UBE2U (ubiquitin conjugating enzyme E2 U) - Rat Genome Database

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Gene: UBE2U (ubiquitin conjugating enzyme E2 U) Homo sapiens
Analyze
Symbol: UBE2U
Name: ubiquitin conjugating enzyme E2 U
RGD ID: 1606149
HGNC Page HGNC:28559
Description: Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in DNA repair; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to be part of HULC complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E2 ubiquitin-conjugating enzyme U; MGC35130; RP4-636O23.1; testicular tissue protein Li 216; ubiquitin carrier protein U; ubiquitin conjugating enzyme E2 U (putative); ubiquitin conjugating enzyme E2U (putative); ubiquitin-conjugating enzyme E2 U; ubiquitin-conjugating enzyme E2U (putative); ubiquitin-protein ligase U
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38164,203,623 - 64,267,368 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl164,203,623 - 64,267,368 (+)EnsemblGRCh38hg38GRCh38
GRCh37164,669,306 - 64,733,051 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36164,442,078 - 64,482,615 (+)NCBINCBI36Build 36hg18NCBI36
Celera162,959,589 - 63,000,068 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef162,778,392 - 62,818,851 (+)NCBIHuRef
CHM1_1164,785,215 - 64,825,697 (+)NCBICHM1_1
T2T-CHM13v2.0164,078,756 - 64,143,219 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
HULC complex  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16710414   PMID:19549727   PMID:19690564   PMID:21516116   PMID:21873635   PMID:22496338   PMID:25416956   PMID:26186194   PMID:27903633   PMID:28514442  
PMID:30097011   PMID:31120930   PMID:32814053   PMID:33776059   PMID:33842849   PMID:33961781  


Genomics

Comparative Map Data
UBE2U
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38164,203,623 - 64,267,368 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl164,203,623 - 64,267,368 (+)EnsemblGRCh38hg38GRCh38
GRCh37164,669,306 - 64,733,051 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36164,442,078 - 64,482,615 (+)NCBINCBI36Build 36hg18NCBI36
Celera162,959,589 - 63,000,068 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef162,778,392 - 62,818,851 (+)NCBIHuRef
CHM1_1164,785,215 - 64,825,697 (+)NCBICHM1_1
T2T-CHM13v2.0164,078,756 - 64,143,219 (+)NCBIT2T-CHM13v2.0
Ube2u
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394100,336,064 - 100,407,342 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4100,336,046 - 100,407,344 (+)EnsemblGRCm39 Ensembl
GRCm384100,478,867 - 100,550,145 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4100,478,849 - 100,550,147 (+)EnsemblGRCm38mm10GRCm38
MGSCv374100,151,472 - 100,222,750 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36499,976,799 - 100,048,077 (+)NCBIMGSCv36mm8
Celera498,839,063 - 98,910,791 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map445.72NCBI
Ube2u
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85120,233,749 - 120,301,514 (+)NCBIGRCr8
mRatBN7.25115,118,234 - 115,187,296 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5115,118,495 - 115,186,874 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.05118,574,647 - 118,642,810 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5118,574,801 - 118,642,863 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05122,502,926 - 122,571,096 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45121,128,675 - 121,196,288 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5113,665,335 - 113,733,160 (+)NCBICelera
Cytogenetic Map5q33NCBI
Ube2u
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542325,973,131 - 26,017,733 (-)NCBIChiLan1.0ChiLan1.0
UBE2U
