SPOPL (speckle type BTB/POZ protein like) - Rat Genome Database

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Gene: SPOPL (speckle type BTB/POZ protein like) Homo sapiens
Analyze
Symbol: SPOPL
Name: speckle type BTB/POZ protein like
RGD ID: 1605812
HGNC Page HGNC:27934
Description: Enables identical protein binding activity. Involved in negative regulation of protein ubiquitination and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BTBD33; FLJ53775; HIB homolog 2; roadkill homolog 2; speckle type POZ protein like; speckle-type POZ protein-like
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: SPOPLP1   SPOPLP2   SPOPLP3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382138,501,770 - 138,573,547 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2138,501,770 - 138,574,458 (+)EnsemblGRCh38hg38GRCh38
GRCh372139,259,340 - 139,331,117 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362138,975,841 - 139,047,271 (+)NCBINCBI36Build 36hg18NCBI36
Celera2132,970,983 - 133,042,402 (+)NCBICelera
Cytogenetic Map2q22.1NCBI
HuRef2131,250,702 - 131,322,126 (+)NCBIHuRef
CHM1_12139,263,966 - 139,335,423 (+)NCBICHM1_1
T2T-CHM13v2.02138,947,462 - 139,019,229 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:15146197   PMID:15489334   PMID:16651542   PMID:16740475   PMID:17207965   PMID:21873635   PMID:22632832   PMID:23241943   PMID:25416956   PMID:27008177  
PMID:31515488   PMID:32296183   PMID:33961781   PMID:37523046  


Genomics

Comparative Map Data
SPOPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382138,501,770 - 138,573,547 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2138,501,770 - 138,574,458 (+)EnsemblGRCh38hg38GRCh38
GRCh372139,259,340 - 139,331,117 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362138,975,841 - 139,047,271 (+)NCBINCBI36Build 36hg18NCBI36
Celera2132,970,983 - 133,042,402 (+)NCBICelera
Cytogenetic Map2q22.1NCBI
HuRef2131,250,702 - 131,322,126 (+)NCBIHuRef
CHM1_12139,263,966 - 139,335,423 (+)NCBICHM1_1
T2T-CHM13v2.02138,947,462 - 139,019,229 (+)NCBIT2T-CHM13v2.0
Spopl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39223,382,942 - 23,462,139 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl223,396,232 - 23,462,118 (-)EnsemblGRCm39 Ensembl
GRCm38223,507,466 - 23,572,132 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl223,506,220 - 23,572,106 (-)EnsemblGRCm38mm10GRCm38
MGSCv37223,365,574 - 23,427,624 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36223,332,063 - 23,394,063 (-)NCBIMGSCv36mm8
Celera223,242,836 - 23,304,878 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map215.48NCBI
Spopl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8326,478,535 - 26,552,344 (-)NCBIGRCr8
mRatBN7.236,074,681 - 6,148,508 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl36,078,310 - 6,108,794 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx39,178,010 - 9,238,205 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0317,764,209 - 17,824,402 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0315,954,015 - 16,014,210 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03397,834 - 471,651 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3401,429 - 471,634 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03396,611 - 456,801 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.431,518,951 - 1,579,141 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.131,518,250 - 1,549,357 (-)NCBI
Celera3917,060 - 977,065 (-)NCBICelera
Cytogenetic Map3p13NCBI
Spopl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554405,568,073 - 5,612,677 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554405,594,970 - 5,612,677 (+)NCBIChiLan1.0ChiLan1.0
SPOPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21336,351,382 - 36,422,774 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B36,366,348 - 36,437,740 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B21,280,143 - 21,351,547 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B142,577,019 - 142,648,257 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B142,577,019 - 142,648,257 (+)Ensemblpanpan1.1panPan2
SPOPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11941,167,511 - 41,240,741 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1941,215,826 - 41,236,735 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1941,421,068 - 41,494,005 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01942,603,649 - 42,676,830 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1942,608,284 - 42,674,020 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11941,272,145 - 41,338,798 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01941,415,046 - 41,488,065 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01942,646,187 - 42,713,252 (+)NCBIUU_Cfam_GSD_1.0
Spopl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303103,952,007 - 104,013,819 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646937,603,803 - 37,661,436 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646937,608,044 - 37,661,337 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPOPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1513,134,225 - 13,207,731 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11513,134,221 - 13,207,737 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21515,277,896 - 15,351,897 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPOPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11023,868,104 - 23,934,157 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040175,444,328 - 175,510,428 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spopl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473238,277,686 - 38,293,970 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473238,214,876 - 38,297,363 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SPOPL
25 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001001664.2(SPOPL):c.217C>T (p.Pro73Ser) single nucleotide variant Malignant melanoma [RCV000060329] Chr2:138550919 [GRCh38]
Chr2:139308489 [GRCh37]
Chr2:139024959 [NCBI36]
Chr2:2q22.1
not provided
NM_001001664.2(SPOPL):c.218C>T (p.Pro73Leu) single nucleotide variant Malignant melanoma [RCV000060330] Chr2:138550920 [GRCh38]
Chr2:139308490 [GRCh37]
Chr2:139024960 [NCBI36]
Chr2:2q22.1
not provided
NM_001001664.2(SPOPL):c.-61+1230T>C single nucleotide variant Lung cancer [RCV000091439] Chr2:138503349 [GRCh38]
Chr2:139260919 [GRCh37]
Chr2:2q22.1
uncertain significance
GRCh38/hg38 2q21.3-22.2(chr2:136045480-142845159)x3 copy number gain See cases [RCV000136054] Chr2:136045480..142845159 [GRCh38]
Chr2:136803050..143602728 [GRCh37]
Chr2:136519520..143319198 [NCBI36]
Chr2:2q21.3-22.2
pathogenic
GRCh38/hg38 2q14.3-22.1(chr2:123445762-140592538)x1 copy number loss See cases [RCV000136714] Chr2:123445762..140592538 [GRCh38]
Chr2:124203338..141350107 [GRCh37]
Chr2:123919808..141066577 [NCBI36]
Chr2:2q14.3-22.1
pathogenic
GRCh38/hg38 2q22.1-22.3(chr2:136937358-146681810)x1 copy number loss See cases [RCV000137506] Chr2:136937358..146681810 [GRCh38]
Chr2:137694928..147439378 [GRCh37]
Chr2:137411398..147155848 [NCBI36]
Chr2:2q22.1-22.3
pathogenic
GRCh38/hg38 2q22.1(chr2:137433939-138535492)x3 copy number gain See cases [RCV000143714] Chr2:137433939..138535492 [GRCh38]
Chr2:138191509..139293062 [GRCh37]
Chr2:137907979..139009532 [NCBI36]
Chr2:2q22.1
