Uprt (uracil phosphoribosyltransferase) - Rat Genome Database
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Gene: Uprt (uracil phosphoribosyltransferase) Mus musculus
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Symbol: Uprt
Name: uracil phosphoribosyltransferase
RGD ID: 1614040
MGI Page MGI
Description: Predicted to have kinase activity. Predicted to be involved in UMP biosynthetic process. Predicted to localize to cytosol and nucleoplasm. Orthologous to human UPRT (uracil phosphoribosyltransferase homolog); PARTICIPATES IN pyrimidine metabolic pathway; INTERACTS WITH (+)-schisandrin B (ortholog); (-)-epigallocatechin 3-gallate (ortholog); 17alpha-ethynylestradiol (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D830012I24; D830012I24Rik; Gm774; hypothetical protein LOC320070; RIKEN cDNA D830012I24 gene; uncharacterized protein LOC320070; uracil phosphoribosyltransferase (FUR1) homolog; uracil phosphoribosyltransferase homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X103,526,409 - 103,555,829 (+)NCBIGRCm39mm39
GRCm38X104,482,803 - 104,512,223 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX104,482,818 - 104,507,490 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X101,678,121 - 101,701,601 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X100,685,501 - 100,708,981 (+)NCBImm8
CeleraX91,375,831 - 91,399,185 (+)NCBICelera
Cytogenetic MapXDNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:19433338   PMID:21873635   PMID:27133168  
PMID:27461566  


Genomics

Comparative Map Data
Uprt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X103,526,409 - 103,555,829 (+)NCBIGRCm39mm39
GRCm38X104,482,803 - 104,512,223 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX104,482,818 - 104,507,490 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X101,678,121 - 101,701,601 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X100,685,501 - 100,708,981 (+)NCBImm8
CeleraX91,375,831 - 91,399,185 (+)NCBICelera
Cytogenetic MapXDNCBI
UPRT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX75,156,388 - 75,304,885 (+)EnsemblGRCh38hg38GRCh38
GRCh38X75,156,369 - 75,304,897 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X74,376,204 - 74,524,732 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37X74,493,894 - 74,524,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X74,410,686 - 74,441,159 (+)NCBINCBI36hg18NCBI36
CeleraX74,777,320 - 74,808,158 (+)NCBI
Cytogenetic MapXq13.3NCBI
HuRefX68,128,874 - 68,159,480 (+)NCBIHuRef
CHM1_1X74,386,787 - 74,417,624 (+)NCBICHM1_1
Uprt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X69,516,573 - 69,546,811 (+)NCBI
Rnor_6.0 EnsemblX75,382,598 - 75,407,217 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X75,382,553 - 75,408,541 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X76,184,934 - 76,210,907 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X92,511,044 - 92,535,135 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX70,870,490 - 70,896,599 (+)NCBICelera
Cytogenetic MapXq22NCBI
Uprt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555621,385,611 - 1,415,336 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555621,385,617 - 1,415,277 (+)NCBIChiLan1.0ChiLan1.0
UPRT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X74,639,179 - 74,675,221 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX74,639,179 - 74,675,221 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X64,524,889 - 64,561,439 (+)NCBIMhudiblu_PPA_v0panPan3
UPRT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX58,543,425 - 58,575,926 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X58,570,623 - 58,576,980 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Uprt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366831,432,004 - 1,454,004 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UPRT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX60,426,975 - 60,451,480 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X60,426,955 - 60,448,174 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X68,687,968 - 68,709,136 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UPRT
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X64,815,163 - 64,846,198 (+)NCBI
ChlSab1.1 EnsemblX64,815,183 - 64,849,547 (+)Ensembl
Uprt
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248365,473,129 - 5,502,276 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7360056151324042Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined48090244130864007Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X55000000150000000Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined72410246140302463Mouse
1357500Mdmsc6_mmodifier of muscularity 6 (mouse)Not determinedX76263065110263152Mouse
11075102Modc2_mmodifier of Odc2 (mouse)X81146308115146453Mouse
4141803Lmr30_mleishmaniasis resistance 30 (mouse)Not determined86019000120019114Mouse
13208552Wght12_mweight 12 (mouse)X95000000151000000Mouse
13208556Lgth14_mbody length 14 (mouse)X95000000151000000Mouse
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX103012242163975945Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:613
Count of miRNA genes:414
Interacting mature miRNAs:477
Transcripts:ENSMUST00000087867
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000087867   ⟹   ENSMUSP00000085175
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 EnsemblX104,482,818 - 104,507,490 (+)Ensembl
RefSeq Acc Id: NM_001081189   ⟹   NP_001074658
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X103,526,409 - 103,555,829 (+)NCBI
GRCm38X104,482,803 - 104,512,223 (+)NCBI
MGSCv37X101,678,121 - 101,701,601 (+)RGD
CeleraX91,375,831 - 91,399,185 (+)RGD
cM MapX ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001074658 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI47846 (Get FASTA)   NCBI Sequence Viewer  
  AAI47854 (Get FASTA)   NCBI Sequence Viewer  
  B1AVZ0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001074658   ⟸   NM_001081189
- UniProtKB: B1AVZ0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000085175   ⟸   ENSMUST00000087867

Promoters
RGD ID:6846488
Promoter ID:MM_KWN:61467
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000043701
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X101,677,941 - 101,678,441 (+)MPROMDB
RGD ID:13681152
Promoter ID:EPDNEW_M24725
Type:initiation region
Name:Uprt_1
Description:Mus musculus uracil phosphoribosyltransferase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X104,482,803 - 104,482,863EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685620 AgrOrtholog
Ensembl Genes ENSMUSG00000073016 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000085175 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000087867 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.2020 UniProtKB/Swiss-Prot
InterPro PRibTrfase_dom UniProtKB/Swiss-Prot
  PRTase-like UniProtKB/Swiss-Prot
KEGG Report mmu:331487 UniProtKB/Swiss-Prot
MGD MGI:2685620 ENTREZGENE
NCBI Gene 331487 ENTREZGENE
PhenoGen Uprt PhenoGen
Superfamily-SCOP SSF53271 UniProtKB/Swiss-Prot
UniProt B1AVZ0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-01 Uprt  uracil phosphoribosyltransferase  D830012I24Rik  RIKEN cDNA D830012I24 gene  Data Merged 737654 PROVISIONAL
2016-03-14 Uprt  uracil phosphoribosyltransferase    uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED