Mir486 (microRNA 486) - Rat Genome Database
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Gene: Mir486 (microRNA 486) Mus musculus
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Symbol: Mir486
Name: microRNA 486
RGD ID: 1608179
MGI Page MGI
Description: Is expressed in several structures, including bladder; heart; lower leg muscle; lung; and spleen. Orthologous to human MIR486-1 (microRNA 486-1).
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-486a; Mirn; Mirn486; mmu-mir-4; mmu-mir-486; mmu-mir-486a
RGD Orthologs
Human
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,632,571 - 23,632,698 (+)NCBIGRCm39mm39
GRCm39 Ensembl823,632,571 - 23,632,698 (+)Ensembl
GRCm38823,142,555 - 23,142,682 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl823,142,555 - 23,142,682 (+)EnsemblGRCm38mm10GRCm38
MGSCv37824,253,027 - 24,253,154 (+)NCBIGRCm37mm9NCBIm37
Celera824,638,894 - 24,638,926 (+)NCBICelera
Cytogenetic Map8A2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (IDA)

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:18762567   PMID:18791161   PMID:20142475   PMID:20215419   PMID:20413612   PMID:20548288   PMID:21037258   PMID:21041476   PMID:21267068   PMID:22144232  
PMID:22475820   PMID:23185045   PMID:24342526   PMID:24789910   PMID:25858512   PMID:26107383   PMID:29351846   PMID:30073773   PMID:32710883  


Genomics

Comparative Map Data
Mir486
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,632,571 - 23,632,698 (+)NCBIGRCm39mm39
GRCm39 Ensembl823,632,571 - 23,632,698 (+)Ensembl
GRCm38823,142,555 - 23,142,682 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl823,142,555 - 23,142,682 (+)EnsemblGRCm38mm10GRCm38
MGSCv37824,253,027 - 24,253,154 (+)NCBIGRCm37mm9NCBIm37
Celera824,638,894 - 24,638,926 (+)NCBICelera
Cytogenetic Map8A2NCBI
MIR486-1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl841,660,441 - 41,660,508 (-)EnsemblGRCh38hg38GRCh38
GRCh38841,660,441 - 41,660,508 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37841,517,959 - 41,518,026 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36841,637,115 - 41,637,182 (-)NCBINCBI36hg18NCBI36
Celera840,466,482 - 40,466,549 (-)NCBI
Cytogenetic Map8p11.21NCBI
HuRef840,045,689 - 40,045,756 (-)NCBIHuRef
CHM1_1841,566,127 - 41,566,194 (-)NCBICHM1_1
Mir486
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0 Ensembl1673,680,363 - 73,680,490 (-)EnsemblRnor6.0rn6Rnor6.0

Position Markers
D8Rck1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38823,141,365 - 23,141,570UniSTSGRCm38
MGSCv37824,251,837 - 24,252,042UniSTSGRCm37
Celera824,637,758 - 24,637,909UniSTS
Cytogenetic Map8A2UniSTS
cM Map88.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124701082Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130397432Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131723288Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8490000034600000Mouse
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8716249923263799Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8716249934642953Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8749417341494326Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8761318541613356Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8761318541613356Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8761318541613356Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81339721034854071Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81501654449016701Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81501654449016701Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81607934550079669Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1703261028359439Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81785394351854071Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81898786452987996Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81898786452987996Mouse

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Ptenmmu-miR-486-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot;qRT-PCR;OtFunctional MTI20142475
Pax7mmu-miR-486-5pMirtarbaseexternal_infoImmunocytochemistry//Luciferase reporter assay//MiFunctional MTI21041476
Ptenmmu-miR-486-5pTarbaseexternal_infoqPCRPOSITIVE
Ptenmmu-miR-486-5pTarbaseexternal_infoWesternblitPOSITIVE
Ptenmmu-miR-486-5pTarbaseexternal_infoOtherPOSITIVE
Serpine1mmu-miR-486-5pOncomiRDBexternal_infoNANA22995304
Olfm4mmu-miR-486-5pOncomiRDBexternal_infoNANA21415212

Predicted Targets
Summary Value
Count of predictions:39860
Count of gene targets:16168
Count of transcripts:31702
Interacting mature miRNAs:mmu-miR-486-3p, mmu-miR-486-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000093576
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl823,142,555 - 23,142,682 (+)Ensembl
RefSeq Acc Id: NR_030254
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,632,571 - 23,632,698 (+)NCBI
GRCm38823,142,555 - 23,142,682 (+)ENTREZGENE
MGSCv37824,253,027 - 24,253,154 (+)RGD
Celera824,638,894 - 24,638,926 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Promoters
RGD ID:8666705
Promoter ID:EPDNEW_M11384
Type:multiple initiation site
Name:Mir486_1
Description:Mus musculus microRNA 486 , microRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38823,142,652 - 23,142,712EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3619423 AgrOrtholog
Ensembl Genes ENSMUSG00000070084 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000093576 ENTREZGENE
MGD MGI:3619423 ENTREZGENE
miRBase MI0003493 ENTREZGENE
NCBI Gene 723876 ENTREZGENE
PhenoGen Mir486 PhenoGen
RNAcentral URS0000377E71 RNACentral
  URS00004BF1DC RNACentral
  URS000075A508 RNACentral