likely benign
GRCh37/hg19 2q22.1-22.3(chr2:138578298-144874187)x1 copy number loss See cases [RCV000449099] Chr2:138578298..144874187 [GRCh37]
Chr2:2q22.1-22.3
likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q12.1-24.3(chr2:104172062-168223828)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626436] Chr2:104172062..168223828 [GRCh37]
Chr2:2q12.1-24.3
drug response
NM_001001664.3(SPOPL):c.262T>G (p.Leu88Val) single nucleotide variant not specified [RCV004331988] Chr2:138550964 [GRCh38]
Chr2:139308534 [GRCh37]
Chr2:2q22.1
uncertain significance
GRCh37/hg19 2q14.2-22.1(chr2:120571363-141627287)x1 copy number loss See cases [RCV000512348] Chr2:120571363..141627287 [GRCh37]
Chr2:2q14.2-22.1
pathogenic
GRCh37/hg19 2q22.1(chr2:139261688-139377923)x1 copy number loss not provided [RCV000682006] Chr2:139261688..139377923 [GRCh37]
Chr2:2q22.1
likely benign
GRCh37/hg19 2q22.1(chr2:139096959-139273973)x1 copy number loss not provided [RCV000682023] Chr2:139096959..139273973 [GRCh37]
Chr2:2q22.1
likely benign|uncertain significance
Single allele deletion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3
likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NM_001001664.3(SPOPL):c.1039G>A (p.Ala347Thr) single nucleotide variant not specified [RCV004309446] Chr2:138568940 [GRCh38]
Chr2:139326510 [GRCh37]
Chr2:2q22.1
uncertain significance
Single allele deletion Mowat-Wilson syndrome [RCV001250753] Chr2:137639637..146827604 [GRCh37]
Chr2:2q22.1-22.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q21.3-23.3(chr2:136473383-152727396) copy number gain Global developmental delay [RCV001352659] Chr2:136473383..152727396 [GRCh37]
Chr2:2q21.3-23.3
pathogenic
GRCh37/hg19 2q14.3-22.2(chr2:122699106-143799629)x1 copy number loss not provided [RCV001832883] Chr2:122699106..143799629 [GRCh37]
Chr2:2q14.3-22.2
pathogenic
GRCh37/hg19 2q13-22.3(chr2:111484468-146333604)x3 copy number gain not provided [RCV001832896] Chr2:111484468..146333604 [GRCh37]
Chr2:2q13-22.3
pathogenic
GRCh37/hg19 2q22.1-22.3(chr2:138578298-144874187) copy number loss not specified [RCV002053235] Chr2:138578298..144874187 [GRCh37]
Chr2:2q22.1-22.3
likely pathogenic
GRCh37/hg19 2q13-22.3(chr2:112475655-145691999)x3 copy number gain 2q13q22.3 microduplication syndrome [RCV002226436] Chr2:112475655..145691999 [GRCh37]
Chr2:2q13-22.3
pathogenic
NM_001001664.3(SPOPL):c.485G>A (p.Ser162Asn) single nucleotide variant not specified [RCV004327668] Chr2:138559026 [GRCh38]
Chr2:139316596 [GRCh37]
Chr2:2q22.1
uncertain significance
NM_001001664.3(SPOPL):c.1162C>T (p.Arg388Trp) single nucleotide variant not specified [RCV004164227] Chr2:138569063 [GRCh38]
Chr2:139326633 [GRCh37]
Chr2:2q22.1
uncertain significance
NM_001001664.3(SPOPL):c.471A>C (p.Leu157Phe) single nucleotide variant not specified [RCV004139706] Chr2:138552672 [GRCh38]
Chr2:139310242 [GRCh37]
Chr2:2q22.1
uncertain significance
NM_001001664.3(SPOPL):c.719G>A (p.Arg240Gln) single nucleotide variant not specified [RCV004220695] Chr2:138560809 [GRCh38]
Chr2:139318379 [GRCh37]
Chr2:2q22.1
likely benign
NM_001001664.3(SPOPL):c.252G>T (p.Leu84Phe) single nucleotide variant not specified [RCV004119984] Chr2:138550954 [GRCh38]
Chr2:139308524 [GRCh37]
Chr2:2q22.1
uncertain significance
NM_001001664.3(SPOPL):c.947A>T (p.Gln316Leu) single nucleotide variant not specified [RCV004105775] Chr2:138564817 [GRCh38]
Chr2:139322387 [GRCh37]
Chr2:2q22.1
uncertain significance
NM_001001664.3(SPOPL):c.736T>G (p.Leu246Val) single nucleotide variant not specified [RCV004201542] Chr2:138560826 [GRCh38]
Chr2:139318396 [GRCh37]
Chr2:2q22.1
likely benign
