Mirlet7c-2 (microRNA let7c-2) - Rat Genome Database
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Gene: Mirlet7c-2 (microRNA let7c-2) Mus musculus
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Symbol: Mirlet7c-2
Name: microRNA let7c-2
RGD ID: 1607558
MGI Page MGI
Description: Involved in embryo implantation; long-term synaptic potentiation; and negative regulation of gene expression. Localizes to RISC complex. Is expressed in brain; embryo; and upper jaw incisor. Orthologous to human MIRLET7A3 (microRNA let-7a-3).
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: let-7c-2; Mirnlet; Mirnlet7c-2
RGD Orthologs
Human
Rat
Dog
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391585,590,804 - 85,590,898 (+)NCBIGRCm39mm39
GRCm381585,706,603 - 85,706,697 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1585,706,603 - 85,706,697 (+)EnsemblGRCm38mm10GRCm38
MGSCv371585,537,033 - 85,537,127 (+)NCBIGRCm37mm9NCBIm37
Celera1587,839,385 - 87,839,479 (+)NCBICelera
Cytogenetic Map15E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
atrazine  (ISO)
cisplatin  (ISO)
paracetamol  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
RISC complex  (IDA)

References

References - curated
1. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:12007417   PMID:12919684   PMID:15361871   PMID:15538371   PMID:15845075   PMID:16247770   PMID:16369549   PMID:16381832   PMID:16766679   PMID:17369397   PMID:17604727   PMID:18556655  
PMID:19727952   PMID:19898466   PMID:19949436   PMID:20215419   PMID:20413612   PMID:20424607   PMID:20487000   PMID:21037258   PMID:21267068   PMID:21430230   PMID:22844247   PMID:22895573  
PMID:23185045   PMID:23200853   PMID:23622242   PMID:23667114   PMID:23895693   PMID:25215948   PMID:25294817   PMID:25858512   PMID:26139524   PMID:28049690   PMID:29445149   PMID:30635573  
PMID:31653921  


Genomics

Comparative Map Data
Mirlet7c-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391585,590,804 - 85,590,898 (+)NCBIGRCm39mm39
GRCm381585,706,603 - 85,706,697 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1585,706,603 - 85,706,697 (+)EnsemblGRCm38mm10GRCm38
MGSCv371585,537,033 - 85,537,127 (+)NCBIGRCm37mm9NCBIm37
Celera1587,839,385 - 87,839,479 (+)NCBICelera
Cytogenetic Map15E2NCBI
MIRLET7A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2246,112,749 - 46,112,822 (+)EnsemblGRCh38hg38GRCh38
GRCh382246,112,749 - 46,112,822 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372246,508,629 - 46,508,702 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362244,887,292 - 44,887,365 (+)NCBINCBI36hg18NCBI36
Celera2230,416,003 - 30,416,076 (+)NCBI
Cytogenetic Map22q13.31NCBI
HuRef2229,452,837 - 29,452,910 (+)NCBIHuRef
CHM1_12246,467,543 - 46,467,616 (+)NCBICHM1_1
Mirlet7c2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27116,803,771 - 116,803,865 (+)NCBI
Rnor_6.0 Ensembl7126,590,212 - 126,590,306 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07126,590,212 - 126,590,306 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07126,300,921 - 126,301,015 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera7113,096,624 - 113,096,718 (+)NCBICelera
Cytogenetic Map7q34NCBI
MIRLET7A-1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1020,034,319 - 20,034,387 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11020,034,319 - 20,034,387 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15610000086800000Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156100000100900000Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402117102988123Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800000102100000Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578270103517472Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800000086800000Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154230000095600000Mouse
1300644Fob3_mF-line obesity QTL 3 (mouse)11.3Not determined154414443889377036Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154850000098500000Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548500000101800000Mouse
10412067Pain2_mpain 2 (mouse)Not determined155177349085773777Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155181398385822600Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155193466685934802Mouse
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155370000089700000Mouse
13504731Cath5_mcarotid atherosclerosis 5 (mouse)155491728088917280Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556323312103517472Mouse
27095936Ulnl4_mulna length 4, 5 week (mouse)155690000087800000Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155724515691245304Mouse
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155724515691245304Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156170000095700000Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156327970297279794Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564434485103517472Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156492762598927745Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156545237799456827Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156564117599641298Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567386497101386646Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570461452104043685Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570465070104043685Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570465070104043685Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572498466104043685Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573545941104043685Mouse
1301472Pain1_mpain 1 (mouse)Not determined157544899790928982Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577629711104043685Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78716903102993272Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578716903102993272Mouse
14928306Manh79_mmandible shape 79 (mouse)1578949676104043685Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1579000000104043685Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579265530104043685Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined80011059104043685Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580415753104043685Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580987052104043685Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580987052104043685Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82717593104043685Mouse
11532732Pitm5_mprion incubation time 5 (mouse)158307986087170187Mouse

