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Gene: DENND6B (DENN domain containing 6B) Homo sapiens
Symbol: DENND6B
Name: DENN domain containing 6B
Description: Exhibits Rab guanyl-nucleotide exchange factor activity. Predicted to localize to recycling endosome; INTERACTS WITH 2-methylcholine; aflatoxin B2; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AFI1B; DENN domain-containing protein 6B; DENN/MADD domain containing 6B; FAM116B; family with sequence similarity 116, member B; MGC33692
Mus musculus (house mouse) : Dennd6b (DENN/MADD domain containing 6B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dennd6b (DENN domain containing 6B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dennd6b (DENN domain containing 6B)
Pan paniscus (bonobo/pygmy chimpanzee) : DENND6B (DENN domain containing 6B)
Canis lupus familiaris (dog) : DENND6B (DENN domain containing 6B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dennd6b (DENN domain containing 6B)
Sus scrofa (pig) : DENND6B (DENN domain containing 6B)
Chlorocebus sabaeus (African green monkey) : DENND6B (DENN domain containing 6B)
Heterocephalus glaber (naked mole-rat) : Dennd6b (DENN domain containing 6B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2250,309,030 - 50,327,012 (-)EnsemblGRCh38hg38GRCh38
GRCh382250,309,030 - 50,327,016 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372250,750,392 - 50,765,517 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362249,092,964 - 49,100,010 (-)NCBINCBI36hg18NCBI36
Celera2234,626,857 - 34,634,095 (-)NCBI
Cytogenetic Map22q13.33NCBI
HuRef2233,648,422 - 33,655,557 (-)NCBIHuRef
CHM1_12250,709,132 - 50,724,188 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DENND6B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1606364
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.