NM_001001664.3(SPOPL):c.1042A>G (p.Thr348Ala) single nucleotide variant not specified [RCV004169315] Chr2:138568943 [GRCh38]
Chr2:139326513 [GRCh37]
Chr2:2q22.1
likely benign
NM_001001664.3(SPOPL):c.427C>T (p.Leu143Phe) single nucleotide variant not specified [RCV004184141] Chr2:138552628 [GRCh38]
Chr2:139310198 [GRCh37]
Chr2:2q22.1
uncertain significance
NM_001001664.3(SPOPL):c.426G>T (p.Leu142Phe) single nucleotide variant not specified [RCV004184140] Chr2:138552627 [GRCh38]
Chr2:139310197 [GRCh37]
Chr2:2q22.1
uncertain significance
NM_001001664.3(SPOPL):c.325G>C (p.Ala109Pro) single nucleotide variant not specified [RCV004092814] Chr2:138551027 [GRCh38]
Chr2:139308597 [GRCh37]
Chr2:2q22.1
uncertain significance
NM_001001664.3(SPOPL):c.682A>G (p.Met228Val) single nucleotide variant not specified [RCV004174716] Chr2:138559305 [GRCh38]
Chr2:139316875 [GRCh37]
Chr2:2q22.1
uncertain significance
NM_001001664.3(SPOPL):c.1091C>T (p.Pro364Leu) single nucleotide variant not specified [RCV004277374] Chr2:138568992 [GRCh38]
Chr2:139326562 [GRCh37]
Chr2:2q22.1
uncertain significance
NM_001001664.3(SPOPL):c.332G>A (p.Arg111Lys) single nucleotide variant not specified [RCV004340736] Chr2:138551034 [GRCh38]
Chr2:139308604 [GRCh37]
Chr2:2q22.1
uncertain significance
GRCh37/hg19 2q22.1(chr2:138458639-141918297)x1 copy number loss Syndromic craniosynostosis [RCV003481511] Chr2:138458639..141918297 [GRCh37]
Chr2:2q22.1
likely pathogenic
GRCh37/hg19 2q21.2-23.2(chr2:134589311-149951291)x3 copy number gain not specified [RCV003986337] Chr2:134589311..149951291 [GRCh37]
Chr2:2q21.2-23.2
likely pathogenic
NM_001001664.3(SPOPL):c.1036C>A (p.Gln346Lys) single nucleotide variant not specified [RCV004465202] Chr2:138568937 [GRCh38]
Chr2:139326507 [GRCh37]
Chr2:2q22.1
uncertain significance
NM_001001664.3(SPOPL):c.885T>G (p.Ser295Arg) single nucleotide variant not specified [RCV004465206] Chr2:138564755 [GRCh38]
Chr2:139322325 [GRCh37]
Chr2:2q22.1
uncertain significance
NM_001001664.3(SPOPL):c.298G>A (p.Ala100Thr) single nucleotide variant not specified [RCV004465204] Chr2:138551000 [GRCh38]
Chr2:139308570 [GRCh37]
Chr2:2q22.1
uncertain significance
NM_001001664.3(SPOPL):c.1136G>A (p.Cys379Tyr) single nucleotide variant not specified [RCV004465203] Chr2:138569037 [GRCh38]
Chr2:139326607 [GRCh37]
Chr2:2q22.1
uncertain significance
NM_001001664.3(SPOPL):c.680C>T (p.Ala227Val) single nucleotide variant not specified [RCV004465205] Chr2:138559303 [GRCh38]
Chr2:139316873 [GRCh37]
Chr2:2q22.1
uncertain significance
NM_001001664.3(SPOPL):c.1166T>C (p.Leu389Pro) single nucleotide variant not specified [RCV004675135] Chr2:138569067 [GRCh38]
Chr2:139326637 [GRCh37]
Chr2:2q22.1
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1819
Count of miRNA genes:874
Interacting mature miRNAs:1034
Transcripts:ENST00000280098, ENST00000420679, ENST00000430968, ENST00000467775
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406961950GWAS610926_Hresponse to olanzapine QTL GWAS610926 (human)0.0000001response to olanzapine2138521352138521353Human

Markers in Region
WI-11168  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372139,261,217 - 139,261,341UniSTSGRCh37
Build 362138,977,687 - 138,977,811RGDNCBI36
Celera2132,972,760 - 132,972,884RGD
Cytogenetic Map2q22.1UniSTS
HuRef2131,252,536 - 131,252,660UniSTS
Whitehead-RH Map2767.8UniSTS
RH104408  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372139,326,682 - 139,326,804UniSTSGRCh37
Build 362139,043,152 - 139,043,274RGDNCBI36
Celera2133,038,279 - 133,038,401RGD
Cytogenetic Map2q22.1UniSTS
HuRef2131,318,003 - 131,318,125UniSTS
GeneMap99-GB4 RH Map2484.48UniSTS
D2S1795  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372139,284,728 - 139,284,862UniSTSGRCh37
