RGS22 (regulator of G protein signaling 22) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: RGS22 (regulator of G protein signaling 22) Homo sapiens
Analyze
Symbol: RGS22
Name: regulator of G protein signaling 22
RGD ID: 1606803
HGNC Page HGNC
Description: Exhibits G-protein alpha-subunit binding activity. Predicted to be involved in negative regulation of signal transduction. Localizes to actin cytoskeleton; cytosol; and fibrillar center; INTERACTS WITH 17beta-estradiol; butanal; daidzein.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CT145; DKFZp434I092; FLJ40080; FLJ75004; MGC102908; PRTD-NY2; regulator of G-protein signaling 22
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl899,960,936 - 100,131,268 (-)EnsemblGRCh38hg38GRCh38
GRCh38899,960,936 - 100,106,946 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378100,973,164 - 101,118,277 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368101,042,452 - 101,187,520 (-)NCBINCBI36hg18NCBI36
Celera897,158,760 - 97,303,753 (-)NCBI
Cytogenetic Map8q22.2NCBI
HuRef896,176,263 - 96,321,168 (-)NCBIHuRef
CHM1_18101,013,907 - 101,158,680 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:14702039   PMID:15489334   PMID:18703424   PMID:20379614   PMID:20627871   PMID:21533872   PMID:24403052   PMID:26323264   PMID:27503909   PMID:29038925  
PMID:30021884   PMID:30745168   PMID:30948266  


Genomics

Comparative Map Data
RGS22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl899,960,936 - 100,131,268 (-)EnsemblGRCh38hg38GRCh38
GRCh38899,960,936 - 100,106,946 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378100,973,164 - 101,118,277 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368101,042,452 - 101,187,520 (-)NCBINCBI36hg18NCBI36
Celera897,158,760 - 97,303,753 (-)NCBI
Cytogenetic Map8q22.2NCBI
HuRef896,176,263 - 96,321,168 (-)NCBIHuRef
CHM1_18101,013,907 - 101,158,680 (-)NCBICHM1_1
Rgs22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391535,960,664 - 36,140,718 (-)NCBIGRCm39mm39
GRCm39 Ensembl1536,009,625 - 36,140,546 (-)Ensembl
GRCm381535,960,508 - 36,140,572 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1536,009,479 - 36,140,400 (-)EnsemblGRCm38mm10GRCm38
MGSCv371535,939,234 - 36,070,149 (-)NCBIGRCm37mm9NCBIm37
MGSCv361536,110,459 - 36,242,758 (-)NCBImm8
MGSCv361535,954,066 - 36,087,454 (-)NCBImm8
Celera1536,635,165 - 36,768,269 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
Rgs22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2767,188,531 - 67,308,805 (-)NCBI
Rnor_6.0 Ensembl774,783,019 - 74,901,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0774,783,009 - 74,902,049 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0774,941,150 - 75,058,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4771,526,062 - 71,645,945 (-)NCBIRGSC3.4rn4RGSC3.4
Celera764,271,329 - 64,390,770 (-)NCBICelera
Cytogenetic Map7q22NCBI
Rgs22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541715,282,428 - 15,382,842 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541715,284,368 - 15,381,984 (-)NCBIChiLan1.0ChiLan1.0
RGS22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1898,775,639 - 98,920,786 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl898,775,639 - 98,920,786 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0896,601,282 - 96,747,195 (-)NCBIMhudiblu_PPA_v0panPan3
RGS22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1131,897,525 - 2,026,622 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl131,864,010 - 2,010,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha131,893,394 - 2,027,515 (-)NCBI
ROS_Cfam_1.0132,050,963 - 2,179,426 (-)NCBI
UMICH_Zoey_3.1131,893,147 - 2,023,881 (-)NCBI
UNSW_CanFamBas_1.0132,006,459 - 2,135,926 (-)NCBI
UU_Cfam_GSD_1.0132,008,063 - 2,140,187 (-)NCBI
Rgs22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530335,686,561 - 35,794,613 (+)NCBI
SpeTri2.0NW_00493647043,135,410 - 43,225,788 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl436,856,937 - 37,042,908 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1436,883,805 - 37,042,885 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2439,835,139 - 39,958,926 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RGS22
