FAM133B (family with sequence similarity 133 member B) - Rat Genome Database

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Gene: FAM133B (family with sequence similarity 133 member B) Homo sapiens
Analyze
Symbol: FAM133B
Name: family with sequence similarity 133 member B
RGD ID: 1606931
HGNC Page HGNC:28629
Description: Enables RNA binding activity.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: family with sequence similarity 133, member B; hypothetical protein LOC257415; MGC40405
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: FAM133CP   FAM133DP   LOC100421561  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38792,560,758 - 92,590,390 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl792,560,758 - 92,590,393 (-)EnsemblGRCh38hg38GRCh38
GRCh37792,190,072 - 92,219,704 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36792,028,008 - 92,057,642 (-)NCBINCBI36Build 36hg18NCBI36
Celera786,894,604 - 86,924,236 (-)NCBICelera
Cytogenetic Map7q21.2NCBI
HuRef786,799,447 - 86,829,074 (-)NCBIHuRef
CHM1_1792,120,110 - 92,149,746 (-)NCBICHM1_1
T2T-CHM13v2.0793,802,706 - 93,832,343 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2791,519,294 - 91,548,926 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function
RNA binding  (HDA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11076863   PMID:11230166   PMID:12477932   PMID:12690205   PMID:15489336   PMID:16381901   PMID:21832049   PMID:22190034   PMID:22681889   PMID:24163370   PMID:25852190   PMID:26496610  
PMID:30196744   PMID:30463901   PMID:30472188   PMID:30997501   PMID:31076518   PMID:31527615   PMID:32513696   PMID:32807901   PMID:33961781   PMID:35013218   PMID:35831314   PMID:35944360  
PMID:36574265   PMID:36724073   PMID:37616343   PMID:38113892  


Genomics

Comparative Map Data
FAM133B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38792,560,758 - 92,590,390 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl792,560,758 - 92,590,393 (-)EnsemblGRCh38hg38GRCh38
GRCh37792,190,072 - 92,219,704 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36792,028,008 - 92,057,642 (-)NCBINCBI36Build 36hg18NCBI36
Celera786,894,604 - 86,924,236 (-)NCBICelera
Cytogenetic Map7q21.2NCBI
HuRef786,799,447 - 86,829,074 (-)NCBIHuRef
CHM1_1792,120,110 - 92,149,746 (-)NCBICHM1_1
T2T-CHM13v2.0793,802,706 - 93,832,343 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2791,519,294 - 91,548,926 (-)NCBI
Fam133b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3953,593,833 - 3,620,548 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl53,593,833 - 3,620,238 (+)EnsemblGRCm39 Ensembl
GRCm3853,543,833 - 3,570,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl53,543,833 - 3,570,238 (+)EnsemblGRCm38mm10GRCm38
MGSCv3753,543,833 - 3,570,548 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3653,549,850 - 3,575,817 (+)NCBIMGSCv36mm8
Celera53,479,777 - 3,506,492 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.22NCBI
Fam133b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8431,544,458 - 31,571,056 (-)NCBIGRCr8
mRatBN7.2430,589,646 - 30,616,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl430,589,635 - 30,616,040 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx435,562,476 - 35,588,799 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0431,488,560 - 31,514,883 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0429,884,597 - 29,910,919 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0427,728,883 - 27,755,182 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl427,730,051 - 27,755,103 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0427,632,125 - 27,658,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4427,305,922 - 27,332,221 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1427,332,822 - 27,349,419 (-)NCBI
Celera426,014,093 - 26,040,392 (-)NCBICelera
Cytogenetic Map4q13NCBI
Fam133b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554329,484,972 - 9,502,485 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554329,484,967 - 9,502,484 (-)NCBIChiLan1.0ChiLan1.0
FAM133B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26110,446,977 - 110,476,694 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17158,711,686 - 158,741,352 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0784,559,264 - 84,589,085 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1798,154,953 - 98,184,213 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl798,156,201 - 98,184,114 (-)Ensemblpanpan1.1panPan2