Build 362139,001,198 - 139,001,332RGDNCBI36
Celera2132,996,275 - 132,996,409RGD
Cytogenetic Map2q22.1UniSTS
HuRef2131,276,051 - 131,276,185UniSTS
Whitehead-RH Map2768.3UniSTS
Whitehead-YAC Contig Map2 UniSTS
NCBI RH Map21043.4UniSTS
WI-11856  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372139,329,734 - 139,329,838UniSTSGRCh37
Build 362139,046,204 - 139,046,308RGDNCBI36
Celera2133,041,331 - 133,041,435RGD
Cytogenetic Map2q22.1UniSTS
HuRef2131,321,055 - 131,321,159UniSTS
GeneMap99-GB4 RH Map2484.48UniSTS
Whitehead-RH Map2759.5UniSTS
NCBI RH Map21043.4UniSTS
SHGC-36231  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372139,327,824 - 139,327,930UniSTSGRCh37
Build 362139,044,294 - 139,044,400RGDNCBI36
Celera2133,039,421 - 133,039,527RGD
Cytogenetic Map2q22.1UniSTS
HuRef2131,319,145 - 131,319,251UniSTS
GeneMap99-G3 RH Map26658.0UniSTS
D2S2867  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372139,329,631 - 139,329,767UniSTSGRCh37
Build 362139,046,101 - 139,046,237RGDNCBI36
Celera2133,041,228 - 133,041,364RGD
Cytogenetic Map2q22.1UniSTS
HuRef2131,320,952 - 131,321,088UniSTS
Stanford-G3 RH Map25754.0UniSTS
GeneMap99-G3 RH Map26658.0UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2437 2788 2248 4964 1725 2350 5 623 1947 465 2269 7293 6460 52 3727 851 1742 1615 174 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001001664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005263655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005263656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005263657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047444115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047444116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054341697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054341698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA737682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC092620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC114763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK094583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC071613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX538143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD643025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN315400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000280098   ⟹   ENSP00000280098
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2138,501,770 - 138,573,547 (+)Ensembl
Ensembl Acc Id: ENST00000420679   ⟹   ENSP00000396006
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2138,550,157 - 138,569,130 (+)Ensembl
Ensembl Acc Id: ENST00000430968   ⟹   ENSP00000410201
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2138,501,932 - 138,552,582 (+)Ensembl
Ensembl Acc Id: ENST00000449869   ⟹   ENSP00000520629
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2138,501,773 - 138,572,305 (+)Ensembl
Ensembl Acc Id: ENST00000458007
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2138,569,090 - 138,574,458 (+)Ensembl
Ensembl Acc Id: ENST00000467775
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2138,564,388 - 138,565,019 (+)Ensembl
RefSeq Acc Id: NM_001001664   ⟹   NP_001001664
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382138,501,770 - 138,573,547 (+)NCBI
GRCh372139,259,350 - 139,330,805 (+)RGD
Build 362138,975,841 - 139,047,271 (+)NCBI Archive
Celera2132,970,983 - 133,042,402 (+)RGD
HuRef2131,250,702 - 131,322,126 (+)ENTREZGENE
CHM1_12139,263,966 - 139,335,423 (+)NCBI
T2T-CHM13v2.02138,947,462 - 139,019,229 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047444115   ⟹   XP_047300071
