Mir29b-2 (microRNA 29b-2) - Rat Genome Database

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Gene: Mir29b-2 (microRNA 29b-2) Mus musculus
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Symbol: Mir29b-2
Name: microRNA 29b-2
RGD ID: 1607561
MGI Page MGI
Description: Acts upstream of or within several processes, including cellular hyperosmotic salinity response; cellular response to leukemia inhibitory factor; and long-term synaptic potentiation. Is expressed in alimentary system; axial skeleton; brain; and cranium. Orthologous to human MIR29B2 (microRNA 29b-2).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-29b-2; Mirn29; Mirn29b-2
RGD Orthologs
Human
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,719,348 - 194,719,428 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,719,348 - 194,719,428 (+)EnsemblGRCm39 Ensembl
GRCm381195,037,040 - 195,037,120 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,037,040 - 195,037,120 (+)EnsemblGRCm38mm10GRCm38
MGSCv371196,863,234 - 196,863,314 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1201,936,850 - 201,936,930 (+)NCBICelera
Cytogenetic Map1H6NCBI
cM Map198.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular hyperosmotic salinity response  (IDA)
cellular response to leukemia inhibitory factor  (IEP)
cellular response to lipopolysaccharide  (IDA)
epigenetic regulation of gene expression  (ISO)
long-term synaptic potentiation  (IEP)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of amyloid precursor protein catabolic process  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cellular response to transforming growth factor beta stimulus  (ISO)
negative regulation of circulating fibrinogen levels  (ISO)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of cytokine-mediated signaling pathway  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of gene expression  (IDA,ISO)
negative regulation of interleukin-32 production  (ISO)
negative regulation of mesenchymal stem cell proliferation  (ISO)
negative regulation of non-canonical NF-kappaB signal transduction  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of potassium ion transmembrane transport  (ISO)
negative regulation of Rac protein signal transduction  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of type III interferon production  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO)
regulation of epithelium regeneration  (ISO)
regulation of membrane repolarization  (ISO)
sensory perception of sound  (IEP)
tissue remodeling  (IGI)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12007417   PMID:12919684   PMID:15538371   PMID:15634332   PMID:15845075   PMID:16369549   PMID:16381832   PMID:16682203   PMID:17028171   PMID:17369397   PMID:17604727   PMID:17936263  
PMID:18723672   PMID:18762567   PMID:19342382   PMID:20164119   PMID:20215419   PMID:20413612   PMID:20439489   PMID:20668074   PMID:21037258   PMID:21267068   PMID:21364282   PMID:21522133  
PMID:21646425   PMID:21718763   PMID:21822254   PMID:21930776   PMID:22132122   PMID:22269326   PMID:22393047   PMID:22614019   PMID:22772450   PMID:22931209   PMID:23646144   PMID:24074615  
PMID:24967703   PMID:25203514   PMID:25239947   PMID:25277410   PMID:25356754   PMID:25858512   PMID:26003733   PMID:26020233   PMID:26107383   PMID:26130713   PMID:27328306   PMID:27449102  
PMID:27589684   PMID:28234907   PMID:29158499   PMID:30346946   PMID:30362585   PMID:30640591   PMID:30876926   PMID:31093317   PMID:31251698   PMID:31747615   PMID:31767948   PMID:32235655  
PMID:34116030   PMID:34116237   PMID:37371137   PMID:37428806   PMID:38643118  