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1894,806,493 - 94,950,188 (-)NCBI
ChlSab1.1 Ensembl894,805,855 - 94,937,451 (-)Ensembl
Rgs22
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247636,922,059 - 7,059,827 (-)NCBI

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1934
Count of miRNA genes:863
Interacting mature miRNAs:973
Transcripts:ENST00000360863, ENST00000517769, ENST00000517828, ENST00000517843, ENST00000518474, ENST00000518719, ENST00000519092, ENST00000519408, ENST00000519421, ENST00000519725, ENST00000520117, ENST00000520923, ENST00000522064, ENST00000523287, ENST00000523437, ENST00000523600, ENST00000524182
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 2 1 11 495 18
Low 409 766 423 7 70 6 2501 133 2065 84 734 657 2 1110 1423 1
Below cutoff 1887 1770 1003 348 1054 191 1632 1919 1590 210 131 762 160 94 1278 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001286692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_015668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005250856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005250857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005250858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005250860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006716540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC021590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK097399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL117544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP005356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY009106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC047060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM684810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000360863   ⟹   ENSP00000354109
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl899,960,936 - 100,106,049 (-)Ensembl
RefSeq Acc Id: ENST00000517769
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl899,961,058 - 100,041,967 (-)Ensembl
RefSeq Acc Id: ENST00000517828   ⟹   ENSP00000427754
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl899,999,347 - 100,125,798 (-)Ensembl
RefSeq Acc Id: ENST00000517843   ⟹   ENSP00000430378
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl899,961,066 - 99,978,051 (-)Ensembl
RefSeq Acc Id: ENST00000518474
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,038,523 - 100,042,768 (-)Ensembl
RefSeq Acc Id: ENST00000518719
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,093,162 - 100,106,000 (-)Ensembl
RefSeq Acc Id: ENST00000519092   ⟹   ENSP00000430903
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,071,410 - 100,105,624 (-)Ensembl
RefSeq Acc Id: ENST00000519408   ⟹   ENSP00000427930
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,071,429 - 100,106,317 (-)Ensembl
RefSeq Acc Id: ENST00000519421
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,002,322 - 100,008,526 (-)Ensembl
RefSeq Acc Id: ENST00000519725   ⟹   ENSP00000427798
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,008,497 - 100,106,000 (-)Ensembl
RefSeq Acc Id: ENST00000520117   ⟹   ENSP00000429198
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,066,239 - 100,131,268 (-)Ensembl
RefSeq Acc Id: ENST00000520923
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,038,520 - 100,080,274 (-)Ensembl
RefSeq Acc Id: ENST00000522064
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,080,295 - 100,105,621 (-)Ensembl
RefSeq Acc Id: ENST00000523287   ⟹   ENSP00000429382
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl899,961,051 - 100,105,619 (-)Ensembl
RefSeq Acc Id: ENST00000523437   ⟹   ENSP00000428212
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl899,961,067 - 100,105,962 (-)Ensembl
RefSeq Acc Id: ENST00000523600
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,080,694 - 100,105,613 (-)Ensembl
RefSeq Acc Id: ENST00000524182
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8100,046,233 - 100,050,896 (-)Ensembl
RefSeq Acc Id: ENST00000617334   ⟹   ENSP00000479205
