OR2J1 (olfactory receptor family 2 subfamily J member 1) - Rat Genome Database

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Gene: OR2J1 (olfactory receptor family 2 subfamily J member 1) Homo sapiens
Analyze
Symbol: OR2J1
Name: olfactory receptor family 2 subfamily J member 1
RGD ID: 1606623
HGNC Page HGNC:8259
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in membrane. Predicted to be active in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6M1-4P; dJ80I19.2; hs6M1-4; olfactory receptor 2J1; olfactory receptor 6-5; olfactory receptor family 2 subfamily J member 1 (gene/pseudogene); olfactory receptor OR6-15; olfactory receptor, family 2, subfamily J, member 1 pseudogene; OR2J1P; OR6-15; OR6-5
RGD Orthologs
Bonobo
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38629,099,490 - 29,102,701 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl629,099,490 - 29,102,701 (+)EnsemblGRCh38hg38GRCh38
GRCh37629,067,267 - 29,070,478 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36629,176,699 - 29,177,634 (+)NCBINCBI36Build 36hg18NCBI36
Celera630,674,831 - 30,675,766 (+)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef628,876,071 - 28,877,006 (+)NCBIHuRef
CHM1_1629,070,996 - 29,071,931 (+)NCBICHM1_1
T2T-CHM13v2.0628,974,213 - 28,977,431 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA,TAS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14983052   PMID:21873635  


Genomics

Comparative Map Data
OR2J1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38629,099,490 - 29,102,701 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl629,099,490 - 29,102,701 (+)EnsemblGRCh38hg38GRCh38
GRCh37629,067,267 - 29,070,478 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36629,176,699 - 29,177,634 (+)NCBINCBI36Build 36hg18NCBI36
Celera630,674,831 - 30,675,766 (+)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef628,876,071 - 28,877,006 (+)NCBIHuRef
CHM1_1629,070,996 - 29,071,931 (+)NCBICHM1_1
T2T-CHM13v2.0628,974,213 - 28,977,431 (+)NCBIT2T-CHM13v2.0
LOC100989679
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2543,732,437 - 43,735,655 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1639,732,937 - 39,736,155 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0628,997,993 - 28,999,258 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1629,652,396 - 29,653,322 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl629,582,244 - 29,587,997 (+)NCBIpanpan1.1panPan2
PanPan1.1 Ensembl629,582,244 - 29,587,997 (+)Ensemblpanpan1.1panPan2


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p22.3-21.33(chr6:18120520-30767516)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|See cases [RCV000052180] Chr6:18120520..30767516 [GRCh38]
Chr6:18120751..30735293 [GRCh37]
Chr6:18228730..30843272 [NCBI36]
Chr6:6p22.3-21.33		 pathogenic
GRCh38/hg38 6p22.1(chr6:28954915-29358240)x1 copy number loss See cases [RCV000138326] Chr6:28954915..29358240 [GRCh38]
Chr6:28922692..29326017 [GRCh37]
Chr6:29030671..29433996 [NCBI36]
Chr6:6p22.1		 likely benign
GRCh38/hg38 6p25.2-21.33(chr6:3224310-30657190)x3 copy number gain See cases [RCV000138956] Chr6:3224310..30657190 [GRCh38]
Chr6:3224544..30624967 [GRCh37]
Chr6:3169543..30732946 [NCBI36]
Chr6:6p25.2-21.33		 pathogenic
GRCh38/hg38 6p22.1(chr6:28954920-29358310)x3 copy number gain See cases [RCV000139079] Chr6:28954920..29358310 [GRCh38]
Chr6:28922697..29326087 [GRCh37]
Chr6:29030676..29434066 [NCBI36]
Chr6:6p22.1		 likely benign
GRCh38/hg38 6p22.1(chr6:28763187-29769828)x3 copy number gain See cases [RCV000141858] Chr6:28763187..29769828 [GRCh38]
Chr6:28730964..29737605 [GRCh37]
Chr6:28838943..29845584 [NCBI36]
Chr6:6p22.1		 uncertain significance
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:131
Interacting mature miRNAs:133
Transcripts:ENST00000377171
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 1 1 1 1 1
Below cutoff 66 80 49 9 57 6 108 46 112 3 280 44 3 28 76

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001348294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ302559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ302560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ302561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ302562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ302563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ302564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ302565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ302566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ302567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ302568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ302569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ302570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL022727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL645937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL929561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK004663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX248093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR388415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR547123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR933783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR942175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP290400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP290592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000377171   ⟹   ENSP00000366376
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl629,100,609 - 29,101,881 (+)Ensembl
RefSeq Acc Id: ENST00000641659   ⟹   ENSP00000493312
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl629,099,490 - 29,102,701 (+)Ensembl
RefSeq Acc Id: NM_001348294   ⟹   NP_001335223
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38629,099,490 - 29,102,701 (+)NCBI
T2T-CHM13v2.0628,974,213 - 28,977,431 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001335223   ⟸   NM_001348294
- UniProtKB: B0V1T2 (UniProtKB/Swiss-Prot),   A2AAS1 (UniProtKB/Swiss-Prot),   Q9GZK1 (UniProtKB/Swiss-Prot),   Q9GZK6 (UniProtKB/Swiss-Prot),   A0A126GVX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000366376   ⟸   ENST00000377171
RefSeq Acc Id: ENSP00000493312   ⟸   ENST00000641659
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9GZK6-F1-model_v2 AlphaFold Q9GZK6 1-312 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8259 AgrOrtholog
COSMIC OR2J1 COSMIC
Ensembl Genes ENSG00000204702 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000226931 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000377171.3 UniProtKB/Swiss-Prot
  ENST00000427659.2 UniProtKB/Swiss-Prot
  ENST00000641659 ENTREZGENE
  ENST00000641659.2 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000204702 GTEx
  ENSG00000226931 GTEx
HGNC ID HGNC:8259 ENTREZGENE
Human Proteome Map OR2J1 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:442185 UniProtKB/Swiss-Prot
NCBI Gene 442185 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 2J1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA32176 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A126GVX8 ENTREZGENE, UniProtKB/TrEMBL
  A0A126GWF4_HUMAN UniProtKB/TrEMBL
  A2AAS1 ENTREZGENE
  B0V1T2 ENTREZGENE
  OR2J1_HUMAN UniProtKB/Swiss-Prot
  Q9GZK1 ENTREZGENE
  Q9GZK6 ENTREZGENE
UniProt Secondary A2AAS1 UniProtKB/Swiss-Prot
  B0V1T2 UniProtKB/Swiss-Prot
  Q9GZK1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-05-11 OR2J1  olfactory receptor family 2 subfamily J member 1  OR2J1  olfactory receptor family 2 subfamily J member 1 (gene/pseudogene)  Symbol and/or name change 19259463 PROVISIONAL
2015-12-15 OR2J1  olfactory receptor family 2 subfamily J member 1 (gene/pseudogene)  OR2J1  olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene)  Symbol and/or name change 5135510 APPROVED
2011-09-06 OR2J1  olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene)  OR2J1  olfactory receptor, family 2, subfamily J, member 1  Symbol and/or name change 5135510 APPROVED