SAMD15 (sterile alpha motif domain containing 15)

Gene: SAMD15 (sterile alpha motif domain containing 15) Homo sapiens

Analyze

Symbol:

SAMD15

Name:

sterile alpha motif domain containing 15

RGD ID:

1606691

HGNC Page

HGNC:18631

Description:

ASSOCIATED WITH genetic disease; hereditary sensory and autonomic neuropathy type 1C; INTERACTS WITH atrazine; benzo[a]pyrene; bis(2-ethylhexyl) phthalate

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

C14orf174; FAM15A; family with sequence similarity 15, member A; FLJ35963; MGC132494; MGC132496; SAM domain-containing protein 15; SAM domain-containing protein C14orf174; sterile alpha motif domain-containing protein 15

RGD Orthologs

Alliance Genes

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	77,377,379 - 77,392,163 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	77,376,689 - 77,392,163 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	77,843,722 - 77,858,506 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	76,913,515 - 76,927,340 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	14	57,882,338 - 57,896,164 (+)	NCBI		Celera
Cytogenetic Map	14	q24.3	NCBI
HuRef	14	58,009,829 - 58,023,826 (+)	NCBI		HuRef
CHM1_1	14	77,783,197 - 77,797,022 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	71,586,754 - 71,601,542 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (IAGP)

hereditary sensory and autonomic neuropathy type 1C (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-Tetrachlorodibenzofuran (ISO)

acetamide (ISO)

aldehydo-D-glucose (ISO)

amitrole (ISO)

atrazine (EXP)

benzo[a]pyrene (EXP)

bis(2-ethylhexyl) phthalate (EXP)

cisplatin (EXP)

D-glucose (ISO)

folic acid (EXP)

fructose (ISO)

glucose (ISO)

methimazole (ISO)

methyl methanesulfonate (EXP)

pentanal (EXP)

phenobarbital (ISO)

sotorasib (EXP)

sulfadimethoxine (ISO)

sunitinib (EXP)

trametinib (EXP)

triptonide (ISO)

urethane (EXP)

valproic acid (EXP)

References

References - curated

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:12508121	PMID:14702039	PMID:15489334	PMID:32393512

Genomics

Comparative Map Data

SAMD15
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	77,377,379 - 77,392,163 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	77,376,689 - 77,392,163 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	77,843,722 - 77,858,506 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	76,913,515 - 76,927,340 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	14	57,882,338 - 57,896,164 (+)	NCBI		Celera
Cytogenetic Map	14	q24.3	NCBI
HuRef	14	58,009,829 - 58,023,826 (+)	NCBI		HuRef
CHM1_1	14	77,783,197 - 77,797,022 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	71,586,754 - 71,601,542 (+)	NCBI		T2T-CHM13v2.0

Samd15
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	87,247,240 - 87,260,315 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	87,246,497 - 87,260,315 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	87,194,484 - 87,213,541 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	87,199,723 - 87,213,541 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	88,541,290 - 88,554,323 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	88,089,443 - 88,102,476 (+)	NCBI		MGSCv36	mm8
Celera	12	88,664,925 - 88,677,955 (+)	NCBI		Celera
Cytogenetic Map	12	D2	NCBI
cM Map	12	41.4	NCBI

Samd15
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	112,572,352 - 112,587,142 (+)	NCBI		GRCr8
mRatBN7.2	6	106,841,405 - 106,856,197 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	106,840,781 - 106,860,423 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	107,009,218 - 107,024,233 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	107,308,054 - 107,323,065 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	106,677,727 - 106,692,748 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	111,223,026 - 111,241,326 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	111,223,026 - 111,241,303 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	120,506,887 - 120,526,580 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	6	104,662,735 - 104,681,776 (+)	NCBI		Celera
Cytogenetic Map	6	q31	NCBI

Samd15
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955438	1,273,054 - 1,283,424 (+)	NCBI	ChiLan1.0	ChiLan1.0

