ERICH5 (glutamate rich 5) - Rat Genome Database

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Gene: ERICH5 (glutamate rich 5) Homo sapiens
Analyze
Symbol: ERICH5
Name: glutamate rich 5
RGD ID: 1606129
HGNC Page HGNC
Description: INTERACTS WITH aflatoxin B1; antirheumatic drug; benzo[a]pyrene
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C8orf47; FLJ39553; glutamate-rich 5; glutamate-rich protein 5; hypothetical protein LOC203111; uncharacterized protein C8orf47
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl898,064,522 - 98,093,610 (+)EnsemblGRCh38hg38GRCh38
GRCh38898,064,568 - 98,093,609 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37899,076,796 - 99,105,837 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36899,145,926 - 99,175,014 (+)NCBINCBI36hg18NCBI36
Celera895,262,686 - 95,291,703 (+)NCBI
Cytogenetic Map8q22.2NCBI
HuRef894,280,474 - 94,309,531 (+)NCBIHuRef
CHM1_1899,117,578 - 99,146,611 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:20208534   PMID:26186194   PMID:26638075   PMID:28514442   PMID:30021884   PMID:32296183  


Genomics

Comparative Map Data
ERICH5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl898,064,522 - 98,093,610 (+)EnsemblGRCh38hg38GRCh38
GRCh38898,064,568 - 98,093,609 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37899,076,796 - 99,105,837 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36899,145,926 - 99,175,014 (+)NCBINCBI36hg18NCBI36
Celera895,262,686 - 95,291,703 (+)NCBI
Cytogenetic Map8q22.2NCBI
HuRef894,280,474 - 94,309,531 (+)NCBIHuRef
CHM1_1899,117,578 - 99,146,611 (+)NCBICHM1_1
Erich5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391534,453,458 - 34,474,038 (+)NCBIGRCm39mm39
GRCm39 Ensembl1534,453,451 - 34,474,038 (+)Ensembl
GRCm381534,453,312 - 34,473,892 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1534,453,305 - 34,473,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv371534,383,067 - 34,403,647 (+)NCBIGRCm37mm9NCBIm37
MGSCv361534,397,901 - 34,418,481 (+)NCBImm8
Celera1535,081,140 - 35,101,694 (+)NCBICelera
Cytogenetic Map15B3.1NCBI
Erich5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2765,655,829 - 65,682,221 (+)NCBI
Rnor_6.0 Ensembl773,222,730 - 73,242,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0773,222,331 - 73,243,684 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0773,389,891 - 73,409,637 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4769,889,633 - 69,915,564 (+)NCBIRGSC3.4rn4RGSC3.4
Celera762,758,284 - 62,779,616 (+)NCBICelera
Cytogenetic Map7q22NCBI
Erich5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541713,776,429 - 13,802,830 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541713,776,609 - 13,804,241 (+)NCBIChiLan1.0ChiLan1.0
ERICH5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1896,885,774 - 96,914,837 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl896,885,774 - 96,914,837 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0894,700,821 - 94,730,383 (+)NCBIMhudiblu_PPA_v0panPan3
ERICH5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.113333,051 - 340,832 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha13308,303 - 333,201 (+)NCBI
ROS_Cfam_1.013463,261 - 488,143 (+)NCBI
UMICH_Zoey_3.113306,841 - 331,732 (+)NCBI
UNSW_CanFamBas_1.013414,631 - 439,515 (+)NCBI
UU_Cfam_GSD_1.013420,685 - 445,563 (+)NCBI
Erich5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530337,301,031 - 37,324,376 (-)NCBI
SpeTri2.0NW_00493647044,728,531 - 44,750,472 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERICH5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1438,669,327 - 38,702,114 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2441,821,138 - 41,854,393 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ERICH5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1892,978,630 - 93,003,578 (+)NCBI
Erich5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247635,215,125 - 5,236,501 (+)NCBI

