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Gene: TAAR2 (trace amine associated receptor 2) Homo sapiens

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Symbol:

TAAR2

Name:

trace amine associated receptor 2

RGD ID:

1606827

HGNC Page

HGNC:4514

Description:

Predicted to enable trace-amine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

G protein-coupled receptor 58; G-protein coupled receptor 58; GPR58; taR-2; trace amine associated receptor 2 (gene/pseudogene); trace amine receptor 2; trace amine-associated receptor 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	132,617,150 - 132,624,275 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	132,617,022 - 132,624,275 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	132,938,289 - 132,945,414 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	132,979,982 - 132,987,107 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	6	133,685,125 - 133,692,251 (-)	NCBI		Celera
Cytogenetic Map	6	q23.2	NCBI
HuRef	6	130,513,205 - 130,520,335 (-)	NCBI		HuRef
CHM1_1	6	133,201,961 - 133,209,075 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	133,812,108 - 133,819,243 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

aflatoxin B1 (EXP)

atrazine (EXP)

benzo[a]pyrene (EXP)

bisphenol A (EXP,ISO)

CGP 52608 (EXP)

trichloroethene (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

G protein-coupled receptor signaling pathway (IBA,IEA,TAS)

Cellular Component

membrane (IEA)

plasma membrane (IBA,IEA)

Molecular Function

G protein-coupled receptor activity (IEA,TAS)

trace-amine receptor activity (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10684976	PMID:12477932	PMID:14574404	PMID:15489334	PMID:15718104	PMID:16878137	PMID:18240029	PMID:21873635	PMID:23315425	PMID:24163370

Genomics

Comparative Map Data

TAAR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	132,617,150 - 132,624,275 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	132,617,022 - 132,624,275 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	132,938,289 - 132,945,414 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	132,979,982 - 132,987,107 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	6	133,685,125 - 133,692,251 (-)	NCBI		Celera
Cytogenetic Map	6	q23.2	NCBI
HuRef	6	130,513,205 - 130,520,335 (-)	NCBI		HuRef
CHM1_1	6	133,201,961 - 133,209,075 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	133,812,108 - 133,819,243 (-)	NCBI		T2T-CHM13v2.0

Taar2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	23,814,470 - 23,817,481 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	23,814,470 - 23,817,481 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	23,938,572 - 23,941,583 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	23,938,572 - 23,941,583 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	23,658,378 - 23,661,389 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	23,627,988 - 23,630,999 (+)	NCBI		MGSCv36	mm8
Celera	10	24,872,067 - 24,875,079 (+)	NCBI		Celera
Cytogenetic Map	10	A4	NCBI
cM Map	10	11.4	NCBI

Taar2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	23,319,526 - 23,323,495 (-)	NCBI		GRCr8
mRatBN7.2	1	21,500,290 - 21,504,259 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	21,500,067 - 21,504,299 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	21,277,273 - 21,281,245 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	27,277,318 - 27,281,290 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	21,476,907 - 21,480,882 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	22,578,025 - 22,581,994 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	22,578,025 - 22,581,994 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	24,052,952 - 24,056,922 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	22,027,912 - 22,031,881 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	22,030,856 - 22,034,826 (-)	NCBI
Celera	1	20,243,653 - 20,247,622 (-)	NCBI		Celera
Cytogenetic Map	1	p12	NCBI

TAAR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	152,599,973 - 152,600,967 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	150,507,054 - 150,508,048 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	130,393,716 - 130,394,710 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	134,501,267 - 134,502,261 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	134,501,267 - 134,508,387 (-)	Ensembl	panpan1.1		panPan2

LOC100686959
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Dog10K_Boxer_Tasha	1	26,653,606 - 26,654,633 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	25,577,519 - 25,578,547 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	1	25,623,590 - 25,624,617 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	25,522,382 - 25,523,409 (-)	NCBI		UNSW_CanFamBas_1.0