FAM133B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11418,145,882 - 18,168,367 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl130,781,898 - 30,783,509 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1418,147,576 - 18,168,274 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1417,706,754 - 17,729,075 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01417,952,687 - 17,975,186 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11418,113,143 - 18,135,428 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01417,825,217 - 17,847,483 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01418,099,459 - 18,121,970 (-)NCBIUU_Cfam_GSD_1.0
Fam133b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511831,533,094 - 31,556,759 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368031,243,268 - 1,265,292 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368031,243,180 - 1,266,500 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM133B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl972,472,338 - 72,503,756 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1972,470,990 - 72,503,822 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2979,200,174 - 79,232,806 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FAM133B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12156,420,342 - 56,449,685 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604247,830,947 - 47,860,341 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam133b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624809597,656 - 640,691 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624809597,535 - 643,122 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FAM133B
11 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q21.11-21.3(chr7:84002634-95228883)x1 copy number loss See cases [RCV000143271] Chr7:84002634..95228883 [GRCh38]
Chr7:83631950..94858195 [GRCh37]
Chr7:83469886..94696131 [NCBI36]
Chr7:7q21.11-21.3		 pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
Single allele deletion not provided [RCV000677988] Chr7:73591993..93683437 [GRCh37]
Chr7:7q11.23-21.3		 uncertain significance
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q21.12-22.1(chr7:87477185-100333327) copy number gain Isolated Pierre-Robin syndrome [RCV001352649] Chr7:87477185..100333327 [GRCh37]
Chr7:7q21.12-22.1		 pathogenic
GRCh37/hg19 7q21.11-21.3(chr7:77821356-93340137) copy number gain not specified [RCV002053701] Chr7:77821356..93340137 [GRCh37]
Chr7:7q21.11-21.3		 pathogenic
GRCh37/hg19 7q21.2-21.3(chr7:92044792-93320149) copy number loss not specified [RCV002053709] Chr7:92044792..93320149 [GRCh37]
Chr7:7q21.2-21.3		 uncertain significance
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3		 uncertain significance
NM_152789.4(FAM133B):c.463A>C (p.Lys155Gln) single nucleotide variant Inborn genetic diseases [RCV002850614] Chr7:92577105 [GRCh38]
Chr7:92206419 [GRCh37]
Chr7:7q21.2		 uncertain significance
NM_152789.4(FAM133B):c.221A>G (p.Glu74Gly) single nucleotide variant Inborn genetic diseases [RCV003211774] Chr7:92578374 [GRCh38]
Chr7:92207688 [GRCh37]
Chr7:7q21.2		 uncertain significance
NM_152789.4(FAM133B):c.631A>C (p.Ser211Arg) single nucleotide variant Inborn genetic diseases [RCV003305198] Chr7:92566040 [GRCh38]
Chr7:92195354 [GRCh37]
Chr7:7q21.2		 uncertain significance
NM_152789.4(FAM133B):c.143T>C (p.Leu48Pro) single nucleotide variant Inborn genetic diseases [RCV003360341] Chr7:92579375 [GRCh38]
Chr7:92208689 [GRCh37]
Chr7:7q21.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1874
Count of miRNA genes:704
Interacting mature miRNAs:815
Transcripts:ENST00000415397, ENST00000427372, ENST00000438306, ENST00000445716, ENST00000456502, ENST00000468931, ENST00000480397, ENST00000481407, ENST00000490747, ENST00000492686, ENST00000494079
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G31807  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37792,195,233 - 92,195,336UniSTSGRCh37
Build 36792,033,169 - 92,033,272RGDNCBI36
Celera786,899,765 - 86,899,868RGD
Cytogenetic Map7q21.2UniSTS
HuRef786,804,608 - 86,804,711UniSTS
