Mir19b-2 (microRNA 19b-2) - Rat Genome Database

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Gene: Mir19b-2 (microRNA 19b-2) Mus musculus
Analyze
Symbol: Mir19b-2
Name: microRNA 19b-2
RGD ID: 1608296
MGI Page MGI
Description: Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; long-term synaptic potentiation; and negative regulation of B cell apoptotic process. Part of RISC complex. Is expressed in several structures, including alimentary system; brain; liver; lung; and submandibular gland primordium. Orthologous to human MIR19B2 (microRNA 19b-2).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: miR-19b; mir-19b-2; Mirn; Mirn19; Mirn19b; Mirn19b-2
RGD Orthologs
Human
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X51,830,860 - 51,830,943 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX51,830,860 - 51,830,943 (-)EnsemblGRCm39 Ensembl
GRCm38X52,741,983 - 52,742,066 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX52,741,983 - 52,742,066 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X50,095,160 - 50,095,243 (-)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX40,158,203 - 40,158,286 (-)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX29.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell apoptotic process  (IGI)
cellular response to bacterial lipopeptide  (ISO)
cellular response to leukemia inhibitory factor  (IEP)
cholesterol homeostasis  (ISO)
long-term synaptic potentiation  (IEP)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of apolipoprotein A-I-mediated signaling pathway  (ISO)
negative regulation of apoptotic process  (IGI)
negative regulation of B cell apoptotic process  (IGI)
negative regulation of cardiac epithelial to mesenchymal transition  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cellular response to transforming growth factor beta stimulus  (ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of coagulation  (ISO)
negative regulation of extracellular matrix assembly  (ISO)
negative regulation of fibroblast migration  (ISO)
negative regulation of G2/M transition of mitotic cell cycle  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response to antigenic stimulus  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of matrix metallopeptidase secretion  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
ossification  (IDA)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
response to bacterium  (IEP)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12007417   PMID:12554860   PMID:12919684   PMID:15634332   PMID:16369549   PMID:16381832   PMID:16736490   PMID:17369397   PMID:17604727   PMID:17765889   PMID:18329372   PMID:19559694  
PMID:20215419   PMID:20413612   PMID:20439489   PMID:21037258   PMID:21267068   PMID:21371421   PMID:21412408   PMID:21501375   PMID:21660949   PMID:21718763   PMID:21781967   PMID:21892160  
PMID:21972292   PMID:22095742   PMID:22187428   PMID:22382630   PMID:22511778   PMID:22874921   PMID:23185045   PMID:23443808   PMID:23940725   PMID:24205035   PMID:24644282   PMID:24928431  
PMID:25084135   PMID:25184675   PMID:25378171   PMID:25751060   PMID:25765596   PMID:25858512   PMID:26934100   PMID:27822884   PMID:28472780   PMID:29572892   PMID:29664809   PMID:33539284  
PMID:33760339   PMID:34910364   PMID:35126805   PMID:35978367   PMID:36193848   PMID:37101174  


Genomics

Comparative Map Data
Mir19b-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X51,830,860 - 51,830,943 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX51,830,860 - 51,830,943 (-)EnsemblGRCm39 Ensembl
GRCm38X52,741,983 - 52,742,066 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX52,741,983 - 52,742,066 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X50,095,160 - 50,095,243 (-)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX40,158,203 - 40,158,286 (-)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX29.15NCBI
MIR19B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X134,169,671 - 134,169,766 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX134,169,671 - 134,169,766 (-)EnsemblGRCh38hg38GRCh38
GRCh37X133,303,701 - 133,303,796 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X133,131,366 - 133,131,461 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX133,690,534 - 133,690,629 (-)NCBICelera
Cytogenetic MapXq26.2NCBI
HuRefX122,701,740 - 122,701,835 (-)NCBIHuRef
CHM1_1X133,215,397 - 133,215,492 (-)NCBICHM1_1
T2T-CHM13v2.0X132,494,818 - 132,494,913 (-)NCBIT2T-CHM13v2.0
Mir19b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X137,343,058 - 137,343,153 (-)NCBIGRCr8
mRatBN7.2X132,422,072 - 132,422,167 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX132,422,072 - 132,422,167 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX134,584,480 - 134,584,575 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X138,166,421 - 138,166,516 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X135,732,125 - 135,732,220 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X140,117,379 - 140,117,474 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX140,117,379 - 140,117,474 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X140,167,226 - 140,167,321 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX131,322,287 - 131,322,382 (-)NCBICelera
Cytogenetic MapXq36NCBI
MIR19B-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X104,895,962 - 104,896,025 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX104,895,962 - 104,896,025 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX91,006,321 - 91,006,384 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X106,755,718 - 106,755,781 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX106,755,718 - 106,755,781 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X104,168,894 - 104,168,957 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X106,034,839 - 106,034,902 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X105,820,105 - 105,820,168 (-)NCBIUU_Cfam_GSD_1.0
MIR19B-2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX110,113,855 - 110,113,934 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X110,113,855 - 110,113,934 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X126,199,650 - 126,199,729 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mir19b-2
5 total Variants
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:13674
Count of gene targets:6278
Count of transcripts:9895
Interacting mature miRNAs:mmu-miR-19b-2-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
13208553Wght11_mweight 11 (mouse)X1186623959045360Mouse
13208557Lgth13_mbody length 13 (mouse)X1186623959045360Mouse
27226750Femd9_mfemur midshaft diameter 9, 10 week (mouse)X3333746355845360Mouse
27226780Femd12_mfemur midshaft diameter 12, 16 week (mouse)X3466365356845360Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3526365377043606Mouse
1301009Pbwg7_mpostnatal body weight growth 7 (mouse)Not determinedX3911371473113814Mouse
4141565Pbwg21_mpostnatal body weight growth 21 (mouse)Not determinedX3911371473113814Mouse
1300794Spha2_msperm head anomaly 2 (mouse)Not determinedX3992149886260137Mouse
4142200Rtwq1_mreduced testis weight QTL 1 (mouse)Not determined4147706075477203Mouse
1301278Bdln1_mbody length 1 (mouse)Not determinedX4170210675702218Mouse
1300702Fcsa4_mfemoral cross-sectional area 4 (mouse)Not determinedX4602744480027567Mouse
1301212Bw19_mbody weight QTL 19 (mouse)Not determinedX4637692052412327Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
1300853Aggr2_maggression 2 (mouse)Not determinedX4907116752259196Mouse
1301351Obq6_mobesity QTL 6 (mouse)Not determinedX5077237570434751Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000083539
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX51,830,860 - 51,830,943 (-)Ensembl
GRCm38.p6 EnsemblX52,741,983 - 52,742,066 (-)Ensembl
RefSeq Acc Id: NR_029715
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X51,830,860 - 51,830,943 (-)NCBI
GRCm38X52,741,983 - 52,742,066 (-)ENTREZGENE
MGSCv37X50,095,160 - 50,095,243 (-)RGD
CeleraX40,158,203 - 40,158,286 (-)RGD
cM MapX ENTREZGENE
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2676868 AgrOrtholog
Ensembl Genes ENSMUSG00000065473 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083539 ENTREZGENE
MGD MGI:2676868 ENTREZGENE
miRBase MI0000546 ENTREZGENE
NCBI Gene 387195 ENTREZGENE
PhenoGen Mir19b-2 PhenoGen
RNAcentral URS000013D17D RNACentral
  URS000075C542 RNACentral
  URS000075E066 RNACentral