Slc22a14 (solute carrier family 22 (organic cation transporter), member 14) - Rat Genome Database

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Gene: Slc22a14 (solute carrier family 22 (organic cation transporter), member 14) Mus musculus
Analyze
Symbol: Slc22a14
Name: solute carrier family 22 (organic cation transporter), member 14
RGD ID: 1614018
MGI Page MGI
Description: Enables riboflavin transmembrane transporter activity. Acts upstream of or within flagellated sperm motility and sperm capacitation. Located in sperm principal piece. Is active in mitochondrial inner membrane. Orthologous to human SLC22A14 (solute carrier family 22 member 14).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gm1128; MGC118292; organic cation transporter like 4; solute carrier family 22 member 14
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399118,998,521 - 119,019,496 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9118,998,523 - 119,019,473 (-)EnsemblGRCm39 Ensembl
GRCm389119,169,453 - 119,190,430 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,169,455 - 119,365,553 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,078,574 - 119,099,511 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,018,154 - 119,039,091 (-)NCBIMGSCv36mm8
Celera9119,637,344 - 119,658,281 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14681479   PMID:16141072   PMID:16141073   PMID:21677750   PMID:27811987   PMID:31666509  
PMID:33882315   PMID:34704967  


Genomics

Comparative Map Data
Slc22a14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399118,998,521 - 119,019,496 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9118,998,523 - 119,019,473 (-)EnsemblGRCm39 Ensembl
GRCm389119,169,453 - 119,190,430 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,169,455 - 119,365,553 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,078,574 - 119,099,511 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,018,154 - 119,039,091 (-)NCBIMGSCv36mm8
Celera9119,637,344 - 119,658,281 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
SLC22A14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,278,832 - 38,318,575 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl338,282,294 - 38,318,575 (+)EnsemblGRCh38hg38GRCh38
GRCh37338,323,785 - 38,360,066 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,322,449 - 38,334,863 (+)NCBINCBI36Build 36hg18NCBI36
Build 34338,322,430 - 38,335,069NCBI
Celera338,283,102 - 38,295,539 (+)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef338,389,428 - 38,401,865 (+)NCBIHuRef
CHM1_1338,299,121 - 38,311,552 (+)NCBICHM1_1
T2T-CHM13v2.0338,284,541 - 38,324,319 (+)NCBIT2T-CHM13v2.0
Slc22a14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,772,275 - 127,794,222 (-)NCBIGRCr8
mRatBN7.28118,894,537 - 118,916,416 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,895,259 - 118,908,255 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,496,296 - 124,517,815 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,695,253 - 122,716,782 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,528,109 - 120,549,961 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,858,425 - 127,871,192 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08127,065,929 - 127,078,390 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,132,131 - 124,145,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,153,605 - 124,167,928 (-)NCBI
Celera8118,069,008 - 118,081,349 (-)NCBICelera
Cytogenetic Map8q32NCBI
Slc22a14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554215,009,279 - 5,020,221 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554215,009,560 - 5,023,833 (-)NCBIChiLan1.0ChiLan1.0
LOC100994888
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2238,217,886 - 38,272,511 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1338,240,382 - 38,277,275 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0338,179,107 - 38,216,934 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1338,463,156 - 38,499,098 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,486,595 - 38,498,833 (+)Ensemblpanpan1.1panPan2
SLC22A14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1238,075,485 - 8,104,214 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,075,539 - 8,101,828 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha238,116,633 - 8,145,060 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0238,364,930 - 8,393,605 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,364,980 - 8,391,456 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1238,179,216 - 8,207,948 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0238,319,389 - 8,348,059 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0238,313,019 - 8,341,739 (+)NCBIUU_Cfam_GSD_1.0
Slc22a14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118194,347,314 - 194,387,615 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647327,486,083 - 27,500,165 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647327,487,459 - 27,501,226 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,149,231 - 23,159,598 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,148,924 - 23,162,263 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,363,455 - 25,399,166 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,097,989 - 1,111,253 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl151,098,235 - 1,110,868 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660639,829,218 - 9,842,987 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc22a14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477319,969,763 - 19,980,009 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477319,964,690 - 19,980,122 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc22a14
715 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:597
Count of miRNA genes:289
Interacting mature miRNAs:317
Transcripts:ENSMUST00000093775, ENSMUST00000127794, ENSMUST00000152061, ENSMUST00000170400
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse

