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Gene: Map3k15 (mitogen-activated protein kinase kinase kinase 15) Mus musculus

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Symbol:

Map3k15

Name:

mitogen-activated protein kinase kinase kinase 15

RGD ID:

1612412

MGI Page

MGI

Description:

Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in JNK cascade and p38MAPK cascade. Is expressed in pancreas. Orthologous to human MAP3K15 (mitogen-activated protein kinase kinase kinase 15).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

BC031147; MAPK/ERK kinase kinase 15; MEK kinase 15; MEKK 15; MEKK15

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	158,771,200 - 158,906,342 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	158,771,429 - 158,906,347 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	159,988,204 - 160,123,346 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	159,988,433 - 160,123,351 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	156,426,365 - 156,561,283 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
Celera	X	143,246,363 - 143,367,779 (+)	NCBI		Celera
Cytogenetic Map	X	F4	NCBI
cM Map	X	73.95	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Coffin-Lowry syndrome (ISO)

developmental and epileptic encephalopathy 2 (ISO)

glycogen storage disease IXA (ISO)

Leigh Syndrome, X-Linked (ISO)

Nance-Horan syndrome (ISO)

Neurodevelopmental Disorders (ISO)

pyruvate decarboxylase deficiency (ISO)

Pyruvate Dehydrogenase E1 Alpha Deficiency (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

3-chloropropane-1,2-diol (ISO)

4,4'-sulfonyldiphenol (EXP)

6-propyl-2-thiouracil (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (ISO)

butanal (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

methapyrilene (ISO)

monosodium L-glutamate (EXP)

pregnenolone 16alpha-carbonitrile (EXP)

tetrachloromethane (ISO)

titanium dioxide (EXP)

triclosan (ISO)

triptonide (EXP)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

JNK cascade (IBA)

MAPK cascade (IEA)

p38MAPK cascade (IBA)

Molecular Function

ATP binding (IEA)

JUN kinase kinase kinase activity (IEA)

MAP kinase kinase kinase activity (IBA,ISO,ISS)

metal ion binding (IEA)

protein serine kinase activity (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal cell physiology (IAGP)

abnormal kidney physiology (IAGP)

hypertension (IAGP)

increased systemic arterial systolic blood pressure (IAGP)

salt-sensitive hypertension (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:18855897	PMID:21267068	PMID:21677750	PMID:21873635	PMID:23250415	PMID:24336151	PMID:27708103	PMID:29555767	PMID:32325033	PMID:33431691

Genomics

Comparative Map Data

Map3k15
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	158,771,200 - 158,906,342 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	158,771,429 - 158,906,347 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	159,988,204 - 160,123,346 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	159,988,433 - 160,123,351 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	156,426,365 - 156,561,283 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
Celera	X	143,246,363 - 143,367,779 (+)	NCBI		Celera
Cytogenetic Map	X	F4	NCBI
cM Map	X	73.95	NCBI

MAP3K15
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	19,360,059 - 19,515,508 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	19,360,056 - 19,515,508 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	19,378,177 - 19,533,626 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	19,288,095 - 19,410,315 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	19,137,830 - 19,260,051	NCBI
Celera	X	23,499,514 - 23,656,927 (-)	NCBI		Celera
Cytogenetic Map	X	p22.12	NCBI
HuRef	X	17,127,352 - 17,281,966 (-)	NCBI		HuRef
CHM1_1	X	19,409,233 - 19,563,759 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	18,942,795 - 19,098,393 (-)	NCBI		T2T-CHM13v2.0

Map3k15
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	38,522,143 - 38,667,746 (-)	NCBI		GRCr8
mRatBN7.2	X	34,713,150 - 34,859,054 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	34,713,175 - 34,858,807 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	X	37,342,251 - 37,755,373 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	37,643,169 - 37,705,263 (-)	NCBI	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	37,654,122 - 38,059,872 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	55,912,157 - 56,042,817 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	35,385,725 - 35,526,200 (-)	NCBI		Celera
Cytogenetic Map	X	q14	NCBI

Map3k15
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955586	5,345 - 99,534 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955586	5,856 - 99,662 (+)	NCBI	ChiLan1.0	ChiLan1.0

MAP3K15
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	21,160,443 - 21,315,845 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	21,163,833 - 21,319,232 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	11,984,867 - 12,137,090 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	19,346,814 - 19,518,249 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	19,346,814 - 19,518,249 (-)	Ensembl	panpan1.1		panPan2