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl899,960,940 - 100,106,116 (-)Ensembl
RefSeq Acc Id: NM_001286692   ⟹   NP_001273621
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38899,960,936 - 100,106,049 (-)NCBI
HuRef896,176,151 - 96,321,168 (-)NCBI
CHM1_18101,013,907 - 101,158,680 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001286693   ⟹   NP_001273622
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38899,960,936 - 100,105,626 (-)NCBI
HuRef896,176,151 - 96,321,168 (-)NCBI
CHM1_18101,013,907 - 101,158,190 (-)NCBI
Sequence:
RefSeq Acc Id: NM_015668   ⟹   NP_056483
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38899,960,936 - 100,106,049 (-)NCBI
GRCh378100,973,164 - 101,118,344 (-)NCBI
Build 368101,042,452 - 101,187,520 (-)NCBI Archive
Celera897,158,760 - 97,303,753 (-)RGD
HuRef896,176,151 - 96,321,168 (-)NCBI
CHM1_18101,013,907 - 101,158,680 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005250856   ⟹   XP_005250913
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38899,961,043 - 100,106,946 (-)NCBI
GRCh378100,973,164 - 101,118,344 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005250857   ⟹   XP_005250914
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38899,961,043 - 100,106,946 (-)NCBI
GRCh378100,973,164 - 101,118,344 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005250858   ⟹   XP_005250915
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38899,961,043 - 100,106,946 (-)NCBI
GRCh378100,973,164 - 101,118,344 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005250860   ⟹   XP_005250917
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,004,082 - 100,106,946 (-)NCBI
GRCh378100,973,164 - 101,118,344 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006716540   ⟹   XP_006716603
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38899,961,043 - 100,105,626 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011516957   ⟹   XP_011515259
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38899,961,043 - 100,105,613 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011516958   ⟹   XP_011515260
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38899,961,043 - 100,105,621 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011516959   ⟹   XP_011515261
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,008,527 - 100,106,946 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013309   ⟹   XP_016868798
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38899,961,043 - 100,106,946 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013310   ⟹   XP_016868799
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38899,961,043 - 100,106,946 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013311   ⟹   XP_016868800
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38899,961,043 - 100,066,256 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024447121   ⟹   XP_024302889
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38899,961,043 - 100,042,798 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024447122   ⟹   XP_024302890
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38899,961,043 - 100,047,596 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001273621 (Get FASTA)   NCBI Sequence Viewer  
  NP_001273622 (Get FASTA)   NCBI Sequence Viewer  
  NP_056483 (Get FASTA)   NCBI Sequence Viewer  
  XP_005250913 (Get FASTA)   NCBI Sequence Viewer  
  XP_005250914 (Get FASTA)   NCBI Sequence Viewer  
  XP_005250915 (Get FASTA)   NCBI Sequence Viewer  
  XP_005250917 (Get FASTA)   NCBI Sequence Viewer  
  XP_006716603 (Get FASTA)   NCBI Sequence Viewer  
  XP_011515259 (Get FASTA)   NCBI Sequence Viewer  
  XP_011515260 (Get FASTA)   NCBI Sequence Viewer  
  XP_011515261 (Get FASTA)   NCBI Sequence Viewer  
  XP_016868798 (Get FASTA)   NCBI Sequence Viewer  
  XP_016868799 (Get FASTA)   NCBI Sequence Viewer  
  XP_016868800 (Get FASTA)   NCBI Sequence Viewer  
  XP_024302889 (Get FASTA)   NCBI Sequence Viewer  
  XP_024302890 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG49397 (Get FASTA)   NCBI Sequence Viewer  