Markers in Region
Slc22a14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F3UniSTS
cM Map971.33UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000093775   ⟹   ENSMUSP00000091289
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9118,998,523 - 119,019,473 (-)Ensembl
GRCm38.p6 Ensembl9119,169,455 - 119,190,407 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127794   ⟹   ENSMUSP00000120144
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9119,010,032 - 119,019,428 (-)Ensembl
GRCm38.p6 Ensembl9119,180,966 - 119,190,362 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152061   ⟹   ENSMUSP00000117967
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9118,998,736 - 119,002,718 (-)Ensembl
GRCm38.p6 Ensembl9119,169,668 - 119,173,652 (-)Ensembl
RefSeq Acc Id: ENSMUST00000170400   ⟹   ENSMUSP00000131982
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9118,998,524 - 119,194,619 (-)Ensembl
GRCm38.p6 Ensembl9119,169,456 - 119,365,553 (-)Ensembl
RefSeq Acc Id: NM_001037749   ⟹   NP_001032838
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399118,998,524 - 119,019,461 (-)NCBI
GRCm389119,169,456 - 119,190,395 (-)NCBI
MGSCv379119,078,574 - 119,099,511 (-)RGD
Celera9119,637,344 - 119,658,281 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001410636   ⟹   NP_001397565
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399118,998,523 - 119,019,461 (-)NCBI
RefSeq Acc Id: XM_011242981   ⟹   XP_011241283
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399118,998,521 - 119,019,496 (-)NCBI
GRCm389119,169,453 - 119,190,430 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242982   ⟹   XP_011241284
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399118,998,521 - 119,019,418 (-)NCBI
GRCm389119,169,453 - 119,190,352 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242983   ⟹   XP_011241285
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399118,998,521 - 119,019,418 (-)NCBI
GRCm389119,169,453 - 119,190,352 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001032838   ⟸   NM_001037749
- UniProtKB: Q497L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011241283   ⟸   XM_011242981
- Peptide Label: isoform X1
- UniProtKB: Q497L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011241285   ⟸   XM_011242983
- Peptide Label: isoform X1
- UniProtKB: Q497L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011241284   ⟸   XM_011242982
- Peptide Label: isoform X1
- UniProtKB: Q497L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000131982   ⟸   ENSMUST00000170400
RefSeq Acc Id: ENSMUSP00000120144   ⟸   ENSMUST00000127794
RefSeq Acc Id: ENSMUSP00000091289   ⟸   ENSMUST00000093775
RefSeq Acc Id: ENSMUSP00000117967   ⟸   ENSMUST00000152061
RefSeq Acc Id: NP_001397565   ⟸   NM_001410636
- UniProtKB: Q497L9 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q497L9-F1-model_v2 AlphaFold Q497L9 1-629 view protein structure

Promoters
RGD ID:6845158
Promoter ID:MM_KWN:59121
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000068011,   OTTMUST00000068012
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,100,021 - 119,100,521 (-)MPROMDB
RGD ID:8671180
Promoter ID:EPDNEW_M13621
Type:initiation region
Name:Slc22a14_1
Description:Mus musculus solute carrier family 22 , member 14 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389119,190,395 - 119,190,455EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685974 AgrOrtholog
Ensembl Genes ENSMUSG00000070280 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000093775 ENTREZGENE
  ENSMUST00000093775.12 UniProtKB/Swiss-Prot
  ENSMUST00000127794.2 UniProtKB/TrEMBL
  ENSMUST00000152061.2 UniProtKB/TrEMBL
  ENSMUST00000170400.9 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
InterPro MFS_dom UniProtKB/Swiss-Prot
  MFS_sugar_transport-like UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
KEGG Report mmu:382113 UniProtKB/Swiss-Prot
MGD MGI:2685974 ENTREZGENE
NCBI Gene 382113 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/Swiss-Prot
  SOLUTE CARRIER FAMILY 22 MEMBER 14 UniProtKB/Swiss-Prot
Pfam Sugar_tr UniProtKB/Swiss-Prot
PhenoGen Slc22a14 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt D3YUH1_MOUSE UniProtKB/TrEMBL
  F7AMC9_MOUSE UniProtKB/TrEMBL
  Q497L9 ENTREZGENE, UniProtKB/Swiss-Prot