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21162,588,031 - 162,652,315 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11161,738,576 - 161,802,902 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0163,458,063 - 63,521,812 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1165,346,777 - 65,389,265 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl165,346,777 - 65,410,228 (+)Ensemblpanpan1.1panPan2
UBE2U
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1545,947,637 - 45,998,353 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl545,947,639 - 45,997,722 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha546,005,599 - 46,055,826 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0546,124,819 - 46,175,053 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl546,124,821 - 46,175,032 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1546,087,154 - 46,137,423 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0546,033,137 - 46,083,352 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0546,290,882 - 46,341,107 (-)NCBIUU_Cfam_GSD_1.0
Ube2u
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505877,399,087 - 77,495,543 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366921,714,511 - 1,792,910 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366921,714,533 - 1,765,348 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBE2U
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6148,233,412 - 148,305,330 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16148,233,498 - 148,314,193 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26136,685,350 - 136,757,434 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UBE2U
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12068,799,501 - 68,865,893 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603348,649,297 - 48,711,899 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in UBE2U
14 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p32.1-31.1(chr1:60473800-70944955)x1 copy number loss See cases [RCV000050703] Chr1:60473800..70944955 [GRCh38]
Chr1:60939472..71410638 [GRCh37]
Chr1:60712060..71183226 [NCBI36]
Chr1:1p32.1-31.1		 pathogenic
GRCh38/hg38 1p32.3-31.1(chr1:52595352-76767765)x3 copy number gain See cases [RCV000051822] Chr1:52595352..76767765 [GRCh38]
Chr1:53061024..77233450 [GRCh37]
Chr1:52833612..77006038 [NCBI36]
Chr1:1p32.3-31.1		 pathogenic
GRCh38/hg38 1p31.3(chr1:61922650-66445757)x3 copy number gain See cases [RCV000051824] Chr1:61922650..66445757 [GRCh38]
Chr1:62388322..66911440 [GRCh37]
Chr1:62160910..66684028 [NCBI36]
Chr1:1p31.3		 pathogenic
GRCh38/hg38 1p32.2-31.1(chr1:57350574-71325924)x1 copy number loss See cases [RCV000053841] Chr1:57350574..71325924 [GRCh38]
Chr1:57816246..71791607 [GRCh37]
Chr1:57588834..71564195 [NCBI36]
Chr1:1p32.2-31.1		 pathogenic
GRCh38/hg38 1p32.1-31.1(chr1:59632500-76730877)x1 copy number loss See cases [RCV000053842] Chr1:59632500..76730877 [GRCh38]
Chr1:60098172..77196562 [GRCh37]
Chr1:59870760..76969150 [NCBI36]
Chr1:1p32.1-31.1		 pathogenic
GRCh38/hg38 1p32.1-31.2(chr1:58819605-69107108)x1 copy number loss See cases [RCV000134142] Chr1:58819605..69107108 [GRCh38]
Chr1:59285277..69572791 [GRCh37]
Chr1:59057865..69345379 [NCBI36]
Chr1:1p32.1-31.2		 pathogenic
GRCh38/hg38 1p32.1-22.3(chr1:58819605-86098611)x1 copy number loss See cases [RCV000136913] Chr1:58819605..86098611 [GRCh38]
Chr1:59285277..86564294 [GRCh37]
Chr1:59057865..86336882 [NCBI36]
Chr1:1p32.1-22.3		 pathogenic
GRCh38/hg38 1p31.3(chr1:63873863-64333572)x1 copy number loss See cases [RCV000139923] Chr1:63873863..64333572 [GRCh38]
Chr1:64339534..64799255 [GRCh37]
Chr1:64112122..64571843 [NCBI36]
Chr1:1p31.3		 uncertain significance
GRCh38/hg38 1p32.3-31.3(chr1:53627272-64248854)x1 copy number loss See cases [RCV000139470] Chr1:53627272..64248854 [GRCh38]
Chr1:54092945..64714537 [GRCh37]
Chr1:53865533..64487125 [NCBI36]
Chr1:1p32.3-31.3		 pathogenic
GRCh38/hg38 1p32.3-31.3(chr1:52787503-67339873)x3 copy number gain See cases [RCV000141758] Chr1:52787503..67339873 [GRCh38]
