,393,534 (+)	Ensembl

RefSeq Acc Id:

NM_001114678 ⟹ NP_001108150

RefSeq Status:

INFERRED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	X	90,436,106 - 90,437,140 (+)	NCBI
GRCm38	X	91,392,500 - 91,393,534 (+)	ENTREZGENE
MGSCv37	X	88,637,839 - 88,638,873 (+)	RGD
cM Map	X		ENTREZGENE

Sequence:

show sequence

ATGCCTAGAGGCAACAAGAGCAAGAGCCGATCCAGGGCCAAAAGGCAGCAGATGCGGGGAGAGA
AGCCTAAACTCCAGGGTGCTCAGCCCACTGGGAAGGAGGAGGGGAAAGCAGCATCTCCTGCTCT
TGACCAGGGAGATGGCCCCAGCTCCTCTGATAGAGGCACTGCTCAGGAGTCCCAGGAGGCTGCA
TCCCATATCTCTCCTGAGTTAAATGTGTCTCATCCAGTCCATGATGTTGGTGCTGAGGGTTCCT
TTGCAGGTGTGGATGAGAGACGTGCAAATGTCTCCATTATAGCAGATGCCATCCAATGTGCACG
CAGAGATCCTCTGACCAGGAAGGCCAGCAAGGTACTTCACTATCTGCTGGAGAAGTACCAAAAG
GATGAGCAACCTGTAGAGGGAGAGATGCTGAAGCTGATAGGCAGGAAGTACAAGGTTCACTTCC
CCCAGATCCTGGAGAAAGCCACCTATCAGCTAGAGCTCGTCTATGGTCTGGAGTTGAAGGTAGA
CAACCCTGCCACTCACTCCTATGTCCTTGTTAGCAAGCTACCCATCCTCCCTGGGGCAGATGTG
GGTGGCAGGAGAGAATTGCCTAAGACAGGTCTCATCCTGACCATCCTGGGTATGATCTTCATGA
AGGGCAACCGTGCCACTGAGGAAGAGGTCTGGCAGTTTCTCCACATGCAGGGGATATATCCTGG
GAGGAGGCACTTAATTTTTGGGGAGCCCCGGAATTTCATCACCAAAGTGTTAGTTGAGCAAAAT
TATGTGGAGTACCGCCAGGTTCCTGGAAGTGATCCCCCAACTCATGAGTTCCTATGGGGTCCCA
GAGCCCATGAGGAATCTACTTACAGGAAAGTTATGGATATTTTAGCTAAAATCAAGAGTGCCAT
TCCTAGTTACTATCCTCAACAGTATGAGGAGACTCTCAGTAACCAGGCTGAGAGAGCAGCAAGG
AGAGATGAGGCTGGGGGTTTTCATGCTGCCAGGATTCCCTCACATGCCCAAGCTAGCAGCTCCT
CCCACATTTAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001108150	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000064613
	ENSMUSP00000064613.5
	ENSMUSP00000098944.3

RefSeq Acc Id:

NP_001108150 ⟸ NM_001114678

- UniProtKB:

A2AHM1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPRGNKSKSRSRAKRQQMRGEKPKLQGAQPTGKEEGKAASPALDQGDGPSSSDRGTAQESQEAA
SHISPELNVSHPVHDVGAEGSFAGVDERRANVSIIADAIQCARRDPLTRKASKVLHYLLEKYQK
DEQPVEGEMLKLIGRKYKVHFPQILEKATYQLELVYGLELKVDNPATHSYVLVSKLPILPGADV
GGRRELPKTGLILTILGMIFMKGNRATEEEVWQFLHMQGIYPGRRHLIFGEPRNFITKVLVEQN
YVEYRQVPGSDPPTHEFLWGPRAHEESTYRKVMDILAKIKSAIPSYYPQQYEETLSNQAERAAR
RDEAGGFHAARIPSHAQASSSSHI

hide sequence

RefSeq Acc Id:

ENSMUSP00000064613 ⟸ ENSMUST00000063726

Protein Domains

MAGE

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A2AHM1-F1-model_v2	AlphaFold	A2AHM1	1-344	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:3643982	AgrOrtholog
Ensembl Genes	ENSMUSG00000094861	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSMUSG00000096072	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000063726	ENTREZGENE
	ENSMUST00000063726.5	UniProtKB/TrEMBL
	ENSMUST00000101396.3	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.1200	UniProtKB/TrEMBL
	1.10.10.1210	UniProtKB/TrEMBL
InterPro	MAGE	UniProtKB/TrEMBL
	MAGE	UniProtKB/TrEMBL
	MAGE_WH1	UniProtKB/TrEMBL
	MAGE_WH2	UniProtKB/TrEMBL
	Melanoma_ass_antigen_N	UniProtKB/TrEMBL
KEGG Report	mmu:278167	UniProtKB/TrEMBL
MGD	MGI:3643982	ENTREZGENE
NCBI Gene	278167	ENTREZGENE
PANTHER	MAGE FAMILY MEMBER B6B	UniProtKB/TrEMBL
	PTHR11736	UniProtKB/TrEMBL
Pfam	MAGE	UniProtKB/TrEMBL
	MAGE_N	UniProtKB/TrEMBL
PhenoGen	Mageb6b1	PhenoGen
PROSITE	MAGE	UniProtKB/TrEMBL
SMART	MAGE	UniProtKB/TrEMBL
	MAGE_N	UniProtKB/TrEMBL
UniProt	A2AHM1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-08-17	Mageb6b1	MAGE family member B6B1	Gm5072	predicted gene 5072	Symbol and/or name updated	27372883	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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