KRT222 (keratin 222) - Rat Genome Database

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Gene: KRT222 (keratin 222) Homo sapiens
Analyze
Symbol: KRT222
Name: keratin 222
RGD ID: 1606170
HGNC Page HGNC:28695
Description: Predicted to enable structural molecule activity. Predicted to be located in intermediate filament.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KA21; keratin 222 pseudogene; keratin 222, type II; keratin-222; keratin-222 pseudogene; keratin-like protein KRT222; KRT222P; MGC45562; truncated type I keratin KA21
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: Although this gene is named as a pseudogene (PubMed 16831889), it is not yet established that the predicted protein is not translated. The NCBI RefSeq Project therefore continues to treat this as a protein coding gene. [11 Apr 2007]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,654,665 - 40,665,177 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,654,665 - 40,665,181 (-)EnsemblGRCh38hg38GRCh38
GRCh371738,810,917 - 38,821,429 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361736,065,398 - 36,074,942 (-)NCBINCBI36Build 36hg18NCBI36
Celera1735,473,458 - 35,483,002 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1734,606,449 - 34,615,992 (-)NCBIHuRef
CHM1_11739,047,218 - 39,056,765 (-)NCBICHM1_1
T2T-CHM13v2.01741,519,043 - 41,529,554 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:15085952   PMID:16831889   PMID:23455924   PMID:29845934   PMID:30021884   PMID:31862882   PMID:32296183   PMID:32814053   PMID:33961781   PMID:35914814  
PMID:36724073   PMID:36976175   PMID:37071682  


