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Gene: CLCF1 (cardiotrophin like cytokine factor 1) Homo sapiens
Symbol: CLCF1
Name: cardiotrophin like cytokine factor 1
RGD ID: 1606817
Description: Exhibits ciliary neurotrophic factor receptor binding activity. Contributes to cytokine activity. Involved in negative regulation of neuron apoptotic process; positive regulation of cell population proliferation; and positive regulation of tyrosine phosphorylation of STAT protein. Localizes to CNTFR-CLCF1 complex and CRLF-CLCF1 complex. Implicated in cold-induced sweating syndrome 2. Biomarker of severe acute respiratory syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: B-cell stimulating factor 3; B-cell stimulatory factor 3; B-cell-stimulating factor 3; BSF-3; BSF3; cardiotrophin-like cytokine factor 1; CISS2; CLC; CRLF1 associated cytokine-like factor 1; neurotrophin-1/B-cell stimulating factor-3; NNT-1; NNT1; novel neurotrophin-1; NR6
Mus musculus (house mouse) : Clcf1 (cardiotrophin-like cytokine factor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Clcf1 (cardiotrophin-like cytokine factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clcf1 (cardiotrophin like cytokine factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CLCF1 (cardiotrophin like cytokine factor 1)
Canis lupus familiaris (dog) : CLCF1 (cardiotrophin like cytokine factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clcf1 (cardiotrophin like cytokine factor 1)
Sus scrofa (pig) : CLCF1 (cardiotrophin like cytokine factor 1)
Chlorocebus sabaeus (African green monkey) : CLCF1 (cardiotrophin like cytokine factor 1)
Heterocephalus glaber (naked mole-rat) : Clcf1 (cardiotrophin like cytokine factor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1167,364,168 - 67,374,177 (-)EnsemblGRCh38hg38GRCh38
GRCh381167,364,168 - 67,374,177 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371167,131,635 - 67,141,648 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,888,215 - 66,897,782 (-)NCBINCBI36hg18NCBI36
Celera1164,464,792 - 64,474,817 (-)NCBI
Cytogenetic Map11q13.2NCBI
HuRef1163,460,623 - 63,470,003 (-)NCBIHuRef
CHM1_11167,014,667 - 67,024,689 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CLCF1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1606817
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.