SAMD15
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	78,460,994 - 78,494,894 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	77,677,498 - 77,711,398 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	57,930,369 - 58,007,893 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	77,131,795 - 77,145,765 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	77,131,795 - 77,145,765 (+)	Ensembl	panpan1.1		panPan2

SAMD15
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	50,182,282 - 50,193,262 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	50,183,700 - 50,193,080 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	49,869,999 - 49,881,035 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	50,416,115 - 50,427,154 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	50,417,591 - 50,426,972 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	50,078,713 - 50,089,749 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	50,102,003 - 50,112,815 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	50,499,750 - 50,510,788 (+)	NCBI		UU_Cfam_GSD_1.0

Samd15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	25,850,296 - 25,862,399 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936488	6,206,563 - 6,218,676 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936488	6,206,570 - 6,217,766 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SAMD15
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	7	100,449,558 - 100,463,889 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	106,492,003 - 106,507,856 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SAMD15
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	54,636,263 - 54,650,295 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	54,636,280 - 54,650,239 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	42,828,610 - 42,842,344 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Samd15
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	24,518,215 - 24,526,110 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	24,517,134 - 24,526,203 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in SAMD15
26 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 14q24.3(chr14:73877072-78042422)x1	copy number loss	See cases [RCV000051548]	Chr14:73877072..78042422 [GRCh38] Chr14:74343775..78508765 [GRCh37] Chr14:73413528..77578518 [NCBI36] Chr14:14q24.3	pathogenic
GRCh38/hg38 14q24.3-31.1(chr14:75489052-79610332)x1	copy number loss	See cases [RCV000051549]	Chr14:75489052..79610332 [GRCh38] Chr14:75955395..80076675 [GRCh37] Chr14:75025148..79146428 [NCBI36] Chr14:14q24.3-31.1	pathogenic
GRCh38/hg38 14q24.2-32.2(chr14:72787506-99596719)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]\|See cases [RCV000052293]	Chr14:72787506..99596719 [GRCh38] Chr14:73254214..100063056 [GRCh37] Chr14:72323967..99132809 [NCBI36] Chr14:14q24.2-32.2	pathogenic
NM_001010860.1(SAMD15):c.1752C>T (p.Leu584=)	single nucleotide variant	Malignant melanoma [RCV000070619]	Chr14:77380445 [GRCh38] Chr14:77846788 [GRCh37] Chr14:76916541 [NCBI36] Chr14:14q24.3	not provided
NM_001010860.1(SAMD15):c.1839C>T (p.Phe613=)	single nucleotide variant	Malignant melanoma [RCV000070620]	Chr14:77391058 [GRCh38] Chr14:77857401 [GRCh37] Chr14:76927154 [NCBI36] Chr14:14q24.3	not provided
NM_001010860.1(SAMD15):c.1876G>A (p.Gly626Ser)	single nucleotide variant	Malignant melanoma [RCV000070621]	Chr14:77391095 [GRCh38] Chr14:77857438 [GRCh37] Chr14:76927191 [NCBI36] Chr14:14q24.3	not provided