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382138,550,512 - 138,573,547 (+)NCBI
RefSeq Acc Id: XM_047444116   ⟹   XP_047300072
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382138,550,229 - 138,573,547 (+)NCBI
RefSeq Acc Id: XM_054341697   ⟹   XP_054197672
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.02138,996,210 - 139,019,229 (+)NCBI
RefSeq Acc Id: XM_054341698   ⟹   XP_054197673
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.02138,995,927 - 139,019,229 (+)NCBI
RefSeq Acc Id: NP_001001664   ⟸   NM_001001664
- UniProtKB: Q6IQ16 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000280098   ⟸   ENST00000280098
Ensembl Acc Id: ENSP00000410201   ⟸   ENST00000430968
Ensembl Acc Id: ENSP00000396006   ⟸   ENST00000420679
RefSeq Acc Id: XP_047300072   ⟸   XM_047444116
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047300071   ⟸   XM_047444115
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054197673   ⟸   XM_054341698
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054197672   ⟸   XM_054341697
- Peptide Label: isoform X1
Ensembl Acc Id: ENSP00000520629   ⟸   ENST00000449869
Protein Domains
BTB   MATH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IQ16-F1-model_v2 AlphaFold Q6IQ16 1-392 view protein structure

Promoters
RGD ID:6861664
Promoter ID:EPDNEW_H3997
Type:initiation region
Name:SPOPL_1
Description:speckle type BTB/POZ protein like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3998  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382138,501,770 - 138,501,830EPDNEW
RGD ID:6861666
Promoter ID:EPDNEW_H3998
Type:initiation region
Name:SPOPL_2
Description:speckle type BTB/POZ protein like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3997  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382138,501,931 - 138,501,991EPDNEW
RGD ID:6798289
Promoter ID:HG_KWN:35219
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000331836,   OTTHUMT00000331837,   OTTHUMT00000331897,   OTTHUMT00000331899
Position:
Human AssemblyChrPosition (strand)Source
Build 362138,975,581 - 138,976,577 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:27934 AgrOrtholog
COSMIC SPOPL COSMIC
Ensembl Genes ENSG00000144228 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000280098 ENTREZGENE
  ENST00000280098.9 UniProtKB/Swiss-Prot
  ENST00000420679.1 UniProtKB/TrEMBL
  ENST00000430968.5 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.3030 UniProtKB/Swiss-Prot
  6.20.250.50 UniProtKB/Swiss-Prot
GTEx ENSG00000144228 GTEx
HGNC ID HGNC:27934 ENTREZGENE
Human Proteome Map SPOPL Human Proteome Map
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot
  MATH/TRAF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
  TRAF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:339745 UniProtKB/Swiss-Prot
NCBI Gene 339745 ENTREZGENE
PANTHER SPECKLE-TYPE POZ PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPECKLE-TYPE POZ PROTEIN-LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB UniProtKB/Swiss-Prot
  MATH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA162404650 PharmGKB
PROSITE BTB UniProtKB/Swiss-Prot
  MATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BTB UniProtKB/Swiss-Prot
  MATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot
  TRAF domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F8WBB7_HUMAN UniProtKB/TrEMBL
  F8WD02_HUMAN UniProtKB/TrEMBL
  Q6IQ16 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-16 SPOPL  speckle type BTB/POZ protein like    speckle type POZ protein like  Symbol and/or name change 5135510 APPROVED
2015-11-24 SPOPL  speckle type POZ protein like    speckle-type POZ protein-like  Symbol and/or name change 5135510 APPROVED