MAP3K15
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	15,353,081 - 15,465,862 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	15,353,081 - 15,465,992 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	X	15,301,710 - 15,425,913 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	15,312,525 - 15,426,249 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	15,362,476 - 15,474,546 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	15,364,256 - 15,476,439 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	15,419,523 - 15,543,818 (-)	NCBI		UU_Cfam_GSD_1.0

Map3k15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	8,417,779 - 8,469,243 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936844	905,658 - 956,879 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936844	905,249 - 958,946 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAP3K15
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	15,715,991 - 15,867,120 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	15,716,898 - 15,867,377 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	16,964,353 - 17,118,068 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAP3K15
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	17,820,316 - 17,981,894 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	17,819,474 - 17,981,402 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666056	19,688,358 - 19,839,732 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Map3k15
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624829	4,169,717 - 4,318,578 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624829	4,169,679 - 4,318,966 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Map3k15
2942 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	138
Count of miRNA genes:	129
Interacting mature miRNAs:	134
Transcripts:	ENSMUST00000033665
Prediction methods:	Miranda, Pita, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10401118	Pgia39_m	proteoglycan induced arthritis 39 (mouse)			Not determined		X	144474380	169476592	Mouse
1558900	Bw3_m	body weight QTL 3 (mouse)			Not determined		X	133540040	165298595	Mouse
1302000	Pgia25_m	proteoglycan induced arthritis 2 (mouse)			Not determined		X	144474380	169476592	Mouse
12738421	Lfibq17_m	liver fibrosis QTL 17 (mouse)					X	148148453	164945064	Mouse
1301209	Cia19_m	collagen induced arthritis 19 (mouse)			Not determined		X	120993165	160213038	Mouse
10412164	Cmv2_m	cytomegalovirus resistance 2 (mouse)			Not determined		X	125685149	159685269	Mouse
1357823	Spha3_m	sperm head anomaly 3 (mouse)			Not determined		X	102055848	162758941	Mouse

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001163085	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AL845167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL929452	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC031147	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC043943	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000033665 ⟹ ENSMUSP00000033665

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	X	158,771,429 - 158,906,347 (+)	Ensembl
GRCm38.p6 Ensembl	X	159,988,433 - 160,123,351 (+)	Ensembl

RefSeq Acc Id:

NM_001163085 ⟹ NP_001156557

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	X	158,771,200 - 158,906,342 (+)	NCBI
GRCm38	X	159,988,204 - 160,123,346 (+)	NCBI
MGSCv37	X	156,426,365 - 156,561,283 (+)	RGD
Celera	X	143,246,364 - 143,367,779 (+)	ENTREZGENE
cM Map	X		ENTREZGENE

Sequence:

show sequence

GCGGGCTTTCAAAGGGCGCTCGGGGCAAGCCGGCCCTGAGCTCCGCTCCGCCGGCCGCCGGAGA
ACCCGTGGTCACCTGCCCGCCCCGGCCTCTGCGCCCGCCCCCTGCTCCGGCTCCCTGCGGCCGC
CGTCCGTCCTCCGGTCCGCCCGTCCGTCATCCGCCTGTGCAGCAGGTGTCTCGGGGAAGAGCAC
CTGGGCTTCGAAGCCGCCAGCCCCGCGGGCCAGTCACATGGAGGGCGGCGGCGGCAGCGGCGGC
GGCGGCGGGCCAGTCCCTGCCGAGGCTCCGGAGGAAGCCGGCGAGCCGCCCCAGGGCAGGCTGC
CCCCGGGGCCCGAGGGCGCGGCGGGGCTGGCGGAGCCCGAGAGCACGGGGGACGCGGCGGGCGG
CGAGGCCGAGGGCGGGCGCGGGCCACGCCGGGCTCTGCGGGCTGTCTACGTGCGCAGCGAAAGT
TCGCAGGGGGCAGCCGCCGGCGGCGGCCCCGAGGCCGGGGCGCTCAAGTGCCTGCTTCGGGCTT
GCGAAGCCGAGGGCGCCCACCTCACCTCCGTCCCCTTCGGGGAGCTCGACTTCGGGGAGACGGC
CGTGCTCGATGCCTTCTACGATGCAGATGTTGCCATTGTGGACATGAGTGATATCTCCAGACAG
CCTTCCCTTTTCTACCATCTTGGAGTCCGAGAGAGTTTTGACATGGCTAACAATGTAATTCTCT
ACTATGATACTGATGCTGACACTGCTCTGTCATTGAAGGATATGGTCACTCAAAAAAACACAGC
ATCCAGTGGAAATTATTATTTTATCCCCTACACTGTGACACCATGTGCTGACTATTTTTGCTGT
GAGAGTGATGCCCAAAGGAGAGCCTCAGAGTACATGCAGCCTAACTGGGACACCATACTGGGCC
CGCTGTGTATGCCCCTGGTCGACAGGTTCACTAGCCTCCTTAAGGACATCCGTGTGACTTCATG
TGCTTATTATAAAGAAACATTGTTAAATGACATCCGGAAAGCCAGAGAGAAATACCAAGGTGAT
GAACTGGCGAAAGAGTTGACTCGGATCAAATTCCGTATGGATAACATTGAGGTTCTGACATCGG
ACATCATCATTAACTTACTTCTGTCCTACCGTGATATCCAGGACTACGATGCAATGGTCAAGCT
GGTAGAGACACTGAAGATGCTGCCAACGTGTGATTTGGCTGATCAGCACAACATTAAATTTCAC
TATGCATTTGCACTGAATAGGAGAAACAGCACAGGTGACCGTGAAAAGGCTCTTCAGGTTATGC
TCCAAGTTCTGCAAAGCTGTGACCACCCAGCTCCTGACATGTTTTGCCTGTGTGGGCGGATATA
CAAGGACATCTTCCTGGATTCAGGTTGTGAAGAGGATGCAAGCAGAGACAGTGCCATTGAGTGG
TATCGCAAAGGGTTTGAACTCCAGTCATCCCTTTATTCAGGAATTAACCTTGCAGTTTTGCTGA
TAGTTTCTGGACAACAGTTTGAAACTTCGATGGAACTAAGGAAAATAGGTGTCCGGCTGAACAG
TTTATTGGGAAGAAAAGGGAGCCTGGAGAAAATGAACAATTACTGGGATGTAGGTCAGTTCTTC
ACCGTCAGCATGCTGGCAAGTGATATTGGGAAAGCTGTCCAGGCAGCAGAGAGGTTGTTCAAAC
TGAAACCCCCAGTCTGGTACCTGCGGTCATTAGTTCAGAACTTGCTGTTAATTCAACGCTTCAA
GAAACCCATTACAGAACATTCACCCAGGCAGGAACGGCTTAACTTCTGGTTAGATATCATTTTT
GAAGCAACGAATGAAGTTACTAATGGACTCAGATTTCCAGTTCTGGTAATAGAGCCAACCAAAG
TCTACCAGCCTTCTTATGTTTCTATCAACAATGAAGCTGAAGAAAGAACTGTTTCTTTATGGCA
TGTCTCACCCACAGAAATGAAACAAATCCATGAGTGGAATTTTACAGCCTCTTCTATTAAAGGA
ATAAGCCTATCCAAGTTTGATGAACGGTGCTGTTTTCTTTATGTCCATGATAATTCTGATGACT
TTCAAATCTACTTTTCCACCGAAGACCAGTGTAATAGATTTTGTTCTTTGGTCAAAGAGATGCT
AAACAATGGAGTGGGCAGTACAGTGGAGTTGGAGGGAGAGGCTGATGGAGACACCTTAGAGTAT
GAGTATGACCATGATGCGAATGGGGAGAGAGTTGTCTTGGGGAAAGGCTCCTATGGGATTGTGT
ATGCCGGCCGTGATCTCAGTAATCAAGTACGGATAGCCATCAAGGAAATCCCAGAGAGAGATAT
CAGGTACTCTCAGCCTCTGCATGAAGAAATAGCTCTGCACAAGTATCTCAAACATCGCAACATC