GRCh38/hg38 14q24.1-31.1(chr14:69562099-81975384)x1	copy number loss	See cases [RCV000134154]	Chr14:69562099..81975384 [GRCh38] Chr14:70028816..82441728 [GRCh37] Chr14:69098569..81511481 [NCBI36] Chr14:14q24.1-31.1	pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3	copy number gain	See cases [RCV000134000]	Chr14:73655772..106879298 [GRCh38] Chr14:74122475..107287505 [GRCh37] Chr14:73192228..106358550 [NCBI36] Chr14:14q24.3-32.33	pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3	copy number gain	See cases [RCV000135543]	Chr14:20151149..106855263 [GRCh38] Chr14:20619308..107263478 [GRCh37] Chr14:19689148..106334523 [NCBI36] Chr14:14q11.2-32.33	pathogenic
GRCh38/hg38 14q24.3-31.1(chr14:77193005-80476132)x1	copy number loss	See cases [RCV000137421]	Chr14:77193005..80476132 [GRCh38] Chr14:77659348..80942475 [GRCh37] Chr14:76729101..80012228 [NCBI36] Chr14:14q24.3-31.1	likely pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:77222795-106879298)x3	copy number gain	See cases [RCV000138230]	Chr14:77222795..106879298 [GRCh38] Chr14:77689138..107287505 [GRCh37] Chr14:76758891..106358550 [NCBI36] Chr14:14q24.3-32.33	pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3	copy number gain	See cases [RCV000143373]	Chr14:20043514..106877229 [GRCh38] Chr14:20511673..107285437 [GRCh37] Chr14:19581513..106356482 [NCBI36] Chr14:14q11.2-32.33	pathogenic
GRCh38/hg38 14q24.3-31.1(chr14:73343213-78835059)x1	copy number loss	See cases [RCV000143265]	Chr14:73343213..78835059 [GRCh38] Chr14:73809921..79301402 [GRCh37] Chr14:72879674..78371155 [NCBI36] Chr14:14q24.3-31.1	pathogenic\|likely pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3	copy number gain	See cases [RCV000446256]	Chr14:19794561..107234280 [GRCh37] Chr14:14q11.2-32.33	pathogenic
GRCh37/hg19 14q23.2-32.33(chr14:62493932-107285437)x3	copy number gain	See cases [RCV000448557]	Chr14:62493932..107285437 [GRCh37] Chr14:14q23.2-32.33	pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437)	copy number gain	See cases [RCV000512041]	Chr14:20511673..107285437 [GRCh37] Chr14:14q11.2-32.33	pathogenic
GRCh37/hg19 14q24.3(chr14:76082940-78372356)x1	copy number loss	See cases [RCV000511668]	Chr14:76082940..78372356 [GRCh37] Chr14:14q24.3	uncertain significance
GRCh37/hg19 14q24.2-32.33(chr14:73750741-107285437)x3	copy number gain	See cases [RCV000512497]	Chr14:73750741..107285437 [GRCh37] Chr14:14q24.2-32.33	pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3	copy number gain	not provided [RCV000738412]	Chr14:19000422..107289053 [GRCh37] Chr14:14q11.1-32.33	pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3	copy number gain	not provided [RCV000738413]	Chr14:19280733..107287663 [GRCh37] Chr14:14q11.2-32.33	pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3	copy number gain	not provided [RCV000738414]	Chr14:19327823..107287663 [GRCh37] Chr14:14q11.2-32.33	pathogenic
NC_000014.8:g.(?_77743699)_(78082942_?)dup	duplication	Neuropathy, hereditary sensory and autonomic, type 1C [RCV000820601]	Chr14:77277356..77616599 [GRCh38] Chr14:77743699..78082942 [GRCh37] Chr14:14q24.3	uncertain significance
GRCh37/hg19 14q24.3-32.11(chr14:77274990-89803137)x1	copy number loss	not provided [RCV000847566]	Chr14:77274990..89803137 [GRCh37] Chr14:14q24.3-32.11	pathogenic
NM_001010860.4(SAMD15):c.130G>T (p.Asp44Tyr)	single nucleotide variant	Inborn genetic diseases [RCV003271256]	Chr14:77377548 [GRCh38] Chr14:77843891 [GRCh37] Chr14:14q24.3	uncertain significance