TAAR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	31,073,654 - 31,074,574 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	31,067,713 - 31,074,574 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	34,587,889 - 34,594,760 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TAAR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	40,901,944 - 40,929,519 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	40,921,295 - 40,928,506 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	13,110,187 - 13,117,320 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Taar2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624952	721,912 - 727,169 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TAAR2
29 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 6q23.2(chr6:132455272-133141153)x3	copy number gain	See cases [RCV000053388]	Chr6:132455272..133141153 [GRCh38] Chr6:132776411..133462292 [GRCh37] Chr6:132818104..133503985 [NCBI36] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.900G>A (p.Leu300=)	single nucleotide variant	Malignant melanoma [RCV000067125]	Chr6:132617306 [GRCh38] Chr6:132938445 [GRCh37] Chr6:132980138 [NCBI36] Chr6:6q23.2	not provided
NM_001033080.1(TAAR2):c.420T>C (p.Asp140=)	single nucleotide variant	Lung cancer [RCV000096534]	Chr6:132617786 [GRCh38] Chr6:132938925 [GRCh37] Chr6:6q23.2	uncertain significance
GRCh38/hg38 6q13-24.1(chr6:74382807-142040500)x3	copy number gain	See cases [RCV000139729]	Chr6:74382807..142040500 [GRCh38] Chr6:75092523..142361637 [GRCh37] Chr6:75149243..142403330 [NCBI36] Chr6:6q13-24.1	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3	copy number gain	See cases [RCV000512067]	Chr6:156975..170919482 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)	copy number gain	See cases [RCV000510595]	Chr6:156975..170919482 [GRCh37] Chr6:6p25.3-q27	pathogenic
NM_001033080.1(TAAR2):c.533T>A (p.Val178Glu)	single nucleotide variant	not specified [RCV004320722]	Chr6:132617673 [GRCh38] Chr6:132938812 [GRCh37] Chr6:6q23.2	uncertain significance
GRCh37/hg19 6q23.2-23.3(chr6:131388023-137469640)x1	copy number loss	not provided [RCV000682724]	Chr6:131388023..137469640 [GRCh37] Chr6:6q23.2-23.3	pathogenic
GRCh37/hg19 6q23.2-23.3(chr6:132002460-137160850)x1	copy number loss	not provided [RCV000682725]	Chr6:132002460..137160850 [GRCh37] Chr6:6q23.2-23.3	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3	copy number gain	not provided [RCV000745400]	Chr6:60107..171054786 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3	copy number gain	not provided [RCV000745403]	Chr6:108666..170980171 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3	copy number gain	not provided [RCV000745404]	Chr6:165632..170919470 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6q23.2(chr6:132926920-133314722)x3	copy number gain	not provided [RCV000849414]	Chr6:132926920..133314722 [GRCh37] Chr6:6q23.2	uncertain significance
Single allele	deletion	Interstitial 6q microdeletion syndrome [RCV002280353]	Chr6:115941808..133892653 [GRCh38] Chr6:6q22.1-23.2	pathogenic
GRCh37/hg19 6q23.2(chr6:132875123-133509642)x3	copy number gain	not provided [RCV001834192]	Chr6:132875123..133509642 [GRCh37] Chr6:6q23.2	uncertain significance
GRCh37/hg19 6q23.1-23.3(chr6:130769034-136009217)x1	copy number loss	not provided [RCV001829086]	Chr6:130769034..136009217 [GRCh37] Chr6:6q23.1-23.3	pathogenic
NM_001033080.1(TAAR2):c.382A>G (p.Ile128Val)	single nucleotide variant	not specified [RCV004100860]	Chr6:132617824 [GRCh38] Chr6:132938963 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.115T>C (p.Ser39Pro)	single nucleotide variant	not specified [RCV004138820]	Chr6:132618091 [GRCh38] Chr6:132939230 [GRCh37] Chr6:6q23.2	likely benign
NM_001033080.1(TAAR2):c.1025C>A (p.Thr342Asn)	single nucleotide variant	not specified [RCV004085511]	Chr6:132617181 [GRCh38] Chr6:132938320 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.668C>A (p.Ser223Tyr)	single nucleotide variant	not specified [RCV004163066]	Chr6:132617538 [GRCh38] Chr6:132938677 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.772A>C (p.Lys258Gln)	single nucleotide variant	not specified [RCV004166867]	Chr6:132617434 [GRCh38] Chr6:132938573 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.942A>G (p.Ile314Met)	single nucleotide variant	not specified [RCV004201383]	Chr6:132617264 [GRCh38] Chr6:132938403 