GTCCAGTACCTAGGCTCTGTTTCAGAGAATGGCTACATTAAGATATTTATGGAGCAGGTGCCTG
GAGGAAGCCTTTCTGCTCTCTTACGATCTAAATGGGGACCTATGAAGGAACCCACTATCAAGTT
TTATACCAAACAGATCCTGGAAGGCCTGAAGTATCTCCATGAAAACCAGATAGTGCACAGAGAC
ATAAAGGGAGATAATGTTCTGGTGAACACCTATAGTGGAGTGGTAAAAATCTCTGATTTTGGAA
CCTCTAAACGCCTCGCAGGAATTAACCCATGCACCGAGACCTTTACAGGAACTCTGCAGTACAT
GGCACCTGAGATTATTGATCAAGGACCTCGGGGATATGGTGCTCCAGCTGATATCTGGTCCTTG
GGCTGCACCATCATTGAGATGGCAACCAGCAGGCCTCCATTCCATGAGCTTGGTGAGCCCCAAG
CAGCCATGTTTAAGGTAGGGATGTTTAAGATCCACCCTGAAATTCCAGAGGCCCTTTCAGCTGA
AGCCAGAGCCTTCATCTTGTCTTGTTTTGAGCCTGACCCTCAGAAACGTGTCACTGCTGCTGAC
CTTCTCCAAGAAGGGTTCTTAAGGCAGGTGAACAAAGGCAAAAAGAACCGAATTGCTTTCAAGC
CTTCAGAGGGTGTTCGGAGTGGCACTGGTACTCTGGCTCTGCCTTCATCAGGAGAGCTTGTGGG
CAGCAGCAGCAGCGAGCATGGCTCAATCTCCCCAGACTCGGATGCCCAGCCTGATGCATTCTTT
GAGAAAGTCCAGGTGCCCAAACATCAGCTCAGCCACCTTCTCAGTGTCCCAGATGAAAGCCCAG
CCTTAGATGACCGAAGCACAGCCTTACCCCCAGAGGAGAGGGACCCTGGTCTCTTTCTGCTGCG
CAAGGACAGTGAGCGCAGAGCCATCCTTTACAGAATCCTTTGGGAGGAACAGAACCAAGTGGCT
TCCAACTTGCAAGAGTGTGTGGTCCAGAGTTCAGAAGAGTTGCTTCTCTCAGTTAGCCACATCA
AACAGATAATTGGAATCCTGAGGGACTTCATCCGCTCCCCAGAGCACAGGGTGATGGCAGCCAC
AATATCAAAACTAAAGGTGGACCTGGACTTTGACAGCTCATCCATCAACCAGATTCACCTGATT
CTGTTTGGGTTCCAAGATGCTGTCAATAGAATTTTGAGAAACCACTTAATTAGGCCCCACTGGA
TGTTTGCAATGGACAACATCATTCGCAGAGCTGTGCAGGCTGCAGTCACCATTCTCATTCCAGA
GCTCCAAGCCCACTTTGAGCCTGCTTCTGAGACTGAAGGGGTAGACAAGGACACAGAAGTAGAA
GGGGACTATCCCCTAGTAGACCTCCTCAGCCAAGAAGTGCATGTGACACCTAGAGGCACCAGAC
CTGGCTCAGTGGCTATCCAGGAGGGCCAGCCCCACCAGCAAGACCCAAGTCTCCAACTGAGCAA
GCTCAGGCAAGAGACCAACAGACTTTGGGAACACCTAGTTCAAAAAGAGAGGGAGTACCAGAAT
CTTCTTCGCCTAATTCTAGACCAGAAAACTCAAGAATTGTATCACCTTCAGTTACAGTACAAAT
CCAATGGTGGTACAGAGAACCCTCCACCCCCTGATGGACTGGGAACCGACAGAGAGCTTATAGA
CTGGTTGCAACTACAAGGAGTGGATGCCAATACAATAGAAAAGATTGTTGAAGAGGACTATACA
CTTTCTGATATTCTCAATGATATCACTAAGGAAGACCTAAGGTGCCTCCGACTACGGGGTGGTG
TCCTCTGTAGGCTCTGGCATGCAGTCTCCCAGCACAGAAGACAAATGCAGGAGTCTTCACAGTG
AGCCAAGCCTGGGGAGAATGGGCAAAAAGTCCCCTACACCTGCTCATGATTAAAGCTTCTGTTG
GTGTACTCACAAACTCCGAGTTTCCACAGAAAGACCCTTGTCCATTTAATTCAAGCACGTGTGA
TTGTAGAGCATCCTTGTTTATAAACAAGATTGTAAGTAATGTCAGCCCTGACCTAATATTTAAA
AAGTCAGCATATCGCTGGAAAGATAAAGCATACGTATTTTATAAACTAGTGTAATTACTTAAAT
GTGAAAGGTTAAAAAGTGTGCCTTGCAATGGGAGTACAGTTTCATGTATGTTAAATGTCTAAAT
GGAAAAAATTAAACTATTTTACCTTTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001156557	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	A2AQW0	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000033665
	ENSMUSP00000033665.9