  AAH36665 (Get FASTA)   NCBI Sequence Viewer  
  AAH47060 (Get FASTA)   NCBI Sequence Viewer  
  AAH92411 (Get FASTA)   NCBI Sequence Viewer  
  BAF85248 (Get FASTA)   NCBI Sequence Viewer  
  BAG53465 (Get FASTA)   NCBI Sequence Viewer  
  BAG63763 (Get FASTA)   NCBI Sequence Viewer  
  CAB55986 (Get FASTA)   NCBI Sequence Viewer  
  EAW91794 (Get FASTA)   NCBI Sequence Viewer  
  EAW91795 (Get FASTA)   NCBI Sequence Viewer  
  EAW91796 (Get FASTA)   NCBI Sequence Viewer  
  EAW91797 (Get FASTA)   NCBI Sequence Viewer  
  Q8NE09 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_056483   ⟸   NM_015668
- Peptide Label: isoform 1
- UniProtKB: Q8NE09 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005250913   ⟸   XM_005250856
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005250915   ⟸   XM_005250858
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005250914   ⟸   XM_005250857
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005250917   ⟸   XM_005250860
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: NP_001273621   ⟸   NM_001286692
- Peptide Label: isoform 2
- UniProtKB: Q8NE09 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001273622   ⟸   NM_001286693
- Peptide Label: isoform 3
- UniProtKB: G3V112 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006716603   ⟸   XM_006716540
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011515260   ⟸   XM_011516958
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011515259   ⟸   XM_011516957
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011515261   ⟸   XM_011516959
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_016868799   ⟸   XM_017013310
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_016868798   ⟸   XM_017013309
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_016868800   ⟸   XM_017013311
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_024302890   ⟸   XM_024447122
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_024302889   ⟸   XM_024447121
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: ENSP00000427754   ⟸   ENST00000517828
RefSeq Acc Id: ENSP00000430378   ⟸   ENST00000517843
RefSeq Acc Id: ENSP00000430903   ⟸   ENST00000519092
RefSeq Acc Id: ENSP00000427930   ⟸   ENST00000519408
RefSeq Acc Id: ENSP00000427798   ⟸   ENST00000519725
RefSeq Acc Id: ENSP00000354109   ⟸   ENST00000360863
RefSeq Acc Id: ENSP00000429198   ⟸   ENST00000520117
RefSeq Acc Id: ENSP00000428212   ⟸   ENST00000523437
RefSeq Acc Id: ENSP00000429382   ⟸   ENST00000523287
RefSeq Acc Id: ENSP00000479205   ⟸   ENST00000617334
Protein Domains
RGS

Promoters
RGD ID:7213885
Promoter ID:EPDNEW_H12687
Type:initiation region
Name:RGS22_1
Description:regulator of G protein signaling 22
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388100,106,018 - 100,106,078EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q22.2-22.3(chr8:100023254-101190270)x3 copy number gain See cases [RCV000050759] Chr8:100023254..101190270 [GRCh38]
Chr8:101035482..102202498 [GRCh37]
Chr8:101104658..102271674 [NCBI36]
Chr8:8q22.2-22.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
NM_015668.4(RGS22):c.1187G>A (p.Ser396Asn) single nucleotide variant Malignant melanoma [RCV000068046] Chr8:100063581 [GRCh38]
Chr8:101075809 [GRCh37]
Chr8:101144985 [NCBI36]
Chr8:8q22.2
not provided
NM_015668.4(RGS22):c.507C>T (p.Ile169=) single nucleotide variant Malignant melanoma [RCV000068047] Chr8:100071456 [GRCh38]
Chr8:101083684 [GRCh37]
Chr8:101152860 [NCBI36]
Chr8:8q22.2
not provided
NM_015668.4(RGS22):c.2344C>T (p.Gln782Ter) single nucleotide variant Malignant melanoma [RCV000061715] Chr8:100008392 [GRCh38]
Chr8:101020620 [GRCh37]
Chr8:101089796 [NCBI36]
Chr8:8q22.2
not provided
NM_015668.4(RGS22):c.379G>A (p.Glu127Lys) single nucleotide variant Malignant melanoma [RCV000061716] Chr8:100072191 [GRCh38]
Chr8:101084419 [GRCh37]
Chr8:101153595 [NCBI36]
Chr8:8q22.2
not provided
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8q22.2-22.3(chr8:99580206-101547228)x1 copy number loss See cases [RCV000137322] Chr8:99580206..101547228 [GRCh38]
Chr8:100592434..102559456 [GRCh37]
