TMEM81 (transmembrane protein 81) - Rat Genome Database
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Gene: TMEM81 (transmembrane protein 81) Homo sapiens
Analyze
Symbol: TMEM81
Name: transmembrane protein 81
RGD ID: 1606867
HGNC Page HGNC
Description: Predicted to localize to integral component of membrane; INTERACTS WITH pentanal; trichostatin A; urethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: HC3107; KVLA2788; MGC75217; UNQ2788
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1205,083,129 - 205,084,460 (-)EnsemblGRCh38hg38GRCh38
GRCh381205,083,129 - 205,084,460 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371205,052,257 - 205,053,588 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361203,318,880 - 203,320,211 (-)NCBINCBI36hg18NCBI36
Celera1178,187,174 - 178,188,505 (-)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1176,217,507 - 176,218,838 (-)NCBIHuRef
CHM1_11206,475,588 - 206,476,919 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12975309  


Genomics

Comparative Map Data
TMEM81
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1205,083,129 - 205,084,460 (-)EnsemblGRCh38hg38GRCh38
GRCh381205,083,129 - 205,084,460 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371205,052,257 - 205,053,588 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361203,318,880 - 203,320,211 (-)NCBINCBI36hg18NCBI36
Celera1178,187,174 - 178,188,505 (-)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1176,217,507 - 176,218,838 (-)NCBIHuRef
CHM1_11206,475,588 - 206,476,919 (-)NCBICHM1_1
Tmem81
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391132,433,968 - 132,436,382 (+)NCBIGRCm39mm39
GRCm381132,506,230 - 132,508,644 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,506,230 - 132,508,639 (+)EnsemblGRCm38mm10GRCm38
MGSCv371134,402,807 - 134,405,216 (+)NCBIGRCm37mm9NCBIm37
MGSCv361134,333,776 - 134,336,183 (+)NCBImm8
Celera1135,114,902 - 135,117,311 (+)NCBICelera
Cytogenetic Map1E4NCBI
Tmem81
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01349,277,722 - 49,280,153 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1349,277,722 - 49,280,151 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01354,353,122 - 54,355,553 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41345,392,327 - 45,394,758 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1344,274,257 - 44,276,688 (+)NCBICelera
Cytogenetic Map13q13NCBI
Tmem81
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540640,865,574 - 40,867,602 (-)NCBIChiLan1.0ChiLan1.0
TMEM81
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11184,971,622 - 184,973,091 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1184,972,046 - 184,972,813 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01180,685,214 - 180,686,789 (-)NCBIMhudiblu_PPA_v0panPan3
TMEM81
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl381,604,288 - 1,605,254 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1381,604,068 - 1,606,594 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tmem81
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365577,291,797 - 7,295,484 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM81
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl965,780,934 - 65,781,891 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1965,780,520 - 65,782,831 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2972,006,389 - 72,007,704 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM81
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12524,255,997 - 24,258,150 (+)NCBI
ChlSab1.1 Ensembl2524,256,951 - 24,257,718 (+)Ensembl
Tmem81
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248076,048,422 - 6,049,961 (+)NCBI

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:267
Count of miRNA genes:234
Interacting mature miRNAs:249
Transcripts:ENST00000367167
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 61 67 95 15 146 16 193 109 775 20 480 135 6 113
Low 2370 2894 1628 607 1778 448 4161 2082 2932 398 968 1473 170 1197 2675 4
Below cutoff 1 23 23 1 2 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000367167   ⟹   ENSP00000356135
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1205,083,129 - 205,084,460 (-)Ensembl
RefSeq Acc Id: NM_203376   ⟹   NP_976310
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381205,083,129 - 205,084,460 (-)NCBI
GRCh371205,052,257 - 205,053,588 (-)RGD
Build 361203,318,880 - 203,320,211 (-)NCBI Archive
Celera1178,187,174 - 178,188,505 (-)RGD
HuRef1176,217,507 - 176,218,838 (-)ENTREZGENE
CHM1_11206,475,588 - 206,476,919 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_976310 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61592 (Get FASTA)   NCBI Sequence Viewer  
  AAQ89440 (Get FASTA)   NCBI Sequence Viewer  
  BAG64482 (Get FASTA)   NCBI Sequence Viewer  
  EAW91535 (Get FASTA)   NCBI Sequence Viewer  
  Q6P7N7 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_976310   ⟸   NM_203376
- Peptide Label: precursor
- UniProtKB: Q6P7N7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000356135   ⟸   ENST00000367167
Protein Domains
Ig-like