NC_000014.8:g.(?_77743719)_(78082922_?)del	deletion	Neuropathy, hereditary sensory and autonomic, type 1C [RCV001996609]	Chr14:77743719..78082922 [GRCh37] Chr14:14q24.3	uncertain significance
GRCh37/hg19 14q13.3-32.33(chr14:37671058-106985955)x2	copy number gain	See cases [RCV002286356]	Chr14:37671058..106985955 [GRCh37] Chr14:14q13.3-32.33	pathogenic
NM_001010860.4(SAMD15):c.524C>G (p.Thr175Arg)	single nucleotide variant	Inborn genetic diseases [RCV002970383]	Chr14:77377942 [GRCh38] Chr14:77844285 [GRCh37] Chr14:14q24.3	uncertain significance
NM_001010860.4(SAMD15):c.10G>T (p.Val4Phe)	single nucleotide variant	Inborn genetic diseases [RCV002687771]	Chr14:77377428 [GRCh38] Chr14:77843771 [GRCh37] Chr14:14q24.3	uncertain significance
NM_001010860.4(SAMD15):c.1325G>A (p.Arg442His)	single nucleotide variant	Inborn genetic diseases [RCV002683829]	Chr14:77378743 [GRCh38] Chr14:77845086 [GRCh37] Chr14:14q24.3	uncertain significance
NM_001010860.4(SAMD15):c.920G>A (p.Arg307Gln)	single nucleotide variant	Inborn genetic diseases [RCV002969953]	Chr14:77378338 [GRCh38] Chr14:77844681 [GRCh37] Chr14:14q24.3	likely benign
NM_001010860.4(SAMD15):c.1813C>T (p.Leu605Phe)	single nucleotide variant	Inborn genetic diseases [RCV002691710]	Chr14:77391032 [GRCh38] Chr14:77857375 [GRCh37] Chr14:14q24.3	uncertain significance
NM_001010860.4(SAMD15):c.1415T>C (p.Ile472Thr)	single nucleotide variant	Inborn genetic diseases [RCV002759571]	Chr14:77378833 [GRCh38] Chr14:77845176 [GRCh37] Chr14:14q24.3	uncertain significance
NM_001010860.4(SAMD15):c.29C>G (p.Ser10Cys)	single nucleotide variant	Inborn genetic diseases [RCV002873812]	Chr14:77377447 [GRCh38] Chr14:77843790 [GRCh37] Chr14:14q24.3	uncertain significance
NM_001010860.4(SAMD15):c.286C>T (p.Pro96Ser)	single nucleotide variant	Inborn genetic diseases [RCV002872951]	Chr14:77377704 [GRCh38] Chr14:77844047 [GRCh37] Chr14:14q24.3	likely benign
NM_001010860.4(SAMD15):c.110C>T (p.Pro37Leu)	single nucleotide variant	Inborn genetic diseases [RCV002934686]	Chr14:77377528 [GRCh38] Chr14:77843871 [GRCh37] Chr14:14q24.3	uncertain significance
NM_001010860.4(SAMD15):c.712C>T (p.Pro238Ser)	single nucleotide variant	Inborn genetic diseases [RCV003010781]	Chr14:77378130 [GRCh38] Chr14:77844473 [GRCh37] Chr14:14q24.3	uncertain significance
NM_001010860.4(SAMD15):c.793C>A (p.Leu265Met)	single nucleotide variant	Inborn genetic diseases [RCV002855233]	Chr14:77378211 [GRCh38] Chr14:77844554 [GRCh37] Chr14:14q24.3	uncertain significance
NM_001010860.4(SAMD15):c.849G>C (p.Glu283Asp)	single nucleotide variant	Inborn genetic diseases [RCV002987851]	Chr14:77378267 [GRCh38] Chr14:77844610 [GRCh37] Chr14:14q24.3	uncertain significance
NM_001010860.4(SAMD15):c.1843C>T (p.Arg615Cys)	single nucleotide variant	Inborn genetic diseases [RCV002813926]	Chr14:77391062 [GRCh38] Chr14:77857405 [GRCh37] Chr14:14q24.3	uncertain significance
NM_001010860.4(SAMD15):c.376A>G (p.Met126Val)	single nucleotide variant	Inborn genetic diseases [RCV003192915]	Chr14:77377794 [GRCh38] Chr14:77844137 [GRCh37] Chr14:14q24.3	likely benign
NM_001010860.4(SAMD15):c.1535A>G (p.Glu512Gly)	single nucleotide variant	Inborn genetic diseases [RCV003361490]	Chr14:77378953 [GRCh38] Chr14:77845296 [GRCh37] Chr14:14q24.3	uncertain significance
GRCh37/hg19 14q23.1-32.33(chr14:58894502-107227240)x3	copy number gain	not provided [RCV003485036]	Chr14:58894502..107227240 [GRCh37] Chr14:14q23.1-32.33	pathogenic