Chr1:53253175..67805556 [GRCh37]
Chr1:53025763..67578144 [NCBI36]
Chr1:1p32.3-31.3		 likely pathogenic
GRCh38/hg38 1p31.3-31.1(chr1:64072618-75518432)x3 copy number gain See cases [RCV000142452] Chr1:64072618..75518432 [GRCh38]
Chr1:64538290..75984117 [GRCh37]
Chr1:64310878..75756705 [NCBI36]
Chr1:1p31.3-31.1		 pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12		 likely benign
GRCh37/hg19 1p31.3(chr1:61785602-67430956)x3 copy number gain See cases [RCV000446769] Chr1:61785602..67430956 [GRCh37]
Chr1:1p31.3		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p31.3-22.3(chr1:64321264-88153669)x1 copy number loss See cases [RCV000511392] Chr1:64321264..88153669 [GRCh37]
Chr1:1p31.3-22.3		 pathogenic|uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p31.3-31.1(chr1:61351024-79583933)x1 copy number loss See cases [RCV000512152] Chr1:61351024..79583933 [GRCh37]
Chr1:1p31.3-31.1		 pathogenic
GRCh37/hg19 1p31.3-31.1(chr1:62434799-71656180)x3 copy number gain not provided [RCV000684577] Chr1:62434799..71656180 [GRCh37]
Chr1:1p31.3-31.1		 pathogenic
GRCh37/hg19 1p31.3(chr1:62468555-65584629)x3 copy number gain not provided [RCV000684578] Chr1:62468555..65584629 [GRCh37]
Chr1:1p31.3		 uncertain significance
GRCh37/hg19 1p31.3(chr1:62830524-65396403)x1 copy number loss not provided [RCV000684579] Chr1:62830524..65396403 [GRCh37]
Chr1:1p31.3		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1		 uncertain significance
Single allele deletion Intellectual disability, severe [RCV000824954] Chr1:59922631..72058653 [GRCh37]
Chr1:1p32.1-31.1		 pathogenic
NM_001366232.2(UBE2U):c.408T>G (p.Asp136Glu) single nucleotide variant not specified [RCV004326906] Chr1:64214883 [GRCh38]
Chr1:64680566 [GRCh37]
Chr1:1p31.3		 uncertain significance
GRCh37/hg19 1p32.3-31.3(chr1:53675707-66644963)x1 copy number loss Chromosome 1p32-p31 deletion syndrome [RCV001263218] Chr1:53675707..66644963 [GRCh37]
Chr1:1p32.3-31.3		 pathogenic
NC_000001.10:g.(?_61548464)_(67861772_?)del deletion not provided [RCV003116397] Chr1:61548464..67861772 [GRCh37]
Chr1:1p31.3		 pathogenic
NM_001366232.2(UBE2U):c.85G>A (p.Val29Ile) single nucleotide variant not specified [RCV004117153] Chr1:64205657 [GRCh38]
Chr1:64671340 [GRCh37]
Chr1:1p31.3		 uncertain significance
NM_001366232.2(UBE2U):c.490C>T (p.Pro164Ser) single nucleotide variant not specified [RCV004186981] Chr1:64220891 [GRCh38]
Chr1:64686574 [GRCh37]
Chr1:1p31.3		 uncertain significance
NM_001366232.2(UBE2U):c.446G>A (p.Arg149Lys) single nucleotide variant not specified [RCV004104950] Chr1:64214921 [GRCh38]
Chr1:64680604 [GRCh37]
Chr1:1p31.3		 uncertain significance
NM_001366232.2(UBE2U):c.500G>A (p.Cys167Tyr) single nucleotide variant not specified [RCV004346501] Chr1:64220901 [GRCh38]
Chr1:64686584 [GRCh37]
Chr1:1p31.3		 uncertain significance
GRCh37/hg19 1p32.1-31.3(chr1:60641326-65216639)x1 copy number loss not specified [RCV003986418] Chr1:60641326..65216639 [GRCh37]
Chr1:1p32.1-31.3		 pathogenic
GRCh37/hg19 1p31.3(chr1:63047044-64769540)x1 copy number loss not specified [RCV003986950] Chr1:63047044..64769540 [GRCh37]
Chr1:1p31.3		 uncertain significance
GRCh37/hg19 1p31.3(chr1:63885043-65190254)x1 copy number loss not specified [RCV003986739] Chr1:63885043..65190254 [GRCh37]
Chr1:1p31.3		 pathogenic
NM_001366232.2(UBE2U):c.362T>A (p.Leu121Gln) single nucleotide variant not specified [RCV004476903] Chr1:64214837 [GRCh38]
Chr1:64680520 [GRCh37]
Chr1:1p31.3		 uncertain significance
NM_001366232.2(UBE2U):c.648T>A (p.Asp216Glu) single nucleotide variant not specified [RCV004476904] Chr1:64241704 [GRCh38]
Chr1:64707387 [GRCh37]
Chr1:1p31.3		 likely benign
NM_001366232.2(UBE2U):c.527T>A (p.Phe176Tyr) single nucleotide variant not specified [RCV004677803] Chr1:64232581 [GRCh38]
Chr1:64698264 [GRCh37]