Chr8:100661610..102628632 [NCBI36]
Chr8:8q22.2-22.3
likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q22.2(chr8:100871620-101253185)x3 copy number gain Ductal breast carcinoma [RCV000207177] Chr8:100871620..101253185 [GRCh37]
Chr8:8q22.2
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.3-24.3(chr8:93047482-141355635)x3 copy number gain See cases [RCV000511761] Chr8:93047482..141355635 [GRCh37]
Chr8:8q21.3-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q21.2-23.3(chr8:86841154-116518125)x3 copy number gain not provided [RCV000683045] Chr8:86841154..116518125 [GRCh37]
Chr8:8q21.2-23.3
pathogenic
GRCh37/hg19 8q22.2-22.3(chr8:100551211-103676738)x1 copy number loss not provided [RCV000683023] Chr8:100551211..103676738 [GRCh37]
Chr8:8q22.2-22.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_015668.5(RGS22):c.744T>C (p.Asp248=) single nucleotide variant not provided [RCV000881357] Chr8:100064024 [GRCh38]
Chr8:101076252 [GRCh37]
Chr8:8q22.2
benign
NM_015668.5(RGS22):c.300C>T (p.Pro100=) single nucleotide variant not provided [RCV000917559] Chr8:100080173 [GRCh38]
Chr8:101092401 [GRCh37]
Chr8:8q22.2
likely benign
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.2(chr8:100791383-101278033)x3 copy number gain not provided [RCV001006126] Chr8:100791383..101278033 [GRCh37]
Chr8:8q22.2
uncertain significance
NM_015668.5(RGS22):c.3793T>C (p.Ter1265Arg) single nucleotide variant not provided [RCV000889201] Chr8:99962441 [GRCh38]
Chr8:100974669 [GRCh37]
Chr8:8q22.2
benign
NM_015668.5(RGS22):c.3651A>G (p.Leu1217=) single nucleotide variant not provided [RCV000956652] Chr8:99962943 [GRCh38]
Chr8:100975171 [GRCh37]
Chr8:8q22.2
benign
NM_015668.5(RGS22):c.63T>C (p.Ser21=) single nucleotide variant not provided [RCV000956653] Chr8:100093501 [GRCh38]
Chr8:101105729 [GRCh37]
Chr8:8q22.2
benign
GRCh37/hg19 8q22.2(chr8:101017828-101094066)x1 copy number loss not provided [RCV001259022] Chr8:101017828..101094066 [GRCh37]
Chr8:8q22.2
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:24499 AgrOrtholog
COSMIC RGS22 COSMIC
Ensembl Genes ENSG00000132554 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000354109 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000427754 UniProtKB/TrEMBL
  ENSP00000427798 UniProtKB/Swiss-Prot
  ENSP00000427930 UniProtKB/TrEMBL
  ENSP00000428212 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000429198 UniProtKB/TrEMBL
  ENSP00000429382 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000430378 UniProtKB/TrEMBL
  ENSP00000430903 UniProtKB/TrEMBL
  ENSP00000479205 UniProtKB/TrEMBL
Ensembl Transcript ENST00000360863 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000517769 ENTREZGENE
  ENST00000517828 UniProtKB/TrEMBL
  ENST00000517843 UniProtKB/TrEMBL
  ENST00000519092 UniProtKB/TrEMBL
  ENST00000519408 UniProtKB/TrEMBL
  ENST00000519725 UniProtKB/Swiss-Prot
  ENST00000520117 UniProtKB/TrEMBL
  ENST00000523287 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000523437 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000617334 UniProtKB/TrEMBL
GTEx ENSG00000132554 GTEx
HGNC ID HGNC:24499 ENTREZGENE
Human Proteome Map RGS22 Human Proteome Map
InterPro RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rgs22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:26166 UniProtKB/Swiss-Prot
NCBI Gene 26166 ENTREZGENE
OMIM 615650 OMIM
PANTHER PTHR46583 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA142671068 PharmGKB
PROSITE RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WV61_HUMAN UniProtKB/TrEMBL
  E5RFV6_HUMAN UniProtKB/TrEMBL
  E5RGJ7_HUMAN UniProtKB/TrEMBL
  E5RHE4_HUMAN UniProtKB/TrEMBL
  E5RJ23_HUMAN UniProtKB/TrEMBL
  G3V112 ENTREZGENE, UniProtKB/TrEMBL
  H0YBV2_HUMAN UniProtKB/TrEMBL
  Q8NE09 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A8K944 UniProtKB/Swiss-Prot
  Q569L2 UniProtKB/Swiss-Prot
  Q86Y71 UniProtKB/Swiss-Prot
  Q9BYZ4 UniProtKB/Swiss-Prot
  Q9UFN6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-18 RGS22  regulator of G protein signaling 22    regulator of G-protein signaling 22  Symbol and/or name change 5135510 APPROVED