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	275
Count of miRNA genes:	202
Interacting mature miRNAs:	208
Transcripts:	ENST00000216471, ENST00000533095
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

RH104344

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	14	77,845,304 - 77,845,440	UniSTS	GRCh37
Build 36	14	76,915,057 - 76,915,193	RGD	NCBI36
Celera	14	57,883,880 - 57,884,016	RGD
Cytogenetic Map	14	q24.3	UniSTS
HuRef	14	58,011,371 - 58,011,507	UniSTS
GeneMap99-GB4 RH Map	14	208.22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

visual system

adipose tissue

appendage

entire extraembryonic component

High

Medium

399

Low

455

403

1218

113

847

698

174

2351

355

711

1316

117

365

Below cutoff

1954

2410

459

470

991

373

3440

1766

1365

340

274

1072

2226

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001010860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC007954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK093282	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK292571	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC104834	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC104836	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENST00000216471 ⟹ ENSP00000216471

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	77,377,379 - 77,392,163 (+)	Ensembl

RefSeq Acc Id:

ENST00000533095 ⟹ ENSP00000450941

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	77,376,689 - 77,391,268 (+)	Ensembl

RefSeq Acc Id:

NM_001010860 ⟹ NP_001010860

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	14	77,377,379 - 77,392,163 (+)	NCBI
GRCh37	14	77,843,762 - 77,857,587 (+)	RGD
Build 36	14	76,913,515 - 76,927,340 (+)	NCBI Archive
Celera	14	57,882,338 - 57,896,164 (+)	RGD
HuRef	14	58,009,829 - 58,023,826 (+)	ENTREZGENE
CHM1_1	14	77,783,197 - 77,797,022 (+)	NCBI
T2T-CHM13v2.0	14	71,586,754 - 71,601,542 (+)	NCBI

Sequence:

show sequence

GGGGTTGCTAGGAAGCCGCGGCGCGTCTGCTAAGCTGCAAATGGCTGAAGTCCCGGAGGATTAT
GATTCCGGCCCAGATGAAGATGGAGAGCTGGAGCCTGAGAGGCCTGAACTGCCTGGACTTCATA
AATTGTATGAAAATGCCGAACCAGACACCATGGCAAAGGCAGACTCGAAGCTACCAGCAGAGAT
TTACCAAGAGCCACAGCCAGAGACCGAGGAAGAGGACTTCAAAGAGGGGGAGCCAGACAGTGCT
AAGAACGTGCAGCTGAAACCTGGCGGGACGTCCCAGGAAGGAATTGCCAAGGAGTCCAAGAGAG
ACGTACCAAGCGAAACTGAACCAGGGATACACCAAGAGGTAAAGTCGGAAACATCCAGAGAGAT
GGGAGAGTTTTTCAAAGATTTGGAGGCCCCTATGGATGAAACGCATAAAGAGTCAGACCTAGAG
CCACCAGAGGAGGCTAAACCAAATGTTACAGAGGATGTGTTCCTAGAGTCAGCTATGGAAACAG
ATCCAGATCCAGTGCCACCAACGGAAACCATGTCTGAGGTTTCGGGGGCCACAGTCAGAGAGAG
AAATTTAGAATTACTAGAGGAGGAGACTGAACCGGGGGTTCCAGAGGAATCACTTAGAGTGCAA
CATGAAGAGACAGGTCTAGAGCCTCCAGAGCAGACCAAACAAGATTTTCCAAGTGAGAAACTAG
GAGAATCACTTGAAGAGACAGATCTTCAGCCACCAAAGATGACCAAACCAGAGACTCCAGAGGA
GACACAAAGAGAGTCAACTGAGAAGAAAAGGACAGAGCCACCCGAGCAGGCTAGACTGGAATTT
CTGGAGAAGGAACCAAGAAAGTCTAGTGAGGAGGCAGGTCTAGAGCCTCCAGAAGAGACTCAAC
CAGAGGTTCCAGAGGAGATGCAAAGAAAGGCAACTGAGGAGAAAGGGACAGAACTACCTGAGCG
GACTAAACCAGACTTTCCAGACCACAAGCCAAGAAAGTCTACTGATGAGAACGTTCCTGAGCCA
CTAGAAGAGATCAAATTAGAGTTTCCTGAGGAAGAATCAAGAAAAACAAATGAGGAAACAATTC
TAGAACAATCAGAAATGATGAAACCAGAAAGTCCAGAAGAGATAAGAAAGTCAAATGAGAAAAA
AAATCCACAGCCACCAGAGGAGACTGGTCCAGTGCTACCACAGGAGATCAACCCACAAGTTGAA
GAGAAAACACAAACAAAGCCAACTGAGAAAATTCTAGAGTTACCAGATGAAACCAAACCAAGGG
AGACACATGTAGAATTTTCCAAGGAAGACAGGCCAGAACCAATAAAGTCTAAGTATTCTGTAGG
AAACGATGAGCTAGAGCACCGTGAGCCTAAAAGAGGAAAGTTGTCACTAAGTGACAAATTTAGA
AAAGAATATTACGCATTAGGATCTCTCAGAGAAAGTGAAGAATCAATTGGTACACATTATGAGT
TTTTGCAACCACTCCAAAAATTGCTTAATGTCAGTGAAGAATGCTCATACTCAGATCCCTCAGA
GTCTCAGACAGAATTAAGTGAGTTCGTTCATGAAAAGGAAGTTGTAGATTTGTCCCAAGAGTTG
AAGGAACGGGTCTCTGAAGATGACGAAACCCAGCCAGAAAAAGGGACTGAGTTACAATTTGAGC
ATCTTAATTGGGATCCAGAGGAAGTTGCAGAGTGGATTAGCCAGCTAGGCTTCCCTCAATACAA
GGAGTGTTTTATCACAAACTTCATCAGTGGCCGAAAACTCATTCACGTCAACTGCTCAAACCTC
CCTCAGATGGGGATAACAAACTTTGAGGACATGAAGGCAATTTCTCGGCATACGCAGGAGCTCC
TGGAAATTGAAGAGCCATTATTCAAACGCTCCATCAGCCTTCCCTATAGGGATATTATCGGCTT
ATATTTAGAGCAAAAAGGTCATACTGGGATAAAATCTGATTCCTTGACTTTATCTGAATTTGTC
AAAGCAGCAGGATTACAGGATTATGCTCCAGAAATAACTGCCCCTGAAGAGAATGAGGAATTAC
CTTGCACTGAACCATAGGGGAAATCCACTTCACAGAGCTTGAAAGATCAAACTAAATTACTTGA
GGGAAGAGGTATGGTCTTTTTTGGTTTTCTTTTTCTCCTTTTTTTTTTTTTTATTTTTTTGAGA
CAGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAATGGCACAGTCTCAGCTCACTGCAACCTTG
CGATTCTCCTGTCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATCCGCCATCATGCCCAGCTA
ATTTTTGTATTTTTAGTAGATATGATGTTTCACCATGTTGGCCAGGCTGGTCTGAAACTCCTAA
CAGTTGATCTGCCCGCCGTGGCGTCCCAAAGTGCTGGGATTACAAGCGTGACCTACCGCACCTG
GCCCTTTTTCTCCTTTTCATTAAGGATCAGTTAGAACTGCTGGCTTCATTCCTAGTTGTGTCTC
TGACTTATGGTACCCTCCCTTTCTTTTTGCAATTTAACCCCTTGTTAAAACAAAGATAGTCACG
CTTATCTTTCTGGGTAATTATAAGAATTCCTGAGCCGGGCAAGGTGGCTCACACCTGTAATCCT
AGCTCTTTGGGTGGCTGAGGCGGGCAGATCACCTAAGGTCAGGATTTCAAGACCAGCCTGGCCA
ACAAGGTGAAGCCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCACATGCCTG
TAGTCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATCATTTGAACCCAGGAAACAGAGGTTATA
GTGAGCTGAGATGGTGCCACTGGACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTAAAACAA
ACAAACAAAACAAAGCAAAACAAAATTCCTGAAAAATTCTAGTAATGCACCTTGTAATAGGAAC
ATGTTGGGGAAATATAATTAAAAATAAAATCTCCTGCCAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001010860	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF62561	(Get FASTA)	NCBI Sequence Viewer
	AAI04835	(Get FASTA)	NCBI Sequence Viewer
	AAI04837	(Get FASTA)	NCBI Sequence Viewer
	BAF85260	(Get FASTA)	NCBI Sequence Viewer
	EAW81284	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000216471
	ENSP00000216471.4
	ENSP00000450941.1
GenBank Protein	Q9P1V8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001010860 ⟸ NM_001010860