Position Markers
SHGC-154724  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37899,080,457 - 99,080,747UniSTSGRCh37
Build 36899,149,633 - 99,149,923RGDNCBI36
Celera895,266,393 - 95,266,683RGD
Cytogenetic Map8q22.2UniSTS
HuRef894,284,181 - 94,284,471UniSTS
TNG Radiation Hybrid Map847056.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:66
Interacting mature miRNAs:66
Transcripts:ENST00000318528, ENST00000545282
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 35 2 159 154 325 156 1 10 2 108 138 95
Low 939 493 938 440 304 289 1132 431 2007 234 1035 767 160 1 282 492 3
Below cutoff 1247 1651 577 25 541 17 2245 1175 1580 46 243 648 11 650 1617

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000318528   ⟹   ENSP00000315614
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,064,568 - 98,093,609 (+)Ensembl
RefSeq Acc Id: ENST00000545282   ⟹   ENSP00000440297
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,064,522 - 98,093,610 (+)Ensembl
RefSeq Acc Id: NM_001170806   ⟹   NP_001164277
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,064,568 - 98,093,609 (+)NCBI
GRCh37899,076,750 - 99,105,838 (+)RGD
Celera895,262,686 - 95,291,703 (+)RGD
HuRef894,280,474 - 94,309,531 (+)RGD
CHM1_1899,117,578 - 99,146,611 (+)NCBI
Sequence:
RefSeq Acc Id: NM_173549   ⟹   NP_775820
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,064,568 - 98,093,609 (+)NCBI
GRCh37899,076,750 - 99,105,838 (+)RGD
Build 36899,145,926 - 99,175,014 (+)NCBI Archive
Celera895,262,686 - 95,291,703 (+)RGD
HuRef894,280,474 - 94,309,531 (+)RGD
CHM1_1899,117,578 - 99,146,611 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_775820   ⟸   NM_173549
- Peptide Label: isoform 1
- UniProtKB: Q6P6B1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001164277   ⟸   NM_001170806
- Peptide Label: isoform 2
- UniProtKB: Q6P6B1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000440297   ⟸   ENST00000545282
RefSeq Acc Id: ENSP00000315614   ⟸   ENST00000318528

Promoters
RGD ID:7213851
Promoter ID:EPDNEW_H12671
Type:initiation region
Name:ERICH5_1
Description:glutamate rich 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12672  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,064,296 - 98,064,356EPDNEW
RGD ID:7213855
Promoter ID:EPDNEW_H12672
Type:initiation region
Name:ERICH5_2
Description:glutamate rich 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12671  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,064,568 - 98,064,628EPDNEW
RGD ID:6806535
Promoter ID:HG_KWN:61775
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:ENST00000396066,   NM_001170806
Position:
Human AssemblyChrPosition (strand)Source
Build 36899,145,676 - 99,146,176 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.3-24.3(chr8:93047482-141355635)x3 copy number gain See cases [RCV000511761] Chr8:93047482..141355635 [GRCh37]
Chr8:8q21.3-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q21.2-23.3(chr8:86841154-116518125)x3 copy number gain not provided [RCV000683045] Chr8:86841154..116518125 [GRCh37]
Chr8:8q21.2-23.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:26823 AgrOrtholog
COSMIC ERICH5 COSMIC
Ensembl Genes ENSG00000177459 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000315614 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000440297 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000318528 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000545282 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000177459 GTEx
HGNC ID HGNC:26823 ENTREZGENE
Human Proteome Map ERICH5 Human Proteome Map
InterPro DUF4573 UniProtKB/Swiss-Prot
KEGG Report hsa:203111 UniProtKB/Swiss-Prot
NCBI Gene 203111 ENTREZGENE
Pfam DUF4573 UniProtKB/Swiss-Prot
PharmGKB PA142672366 PharmGKB
UniProt ERIC5_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V1K4 UniProtKB/Swiss-Prot
  Q8N1L8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-10 ERICH5  glutamate rich 5    glutamate-rich 5  Symbol and/or name change 5135510 APPROVED
2014-03-05 ERICH5  glutamate-rich 5  C8orf47  chromosome 8 open reading frame 47  Symbol and/or name change 5135510 APPROVED