CRA_TCAGchr7v2791,524,455 - 91,524,558UniSTS
WI-17941  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37792,193,830 - 92,193,979UniSTSGRCh37
Build 36792,031,766 - 92,031,915RGDNCBI36
Celera786,898,362 - 86,898,511RGD
Cytogenetic Map7q21.2UniSTS
HuRef786,803,205 - 86,803,354UniSTS
CRA_TCAGchr7v2791,523,052 - 91,523,201UniSTS
GeneMap99-GB4 RH Map7497.56UniSTS
Whitehead-RH Map7462.8UniSTS
NCBI RH Map71036.4UniSTS
G37003  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37792,193,554 - 92,193,697UniSTSGRCh37
Build 36792,031,490 - 92,031,633RGDNCBI36
Celera786,898,086 - 86,898,229RGD
Cytogenetic Map7q21.2UniSTS
HuRef786,802,929 - 86,803,072UniSTS
CRA_TCAGchr7v2791,522,776 - 91,522,919UniSTS
G37002  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37792,207,173 - 92,207,332UniSTSGRCh37
Build 36792,045,109 - 92,045,268RGDNCBI36
Celera786,911,705 - 86,911,864RGD
Cytogenetic Map7q21.2UniSTS
HuRef786,816,548 - 86,816,707UniSTS
CRA_TCAGchr7v2791,536,395 - 91,536,554UniSTS
D17S1560  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q21.2UniSTS
Cytogenetic Map2q24.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 664 440 750 110 477 88 1583 274 1203 185 840 1000 35 436 906 3
Low 1774 2438 975 511 1366 376 2773 1920 2530 234 620 613 138 1 768 1882 2
Below cutoff 112 1 1 108 1 3 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001040057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001288584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_152789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_109929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC005156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL833918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC073952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC090868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU581457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX337761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000415397   ⟹   ENSP00000389559
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl792,561,137 - 92,590,329 (-)Ensembl
RefSeq Acc Id: ENST00000427372   ⟹   ENSP00000402843
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl792,562,282 - 92,590,070 (-)Ensembl
RefSeq Acc Id: ENST00000438306   ⟹   ENSP00000389783
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl792,560,793 - 92,590,393 (-)Ensembl
RefSeq Acc Id: ENST00000445716   ⟹   ENSP00000398401
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl792,560,758 - 92,590,390 (-)Ensembl
RefSeq Acc Id: ENST00000456502   ⟹   ENSP00000407458
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl792,581,506 - 92,590,030 (-)Ensembl
RefSeq Acc Id: ENST00000468931
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl792,566,050 - 92,575,854 (-)Ensembl
RefSeq Acc Id: ENST00000480397
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl792,579,155 - 92,590,338 (-)Ensembl
RefSeq Acc Id: ENST00000481407
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl792,561,216 - 92,590,390 (-)Ensembl
RefSeq Acc Id: ENST00000490747
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl792,569,542 - 92,577,394 (-)Ensembl
RefSeq Acc Id: ENST00000492686
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl792,578,319 - 92,581,806 (-)Ensembl
RefSeq Acc Id: ENST00000494079   ⟹   ENSP00000446324
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl792,565,508 - 92,577,717 (-)Ensembl
RefSeq Acc Id: NM_001040057   ⟹   NP_001035146
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38792,560,758 - 92,590,390 (-)NCBI
GRCh37792,190,072 - 92,219,706 (-)RGD
Build 36792,028,008 - 92,057,642 (-)NCBI Archive
Celera786,894,604 - 86,924,236 (-)RGD
HuRef786,799,447 - 86,829,076 (-)NCBI
CHM1_1792,120,110 - 92,149,748 (-)NCBI
T2T-CHM13v2.0793,802,706 - 93,832,343 (-)NCBI
CRA_TCAGchr7v2791,519,294 - 91,548,926 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001288584   ⟹   NP_001275513
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38792,560,758 - 92,590,049 (-)NCBI
HuRef786,799,447 - 86,829,076 (-)NCBI
CHM1_1792,120,110 - 92,149,424 (-)NCBI
T2T-CHM13v2.0793,802,706 - 93,832,002 (-)NCBI
Sequence:
RefSeq Acc Id: NM_152789   ⟹   NP_690002
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38792,560,758 - 92,590,390 (-)NCBI
GRCh37792,190,072 - 92,219,706 (-)RGD