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Sall4mmu-let-7c-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI20054295
Mycmmu-let-7c-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR;OthFunctional MTI17438130
Mycmmu-let-7c-5pMirtarbaseexternal_infoMicroarray//qRT-PCR//Western blotFunctional MTI20054295
Mycmmu-let-7c-5pTarbaseexternal_infoqPCRPOSITIVE
Pak1mmu-let-7c-5pOncomiRDBexternal_infoNANA23339187
Hmga2mmu-let-7c-5pOncomiRDBexternal_infoNANA23318420
Mycnmmu-let-7c-5pOncomiRDBexternal_infoNANA23042116
Pbx2mmu-let-7c-5pOncomiRDBexternal_infoNANA22964640
Has2mmu-let-7c-5pOncomiRDBexternal_infoNANA22871741
Ezh2mmu-let-7c-5pOncomiRDBexternal_infoNANA22442719
Krasmmu-let-7c-5pOncomiRDBexternal_infoNANA21984339
Fasmmu-let-7c-5pOncomiRDBexternal_infoNANA21530489
Socs1mmu-let-7c-5pOncomiRDBexternal_infoNANA21352471
Lin28ammu-let-7c-5pOncomiRDBexternal_infoNANA21045151
Esr1mmu-let-7c-5pOncomiRDBexternal_infoNANA20535543
Nol3mmu-let-7c-5pOncomiRDBexternal_infoNANA20525879
Bcl2l1mmu-let-7c-5pOncomiRDBexternal_infoNANA20347499
Il6mmu-let-7c-5pOncomiRDBexternal_infoNANA19878981
Hmga2mmu-let-7c-5pOncomiRDBexternal_infoNANA19153603
Dicer1mmu-let-7c-5pOncomiRDBexternal_infoNANA18700235
Hmga2mmu-let-7c-5pOncomiRDBexternal_infoNANA18403645
Hmga2mmu-let-7c-5pOncomiRDBexternal_infoNANA17600087
Hmga2mmu-let-7c-5pOncomiRDBexternal_infoNANA17437991
Hmga2mmu-let-7c-5pOncomiRDBexternal_infoNANA17322030
Krasmmu-let-7c-5pOncomiRDBexternal_infoNANA15766527

Predicted Targets
Summary Value
Count of predictions:29148
Count of gene targets:10642
Count of transcripts:17888
Interacting mature miRNAs:mmu-let-7c-2-3p, mmu-let-7c-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000083674
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1585,706,603 - 85,706,697 (+)Ensembl
RefSeq Acc Id: NR_029729
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391585,590,804 - 85,590,898 (+)NCBI
GRCm381585,706,603 - 85,706,697 (+)ENTREZGENE
MGSCv371585,537,033 - 85,537,127 (+)RGD
Celera1587,839,385 - 87,839,479 (+)RGD
cM Map15 ENTREZGENE
Sequence:
Promoters
RGD ID:8684640
Promoter ID:EPDNEW_M20350
Type:single initiation site
Name:Mirlet7c-2_1
Description:Mus musculus microRNA let7c-2 (Mirlet7c-2), microRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381585,706,618 - 85,706,678EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3619050 AgrOrtholog
Ensembl Genes ENSMUSG00000065608 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083674 ENTREZGENE
MGD MGI:3619050 ENTREZGENE
miRBase MI0000560 ENTREZGENE
NCBI Gene 723966 ENTREZGENE
PhenoGen Mirlet7c-2 PhenoGen
RNAcentral URS000022B6DD RNACentral
  URS000050DE77 RNACentral
  URS000075BB63 RNACentral