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Gene: HINT1 (histidine triad nucleotide binding protein 1) Homo sapiens
Symbol: HINT1
Name: histidine triad nucleotide binding protein 1
Description: Exhibits hydrolase activity. Involved in intrinsic apoptotic signaling pathway by p53 class mediator; purine ribonucleotide catabolic process; and regulation of transcription, DNA-templated. Localizes to the cytosol; histone deacetylase complex; and plasma membrane. Implicated in Gamstorp-Wohlfart syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: adenosine 5'-monophosphoramidase; FLJ30414; FLJ32340; HINT; histidine triad nucleotide-binding protein 1; NMAN; PKCI-1; PRKCNH1; protein kinase C inhibitor 1; protein kinase C-interacting protein 1
Mus musculus (house mouse) : Hint1 (histidine triad nucleotide binding protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hint1 (histidine triad nucleotide binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hint1 (histidine triad nucleotide binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HINT1 (histidine triad nucleotide binding protein 1)
Canis lupus familiaris (dog) : HINT1 (histidine triad nucleotide binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hint1 (histidine triad nucleotide binding protein 1)
Sus scrofa (pig) : HINT1 (histidine triad nucleotide binding protein 1)
Chlorocebus sabaeus (African green monkey) : HINT1 (histidine triad nucleotide binding protein 1)
Heterocephalus glaber (naked mole-rat) : Hint1 (histidine triad nucleotide binding protein 1)
more info ...
Related Pseudogenes: HINT1P1   HINT1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl5131,159,027 - 131,171,735 (-)Ensembl
GRCh385131,159,027 - 131,165,348 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375130,494,976 - 130,501,041 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365130,522,776 - 130,528,935 (-)NCBINCBI36hg18NCBI36
Celera5126,625,253 - 126,631,412 (-)NCBI
Cytogenetic Map5q23.3NCBI
HuRef5125,686,002 - 125,692,067 (-)NCBIHuRef
CHM1_15129,927,969 - 129,934,034 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HINT1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1606034
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.