Build 36792,028,008 - 92,057,642 (-)NCBI Archive
Celera786,894,604 - 86,924,236 (-)RGD
HuRef786,799,447 - 86,829,076 (-)NCBI
CHM1_1792,120,110 - 92,149,748 (-)NCBI
T2T-CHM13v2.0793,802,706 - 93,832,343 (-)NCBI
CRA_TCAGchr7v2791,519,294 - 91,548,926 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NR_109929
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38792,560,758 - 92,590,390 (-)NCBI
HuRef786,799,447 - 86,829,076 (-)NCBI
CHM1_1792,120,110 - 92,149,748 (-)NCBI
T2T-CHM13v2.0793,802,706 - 93,832,343 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001035146   ⟸   NM_001040057
- Peptide Label: isoform 2
- UniProtKB: Q5BKY9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_690002   ⟸   NM_152789
- Peptide Label: isoform 1
- UniProtKB: Q6P5S6 (UniProtKB/Swiss-Prot),   Q05D67 (UniProtKB/Swiss-Prot),   B2R994 (UniProtKB/Swiss-Prot),   Q8N0W8 (UniProtKB/Swiss-Prot),   Q5BKY9 (UniProtKB/Swiss-Prot),   B2RXJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001275513   ⟸   NM_001288584
- Peptide Label: isoform 2
- UniProtKB: Q5BKY9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000389783   ⟸   ENST00000438306
RefSeq Acc Id: ENSP00000402843   ⟸   ENST00000427372
RefSeq Acc Id: ENSP00000389559   ⟸   ENST00000415397
RefSeq Acc Id: ENSP00000446324   ⟸   ENST00000494079
RefSeq Acc Id: ENSP00000407458   ⟸   ENST00000456502
RefSeq Acc Id: ENSP00000398401   ⟸   ENST00000445716

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BKY9-F1-model_v2 AlphaFold Q5BKY9 1-247 view protein structure

Promoters
RGD ID:6805649
Promoter ID:HG_KWN:58579
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Jurkat
Transcripts:OTTHUMT00000342184
Position:
Human AssemblyChrPosition (strand)Source
Build 36792,043,096 - 92,043,596 (-)MPROMDB
RGD ID:6805651
Promoter ID:HG_KWN:58580
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Jurkat
Transcripts:OTTHUMT00000342185,   OTTHUMT00000342188
Position:
Human AssemblyChrPosition (strand)Source
Build 36792,044,396 - 92,045,397 (-)MPROMDB
RGD ID:6805650
Promoter ID:HG_KWN:58581
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Jurkat
Transcripts:OTTHUMT00000342187
Position:
Human AssemblyChrPosition (strand)Source
Build 36792,048,596 - 92,049,096 (-)MPROMDB
RGD ID:6805659
Promoter ID:HG_KWN:58582
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000342060,   OTTHUMT00000342061,   OTTHUMT00000342062,   OTTHUMT00000342181,   OTTHUMT00000342182,   OTTHUMT00000342183,   OTTHUMT00000342186,   UC003UMD.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36792,057,296 - 92,057,796 (-)MPROMDB
RGD ID:7211069
Promoter ID:EPDNEW_H11280
Type:initiation region
Name:FAM133B_1
Description:family with sequence similarity 133 member B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38792,590,345 - 92,590,405EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:28629 AgrOrtholog
COSMIC FAM133B COSMIC
Ensembl Genes ENSG00000234545 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000415397 ENTREZGENE
  ENST00000415397.6 UniProtKB/TrEMBL
  ENST00000427372 ENTREZGENE
  ENST00000427372.5 UniProtKB/Swiss-Prot
  ENST00000438306 ENTREZGENE
  ENST00000438306.5 UniProtKB/Swiss-Prot
  ENST00000445716 ENTREZGENE
  ENST00000445716.6 UniProtKB/Swiss-Prot
  ENST00000456502.1 UniProtKB/TrEMBL
  ENST00000494079.1 UniProtKB/TrEMBL
GTEx ENSG00000234545 GTEx
HGNC ID HGNC:28629 ENTREZGENE
Human Proteome Map FAM133B Human Proteome Map
InterPro Fam133 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:257415 UniProtKB/Swiss-Prot
NCBI Gene 257415 ENTREZGENE
PANTHER PROTEIN FAM133B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR31911 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA162386138 PharmGKB
UniProt B2R994 ENTREZGENE
  B2RXJ1 ENTREZGENE, UniProtKB/TrEMBL
  C9JUX2_HUMAN UniProtKB/TrEMBL
  F133B_HUMAN UniProtKB/Swiss-Prot
  G3XAI9_HUMAN UniProtKB/TrEMBL
  H0YH72_HUMAN UniProtKB/TrEMBL
  Q05D67 ENTREZGENE
  Q5BKY9 ENTREZGENE
  Q6P5S6 ENTREZGENE
  Q8N0W8 ENTREZGENE
UniProt Secondary B2R994 UniProtKB/Swiss-Prot
  Q05D67 UniProtKB/Swiss-Prot
  Q6P5S6 UniProtKB/Swiss-Prot
  Q8N0W8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 FAM133B  family with sequence similarity 133 member B    family with sequence similarity 133, member B  Symbol and/or name change 5135510 APPROVED