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Gene: RIC8B (RIC8 guanine nucleotide exchange factor B) Homo sapiens
Symbol: RIC8B
Name: RIC8 guanine nucleotide exchange factor B
Description: Exhibits G-protein alpha-subunit binding activity. Involved in regulation of G protein-coupled receptor signaling pathway. Localizes to the cytosol and plasma membrane; INTERACTS WITH aflatoxin B1; antirheumatic drug; benzo[e]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: brain synembrin; brain synembryn; FLJ10620; hSyn; MGC39476; resistance to inhibitors of cholinesterase 8 homolog B; RIC8; synembryn-B
Mus musculus (house mouse) : Ric8b (RIC8 guanine nucleotide exchange factor B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ric8b (RIC8 guanine nucleotide exchange factor B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ric8b (RIC8 guanine nucleotide exchange factor B)
Pan paniscus (bonobo/pygmy chimpanzee) : RIC8B (RIC8 guanine nucleotide exchange factor B)
Canis lupus familiaris (dog) : RIC8B (RIC8 guanine nucleotide exchange factor B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ric8b (RIC8 guanine nucleotide exchange factor B)
Sus scrofa (pig) : RIC8B (RIC8 guanine nucleotide exchange factor B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl12106,774,621 - 106,889,316 (+)Ensembl
GRCh3812106,774,621 - 106,889,316 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712107,168,077 - 107,283,094 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612105,692,529 - 105,807,224 (+)NCBINCBI36hg18NCBI36
Celera12106,833,992 - 106,948,676 (+)NCBI
Cytogenetic Map12q23.3NCBI
HuRef12104,228,794 - 104,343,508 (+)NCBIHuRef
CHM1_112107,134,243 - 107,248,934 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RIC8B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1605657
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.