Chr1:1p31.3		 uncertain significance
NM_001366232.2(UBE2U):c.616A>G (p.Ile206Val) single nucleotide variant not specified [RCV004883711] Chr1:64241672 [GRCh38]
Chr1:64707355 [GRCh37]
Chr1:1p31.3		 uncertain significance
GRCh37/hg19 1p34.1-22.2(chr1:44475302-89585894)x3 copy number gain not provided [RCV004819297] Chr1:44475302..89585894 [GRCh37]
Chr1:1p34.1-22.2		 pathogenic
NM_001366232.2(UBE2U):c.664G>A (p.Glu222Lys) single nucleotide variant not specified [RCV004883712] Chr1:64241720 [GRCh38]
Chr1:64707403 [GRCh37]
Chr1:1p31.3		 uncertain significance
GRCh38/hg38 1p32.1-31.1(chr1:59760856-71578052)x1 copy number loss See cases [RCV000133710] Chr1:59760856..71578052 [GRCh38]
Chr1:60226528..72043735 [GRCh37]
Chr1:59999116..71816323 [NCBI36]
Chr1:1p32.1-31.1		 pathogenic
GRCh37/hg19 1p31.3-31.1(chr1:63252828-77402595)x1 copy number loss See cases [RCV000446378] Chr1:63252828..77402595 [GRCh37]
Chr1:1p31.3-31.1		 pathogenic
NC_000001.10:g.(?_61548464)_(67861772_?)dup duplication PGM1-congenital disorder of glycosylation [RCV004584077] Chr1:61548464..67861772 [GRCh37]
Chr1:1p31.3		 uncertain significance
NM_001366232.2(UBE2U):c.67G>A (p.Gly23Ser) single nucleotide variant not specified [RCV004677800] Chr1:64205639 [GRCh38]
Chr1:64671322 [GRCh37]
Chr1:1p31.3		 uncertain significance
NM_001366232.2(UBE2U):c.250C>T (p.His84Tyr) single nucleotide variant not specified [RCV004677801] Chr1:64210750 [GRCh38]
Chr1:64676433 [GRCh37]
Chr1:1p31.3		 uncertain significance
NM_001366232.2(UBE2U):c.572C>G (p.Ala191Gly) single nucleotide variant not specified [RCV004677802] Chr1:64232626 [GRCh38]
Chr1:64698309 [GRCh37]
Chr1:1p31.3		 uncertain significance
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:428
Count of miRNA genes:300
Interacting mature miRNAs:316
Transcripts:ENST00000371076, ENST00000371077, ENST00000464349, ENST00000608020, ENST00000608956
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2314561GLUCO47_HGlucose level QTL 47 (human)1.1Glucose level14477336070773360Human
1578602LDLPS21_HLow density lipoprotein particle size QTL 21 (human)2.050.00037LDL particle size15253110578531105Human
1578620LDLPS20_HLow density lipoprotein particle size QTL 21 (human)2.040.00046LDL particle size15253110578531105Human
597025233GWAS1121307_Hbacterial meningitis QTL GWAS1121307 (human)2e-08bacterial meningitis16421509264215093Human
597143136GWAS1239210_HS-7-hydroxywarfarin to S-warfarin ratio measurement QTL GWAS1239210 (human)0.000001S-7-hydroxywarfarin to S-warfarin ratio measurement16421473264214733Human
1578594LDLPS19_HLow density lipoprotein particle size QTL 19 (human)2.560.00009LDL particle size15253110578531105Human

Markers in Region
RH102555  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37164,709,843 - 64,709,964UniSTSGRCh37
Build 36164,482,431 - 64,482,552RGDNCBI36
Celera162,999,884 - 63,000,005RGD
Cytogenetic Map1p31.3UniSTS
HuRef162,818,667 - 62,818,788UniSTS
GeneMap99-GB4 RH Map1171.54UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
449 851 947 857 2218 641 883 5 221 260 145 1129 1931 1764 13 1408 302 842 665 78

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001366232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001366233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001366234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001366235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_152489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_158768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_158769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006710379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011540764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017000379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017000380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017000381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