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.407C>T (p.Ser136Leu)	single nucleotide variant	not specified [RCV004119468]	Chr6:132617799 [GRCh38] Chr6:132938938 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.740G>A (p.Arg247Gln)	single nucleotide variant	not specified [RCV004236824]	Chr6:132617466 [GRCh38] Chr6:132938605 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.301A>G (p.Met101Val)	single nucleotide variant	not specified [RCV004124743]	Chr6:132617905 [GRCh38] Chr6:132939044 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.943T>C (p.Tyr315His)	single nucleotide variant	not specified [RCV004071175]	Chr6:132617263 [GRCh38] Chr6:132938402 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.642T>G (p.Phe214Leu)	single nucleotide variant	not specified [RCV004124858]	Chr6:132617564 [GRCh38] Chr6:132938703 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.311C>G (p.Ser104Trp)	single nucleotide variant	not specified [RCV004087786]	Chr6:132617895 [GRCh38] Chr6:132939034 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.658A>G (p.Thr220Ala)	single nucleotide variant	not specified [RCV004222619]	Chr6:132617548 [GRCh38] Chr6:132938687 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.729C>G (p.Ile243Met)	single nucleotide variant	not specified [RCV004249078]	Chr6:132617477 [GRCh38] Chr6:132938616 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.611T>C (p.Met204Thr)	single nucleotide variant	not specified [RCV004325541]	Chr6:132617595 [GRCh38] Chr6:132938734 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.935C>T (p.Pro312Leu)	single nucleotide variant	not specified [RCV004258236]	Chr6:132617271 [GRCh38] Chr6:132938410 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.716A>G (p.His239Arg)	single nucleotide variant	not specified [RCV004344492]	Chr6:132617490 [GRCh38] Chr6:132938629 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.158C>T (p.Ser53Phe)	single nucleotide variant	not specified [RCV004358348]	Chr6:132618048 [GRCh38] Chr6:132939187 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.731A>G (p.Asn244Ser)	single nucleotide variant	not specified [RCV004359264]	Chr6:132617475 [GRCh38] Chr6:132938614 [GRCh37] Chr6:6q23.2	uncertain significance
GRCh37/hg19 6q23.2(chr6:132926527-133319409)x3	copy number gain	not provided [RCV003484652]	Chr6:132926527..133319409 [GRCh37] Chr6:6q23.2	uncertain significance
GRCh37/hg19 6q22.31-23.3(chr6:120218852-137160850)x1	copy number loss	not provided [RCV003482930]	Chr6:120218852..137160850 [GRCh37] Chr6:6q22.31-23.3	pathogenic
GRCh37/hg19 6q23.2-24.2(chr6:131569837-145572239)x3	copy number gain	not specified [RCV003986663]	Chr6:131569837..145572239 [GRCh37] Chr6:6q23.2-24.2	pathogenic
GRCh37/hg19 6q23.2(chr6:132926526-133319409)x3	copy number gain	not specified [RCV003986643]	Chr6:132926526..133319409 [GRCh37] Chr6:6q23.2	uncertain significance
GRCh37/hg19 6q22.31-25.3(chr6:119840686-156623091)x3	copy number gain	not specified [RCV003986631]	Chr6:119840686..156623091 [GRCh37] Chr6:6q22.31-25.3	pathogenic
NM_001033080.1(TAAR2):c.335G>A (p.Gly112Glu)	single nucleotide variant	not specified [RCV004466077]	Chr6:132617871 [GRCh38] Chr6:132939010 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.1012T>C (p.Cys338Arg)	single nucleotide variant	not specified [RCV004466075]	Chr6:132617194 [GRCh38] Chr6:132938333 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.133G>A (p.Ala45Thr)	single nucleotide variant	not specified [RCV004466076]	Chr6:132618073 [GRCh38] Chr6:132939212 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.676G>A (p.Val226Met)	single nucleotide variant	not specified [RCV004466078]	Chr6:132617530 [GRCh38] Chr6:132938669 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.859T>C (p.Phe287Leu)	single nucleotide variant	not specified [RCV004466079]	Chr6:132617347 [GRCh38] Chr6:132938486 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.349A>G (p.Lys117Glu)	single nucleotide variant	not specified [RCV004681888]	Chr6:132617857 [GRCh38] Chr6:132938996 [GRCh37] Chr6:6q23.2	uncertain significance
NM_001033080.1(TAAR2):c.772A>G (p.Lys258Glu)	single nucleotide variant	not specified [RCV004671024]	Chr6:132617434 [GRCh38] Chr6:132938573 [GRCh37] Chr6:6q23.2	uncertain significance
NC_000006.11:g.(?_131894423)_(133849943_?)del	deletion	not provided [RCV004578838]	Chr6:131894423..133849943 [GRCh37] Chr6:6q23.2	pathogenic

