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Gene: HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) Homo sapiens
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Symbol: HLA-DPA1
Name: major histocompatibility complex, class II, DP alpha 1
Description: Exhibits peptide antigen binding activity. Involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; cellular response to interferon-gamma; and positive regulation of interferon-gamma production. Localizes to MHC class II protein complex; cell surface; and intracellular membrane-bounded organelle. Implicated in several diseases, including Crohn's disease; asthma (multiple); hepatitis B; liver disease (multiple); and onchocerciasis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DP(W3); DP(W4); DPA1; HLA class II histocompatibility antigen, DP alpha 1 chain; HLA class II histocompatibility antigen, DP alpha chain; HLA DPA1; HLA-DP1A; HLA-DPA1*01:03:01:New; HLA-DPA1*02:01:01:NEW; HLA-DPB1; HLA-SB alpha chain; HLADP; HLASB; MHC class II antigen; MHC class II DP alpha chain; MHC class II DP3-alpha; MHC class II DPA1; MHC class II HLA-DPA1 antigen; PLT1; Primed lymphocyte test-1
Orthologs:
Mus musculus (house mouse) : H2-Pa (histocompatibility 2, P region alpha locus)  MGI
Rattus norvegicus (Norway rat) : RT1-Ha (RT1 class II, locus Ha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102025724 (HLA class II histocompatibility antigen, DP alpha 1 chain)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100995577 (HLA class II histocompatibility antigen, DP alpha 1 chain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101958908 (HLA class II histocompatibility antigen, DP alpha 1 chain)
Chlorocebus sabaeus (African green monkey) : MHC-DPA1 (major histocompatibility complex, class II, DP alpha 1)
Heterocephalus glaber (naked mole-rat) : LOC101698463 (HLA class II histocompatibility antigen, DP alpha 1 chain)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl633,064,569 - 33,080,775 (-)EnsemblGRCh38hg38GRCh38
GRCh38633,064,569 - 33,080,748 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37633,032,346 - 33,048,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,140,772 - 33,149,356 (-)NCBINCBI36hg18NCBI36
Celera634,581,565 - 34,590,149 (-)NCBI
Cytogenetic Map6p21.32NCBI
HuRef632,774,786 - 32,790,995 (-)NCBIHuRef
CHM1_1633,034,023 - 33,050,238 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on HLA-DPA1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1605730
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-05-19
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.