017000382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017000383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017000384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017000385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002959500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AL161916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL445205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG773201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX112562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000371076   ⟹   ENSP00000360116
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl164,203,807 - 64,244,344 (+)Ensembl
Ensembl Acc Id: ENST00000371077   ⟹   ENSP00000360117
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl164,203,623 - 64,267,368 (+)Ensembl
Ensembl Acc Id: ENST00000464349
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl164,215,453 - 64,244,340 (+)Ensembl
Ensembl Acc Id: ENST00000608020   ⟹   ENSP00000477356
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl164,214,815 - 64,267,368 (+)Ensembl
Ensembl Acc Id: ENST00000608956   ⟹   ENSP00000476556
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl164,220,864 - 64,267,249 (+)Ensembl
Ensembl Acc Id: ENST00000611228   ⟹   ENSP00000481174
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl164,203,627 - 64,267,368 (+)Ensembl
RefSeq Acc Id: NM_001366232   ⟹   NP_001353161
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38164,203,623 - 64,267,368 (+)NCBI
T2T-CHM13v2.0164,079,586 - 64,143,219 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001366233   ⟹   NP_001353162
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38164,203,623 - 64,267,368 (+)NCBI
T2T-CHM13v2.0164,079,586 - 64,143,219 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001366234   ⟹   NP_001353163
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38164,203,623 - 64,267,368 (+)NCBI
T2T-CHM13v2.0164,079,586 - 64,143,219 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001366235   ⟹   NP_001353164
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38164,203,623 - 64,246,274 (+)NCBI
T2T-CHM13v2.0164,079,586 - 64,122,155 (+)NCBI
Sequence:
RefSeq Acc Id: NM_152489   ⟹   NP_689702
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38164,203,623 - 64,246,274 (+)NCBI
GRCh37164,669,135 - 64,732,969 (+)NCBI
Build 36164,442,078 - 64,482,615 (+)NCBI Archive
Celera162,959,589 - 63,000,068 (+)RGD
HuRef162,778,392 - 62,818,851 (+)ENTREZGENE
CHM1_1164,785,215 - 64,825,697 (+)NCBI
T2T-CHM13v2.0164,079,586 - 64,122,155 (+)NCBI
Sequence:
RefSeq Acc Id: NR_158768
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38164,203,623 - 64,246,274 (+)NCBI
T2T-CHM13v2.0164,079,586 - 64,122,155 (+)NCBI
Sequence:
RefSeq Acc Id: NR_158769
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38164,203,623 - 64,267,368 (+)NCBI
T2T-CHM13v2.0164,079,586 - 64,143,219 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006710379   ⟹   XP_006710442
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38164,204,541 - 64,267,368 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017000379   ⟹   XP_016855868
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38164,214,844 - 64,267,368 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017000380   ⟹   XP_016855869
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38164,214,844 - 64,267,368 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017000381   ⟹   XP_016855870
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38164,214,846 - 64,267,368 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017000382   ⟹   XP_016855871
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38164,214,889 - 64,267,368 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017000383   ⟹   XP_016855872