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	83
Count of miRNA genes:	29
Interacting mature miRNAs:	31
Transcripts:	ENST00000275191, ENST00000367931, ENST00000537809
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
406893042	GWAS542018_H	response to beta blocker, heart rate QTL GWAS542018 (human)		0.000008	response to beta blocker, heart rate	heart rate (CMO:0000002)	6	132623384	132623385	Human

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system	sensory system
26	67	72	67	100	32	52	15	77	7	42	208	203	80	14	384	39	8

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001033080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_014626	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF112460	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL513524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY702304	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY703480	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC067461	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC067462	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC067463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DN693314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	E13892	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000275191 ⟹ ENSP00000275191

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	132,617,022 - 132,618,178 (-)	Ensembl

Ensembl Acc Id:

ENST00000367931 ⟹ ENSP00000356908

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	132,617,150 - 132,624,275 (-)	Ensembl

RefSeq Acc Id:

NM_001033080 ⟹ NP_001028252

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	132,617,150 - 132,624,275 (-)	NCBI
GRCh37	6	132,938,289 - 132,945,414 (-)	RGD
Build 36	6	132,979,982 - 132,987,107 (-)	NCBI Archive
Celera	6	133,685,125 - 133,692,251 (-)	RGD
HuRef	6	130,513,205 - 130,520,335 (-)	ENTREZGENE
CHM1_1	6	133,201,961 - 133,209,075 (-)	NCBI
T2T-CHM13v2.0	6	133,812,108 - 133,819,243 (-)	NCBI

Sequence:

show sequence

ATGGCTGTCTCATCAGAGCAACATGAACTTTCACATTTCAAAAGAACACAGACAAAAAAGGAAA
AATTCAATTGCTCTGAATATGGAAATAGATCTTGCCCAGAAAATGAAAGATCTCTGGGTGTCCG
AGTGGCTATGTATTCATTTATGGCAGGATCCATATTCATCACAATATTTGGCAATCTTGCCATG
ATAATTTCCATTTCCTACTTCAAGCAGCTTCACACACCAACCAACTTCCTCATCCTCTCCATGG
CCATCACTGATTTCCTCCTGGGATTCACCATCATGCCATATAGTATGATCAGATCGGTGGAGAA
CTGCTGGTATTTTGGGCTTACATTTTGCAAGATTTATTATAGTTTTGACCTGATGCTTAGCATA
ACATCCATTTTTCATCTTTGCTCAGTGGCCATTGATAGATTTTATGCTATATGTTACCCATTAC
TTTATTCCACCAAAATAACTATTCCAGTCATTAAAAGATTGCTACTTCTATGTTGGTCGGTCCC
TGGAGCATTTGCCTTCGGGGTGGTCTTCTCAGAGGCCTATGCAGATGGAATAGAGGGCTATGAC
ATCTTGGTTGCTTGTTCCAGTTCCTGCCCAGTGATGTTCAACAAGCTATGGGGGACCACCTTGT
TTATGGCAGGTTTCTTCACTCCTGGGTCTATGATGGTGGGGATTTATGGCAAAATTTTTGCAGT
ATCCAGAAAACATGCTCATGCCATCAATAACTTGCGAGAAAATCAAAATAATCAAGTGAAGAAA
GACAAAAAAGCTGCCAAAACTTTAGGAATAGTGATAGGAGTTTTCTTATTATGTTGGTTTCCTT
GTTTCTTCACAATTTTATTGGATCCCTTTTTGAACTTCTCTACTCCTGTAGTTTTGTTTGATGC
CTTGACATGGTTTGGCTATTTTAACTCCACATGTAATCCGTTAATATATGGTTTCTTCTATCCC
TGGTTTCGCAGAGCACTGAAGTACATTTTGCTAGGTAAAATTTTCAGCTCATGTTTCCATAATA
CTATTTTGTGTATGCAAAAAGAAAGTGAGTAG