RefSeq Acc Id:

NP_001156557 ⟸ NM_001163085

- UniProtKB:

A2AQW0 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MEGGGGSGGGGGPVPAEAPEEAGEPPQGRLPPGPEGAAGLAEPESTGDAAGGEAEGGRGPRRAL
RAVYVRSESSQGAAAGGGPEAGALKCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDADVAI
VDMSDISRQPSLFYHLGVRESFDMANNVILYYDTDADTALSLKDMVTQKNTASSGNYYFIPYTV
TPCADYFCCESDAQRRASEYMQPNWDTILGPLCMPLVDRFTSLLKDIRVTSCAYYKETLLNDIR
KAREKYQGDELAKELTRIKFRMDNIEVLTSDIIINLLLSYRDIQDYDAMVKLVETLKMLPTCDL
ADQHNIKFHYAFALNRRNSTGDREKALQVMLQVLQSCDHPAPDMFCLCGRIYKDIFLDSGCEED
ASRDSAIEWYRKGFELQSSLYSGINLAVLLIVSGQQFETSMELRKIGVRLNSLLGRKGSLEKMN
NYWDVGQFFTVSMLASDIGKAVQAAERLFKLKPPVWYLRSLVQNLLLIQRFKKPITEHSPRQER
LNFWLDIIFEATNEVTNGLRFPVLVIEPTKVYQPSYVSINNEAEERTVSLWHVSPTEMKQIHEW
NFTASSIKGISLSKFDERCCFLYVHDNSDDFQIYFSTEDQCNRFCSLVKEMLNNGVGSTVELEG
EADGDTLEYEYDHDANGERVVLGKGSYGIVYAGRDLSNQVRIAIKEIPERDIRYSQPLHEEIAL
HKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYL
HENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDQGPRGY
GAPADIWSLGCTIIEMATSRPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPD
PQKRVTAADLLQEGFLRQVNKGKKNRIAFKPSEGVRSGTGTLALPSSGELVGSSSSEHGSISPD
SDAQPDAFFEKVQVPKHQLSHLLSVPDESPALDDRSTALPPEERDPGLFLLRKDSERRAILYRI
LWEEQNQVASNLQECVVQSSEELLLSVSHIKQIIGILRDFIRSPEHRVMAATISKLKVDLDFDS
SSINQIHLILFGFQDAVNRILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELQAHFEPASETE
GVDKDTEVEGDYPLVDLLSQEVHVTPRGTRPGSVAIQEGQPHQQDPSLQLSKLRQETNRLWEHL
VQKEREYQNLLRLILDQKTQELYHLQLQYKSNGGTENPPPPDGLGTDRELIDWLQLQGVDANTI
EKIVEEDYTLSDILNDITKEDLRCLRLRGGVLCRLWHAVSQHRRQMQESSQ

hide sequence

Ensembl Acc Id:

ENSMUSP00000033665 ⟸ ENSMUST00000033665

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A2AQW0-F1-model_v2	AlphaFold	A2AQW0	1-1331	view protein structure

Promoters

RGD ID:

13681740

Promoter ID:

EPDNEW_M25019

Type:

multiple initiation site

Name:

Map3k15_1

Description:

Mus musculus mitogen-activated protein kinase kinase kinase 15, mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	X	159,988,438 - 159,988,498	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2448588	AgrOrtholog
Ensembl Genes	ENSMUSG00000031303	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000033665	ENTREZGENE
	ENSMUST00000033665.9	UniProtKB/Swiss-Prot
Gene3D-CATH	Phosphorylase Kinase, domain 1	UniProtKB/Swiss-Prot
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
InterPro	DRHyd-ASK	UniProtKB/Swiss-Prot
	DUF4071	UniProtKB/Swiss-Prot
	HisK-N-like	UniProtKB/Swiss-Prot
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	MAP3K_PH	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot
	SAM/pointed_sf	UniProtKB/Swiss-Prot
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot
KEGG Report	mmu:270672	UniProtKB/Swiss-Prot
MGD	MGI:2448588	ENTREZGENE
NCBI Gene	270672	ENTREZGENE
PANTHER	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 15	UniProtKB/Swiss-Prot
	SERINE/THREONINE PROTEIN KINASE	UniProtKB/Swiss-Prot
Pfam	ASK_PH	UniProtKB/Swiss-Prot
	DRHyd-ASK	UniProtKB/Swiss-Prot
	DUF4071	UniProtKB/Swiss-Prot
	HisK-N-like	UniProtKB/Swiss-Prot
	Pkinase	UniProtKB/Swiss-Prot
PhenoGen	Map3k15	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot
SMART	S_TKc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF47769	UniProtKB/Swiss-Prot
	SSF56112	UniProtKB/Swiss-Prot
UniProt	A2AQW0	ENTREZGENE, UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Mammalian Phenotype