Prrt2 (proline-rich transmembrane protein 2) - Rat Genome Database
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Gene: Prrt2 (proline-rich transmembrane protein 2) Mus musculus
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Symbol: Prrt2
Name: proline-rich transmembrane protein 2
RGD ID: 1613176
MGI Page MGI
Description: Exhibits syntaxin-1 binding activity. Involved in negative regulation of SNARE complex assembly; negative regulation of short-term synaptic potentiation; and synaptic vesicle exocytosis. Localizes to several cellular components, including glutamatergic synapse; integral component of presynaptic membrane; and synaptic vesicle. Is expressed in brain. Used to study episodic kinesigenic dyskinesia 1. Human ortholog(s) of this gene implicated in benign familial neonatal epilepsy and episodic kinesigenic dyskinesia 1. Orthologous to human PRRT2 (proline rich transmembrane protein 2); INTERACTS WITH 3,4-methylenedioxymethamphetamine; benzo[a]pyrene; ethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1500031I19Rik; AI195361; dispanin subfamily B member 3; DSPB3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,616,707 - 126,620,800 (-)NCBIGRCm39mm39
GRCm39 Ensembl7126,616,703 - 126,620,383 (-)Ensembl
GRCm387127,017,542 - 127,021,450 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,017,531 - 127,021,211 (-)EnsemblGRCm38mm10GRCm38
MGSCv377134,161,056 - 134,164,725 (-)NCBIGRCm37mm9NCBIm37
Celera7126,865,670 - 126,869,339 (-)NCBICelera
Cytogenetic Map7F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:18799693   PMID:21677750   PMID:21873635   PMID:22101681  
PMID:22363774   PMID:22832103   PMID:26797119   PMID:27052163   PMID:27172900   PMID:28007585   PMID:29056747   PMID:29111324   PMID:29554219   PMID:29912316   PMID:30884140   PMID:32325033  
PMID:32891704  


Genomics

Comparative Map Data
Prrt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,616,707 - 126,620,800 (-)NCBIGRCm39mm39
GRCm39 Ensembl7126,616,703 - 126,620,383 (-)Ensembl
GRCm387127,017,542 - 127,021,450 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,017,531 - 127,021,211 (-)EnsemblGRCm38mm10GRCm38
MGSCv377134,161,056 - 134,164,725 (-)NCBIGRCm37mm9NCBIm37
Celera7126,865,670 - 126,869,339 (-)NCBICelera
Cytogenetic Map7F3NCBI
PRRT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1629,811,382 - 29,815,892 (+)EnsemblGRCh38hg38GRCh38
GRCh381629,812,193 - 29,815,920 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371629,823,514 - 29,827,202 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361629,730,910 - 29,734,703 (+)NCBINCBI36hg18NCBI36
Celera1672,969,059 - 72,972,852 (-)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1627,484,047 - 27,487,840 (+)NCBIHuRef
CHM1_11631,039,218 - 31,043,011 (+)NCBICHM1_1
Prrt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21181,625,243 - 181,628,905 (-)NCBI
Rnor_6.0 Ensembl1198,451,324 - 198,454,914 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01198,451,042 - 198,454,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01205,431,478 - 205,435,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,196,585 - 186,199,258 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1179,279,909 - 179,283,499 (-)NCBICelera
Cytogenetic Map1q37NCBI
Prrt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554937,144,389 - 7,148,613 (-)NCBIChiLan1.0ChiLan1.0
PRRT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11630,182,381 - 30,186,015 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,183,352 - 30,187,862 (+)Ensemblpanpan1.1panPan2
PRRT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,872,670 - 17,877,502 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,873,521 - 17,903,184 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,449,454 - 19,454,305 (+)NCBI
ROS_Cfam_1.0618,006,274 - 18,011,127 (+)NCBI
UMICH_Zoey_3.1617,805,776 - 17,810,626 (+)NCBI
UNSW_CanFamBas_1.0617,721,471 - 17,726,322 (+)NCBI
UU_Cfam_GSD_1.0618,036,767 - 18,041,616 (+)NCBI
Prrt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,562,323 - 124,565,929 (-)NCBI
SpeTri2.0NW_00493650112,660,181 - 12,663,788 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRRT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1318,048,614 - 18,052,481 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2318,534,378 - 18,543,204 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRRT2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,838,280 - 26,841,918 (-)NCBI
ChlSab1.1 Ensembl526,839,454 - 26,841,916 (-)Ensembl
Prrt2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478213,390,347 - 13,393,775 (-)NCBI