hide sequence

RefSeq Acc Id:

NM_014626 ⟹ NP_055441

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	132,617,150 - 132,618,093 (-)	NCBI
GRCh37	6	132,938,289 - 132,945,414 (-)	RGD
Celera	6	133,685,125 - 133,692,251 (-)	RGD
HuRef	6	130,513,205 - 130,520,335 (-)	ENTREZGENE
CHM1_1	6	133,201,961 - 133,202,904 (-)	NCBI
T2T-CHM13v2.0	6	133,812,108 - 133,813,051 (-)	NCBI

Sequence:

show sequence

GATCTCTGGGTGTCCGAGTGGCTATGTATTCATTTATGGCAGGATCCATATTCATCACAATATT
TGGCAATCTTGCCATGATAATTTCCATTTCCTACTTCAAGCAGCTTCACACACCAACCAACTTC
CTCATCCTCTCCATGGCCATCACTGATTTCCTCCTGGGATTCACCATCATGCCATATAGTATGA
TCAGATCGGTGGAGAACTGCTGGTATTTTGGGCTTACATTTTGCAAGATTTATTATAGTTTTGA
CCTGATGCTTAGCATAACATCCATTTTTCATCTTTGCTCAGTGGCCATTGATAGATTTTATGCT
ATATGTTACCCATTACTTTATTCCACCAAAATAACTATTCCAGTCATTAAAAGATTGCTACTTC
TATGTTGGTCGGTCCCTGGAGCATTTGCCTTCGGGGTGGTCTTCTCAGAGGCCTATGCAGATGG
AATAGAGGGCTATGACATCTTGGTTGCTTGTTCCAGTTCCTGCCCAGTGATGTTCAACAAGCTA
TGGGGGACCACCTTGTTTATGGCAGGTTTCTTCACTCCTGGGTCTATGATGGTGGGGATTTATG
GCAAAATTTTTGCAGTATCCAGAAAACATGCTCATGCCATCAATAACTTGCGAGAAAATCAAAA
TAATCAAGTGAAGAAAGACAAAAAAGCTGCCAAAACTTTAGGAATAGTGATAGGAGTTTTCTTA
TTATGTTGGTTTCCTTGTTTCTTCACAATTTTATTGGATCCCTTTTTGAACTTCTCTACTCCTG
TAGTTTTGTTTGATGCCTTGACATGGTTTGGCTATTTTAACTCCACATGTAATCCGTTAATATA
TGGTTTCTTCTATCCCTGGTTTCGCAGAGCACTGAAGTACATTTTGCTAGGTAAAATTTTCAGC
TCATGTTTCCATAATACTATTTTGTGTATGCAAAAAGAAAGTGAGTAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001028252	(Get FASTA)	NCBI Sequence Viewer
	NP_055441	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF27278	(Get FASTA)	NCBI Sequence Viewer
	AAH67461	(Get FASTA)	NCBI Sequence Viewer
	AAH67462	(Get FASTA)	NCBI Sequence Viewer
	AAH67463	(Get FASTA)	NCBI Sequence Viewer
	AAV70122	(Get FASTA)	NCBI Sequence Viewer
	AAV70150	(Get FASTA)	NCBI Sequence Viewer
	EAW48024	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000275191
	ENSP00000275191.2
	ENSP00000356908
	ENSP00000356908.1
GenBank Protein	Q9P1P5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001028252 ⟸ NM_001033080
- Peptide Label:	isoform 1
- UniProtKB:	Q6NWS2 (UniProtKB/Swiss-Prot), Q6NWS1 (UniProtKB/Swiss-Prot), Q5QD02 (UniProtKB/Swiss-Prot), Q6NWS3 (UniProtKB/Swiss-Prot), Q9P1P5 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAVSSEQHELSHFKRTQTKKEKFNCSEYGNRSCPENERSLGVRVAMYSFMAGSIFITIFGNLAM IISISYFKQLHTPTNFLILSMAITDFLLGFTIMPYSMIRSVENCWYFGLTFCKIYYSFDLMLSI TSIFHLCSVAIDRFYAICYPLLYSTKITIPVIKRLLLLCWSVPGAFAFGVVFSEAYADGIEGYD ILVACSSSCPVMFNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSRKHAHAINNLRENQNNQVKK DKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLNFSTPVVLFDALTWFGYFNSTCNPLIYGFFYP WFRRALKYILLGKIFSSCFHNTILCMQKESE hide sequence