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11
pathogenic
GRCh38/hg38 1q32.1-32.2(chr1:204990129-210220258)x3 copy number gain See cases [RCV000051859] Chr1:204990129..210220258 [GRCh38]
Chr1:204959257..210572305 [GRCh37]
Chr1:203225880..208638928 [NCBI36]
Chr1:1q32.1-32.2
pathogenic
GRCh38/hg38 1q32.1-42.12(chr1:204764914-225408698)x3 copy number gain See cases [RCV000142054] Chr1:204764914..225408698 [GRCh38]
Chr1:204734042..225596400 [GRCh37]
Chr1:203000665..223663023 [NCBI36]
Chr1:1q32.1-42.12
pathogenic
GRCh37/hg19 1q31.3-42.13(chr1:197811907-228997888)x3 copy number gain See cases [RCV000240137] Chr1:197811907..228997888 [GRCh37]
Chr1:1q31.3-42.13
pathogenic
GRCh37/hg19 1q31.3-44(chr1:195483439-249213000)x3 copy number gain See cases [RCV000449172] Chr1:195483439..249213000 [GRCh37]
Chr1:1q31.3-44
pathogenic
GRCh37/hg19 1q32.1(chr1:204907784-205052260)x3 copy number gain See cases [RCV000447209] Chr1:204907784..205052260 [GRCh37]
Chr1:1q32.1
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q32.1-32.3(chr1:204682513-212815646) copy number loss Global developmental delay [RCV000626524] Chr1:204682513..212815646 [GRCh37]
Chr1:1q32.1-32.3
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NC_000001.11:g.(?_204033173)_(208209798_?)del deletion Autistic disorder of childhood onset [RCV000754138] Chr1:204033173..208209798 [GRCh38]
Chr1:1q32.1-32.2
likely pathogenic
GRCh37/hg19 1q25.3-41(chr1:185644663-221698833)x3 copy number gain not provided [RCV000749265] Chr1:185644663..221698833 [GRCh37]
Chr1:1q25.3-41
pathogenic
GRCh37/hg19 1q32.1(chr1:204954317-205346803)x1 copy number loss not provided [RCV001005168] Chr1:204954317..205346803 [GRCh37]
Chr1:1q32.1
uncertain significance
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44
pathogenic
GRCh37/hg19 1q31.3-32.2(chr1:194356425-210988710)x3 copy number gain not provided [RCV001249273] Chr1:194356425..210988710 [GRCh37]
Chr1:1q31.3-32.2
not provided
GRCh37/hg19 1q32.1-44(chr1:204045948-249218992)x3 copy number gain See cases [RCV001007407] Chr1:204045948..249218992 [GRCh37]
Chr1:1q32.1-44
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:32349 AgrOrtholog
COSMIC TMEM81 COSMIC
Ensembl Genes ENSG00000174529 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000356135 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000367167 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000174529 GTEx
HGNC ID HGNC:32349 ENTREZGENE
Human Proteome Map TMEM81 Human Proteome Map
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  TMEM81 UniProtKB/Swiss-Prot
KEGG Report hsa:388730 UniProtKB/Swiss-Prot
NCBI Gene 388730 ENTREZGENE
PANTHER PTHR35670 UniProtKB/Swiss-Prot
PharmGKB PA143485633 PharmGKB
PROSITE IG_LIKE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt Q6P7N7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q6UVZ4 UniProtKB/Swiss-Prot