Genomics

Comparative Map Data
KRT222
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,654,665 - 40,665,177 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,654,665 - 40,665,181 (-)EnsemblGRCh38hg38GRCh38
GRCh371738,810,917 - 38,821,429 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361736,065,398 - 36,074,942 (-)NCBINCBI36Build 36hg18NCBI36
Celera1735,473,458 - 35,483,002 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1734,606,449 - 34,615,992 (-)NCBIHuRef
CHM1_11739,047,218 - 39,056,765 (-)NCBICHM1_1
T2T-CHM13v2.01741,519,043 - 41,529,554 (-)NCBIT2T-CHM13v2.0
Krt222
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391199,123,587 - 99,134,973 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1199,123,587 - 99,134,911 (-)EnsemblGRCm39 Ensembl
GRCm381199,232,761 - 99,244,147 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1199,232,761 - 99,244,085 (-)EnsemblGRCm38mm10GRCm38
MGSCv371199,094,412 - 99,105,381 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361199,049,188 - 99,060,157 (-)NCBIMGSCv36mm8
Celera11108,900,276 - 108,911,243 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.92NCBI
Krt222
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,680,331 - 84,693,374 (-)NCBIGRCr8
mRatBN7.21084,184,137 - 84,196,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1084,186,173 - 84,196,015 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1089,127,723 - 89,139,567 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,625,843 - 88,637,687 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01084,017,832 - 84,029,677 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01087,143,200 - 87,154,142 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1087,142,116 - 87,153,982 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,940,303 - 86,950,131 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1082,924,965 - 82,935,907 (-)NCBICelera
Cytogenetic Map10q31NCBI
Krt222
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545115,156,315 - 15,164,917 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545115,156,315 - 15,164,607 (-)NCBIChiLan1.0ChiLan1.0
KRT222
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,285,935 - 24,296,577 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,178,036 - 26,188,669 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01716,617,558 - 16,628,193 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11716,844,671 - 16,854,197 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1716,844,671 - 16,854,197 (+)Ensemblpanpan1.1panPan2
KRT222
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,000,847 - 22,010,014 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,000,847 - 22,009,985 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha921,473,839 - 21,483,005 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0922,793,991 - 22,803,156 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl922,794,066 - 22,803,249 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1921,568,394 - 21,577,601 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0921,827,257 - 21,836,423 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0921,951,724 - 21,960,893 (+)NCBIUU_Cfam_GSD_1.0
LOC101976803
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,361,796 - 21,410,052 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,664,764 - 15,675,220 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_00493649015,710,649 - 15,713,290 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,665,846 - 15,713,288 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT222
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1221,768,304 - 21,778,892 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11221,768,053 - 21,778,893 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,121,795 - 22,127,114 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KRT222
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11665,521,578 - 65,532,246 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1665,521,496 - 65,532,372 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607736,403,465 - 36,414,356 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krt222
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247952,698,150 - 2,706,607 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247952,698,194 - 2,708,754 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KRT222
17 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q12-21.31(chr17:39199873-45629579)x3 copy number gain See cases [RCV000052479] Chr17:39199873..45629579 [GRCh38]
Chr17:37356126..43706945 [GRCh37]
Chr17:34609652..41062728 [NCBI36]
Chr17:17q12-21.31
pathogenic
NM_152349.2(KRT222):c.72G>A (p.Glu24=) single nucleotide variant Malignant melanoma [RCV000063210] Chr17:40665028 [GRCh38]
Chr17:38821280 [GRCh37]
Chr17:36074806 [NCBI36]
Chr17:17q21.2
not provided
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
NM_152349.3(KRT222):c.683T>C (p.Ile228Thr) single nucleotide variant not specified [RCV004321295] Chr17:40656607 [GRCh38]
Chr17:38812859 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_152349.3(KRT222):c.23A>G (p.Asn8Ser) single nucleotide variant not specified [RCV004223838] Chr17:40665077 [GRCh38]
Chr17:38821329 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_152349.3(KRT222):c.209A>T (p.Glu70Val) single nucleotide variant not specified [RCV004238126] Chr17:40661932 [GRCh38]
Chr17:38818184 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_152349.3(KRT222):c.547A>G (p.Thr183Ala) single nucleotide variant not specified [RCV004212685] Chr17:40657464 [GRCh38]
Chr17:38813716 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_152349.3(KRT222):c.718C>G (p.Pro240Ala) single nucleotide variant not specified [RCV004156835] Chr17:40656572 [GRCh38]
Chr17:38812824 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_152349.3(KRT222):c.336G>T (p.Arg112Ser) single nucleotide variant not specified [RCV004412242] Chr17:40660097 [GRCh38]
Chr17:38816349 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_152349.3(KRT222):c.406A>G (p.Ile136Val) single nucleotide variant not specified [RCV004412243] Chr17:40660027 [GRCh38]
Chr17:38816279 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_152349.3(KRT222):c.607A>G (p.Ile203Val) single nucleotide variant not specified [RCV004412245] Chr17:40657404 [GRCh38]
Chr17:38813656 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_152349.3(KRT222):c.749G>T (p.Arg250Leu) single nucleotide variant not specified [RCV004412246] Chr17:40656541 [GRCh38]
Chr17:38812793 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_152349.3(KRT222):c.754G>T (p.Asp252Tyr) single nucleotide variant not specified [RCV004412247] Chr17:40656536 [GRCh38]
Chr17:38812788 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_152349.3(KRT222):c.817A>G (p.Ile273Val) single nucleotide variant not specified [RCV004412248] Chr17:40656473 [GRCh38]
Chr17:38812725 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_152349.3(KRT222):c.880G>C (p.Ala294Pro) single nucleotide variant not specified [RCV004412249] Chr17:40656410 [GRCh38]
Chr17:38812662 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_152349.3(KRT222):c.340G>C (p.Gly114Arg) single nucleotide variant not specified [RCV004644449] Chr17:40660093 [GRCh38]
Chr17:38816345 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_152349.3(KRT222):c.667A>C (p.Lys223Gln) single nucleotide variant not specified [RCV004644448] Chr17:40656623 [GRCh38]
Chr17:38812875 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_152349.3(KRT222):c.176G>A (p.Arg59Gln) single nucleotide variant not specified [RCV004644447] Chr17:40661965 [GRCh38]
Chr17:38818217 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_152349.3(KRT222):c.41A>G (p.Tyr14Cys) single nucleotide variant not specified [RCV004633707] Chr17:40665059 [GRCh38]
Chr17:38821311 [GRCh37]
Chr17:17q21.2
uncertain significance
GRCh37/hg19 17q12-22(chr17:41196270-41277589) copy number loss Breast-ovarian cancer, familial, susceptibility to, 1 [RCV004759419] Chr17:41196270..41277589 [GRCh37]
Chr17:17q12-22
pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2169
Count of miRNA genes:902
Interacting mature miRNAs:1077
Transcripts:ENST00000394049, ENST00000394052, ENST00000476049, ENST00000580719, ENST00000581564
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298406BP16_HBlood pressure QTL 16 (human)0.0004Blood pressurehypertension susceptibility171477864740778647Human
597051200GWAS1147274_Hleukocyte count QTL GWAS1147274 (human)2e-09leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)174066419340664194Human

Markers in Region
D17S1519E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371738,811,952 - 38,812,061UniSTSGRCh37
Build 361736,065,478 - 36,065,587RGDNCBI36
Celera1735,473,538 - 35,473,647RGD
Cytogenetic Map17q21.2UniSTS
HuRef1734,606,529 - 34,606,638UniSTS
GeneMap99-GB4 RH Map17314.49UniSTS
NCBI RH Map17475.3UniSTS
A004H08  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371738,812,643 - 38,812,753UniSTSGRCh37
Build 361736,066,169 - 36,066,279RGDNCBI36
Celera1735,474,229 - 35,474,339RGD
Cytogenetic Map17q21.2UniSTS
HuRef1734,607,220 - 34,607,330UniSTS
GeneMap99-GB4 RH Map17309.33UniSTS
NCBI RH Map17506.0UniSTS
D17S2038  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371738,811,916 - 38,812,142UniSTSGRCh37
Build 361736,065,442 - 36,065,668RGDNCBI36
Celera1735,473,502 - 35,473,728RGD
Cytogenetic Map17q21.2UniSTS
HuRef1734,606,493 - 34,606,719UniSTS
Whitehead-YAC Contig Map17 UniSTS
NIB470  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371738,811,913 - 38,812,074UniSTSGRCh37
Build 361736,065,439 - 36,065,600RGDNCBI36
Celera1735,473,499 - 35,473,660RGD
Cytogenetic Map17q21.2UniSTS
HuRef1734,606,490 - 34,606,651UniSTS
GeneMap99-GB4 RH Map17313.88UniSTS
Whitehead-RH Map17338.9UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1203 2489 2697 2210 5187 1938 2671 6 782 1315 625 2435 6915 5829 62 3779 1 1053 1842 1753 173 1

