Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | EXP | | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of METTL8 mRNA | CTD | PMID:22079256 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of METTL8 mRNA | CTD | PMID:31614463 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Mettl8 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of METTL8 mRNA | CTD | PMID:21570461 | 4,4'-sulfonyldiphenol | increases expression | ISO | Mettl8 (Mus musculus) | 6480464 | bisphenol S results in increased expression of METTL8 mRNA | CTD | PMID:31881267 | 6-propyl-2-thiouracil | decreases expression | ISO | Mettl8 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of METTL8 mRNA | CTD | PMID:24780913 and PMID:30047161 | acrolein | multiple interactions | EXP | | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of METTL8 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of METTL8 mRNA | CTD | PMID:32699268 | acrylamide | increases expression | ISO | Mettl8 (Mus musculus) | 6480464 | Acrylamide results in increased expression of METTL8 mRNA | CTD | PMID:30807115 | aflatoxin B1 | increases methylation | EXP | | 6480464 | Aflatoxin B1 results in increased methylation of METTL8 intron | CTD | PMID:30157460 | Aflatoxin B2 alpha | increases methylation | EXP | | 6480464 | aflatoxin B2 results in increased methylation of METTL8 intron | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of METTL8 mRNA | CTD | PMID:23724009 and PMID:33167477 | alpha-pinene | multiple interactions | EXP | | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of METTL8 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of METTL8 mRNA | CTD | PMID:32699268 | amitrole | decreases expression | ISO | Mettl8 (Rattus norvegicus) | 6480464 | Amitrole results in decreased expression of METTL8 mRNA | CTD | PMID:30047161 | arsenite(3-) | multiple interactions | EXP | | 6480464 | arsenite promotes the reaction [G3BP1 protein binds to METTL8 mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | decreases expression | ISO | Mettl8 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of METTL8 mRNA | CTD | PMID:19770486 and PMID:21715664 | benzo[a]pyrene | decreases methylation | ISO | Mettl8 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased methylation of METTL8 intron | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of METTL8 mRNA | CTD | PMID:26238291 | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of METTL8 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | Mettl8 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of METTL8 mRNA | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | increases expression | EXP | | 6480464 | 7 more ... | CTD | PMID:26238291 | benzo[e]pyrene | increases methylation | EXP | | 6480464 | benzo(e)pyrene results in increased methylation of METTL8 intron | CTD | PMID:30157460 | calcitriol | decreases expression | EXP | | 6480464 | Calcitriol results in decreased expression of METTL8 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | EXP | | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of METTL8 mRNA | CTD | PMID:21592394 | calcium silicate | increases expression | ISO | Mettl8 (Mus musculus) | 6480464 | calcium silicate results in increased expression of METTL8 mRNA | CTD | PMID:29279043 | chlorpyrifos | decreases expression | ISO | Mettl8 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of METTL8 mRNA | CTD | PMID:37019170 | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of METTL8 mRNA | CTD | PMID:27392435 | cisplatin | multiple interactions | EXP | | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of METTL8 mRNA | CTD | PMID:27392435 | copper atom | multiple interactions | ISO | Mettl8 (Rattus norvegicus) | 6480464 | [Copper co-treated with Dietary Sucrose] results in decreased expression of METTL8 mRNA | CTD | PMID:26033743 | copper(0) | multiple interactions | ISO | Mettl8 (Rattus norvegicus) | 6480464 | [Copper co-treated with Dietary Sucrose] results in decreased expression of METTL8 mRNA | CTD | PMID:26033743 | copper(II) sulfate | decreases expression | EXP | | 6480464 | Copper Sulfate results in decreased expression of METTL8 mRNA | CTD | PMID:19549813 | dioxygen | increases expression | ISO | Mettl8 (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of METTL8 mRNA | CTD | PMID:24205000 | dioxygen | affects methylation | ISO | Mettl8 (Mus musculus) | 6480464 | Oxygen deficiency affects the methylation of METTL8 promoter | CTD | PMID:24205000 | dorsomorphin | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of METTL8 mRNA | CTD | PMID:29803840 | entinostat | increases expression | EXP | | 6480464 | entinostat results in increased expression of METTL8 mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of METTL8 mRNA | CTD | PMID:27188386 | epoxiconazole | decreases expression | ISO | Mettl8 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of METTL8 mRNA | CTD | PMID:35436446 | formaldehyde | decreases expression | EXP | | 6480464 | Formaldehyde results in decreased expression of METTL8 mRNA | CTD | PMID:27664576 | gallic acid | increases expression | EXP | | 6480464 | Gallic Acid results in increased expression of METTL8 mRNA | CTD | PMID:34408198 | methamphetamine | decreases expression | ISO | Mettl8 (Mus musculus) | 6480464 | Methamphetamine results in decreased expression of METTL8 mRNA | CTD | PMID:26307267 | methapyrilene | increases methylation | EXP | | 6480464 | Methapyrilene results in increased methylation of METTL8 intron | CTD | PMID:30157460 | methimazole | decreases expression | ISO | Mettl8 (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of METTL8 mRNA | CTD | PMID:30047161 | methoxychlor | affects methylation | ISO | Mettl8 (Rattus norvegicus) | 6480464 | Methoxychlor affects the methylation of METTL8 gene | CTD | PMID:35440735 | methylmercury chloride | increases expression | EXP | | 6480464 | methylmercuric chloride results in increased expression of METTL8 mRNA | CTD | PMID:28001369 | ozone | multiple interactions | EXP | | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of METTL8 mRNA more ... | CTD | PMID:32699268 | paracetamol | affects expression | ISO | Mettl8 (Mus musculus) | 6480464 | Acetaminophen affects the expression of METTL8 mRNA | CTD | PMID:17562736 | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of METTL8 mRNA | CTD | PMID:19159669 | phenylmercury acetate | increases expression | EXP | | 6480464 | Phenylmercuric Acetate results in increased expression of METTL8 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of METTL8 mRNA | CTD | PMID:27188386 | potassium chromate | multiple interactions | EXP | | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of METTL8 mRNA | CTD | PMID:22079256 | potassium chromate | decreases expression | EXP | | 6480464 | potassium chromate(VI) results in decreased expression of METTL8 mRNA | CTD | PMID:22079256 | SB 431542 | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sulfadimethoxine | decreases expression | ISO | Mettl8 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in decreased expression of METTL8 mRNA | CTD | PMID:30047161 | testosterone | decreases expression | EXP | | 6480464 | Testosterone results in decreased expression of METTL8 mRNA | CTD | PMID:21592394 | testosterone | multiple interactions | EXP | | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of METTL8 mRNA | CTD | PMID:21592394 | tetrachloromethane | decreases expression | ISO | Mettl8 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in decreased expression of METTL8 mRNA | CTD | PMID:31150632 | tetrachloromethane | decreases expression | ISO | Mettl8 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of METTL8 mRNA | CTD | PMID:31919559 | thioacetamide | decreases expression | ISO | Mettl8 (Rattus norvegicus) | 6480464 | Thioacetamide results in decreased expression of METTL8 mRNA | CTD | PMID:34492290 | trichostatin A | increases expression | EXP | | 6480464 | trichostatin A results in increased expression of METTL8 mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of METTL8 mRNA | CTD | PMID:27188386 | urethane | decreases expression | EXP | | 6480464 | Urethane results in decreased expression of METTL8 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of METTL8 mRNA | CTD | PMID:25979313 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of METTL8 mRNA | CTD | PMID:23179753 and PMID:26272509 | valproic acid | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of METTL8 mRNA | CTD | PMID:27188386 | |