Mir135a-1 (microRNA 135a-1) - Rat Genome Database
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Gene: Mir135a-1 (microRNA 135a-1) Mus musculus
Analyze
Symbol: Mir135a-1
Name: microRNA 135a-1
RGD ID: 1608337
MGI Page MGI
Description: Exhibits mRNA 3'-UTR binding activity and mRNA binding activity involved in posttranscriptional gene silencing. Involved in several processes, including cellular response to leukemia inhibitory factor; miRNA mediated inhibition of translation; and negative regulation of osteoblast differentiation. Is expressed in several structures, including brain; early conceptus; lung; and oocyte. Orthologous to human MIR135A1 (microRNA 135a-1).
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-135a-1; Mir135a01; Mirn; Mirn13; Mirn135; Mirn135a-1
RGD Orthologs
Human
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,031,323 - 106,031,412 (+)NCBIGRCm39mm39
GRCm389106,154,124 - 106,154,213 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,154,124 - 106,154,213 (+)EnsemblGRCm38mm10GRCm38
MGSCv379106,056,455 - 106,056,544 (+)NCBIGRCm37mm9NCBIm37
Celera9105,778,138 - 105,778,227 (+)NCBICelera
Cytogenetic Map9F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
sodium fluoride  (EXP)
toluene  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12007417   PMID:15634332   PMID:16369549   PMID:16381832   PMID:17369397   PMID:17604727   PMID:18452032   PMID:19559694   PMID:20215419   PMID:20413612   PMID:20439489   PMID:21037258  
PMID:21267068   PMID:21307095   PMID:21628588   PMID:21718763   PMID:21822254   PMID:22000014   PMID:22115756   PMID:22132158   PMID:23579070   PMID:23946534   PMID:24348261   PMID:24535612  
PMID:24667771   PMID:25639612   PMID:26079807   PMID:26134897   PMID:26208701   PMID:26418311   PMID:27048518   PMID:27276245   PMID:27842305   PMID:28147298   PMID:28488209   PMID:29332916  
PMID:29663503   PMID:30578296   PMID:31024564   PMID:31130358   PMID:31398367   PMID:31545249   PMID:32109384  


Genomics

Comparative Map Data
Mir135a-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,031,323 - 106,031,412 (+)NCBIGRCm39mm39
GRCm389106,154,124 - 106,154,213 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,154,124 - 106,154,213 (+)EnsemblGRCm38mm10GRCm38
MGSCv379106,056,455 - 106,056,544 (+)NCBIGRCm37mm9NCBIm37
Celera9105,778,138 - 105,778,227 (+)NCBICelera
Cytogenetic Map9F1NCBI
MIR135A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl352,294,219 - 52,294,308 (-)EnsemblGRCh38hg38GRCh38
GRCh38352,294,219 - 52,294,308 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37352,328,235 - 52,328,324 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,303,274 - 52,303,363 (-)NCBINCBI36hg18NCBI36
Celera352,307,558 - 52,307,647 (-)NCBI
Cytogenetic Map3p21.2NCBI
HuRef352,390,877 - 52,390,966 (-)NCBIHuRef
CHM1_1352,280,770 - 52,280,859 (-)NCBICHM1_1
MIR135A-1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2037,461,817 - 37,461,903 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12037,461,817 - 37,461,903 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
MIR135-1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,441,079 - 34,441,168 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,441,079 - 34,441,168 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,564,051 - 37,564,140 (+)NCBISscrofa10.2Sscrofa10.2susScr3


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Smad5mmu-miR-135a-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI18784367
Appmmu-miR-135a-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI20619502
Ptk2mmu-miR-135a-5pOncomiRDBexternal_infoNANA23438844
Nol3mmu-miR-135a-5pOncomiRDBexternal_infoNANA23176581
Mtss1mmu-miR-135a-5pOncomiRDBexternal_infoNANA23017832
Hoxa10mmu-miR-135a-5pOncomiRDBexternal_infoNANA22439757
Jak2mmu-miR-135a-5pOncomiRDBexternal_infoNANA22310976
Stat6mmu-miR-135a-5pOncomiRDBexternal_infoNANA22139076
Mtss1mmu-miR-135a-5pOncomiRDBexternal_infoNANA21888875
Cyp1a2mmu-miR-135a-5pOncomiRDBexternal_infoNANA21552288
Jak2mmu-miR-135a-5pOncomiRDBexternal_infoNANA19666866
Cyp1a2mmu-miR-135a-5pOncomiRDBexternal_infoNANA18632633

Predicted Targets
Summary Value
Count of predictions:12848
Count of gene targets:5990
Count of transcripts:9257
Interacting mature miRNAs:mmu-miR-135a-1-3p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000083473
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,154,124 - 106,154,213 (+)Ensembl
RefSeq Acc Id: NR_029549
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399106,031,323 - 106,031,412 (+)NCBI
GRCm389106,154,124 - 106,154,213 (+)ENTREZGENE
MGSCv379106,056,455 - 106,056,544 (+)RGD
Celera9105,778,138 - 105,778,227 (+)RGD
cM Map9 ENTREZGENE
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2676820 AgrOrtholog
Ensembl Genes ENSMUSG00000065407 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083473 ENTREZGENE
MGD MGI:2676820 ENTREZGENE
miRBase MI0000161 ENTREZGENE
NCBI Gene 387153 ENTREZGENE
PhenoGen Mir135a-1 PhenoGen
RNAcentral URS00000DF6D0 RNACentral
  URS0000169868 RNACentral
  URS000063A10C RNACentral