Mplkipl1 (M-phase specific PLK1 intereacting protein like 1) - Rat Genome Database

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Gene: Mplkipl1 (M-phase specific PLK1 intereacting protein like 1) Mus musculus
Analyze
No known orthologs.
Symbol: Mplkipl1
Name: M-phase specific PLK1 intereacting protein like 1
RGD ID: 1613804
MGI Page MGI
Description: Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in centrosome; midbody; and nucleus. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 4. Orthologous to human MPLKIP (M-phase specific PLK1 interacting protein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EG633057; Gm7102; TTD non-photosensitive 1 protein homolog; TTD non-photosensitive 1-like protein
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391961,163,124 - 61,164,747 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1961,163,124 - 61,164,747 (-)EnsemblGRCm39 Ensembl
GRCm381961,174,686 - 61,176,309 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1961,174,686 - 61,176,309 (-)EnsemblGRCm38mm10GRCm38
MGSCv371961,250,589 - 61,252,212 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361961,229,349 - 61,230,972 (-)NCBIMGSCv36mm8
Celera1963,371,287 - 63,372,235 (-)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1956.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:16141072   PMID:16141073   PMID:21873635  


Genomics

Variants

.
Variants in Mplkipl1
35 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:155
Count of miRNA genes:143
Interacting mature miRNAs:149
Transcripts:ENSMUST00000180168
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193959606661420004Mouse
1300585Pgia12_mproteoglycan induced arthritis 12 (mouse)Not determined194258685961420004Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000180168   ⟹   ENSMUSP00000137574
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1961,163,124 - 61,164,747 (-)Ensembl
GRCm38.p6 Ensembl1961,174,686 - 61,176,309 (-)Ensembl
RefSeq Acc Id: NM_001177513   ⟹   NP_001170984
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391961,163,124 - 61,164,747 (-)NCBI
GRCm381961,174,686 - 61,176,309 (-)ENTREZGENE
MGSCv371961,250,589 - 61,252,212 (-)RGD
cM Map19 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001170984 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAE37244 (Get FASTA)   NCBI Sequence Viewer  
  EDL01854 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000137574
  ENSMUSP00000137574.2
Reference Protein Sequences
RefSeq Acc Id: NP_001170984   ⟸   NM_001177513
- UniProtKB: J3QQ10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000137574   ⟸   ENSMUST00000180168

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-J3QQ10-F1-model_v2 AlphaFold J3QQ10 1-178 view protein structure

Promoters
RGD ID:13679928
Promoter ID:EPDNEW_M24112
Type:single initiation site
Name:Gm7102_1
Description:Mus musculus predicted gene 7102 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381961,176,305 - 61,176,365EPDNEW
RGD ID:6830006
Promoter ID:MM_KWN:27495
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:AK163227_GM7102,   ENSMUST00000095911
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361961,251,731 - 61,252,231 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3648735 AgrOrtholog
Ensembl Genes ENSMUSG00000094649 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000180168 ENTREZGENE
  ENSMUST00000180168.2 UniProtKB/TrEMBL
InterPro MPLKIP UniProtKB/TrEMBL
  MPLKIP-like UniProtKB/TrEMBL
KEGG Report mmu:633057 UniProtKB/TrEMBL
MGD MGI:3648735 ENTREZGENE
NCBI Gene 633057 ENTREZGENE
PANTHER M-PHASE-SPECIFIC PLK1-INTERACTING PROTEIN UniProtKB/TrEMBL
  PTHR22446 UniProtKB/TrEMBL
Pfam MPLKIP UniProtKB/TrEMBL
PhenoGen Mplkipl1 PhenoGen
UniProt J3QQ10 ENTREZGENE, UniProtKB/TrEMBL
  Q3TQY8_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-15 Mplkipl1  M-phase specific PLK1 intereacting protein like 1  Gm7102  predicted gene 7102  Symbol and/or name updated 27372883 PROVISIONAL