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Gene: USP9X (ubiquitin specific peptidase 9 X-linked) Homo sapiens
Symbol: USP9X
Name: ubiquitin specific peptidase 9 X-linked
Description: Exhibits Lys48-specific deubiquitinase activity; co-SMAD binding activity; and thiol-dependent ubiquitinyl hydrolase activity. Involved in several processes, including generation of neurons; positive regulation of DNA demethylation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to the cytosol and growth cone. Implicated in non-syndromic X-linked intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: deubiquitinating enzyme FAF-X; DFFRX; Drosophila fat facets related, X-linked; FAF; FAM; fat facets in mammals; fat facets protein related, X-linked; fat facets protein-related, X-linked; hFAM; MRX99; MRXS99F; probable ubiquitin carboxyl-terminal hydrolase FAF-X; RP5-1172N10.4; ubiquitin specific peptidase 9, X-linked; ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila); ubiquitin thioesterase FAF-X; ubiquitin thiolesterase FAF-X; ubiquitin-specific processing protease FAF-X; ubiquitin-specific protease 9, X chromosome; ubiquitin-specific-processing protease FAF-X
Mus musculus (house mouse) : Usp9x (ubiquitin specific peptidase 9, X chromosome)  MGI  Alliance
Rattus norvegicus (Norway rat) : Usp9x (ubiquitin specific peptidase 9, X-linked)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Usp9x (ubiquitin specific peptidase 9 X-linked)
Pan paniscus (bonobo/pygmy chimpanzee) : USP9X (ubiquitin specific peptidase 9, X-linked)
Canis lupus familiaris (dog) : USP9X (ubiquitin specific peptidase 9 X-linked)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Usp9x (ubiquitin specific peptidase 9 X-linked)
Sus scrofa (pig) : USP9X (ubiquitin specific peptidase 9 X-linked)
Chlorocebus sabaeus (African green monkey) : USP9X (ubiquitin specific peptidase 9 X-linked)
Heterocephalus glaber (naked mole-rat) : Usp9x (ubiquitin specific peptidase 9 X-linked)
more info ...
Related Pseudogenes: USP9YP7  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX41,085,445 - 41,236,579 (+)Ensembl
GRCh38X41,085,420 - 41,236,579 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X40,944,727 - 41,095,832 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X40,829,832 - 40,980,776 (+)NCBINCBI36hg18NCBI36
CeleraX45,085,646 - 45,236,596 (+)NCBI
Cytogenetic MapXp11.4NCBI
HuRefX38,676,295 - 38,826,441 (+)NCBIHuRef
CHM1_1X40,977,600 - 41,128,503 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on USP9X
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1606030
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.