Genomics

Comparative Map Data
Mir29b-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,719,348 - 194,719,428 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,719,348 - 194,719,428 (+)EnsemblGRCm39 Ensembl
GRCm381195,037,040 - 195,037,120 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,037,040 - 195,037,120 (+)EnsemblGRCm38mm10GRCm38
MGSCv371196,863,234 - 196,863,314 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1201,936,850 - 201,936,930 (+)NCBICelera
Cytogenetic Map1H6NCBI
cM Map198.41NCBI
MIR29B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381207,802,443 - 207,802,523 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1207,802,443 - 207,802,523 (-)EnsemblGRCh38hg38GRCh38
GRCh371207,975,788 - 207,975,868 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361206,042,410 - 206,042,490 (-)NCBINCBI36Build 36hg18NCBI36
Celera1181,206,266 - 181,206,346 (-)NCBICelera
Cytogenetic Map1q32.2NCBI
HuRef1178,650,018 - 178,650,098 (-)NCBIHuRef
CHM1_11209,248,186 - 209,248,266 (-)NCBICHM1_1
T2T-CHM13v2.01207,049,202 - 207,049,282 (-)NCBIT2T-CHM13v2.0
Mir29b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813109,098,831 - 109,098,911 (+)NCBIGRCr8
mRatBN7.213106,570,371 - 106,570,451 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13106,570,367 - 106,570,456 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13109,087,735 - 109,087,815 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013110,471,562 - 110,471,642 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013107,696,051 - 107,696,131 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013113,782,057 - 113,782,137 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13113,782,057 - 113,782,140 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013118,329,450 - 118,329,530 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413110,967,520 - 110,967,600 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera13105,994,323 - 105,994,403 (+)NCBICelera
Cytogenetic Map13q27NCBI
MIR29B-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.176,651,878 - 6,651,943 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl76,651,866 - 6,651,955 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha76,214,630 - 6,214,695 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.076,340,469 - 6,340,534 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.176,273,321 - 6,273,386 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.076,375,830 - 6,375,895 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.076,416,783 - 6,416,848 (-)NCBIUU_Cfam_GSD_1.0
MIR29B-2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9135,019,075 - 135,019,164 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19135,019,079 - 135,019,162 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29148,552,438 - 148,552,521 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:30300
Count of gene targets:11282
Count of transcripts:19271
Interacting mature miRNAs:mmu-miR-29b-2-5p, mmu-miR-29b-3p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1167954584195154279Mouse
1559024Zit1_mzinc induced tolerance 1 (mouse)Not determined1167462514195154279Mouse
1301652Cpfd2_mcerebellum pattern fissures (mouse)Not determined1172303451195154279Mouse
1301339Hdlq15_mHDL QTL 15 (mouse)Not determined1165873675195154279Mouse
12880429V25Dq1_mvitamin D inactive form serum level QTL 1 (mouse)1172632197195154279Mouse
10043863Swrl5_mSWR lupus locus 5 (mouse)Not determined1172303451195154279Mouse
12880426V25Dq2_mvitamin D inactive form serum level QTL 2 (mouse)1172532197195154279Mouse
11049575Lmr8b_mleishmaniasis resistance 8b (mouse)1172303451195154279Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168213823195154279Mouse
1357732Tbbmd1_mtotal body bone mineral density 1 (mouse)Not determined1171983110195154279Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161201261195154279Mouse
4141483Femwf7_mfemur work to failure 7 (mouse)Not determined167462514195154279Mouse
1302023Orch4_mautoimmune orchitis resistance 4 (mouse)Not determined1175211318195154279Mouse
1302158Fembrs5_mfemur breaking strength 5 (mouse)Not determined1167462514195154279Mouse
1301132Mors1_mmodifier of obesity related sterility 1 (mouse)Not determined1170379500195154279Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000083478
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1194,719,348 - 194,719,428 (+)Ensembl
GRCm38.p6 Ensembl1195,037,040 - 195,037,120 (+)Ensembl
RefSeq Acc Id: NR_029809
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391194,719,348 - 194,719,428 (+)NCBI
GRCm381195,037,040 - 195,037,120 (+)ENTREZGENE
MGSCv371196,863,234 - 196,863,314 (+)RGD
Celera1201,936,850 - 201,936,930 (+)RGD
cM Map1 ENTREZGENE
Sequence:
Promoters
RGD ID:6876190
Promoter ID:EPDNEW_M1546
Type:single initiation site
Name:Mir29b-2_1
Description:Mus musculus microRNA 29b-2 (Mir29b-2), microRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381195,037,117 - 195,037,177EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3619047 AgrOrtholog
Ensembl Genes ENSMUSG00000065412 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083478 ENTREZGENE
MGD MGI:3619047 ENTREZGENE
miRBase MI0000712 ENTREZGENE
NCBI Gene 723963 ENTREZGENE
PhenoGen Mir29b-2 PhenoGen
RNAcentral URS00001E96DA RNACentral
  URS000024463E RNACentral
  URS00003DA595 RNACentral