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38164,214,844 - 64,267,368 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017000384   ⟹   XP_016855873
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38164,214,857 - 64,267,368 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054334589   ⟹   XP_054190564
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0164,078,756 - 64,143,219 (+)NCBI
RefSeq Acc Id: XM_054334590   ⟹   XP_054190565
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0164,080,504 - 64,143,219 (+)NCBI
RefSeq Acc Id: XM_054334591   ⟹   XP_054190566
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0164,090,795 - 64,143,219 (+)NCBI
RefSeq Acc Id: XM_054334592   ⟹   XP_054190567
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0164,090,795 - 64,143,219 (+)NCBI
RefSeq Acc Id: XM_054334593   ⟹   XP_054190568
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0164,090,797 - 64,143,219 (+)NCBI
RefSeq Acc Id: XM_054334594   ⟹   XP_054190569
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0164,090,840 - 64,143,219 (+)NCBI
RefSeq Acc Id: XM_054334595   ⟹   XP_054190570
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0164,090,795 - 64,143,219 (+)NCBI
RefSeq Acc Id: XM_054334596   ⟹   XP_054190571
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0164,090,808 - 64,143,219 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001353161 (Get FASTA)   NCBI Sequence Viewer  
  NP_001353162 (Get FASTA)   NCBI Sequence Viewer  
  NP_001353163 (Get FASTA)   NCBI Sequence Viewer  
  NP_001353164 (Get FASTA)   NCBI Sequence Viewer  
  NP_689702 (Get FASTA)   NCBI Sequence Viewer  
  XP_006710442 (Get FASTA)   NCBI Sequence Viewer  
  XP_016855868 (Get FASTA)   NCBI Sequence Viewer  
  XP_016855869 (Get FASTA)   NCBI Sequence Viewer  
  XP_016855870 (Get FASTA)   NCBI Sequence Viewer  
  XP_016855871 (Get FASTA)   NCBI Sequence Viewer  
  XP_016855872 (Get FASTA)   NCBI Sequence Viewer  
  XP_016855873 (Get FASTA)   NCBI Sequence Viewer  
  XP_054190564 (Get FASTA)   NCBI Sequence Viewer  
  XP_054190565 (Get FASTA)   NCBI Sequence Viewer  
  XP_054190566 (Get FASTA)   NCBI Sequence Viewer  
  XP_054190567 (Get FASTA)   NCBI Sequence Viewer  
  XP_054190568 (Get FASTA)   NCBI Sequence Viewer  
  XP_054190569 (Get FASTA)   NCBI Sequence Viewer  
  XP_054190570 (Get FASTA)   NCBI Sequence Viewer  
  XP_054190571 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH29895 (Get FASTA)   NCBI Sequence Viewer  
  AEE61126 (Get FASTA)   NCBI Sequence Viewer  
  EAX06552 (Get FASTA)   NCBI Sequence Viewer  
  EAX06553 (Get FASTA)   NCBI Sequence Viewer  
  EAX06554 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000360116
  ENSP00000360116.3
  ENSP00000360117
  ENSP00000477356
  ENSP00000481174.1
GenBank Protein Q5VVX9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_689702   ⟸   NM_152489
- Peptide Label: isoform 4
- UniProtKB: A0A140VJY9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006710442   ⟸   XM_006710379
- Peptide Label: isoform X1
- UniProtKB: Q8N1D4 (UniProtKB/Swiss-Prot),   Q5VVX9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016855869   ⟸   XM_017000380
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016855872   ⟸   XM_017000383
- Peptide Label: isoform X3
- UniProtKB: V9GZ31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016855868   ⟸   XM_017000379
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016855870   ⟸   XM_017000381
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016855873   ⟸   XM_017000384
- Peptide Label: isoform X3
- UniProtKB: V9GZ31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016855871   ⟸   XM_017000382
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001353161   ⟸   NM_001366232
- Peptide Label: isoform 1