RefSeq Acc Id:	NP_055441 ⟸ NM_014626
- Peptide Label:	isoform 2
- UniProtKB:	Q9P1P5 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MYSFMAGSIFITIFGNLAMIISISYFKQLHTPTNFLILSMAITDFLLGFTIMPYSMIRSVENCW YFGLTFCKIYYSFDLMLSITSIFHLCSVAIDRFYAICYPLLYSTKITIPVIKRLLLLCWSVPGA FAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSR KHAHAINNLRENQNNQVKKDKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLNFSTPVVLFDALT WFGYFNSTCNPLIYGFFYPWFRRALKYILLGKIFSSCFHNTILCMQKESE hide sequence

Ensembl Acc Id:

ENSP00000356908 ⟸ ENST00000367931

Ensembl Acc Id:

ENSP00000275191 ⟸ ENST00000275191

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9P1P5-F1-model_v2	AlphaFold	Q9P1P5	1-351	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:4514	AgrOrtholog
COSMIC	TAAR2	COSMIC
Ensembl Genes	ENSG00000146378	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000275191	ENTREZGENE
	ENST00000275191.2	UniProtKB/Swiss-Prot
	ENST00000367931	ENTREZGENE
	ENST00000367931.1	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot
GTEx	ENSG00000146378	GTEx
HGNC ID	HGNC:4514	ENTREZGENE
Human Proteome Map	TAAR2	Human Proteome Map
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot
	TAAR	UniProtKB/Swiss-Prot
	TAAR_fam	UniProtKB/Swiss-Prot
KEGG Report	hsa:9287	UniProtKB/Swiss-Prot
NCBI Gene	9287	ENTREZGENE
OMIM	604849	OMIM
PANTHER	HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR	UniProtKB/Swiss-Prot
	TRACE AMINE-ASSOCIATED RECEPTOR 2	UniProtKB/Swiss-Prot
Pfam	7tm_1	UniProtKB/Swiss-Prot
PharmGKB	PA28903	PharmGKB
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot
	TRACEAMINER	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot
SMART	7TM_GPCR_Srsx	UniProtKB/Swiss-Prot
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot
UniProt	Q5QD02	ENTREZGENE
	Q6NWS1	ENTREZGENE
	Q6NWS2	ENTREZGENE
	Q6NWS3	ENTREZGENE
	Q9P1P5	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q5QD02	UniProtKB/Swiss-Prot
	Q6NWS1	UniProtKB/Swiss-Prot
	Q6NWS2	UniProtKB/Swiss-Prot
	Q6NWS3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-05-11	TAAR2	trace amine associated receptor 2	TAAR2	trace amine associated receptor 2 (gene/pseudogene)	Symbol and/or name change	19259463	PROVISIONAL
2017-02-07	TAAR2	trace amine associated receptor 2 (gene/pseudogene)		trace amine associated receptor 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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