- UniProtKB:

Q2M3P3 (UniProtKB/Swiss-Prot), Q9P1V8 (UniProtKB/Swiss-Prot), A8K956 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEVPEDYDSGPDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDF
KEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDE
THKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGV
PEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEP
PEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKS
TDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLP
QEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGK
LSLSDKFRKEYYALGSLRESEESIGTHYEFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKE
VVDLSQELKERVSEDDETQPEKGTELQFEHLNWDPEEVAEWISQLGFPQYKECFITNFISGRKL
IHVNCSNLPQMGITNFEDMKAISRHTQELLEIEEPLFKRSISLPYRDIIGLYLEQKGHTGIKSD
SLTLSEFVKAAGLQDYAPEITAPEENEELPCTEP

hide sequence

RefSeq Acc Id:

ENSP00000216471 ⟸ ENST00000216471

RefSeq Acc Id:

ENSP00000450941 ⟸ ENST00000533095

Protein Domains

SAM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9P1V8-F1-model_v2	AlphaFold	Q9P1V8	1-674	view protein structure

Promoters

RGD ID:

6791338

Promoter ID:

HG_KWN:19862

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4

Transcripts:

ENST00000216471, UC001XTO.1, UC010AST.1

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	14	76,912,346 - 76,913,247 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:18631	AgrOrtholog
COSMIC	SAMD15	COSMIC
Ensembl Genes	ENSG00000100583	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENST00000216471	ENTREZGENE
	ENST00000216471.5	UniProtKB/Swiss-Prot
	ENST00000533095.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.150.50	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx	ENSG00000100583	GTEx
HGNC ID	HGNC:18631	ENTREZGENE
Human Proteome Map	SAMD15	Human Proteome Map
InterPro	SAM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SAM/pointed_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:161394	UniProtKB/Swiss-Prot
NCBI Gene	161394	ENTREZGENE
PANTHER	PTHR46829	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 15	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	SAM_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA134903169	PharmGKB
PROSITE	SAM_DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	SAM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SAM/Pointed domain	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt	A8K956	ENTREZGENE, UniProtKB/TrEMBL
	G3V2Z3_HUMAN	UniProtKB/TrEMBL
	Q2M3P3	ENTREZGENE
	Q9P1V8	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q2M3P3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-07-27	SAMD15	sterile alpha motif domain containing 15	C14orf174	chromosome 14 open reading frame 174	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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