Sequence


Ensembl Acc Id: ENST00000394049   ⟹   ENSP00000377613
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1740,654,665 - 40,665,156 (-)Ensembl
Ensembl Acc Id: ENST00000394052   ⟹   ENSP00000377616
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1740,654,665 - 40,665,177 (-)Ensembl
Ensembl Acc Id: ENST00000476049   ⟹   ENSP00000463483
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1740,628,797 - 40,665,141 (-)Ensembl
Ensembl Acc Id: ENST00000580719   ⟹   ENSP00000464647
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1740,660,158 - 40,665,181 (-)Ensembl
Ensembl Acc Id: ENST00000581564   ⟹   ENSP00000463865
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1740,657,209 - 40,665,145 (-)Ensembl
Ensembl Acc Id: ENST00000643255   ⟹   ENSP00000493957
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1740,627,356 - 40,665,135 (-)Ensembl
RefSeq Acc Id: NM_152349   ⟹   NP_689562
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381740,654,665 - 40,665,177 (-)NCBI
GRCh371738,811,872 - 38,821,416 (-)RGD
Build 361736,065,398 - 36,074,942 (-)NCBI Archive
Celera1735,473,458 - 35,483,002 (-)RGD
HuRef1734,606,449 - 34,615,992 (-)ENTREZGENE
CHM1_11739,047,218 - 39,056,765 (-)NCBI
T2T-CHM13v2.01741,519,043 - 41,529,554 (-)NCBI
Sequence:
RefSeq Acc Id: NP_689562   ⟸   NM_152349
- UniProtKB: Q8N1A0 (UniProtKB/Swiss-Prot),   Q7Z368 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000464647   ⟸   ENST00000580719
Ensembl Acc Id: ENSP00000463865   ⟸   ENST00000581564
Ensembl Acc Id: ENSP00000493957   ⟸   ENST00000643255
Ensembl Acc Id: ENSP00000377613   ⟸   ENST00000394049
Ensembl Acc Id: ENSP00000377616   ⟸   ENST00000394052
Ensembl Acc Id: ENSP00000463483   ⟸   ENST00000476049
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8N1A0-F1-model_v2 AlphaFold Q8N1A0 1-295 view protein structure

Promoters
RGD ID:7234945
Promoter ID:EPDNEW_H23219
Type:initiation region
Name:KRT222_1
Description:keratin 222
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381740,665,164 - 40,665,224EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:28695 AgrOrtholog
COSMIC KRT222 COSMIC
Ensembl Genes ENSG00000213424 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000264058 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENST00000394049.5 UniProtKB/TrEMBL
  ENST00000394052 ENTREZGENE
  ENST00000394052.5 UniProtKB/Swiss-Prot
  ENST00000580719.1 UniProtKB/TrEMBL
  ENST00000581564.1 UniProtKB/TrEMBL
  ENST00000643255.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
GTEx ENSG00000213424 GTEx
  ENSG00000264058 GTEx
HGNC ID HGNC:28695 ENTREZGENE
Human Proteome Map KRT222 Human Proteome Map
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_Keratin-like UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot
  Keratin_I UniProtKB/Swiss-Prot
KEGG Report hsa:125113 UniProtKB/Swiss-Prot
NCBI Gene 125113 ENTREZGENE
PANTHER KERATIN-LIKE PROTEIN KRT222 UniProtKB/Swiss-Prot
  KERATIN-LIKE PROTEIN KRT222 UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot
PharmGKB PA165432008 PharmGKB
PRINTS TYPE1KERATIN UniProtKB/Swiss-Prot
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot
UniProt J3QQR9_HUMAN UniProtKB/TrEMBL
  KT222_HUMAN UniProtKB/Swiss-Prot
  Q7Z368 ENTREZGENE
  Q8N1A0 ENTREZGENE
UniProt Secondary Q7Z368 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-14 KRT222  keratin 222    keratin 222, type II  Symbol and/or name change 5135510 APPROVED
2015-01-27 KRT222  keratin 222, type II    keratin 222  Symbol and/or name change 5135510 APPROVED