Position Markers
RH135947  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387127,017,350 - 127,017,543UniSTSGRCm38
MGSCv377134,160,864 - 134,161,057UniSTSGRCm37
Celera7126,865,478 - 126,865,671UniSTS
Cytogenetic Map7F4UniSTS
Cytogenetic Map7F3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)757300000134400000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)779000000137300000Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)781200000127100000Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793792641127792834Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798565687132565775Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798795739132795739Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined7100238481134238481Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7101151499135151620Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7101394038135394119Mouse
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7102094158136094307Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7102094158136094307Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7102094158136094307Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102885996136886157Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105651440139651588Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105750785139750785Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7110108163144108163Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7110108163144108163Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7110108163144108163Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7111365511145365612Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7111365511145365612Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111564398145441459Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111564398145441459Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111564398145441459Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112950524145441459Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7113321003145441459Mouse
38501072Stsl7_mSalmonella typhimurium susceptibility locus 7 (mouse)7116100000128900000Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7117032360145441459Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117600000134500000Mouse
11059561Lmr21a_mleishmaniasis resistance 21a (mouse)7118151499128365612Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7119094158144844577Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119530844145441459Mouse
38501070Tip5_mtuberculosis immunophenotype 5, IFN-g level (mouse)7121000000130700000Mouse
1357613Bsbob2_mBSB obesity 2 (mouse)Not determined7122651440129217600Mouse
1301903Tlsm1_mthymic lymphoma susceptible 1 (mouse)Not determined7122651440135569172Mouse
38501066Tip2_mtuberculosis immunophenotype 2, spleen CFU (mouse)7124700000127300000Mouse
4141945Il4ppq_mIL-4 producing potential QTL (mouse)Not determined7124914439129217600Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1006
Count of miRNA genes:569
Interacting mature miRNAs:662
Transcripts:ENSMUST00000159916, ENSMUST00000160767, ENSMUST00000161728, ENSMUST00000161931
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000159916   ⟹   ENSMUSP00000124520
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7127,017,531 - 127,021,211 (-)Ensembl
RefSeq Acc Id: ENSMUST00000160767
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7127,017,543 - 127,020,974 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161931   ⟹   ENSMUSP00000143833
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7127,018,158 - 127,019,595 (-)Ensembl
RefSeq Acc Id: ENSMUST00000201686   ⟹   ENSMUSP00000144451
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7127,017,648 - 127,019,902 (-)Ensembl
RefSeq Acc Id: ENSMUST00000201963
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7127,018,507 - 127,020,956 (-)Ensembl
RefSeq Acc Id: ENSMUST00000202045   ⟹   ENSMUSP00000144042
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7127,018,704 - 127,021,137 (-)Ensembl
RefSeq Acc Id: ENSMUST00000202936
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7127,019,395 - 127,020,355 (-)Ensembl
RefSeq Acc Id: NM_001102563   ⟹   NP_001096033
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397126,616,714 - 126,620,383 (-)NCBI
GRCm387127,017,542 - 127,021,211 (-)NCBI
MGSCv377134,161,056 - 134,164,725 (-)RGD
Celera7126,865,670 - 126,869,339 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036153413   ⟹   XP_036009306
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397126,616,707 - 126,620,800 (-)NCBI
RefSeq Acc Id: XM_036153414   ⟹   XP_036009307
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397126,616,707 - 126,620,786 (-)NCBI
RefSeq Acc Id: XM_036153415   ⟹   XP_036009308
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397126,616,707 - 126,620,531 (-)NCBI
RefSeq Acc Id: XR_004934182
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397126,617,810 - 126,620,476 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001096033 (Get FASTA)   NCBI Sequence Viewer  
  XP_036009306 (Get FASTA)   NCBI Sequence Viewer  
  XP_036009307 (Get FASTA)   NCBI Sequence Viewer  
  XP_036009308 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein E9PUL5 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001096033   ⟸   NM_001102563
- UniProtKB: E9PUL5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000124520   ⟸   ENSMUST00000159916
RefSeq Acc Id: ENSMUSP00000144042   ⟸   ENSMUST00000202045
RefSeq Acc Id: ENSMUSP00000144451   ⟸   ENSMUST00000201686
RefSeq Acc Id: ENSMUSP00000143833   ⟸   ENSMUST00000161931
RefSeq Acc Id: XP_036009306   ⟸   XM_036153413
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036009307   ⟸   XM_036153414
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036009308   ⟸   XM_036153415
- Peptide Label: isoform X1

Promoters
RGD ID:8665625
Promoter ID:EPDNEW_M10844
Type:initiation region
Name:Prrt2_1
Description:Mus musculus proline-rich transmembrane protein 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387127,021,121 - 127,021,181EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916267 AgrOrtholog
Ensembl Genes ENSMUSG00000045114 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000124520 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000143833 UniProtKB/TrEMBL
  ENSMUSP00000144042 UniProtKB/TrEMBL
  ENSMUSP00000144451 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000159916 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000161931 UniProtKB/TrEMBL
  ENSMUST00000201686 UniProtKB/TrEMBL
  ENSMUST00000202045 UniProtKB/TrEMBL
InterPro CD225/Dispanin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:69017 UniProtKB/Swiss-Prot
MGD MGI:1916267 ENTREZGENE
NCBI Gene 69017 ENTREZGENE
Pfam CD225 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prrt2 PhenoGen
UniProt A0A0J9YTS8_MOUSE UniProtKB/TrEMBL
  A0A0J9YU72_MOUSE UniProtKB/TrEMBL
  A0A0J9YV24_MOUSE UniProtKB/TrEMBL
  E9PUL5 ENTREZGENE, UniProtKB/Swiss-Prot