- UniProtKB: Q8N1D4 (UniProtKB/Swiss-Prot),   Q5VVX9 (UniProtKB/Swiss-Prot),   A0A0A0MRP4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001353163   ⟸   NM_001366234
- Peptide Label: isoform 3
- UniProtKB: Q8N1D4 (UniProtKB/Swiss-Prot),   Q5VVX9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001353162   ⟸   NM_001366233
- Peptide Label: isoform 2
- UniProtKB: Q8N1D4 (UniProtKB/Swiss-Prot),   Q5VVX9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001353164   ⟸   NM_001366235
- Peptide Label: isoform 5
Ensembl Acc Id: ENSP00000360116   ⟸   ENST00000371076
Ensembl Acc Id: ENSP00000360117   ⟸   ENST00000371077
Ensembl Acc Id: ENSP00000481174   ⟸   ENST00000611228
Ensembl Acc Id: ENSP00000476556   ⟸   ENST00000608956
Ensembl Acc Id: ENSP00000477356   ⟸   ENST00000608020
RefSeq Acc Id: XP_054190564   ⟸   XM_054334589
- Peptide Label: isoform X4
- UniProtKB: Q8N1D4 (UniProtKB/Swiss-Prot),   Q5VVX9 (UniProtKB/Swiss-Prot),   A0A0A0MRP4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054190565   ⟸   XM_054334590
- Peptide Label: isoform X1
- UniProtKB: Q8N1D4 (UniProtKB/Swiss-Prot),   Q5VVX9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054190567   ⟸   XM_054334592
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054190570   ⟸   XM_054334595
- Peptide Label: isoform X3
- UniProtKB: V9GZ31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054190566   ⟸   XM_054334591
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054190568   ⟸   XM_054334593
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054190571   ⟸   XM_054334596
- Peptide Label: isoform X3
- UniProtKB: V9GZ31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054190569   ⟸   XM_054334594
- Peptide Label: isoform X2
Protein Domains
UBC core

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5VVX9-F1-model_v2 AlphaFold Q5VVX9 1-321 view protein structure

Promoters
RGD ID:6855762
Promoter ID:EPDNEW_H1046
Type:multiple initiation site
Name:UBE2U_1
Description:ubiquitin conjugating enzyme E2 U
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38164,203,708 - 64,203,768EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:28559 AgrOrtholog
COSMIC UBE2U COSMIC
Ensembl Genes ENSG00000177414 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000371076 ENTREZGENE
  ENST00000371076.7 UniProtKB/Swiss-Prot
  ENST00000371077 ENTREZGENE
  ENST00000608020 ENTREZGENE
  ENST00000611228.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.110.10 UniProtKB/Swiss-Prot
GTEx ENSG00000177414 GTEx
HGNC ID HGNC:28559 ENTREZGENE
Human Proteome Map UBE2U Human Proteome Map
InterPro Ub_conjugating_enzyme UniProtKB/Swiss-Prot
  UBQ-conjugat_E2 UniProtKB/Swiss-Prot
  UBQ-conjugating_AS UniProtKB/Swiss-Prot
  UBQ-conjugating_enzyme/RWD UniProtKB/Swiss-Prot
KEGG Report hsa:148581 UniProtKB/Swiss-Prot
NCBI Gene 148581 ENTREZGENE
PANTHER UBIQUITIN-CONJUGATING ENZYME E2 UniProtKB/Swiss-Prot
Pfam UQ_con UniProtKB/Swiss-Prot
PharmGKB PA142670656 PharmGKB
PROSITE UBIQUITIN_CONJUGAT_1 UniProtKB/Swiss-Prot
  UBIQUITIN_CONJUGAT_2 UniProtKB/Swiss-Prot
SMART UBCc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54495 UniProtKB/Swiss-Prot
UniProt A0A0A0MRP4 ENTREZGENE, UniProtKB/TrEMBL
  A0A140VJY9 ENTREZGENE, UniProtKB/TrEMBL
  Q5VVX9 ENTREZGENE
  Q8N1D4 ENTREZGENE
  UBE2U_HUMAN UniProtKB/Swiss-Prot
  V9GYA6_HUMAN UniProtKB/TrEMBL
  V9GZ31 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q8N1D4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-20 UBE2U  ubiquitin conjugating enzyme E2 U    ubiquitin conjugating enzyme E2 U (putative)  Symbol and/or name change 5135510 APPROVED
2016-03-21 UBE2U  ubiquitin conjugating enzyme E2 U (putative)    ubiquitin conjugating enzyme E2U (putative)  Symbol and/or name change 5135510 APPROVED
2015-11-24 UBE2U  ubiquitin conjugating enzyme E2U (putative)    ubiquitin-conjugating enzyme E2U (putative)  Symbol and/or name change 5135510 APPROVED